European Journal of Clinical Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Comparing AGS Beers 2019, STOPP version 2, and EU(7)-PIM list in Portuguese older adults in primary health care
ConclusionThis study reveals varying prevalence rates of PIM in older adults, as assessed by different criteria, and highlights the need for targeted interventions and improved prescribing practices. In the future, studies should focus on the occurrence of negative outcomes in older adults associated with PIM consumption. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 6, 2024 Category: Drugs & Pharmacology Source Type: research

Association of SGLT2 inhibitor dapagliflozin with risks of acute kidney injury and all-cause mortality in acute myocardial infarction patients
ConclusionSGLT2 inhibitor DAPA was associated with lower risks of incident AKI and all-cause mortality in AMI patients after PCI therapy. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 6, 2024 Category: Drugs & Pharmacology Source Type: research

Feasibility and safety of EGFR-TKI neoadjuvant therapy for EGFR-mutated NSCLC: A meta-analysis
ConclusionsOur meta-analysis confirmed the efficacy and safety of neoadjuvant EGFR-TKIs for the treatment of NSCLC patients with EGFR-positive mutations and that third-generation EGFR-TKIs were superior to first- and second-generation EGFR-TKIs in terms of shrinking tumor volume and lowering tumor stage; however, future large-scale and multicenter randomized controlled trials are needed to confirm this conclusion.Systematic review registrationPROSPERO CRD42023466731 (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 1, 2024 Category: Drugs & Pharmacology Source Type: research

Comment on “Risk of gastric cancer among long‑term proton pump inhibitor users: a population‑based cohort study”
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 31, 2024 Category: Drugs & Pharmacology Source Type: research

Dabigatran-related serious medication errors: an analysis using data from VigiBase
ConclusionBased on the analysis of reports in VigiBase, serious MEs related to dabigatran mainly occurred during prescription and administration. Although the incidence of MEs with clinical consequences in the use of dabigatran cannot be determined, attention should be paid to selection of the appropriate dose to a right patient in the prescription, and to patient compliance and storage in drug administration. The patient harm mainly manifested itself as bleeding or ischemia including fatal outcome in rare patients. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 29, 2024 Category: Drugs & Pharmacology Source Type: research

Association of the predicted free blood concentration of teicoplanin with the development of renal dysfunction
ConclusionElevated free trough concentrations of TEIC were associated with an increased risk of renal dysfunction. Controlling the increase in the predicted free blood concentration may effectively prevent the development of renal dysfunction. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 29, 2024 Category: Drugs & Pharmacology Source Type: research

Estimating the impact of label design on reducing the risk of medication errors by applying HEART in drug administration
ConclusionIncluding labelling design based on HFE might help increase human reliability when administering medications under critical conditions. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 29, 2024 Category: Drugs & Pharmacology Source Type: research

The relationship between use of SGLT2is and incidence of respiratory and infectious diseases and site-specific fractures: a meta-analysis based on 32 large RCTs
ConclusionsOur meta-analysis confirmed the benefits of SGLT2is against 6 kinds of noninfectious respiratory diseases (e.g., Asthma, COPD, and Respiratory failure) and 4 kinds of infectious respiratory diseases (e.g., Bronchitis, and Pneumonia). These findings suggest a likelihood that SGLT2is might be used to prevent or treat these respiratory diseases. Moreover, our meta-analysis for the first time revealed no association between use of SGLT2is and incidence of various site-specific fractures. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 25, 2024 Category: Drugs & Pharmacology Source Type: research

Patterns of inappropriate prescribing and clinical characteristics in patients at admission to an acute care of the elderly unit
ConclusionsWe found statistically significant association between patterns of inappropriate prescribing and clinical and CGA variables such as comorbidity, dependency, dementia or frailty. There is a statistically significant association between patterns of overprescribing among patients admitted to the ACE unit. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 24, 2024 Category: Drugs & Pharmacology Source Type: research