European Journal of Clinical Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Untapped options to reduce waste from blister packaging for tablets and capsules
ConclusionConsidering that other ecological strategies are not yet mature, the optimal arrangement of blister chambers would be a captivatingly simple and, above all, immediately implementable strategy to avoid large amounts of avoidable waste. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 18, 2023 Category: Drugs & Pharmacology Source Type: research

Direct oral anticoagulants and the risk of adverse clinical outcomes among patients with different body weight categories: a large hospital-based study
ConclusionThis study shows the positive effects of DOAC therapy on clinical outcomes, particularly in patients with high body weight. However, this still needs validation by further studies particularly among patients with morbid obesity. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 18, 2023 Category: Drugs & Pharmacology Source Type: research

Effect of intravenous lidocaine on outcomes in patients receiving propofol for gastrointestinal endoscopic procedures: an updated systematic review and meta-analysis
ConclusionOur results show that IV lidocaine improves patient outcomes by reducing post-procedural pain, decreasing propofol usage, shortening recovery time, and lowering pain scores. This study provides compelling evidence supporting the use of intravenous lidocaine as an adjunct to propofol sedation for gastrointestinal endoscopic procedures. However, further research is necessary to optimize the use of lidocaine and fully understand its long-term effects. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 14, 2023 Category: Drugs & Pharmacology Source Type: research

The role of anti-diabetic drugs in NAFLD. Have we found the Holy Grail? A narrative review
ConclusionIn patients with NAFLD and diabetes, pioglitazone, GLP1 RAs, and SGLT2i seem to be logical treatment options. Larger studies are needed before these drugs can be recommended for non-diabetic individuals. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 8, 2023 Category: Drugs & Pharmacology Source Type: research

Factors influencing methotrexate pharmacokinetics highlight the need for individualized dose adjustment: a systematic review
ConclusionsMethotrexate dosage regimens were primarily based on body surface area and renal function. Further studies are needed to evaluate MTX pharmacokinetics and pharmacodynamics in both children (especially infants) and adults. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 7, 2023 Category: Drugs & Pharmacology Source Type: research

The benefit of omeprazole exposure on all-cause mortality and length of ICU/hospital stay might vary with age in critically ill pediatric patients: A cohort study
ConclusionsThis study provided a sign that PPIs used only in the ICU, rather than throughout hospital stay, might provide more benefit for critically ill pediatric patients. Additionally, younger pediatric patients might gain relatively more benefit than older children when receiving PPIs. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 7, 2023 Category: Drugs & Pharmacology Source Type: research

Clinical pharmacokinetics and pharmacodynamics of ivosidenib in Chinese patients with relapsed or refractory IDH1-mutated acute myeloid leukemia
ConclusionThe study indicates that ivosidenib can be used effectively in Chinese patients, and the observed ethnic differences in PK exposure can be explained by concomitant drug effects. The popPK model contributes to a better understanding and optimization of personalized dosing in Chinese patients with mIDH1 R/R AML. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 2, 2023 Category: Drugs & Pharmacology Source Type: research

The reference range of lamotrigine in the treatment of epilepsy in children: a systematic review
ConclusionSeveral studies have estimated the reference range of lamotrigine for childhood epilepsy, while controversy exist and no studies have determined the upper limit of the range based on safety data. To establish the optimal reference range, further high-quality studies are necessary that consider both efficacy and safety data. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 31, 2023 Category: Drugs & Pharmacology Source Type: research

Retrospective review of intermittent and continuous infusion vancomycin for methicillin-resistant Staphylococcus aureus bacteremia
ConclusionFor MRSA bacteremia, CIV enabled patients to achieve the AUC/MIC goal significantly faster than when patients received IIV. Furthermore, patients who were unable to achieve a therapeutic trough on IIV became therapeutic once switched to CIV. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 28, 2023 Category: Drugs & Pharmacology Source Type: research

Empagliflozin and colchicine in patients with reduced left ventricular ejection fraction following ST-elevation myocardial infarction: a randomized, double-blinded, three-arm parallel-group, controlled trial
ConclusionThis study showed that neither the combination treatment of empagliflozin 10 mg/day with colchicine nor the monotherapy of empagliflozin 25 mg/day was superior to empagliflozin 10 mg/day in terms of changes in clinical, inflammatory, and echocardiographic outcome parameters in patients with recent MI with reduced LVEF over 3 months. Further studies are warranted to confirm the findings.Trial registrationClinical trial ID: IRCT20111206008307N39. Registration date: 27 October 2022.https://www.irct.ir/trial/66216 (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 28, 2023 Category: Drugs & Pharmacology Source Type: research

Limited sampling strategy and population pharmacokinetic model of mycophenolic acid in pediatric patients with systemic lupus erythematosus: application of a double gamma absorption model with SAEM algorithm
ConclusionThe POPPK developed in this study adequately estimated the MPA AUC in pediatric patients with SLE based on three samples. The double absorption gamma model developed with the SAEM algorithm showed very accurate fit and reduced computation time. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 28, 2023 Category: Drugs & Pharmacology Source Type: research