Successful treatment of concurrent cold agglutinin disease and myelodysplastic syndrome
Herein, we describe a case of severe anemia presenting with myelodysplastic syndrome with cold agglutinin disease that was successfully treated by a moderate dose of steroids followed by cyclosporine. In patients with myelodysplastic syndrome, autoimmunity in erythroid cells is occasionally demonstrated, and autoimmune hemolytic anemia is seen in some patients. However, hemolytic anemia with cold agglutinin in patients with myelodysplastic syndrome is less common, and the effect of corticosteroids for autoimmune hemolytic anemia caused by cold agglutinin is thought to be limited. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 25, 2024 Category: Hematology Authors: Rie Tabata, Chiharu Tabata Source Type: research
The relationship between prescription rates of oral corticosteroids for respiratory diseases and deprivation in England
npj Primary Care Respiratory Medicine, Published online: 25 April 2024; doi:10.1038/s41533-024-00362-1The relationship between prescription rates of oral corticosteroids for respiratory diseases and deprivation in England (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - April 25, 2024 Category: Primary Care Authors: Erin Barker Jessica Pocock Joe Moss Nick Hex Jordan Rankin Richard Hudson Source Type: research
Molecules, Vol. 29, Pages 1972: Pharmacological Activities of Lonicerae japonicae flos and Its Derivative & mdash; & ldquo;Chrysoeriol & rdquo; in Skin Diseases
Conclusion: The cutaneous route is the best delivery approach to chrysoeriol across the skin barrier. However, toxicity, dosage, and safety assessments of chrysoeriol in a formulation or nanochrysoeriol on the human epidermis for application in skin diseases must be further investigated. (Source: Molecules)
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Siu Kan Law Xiao Xiao Wu Zhou Jiang Christy Wing Sum Tong Wesley Yeuk Lung Chow Dawn Ching Tung Au Tags: Review Source Type: research
Eosinophilic myocarditis: systematic review
Conclusion
EMB is the mainstay for diagnostic testing for EM. CMR is potentially helpful for screening in appropriate clinical scenarios. Regarding treatment, there is no consensus regarding the optimal dosage of corticosteroids. Large clinical trials are warranted to further explore the utility of CMR in the diagnosis of EM and steroid regimen in treating EM. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: Techasatian, W., Gozun, M., Vo, K., Yokoyama, J., Nagamine, T., Shah, P., Vu, K., Zhang, J., Nishimura, Y. Tags: Systematic review Source Type: research
Efficacy and safety of colchicine for the treatment of myopericarditis
Conclusion
In patients with first attack of pericarditis associated with myocardial involvement, colchicine was safe and efficacious for the reduction of recurrences. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: Collini, V., De Martino, M., Andreis, A., De Biasio, M., Gaspard, F., Paneva, E., Tomat, M., Deferrari, G. M., Isola, M., Imazio, M. Tags: Open access, Editor's choice Special populations Source Type: research
Optic neuritis and mydriasis after vaccination: a case report
ConclusionThis study describes a very unusual case of bilateral ON associated with prolonged mydriasis after vaccination against tetanus and diphtheria that regressed after treatment with oral corticosteroids. Prolonged mydriasis was the manifestation that differed from the other cases previously described. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 25, 2024 Category: General Medicine Source Type: research
Preoperative Optimization of Crohn's Patients before Abdominopelvic Surgery
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786380In this article, we review and identify modifiable risk factors associated with postoperative complications of Crohn's disease. We highlight the importance of factors such as nutrition, corticosteroids, immunomodulators, abscesses, ideal timing of surgery, and biologic and small-molecule therapy on surgical outcomes. Herein, we discuss the strategies for attenuating these risk factors. Special consideration is given to venous thromboembolism prophylaxis in this patient population. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAA...
Source: Clinics in Colon and Rectal Surgery - April 25, 2024 Category: Surgery Authors: Moussally, Moustafa Paski, Shirley C. Cohen, Benjamin Holubar, Stefan D. Tags: Review Article Source Type: research
Intraclass comparison of inhaled corticosteroids for the risk of pneumonia in chronic obstructive pulmonary airway disorder: a network meta-analysis and meta-regression
ConclusionICS class differences in pneumonia risk were observed in terms of pooled effect estimates but it is unlikely that any clinically relevant differences exist. Risk –benefit analysis supports ICS use in moderate-severe COPD. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 25, 2024 Category: Drugs & Pharmacology Source Type: research
Mini-dose methotrexate combined with methylprednisolone for the initial treatment of acute GVHD: a multicentre, randomized trial
There is an urgent unmet need for effective initial treatment for acute graft-versus-host disease (aGVHD) adding to the standard first-line therapy with corticosteroids after allogeneic haematopoietic stem cel... (Source: BMC Medicine)
Source: BMC Medicine - April 25, 2024 Category: Internal Medicine Authors: Yu Wang, Qi-Fa Liu, De-Pei Wu, Zheng-Li Xu, Ting-Ting Han, Yu-Qian Sun, Fen Huang, Zhi-Ping Fan, Na Xu, Feng Chen, Ye Zhao, Yuan Kong, Xiao-Dong Mo, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu & hellip; Tags: Research article Source Type: research
Intraclass comparison of inhaled corticosteroids for the risk of pneumonia in chronic obstructive pulmonary airway disorder: a network meta-analysis and meta-regression
ConclusionICS class differences in pneumonia risk were observed in terms of pooled effect estimates but it is unlikely that any clinically relevant differences exist. Risk –benefit analysis supports ICS use in moderate-severe COPD. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 25, 2024 Category: Drugs & Pharmacology Source Type: research
Serious neurological adverse events in immunocompetent children and adolescents caused by viral reactivation in the years following varicella vaccination
Rev Med Virol. 2024 May;34(3):e2538. doi: 10.1002/rmv.2538.ABSTRACTSerious adverse events following vaccination include medical complications that require hospitalisation. The live varicella vaccine that was approved by the Food and Drug Administration in the United States in 1995 has an excellent safety record. Since the vaccine is a live virus, adverse events are more common in immunocompromised children who are vaccinated inadvertently. This review includes only serious adverse events in children considered to be immunocompetent. The serious adverse event called varicella vaccine meningitis was first reported in a hospi...
Source: Herpes - April 24, 2024 Category: Infectious Diseases Authors: Prashanth Ramachandran Charles Grose Source Type: research
Treatment of cryptogenic new-onset refractory status epilepticus (C-NORSE) with tocilizumab: A case report
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3392-23. Online ahead of print.ABSTRACTA 35-year-old woman with no prior history of epilepsy developed status epilepticus (SE), which was highly resistant to multiple antiseizure medications and sedatives. The etiology of SE was not identified despite extensive investigation, and the patient was diagnosed with cryptogenic new-onset refractory status epilepticus (C-NORSE). Although first-line immunotherapies such as high-dose corticosteroids and plasma exchange were ineffective, the patient manifested a resolution of SE after the administration of tocilizumab, which inh...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Yumiko Nakamura Masayuki Ueda Satoshi Kodama Tomohiko Kimura Yuichiro Shirota Masashi Hamada Hiroyuki Ishiura Takahiro Iizuka Tatsushi Toda Source Type: research
Long-term real-world data of ustekinumab in Crohn's disease: the Stockholm ustekinumab study
CONCLUSION: Among difficult-to-treat patients with CD, ustekinumab was effective in the majority, with high drug persistence at 12 and 24 months in combination with a favourable safety profile.PMID:38655034 | PMC:PMC11036920 | DOI:10.1177/17562848241242700 (Source: Adv Data)
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Francesca Bello Samer Muhsen Haider Sabhan Alexandra Borin Fredrik Johansson Charlotte H öög Ole Forsberg Christina Wennerstr öm Charlotte S öderman Mikael L ördal Sven Almer Source Type: research
Treatment of cryptogenic new-onset refractory status epilepticus (C-NORSE) with tocilizumab: A case report
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3392-23. Online ahead of print.ABSTRACTA 35-year-old woman with no prior history of epilepsy developed status epilepticus (SE), which was highly resistant to multiple antiseizure medications and sedatives. The etiology of SE was not identified despite extensive investigation, and the patient was diagnosed with cryptogenic new-onset refractory status epilepticus (C-NORSE). Although first-line immunotherapies such as high-dose corticosteroids and plasma exchange were ineffective, the patient manifested a resolution of SE after the administration of tocilizumab, which inh...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Yumiko Nakamura Masayuki Ueda Satoshi Kodama Tomohiko Kimura Yuichiro Shirota Masashi Hamada Hiroyuki Ishiura Takahiro Iizuka Tatsushi Toda Source Type: research
