Outcome of Human Parainfluenza Virus infection in allogeneic stem cell transplantation recipients: possible impact of ribavirin therapy
ConclusionALC, corticosteroids, and fever increased the risk for progression to LRTD while ribavirin decreased the risk. However, mortality was associated with ALC and co-infections. This study supports further research of ribavirin therapy for hPIV in the allo-HSCT setting. (Source: Infection)
Source: Infection - April 24, 2024 Category: Infectious Diseases Source Type: research
Late Preterm Corticosteroids Exposure and Neurodevelopmental Outcomes
In recent years, there has been a reevaluation of the upper gestational age limit recommended for administration of antenatal corticosteroids. Seven randomized clinical trials (RCTs) published between 2010 and 2022 have evaluated the effects of expanding the limit from 34 to 37 weeks ’ gestation. The largest of these was the Antenatal Late Preterm Steroids (ALPS) trial published in 2016. In this trial, the administration of antenatal corticosteroids yielded a 20% relative reduction in the primary outcome (respiratory morbidity). The absolute reduction in the primary outcome wa s only 2.8% (from 14.4% to 11.65%), and the ...
Source: JAMA - Journal of the American Medical Association - April 24, 2024 Category: General Medicine Source Type: research
Neurodevelopmental Outcomes After Late Preterm Corticosteroids
This prospective follow-up study of a randomized clinical trial evaluates whether antenatal corticosteroids administered to birthing parents at risk of late preterm delivery were associated with adverse neurodevelopmental effects on their offspring. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 24, 2024 Category: General Medicine Source Type: research
Rituximab in non-systemic vasculitic neuropathy: a single-center experience
DiscussionAnti-CD20 therapy might be an alternative in NSVN patients requiring further treatment escalation or treatment switch due to side effects of corticosteroids or cyclophosphamide. (Source: Journal of Neurology)
Source: Journal of Neurology - April 24, 2024 Category: Neurology Source Type: research
Outcome of Human Parainfluenza Virus infection in allogeneic stem cell transplantation recipients: possible impact of ribavirin therapy
ConclusionALC, corticosteroids, and fever increased the risk for progression to LRTD while ribavirin decreased the risk. However, mortality was associated with ALC and co-infections. This study supports further research of ribavirin therapy for hPIV in the allo-HSCT setting. (Source: Infection)
Source: Infection - April 24, 2024 Category: Infectious Diseases Source Type: research
Eosinophilic Pleural Effusion Secondary to Trichinella spiralis Infection in a Patient with Systemic Sclerosis: A Case Report
CONCLUSIONS This report highlights the possibility of developing rare or even not-until-now seen complications when 2 etiologically different diseases are associated. The physician should carefully assess the situation to find and resolve the underlying causes.PMID:38652711 | DOI:10.12659/AJCR.943420 (Source: Pain Physician)
Source: Pain Physician - April 23, 2024 Category: Anesthesiology Authors: M ădălina Ștefania Vulcan Andrei-Daniel Dragne Camelia Georgeta Badea Source Type: research
Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways
CONCLUSIONS: Distinct immunologic ircAE endotypes suggest actionable targets for precision medicine-based interventions.PMID:38652814 | DOI:10.1158/1078-0432.CCR-23-3431 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 23, 2024 Category: Cancer & Oncology Authors: Mario E Lacouture Elena Goleva Neil Shah Veronica Rotemberg Lukas Kraehenbuehl Kwami F Ketosugbo Taha Merghoub Tara Maier Alexander Bang Stephanie Gu Trina Salvador Andrea P Moy Taras Lyubchenko Olivia Xiao Clifton F Hall Evgeny Berdyshev James Crooks Rya Source Type: research
Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways
CONCLUSIONS: Distinct immunologic ircAE endotypes suggest actionable targets for precision medicine-based interventions.PMID:38652814 | DOI:10.1158/1078-0432.CCR-23-3431 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Mario E Lacouture Elena Goleva Neil Shah Veronica Rotemberg Lukas Kraehenbuehl Kwami F Ketosugbo Taha Merghoub Tara Maier Alexander Bang Stephanie Gu Trina Salvador Andrea P Moy Taras Lyubchenko Olivia Xiao Clifton F Hall Evgeny Berdyshev James Crooks Rya Source Type: research
A systematic review of randomised controlled trials on topical nasal steroids
CONCLUSIONS: BDP nasal spray is one of the most frequently prescribed INC for rhinitis and rhinosinusitis. Treatment with BDP resulted in significant and clinically meaningful improvements in nasal symptoms associated with AR and CRS. BDP is well tolerated, and the safety profile is similar to that of placebo in most patients. These results, in conjunction with the significant benefit reported in subjects with CRS and AR, provide convincing evidence of the overall effectiveness of BDP for the treatment of the full spectrum of sinonasal disease.PMID:38651550 | DOI:10.14639/0392-100X-N2745 (Source: Acta Otorhinolaryngologica Italica)
Source: Acta Otorhinolaryngologica Italica - April 23, 2024 Category: ENT & OMF Authors: Chiara Zeroli Armela Gorica Giulia Monti Paolo Giocondo Maria Castelnuovo Maurizio Bignami Alberto Macchi Source Type: research
Acute Myopic Shift after a Single Dose of Acetazolamide: A Case Report and Review of the Literature
We report the case of a 32-year-old male who presented with an acute myopic shift as a result of uveal effusion following a single administration of 250 mg acetazolamide. The drug was discontinued and following cycloplegia and topical steroid therapy, we observed progressive deepening of the anterior chamber, reopening of the iridocorneal angle, and complete resolution of the myopic shift after 5 days. A literature review since 1956 identified 23 cases, including ours, which developed a myopic shift after a median time of 24 h (3 - 24) following a median dose of 500 mg (125 - 1000) acetazolamide, with about a third complic...
Source: Klinische Monatsblatter fur Augenheilkunde - April 23, 2024 Category: Opthalmology Authors: Eirini Kaisari Hana Abouzeid Laurent Magnin Melanie Boeuf Evangelia Gkaragkani Ann Schalenbourg Thomas J Wolfensberger Pierre-Fran çois Kaeser Source Type: research
Eosinophilic Pleural Effusion Secondary to Trichinella spiralis Infection in a Patient with Systemic Sclerosis: A Case Report
CONCLUSIONS This report highlights the possibility of developing rare or even not-until-now seen complications when 2 etiologically different diseases are associated. The physician should carefully assess the situation to find and resolve the underlying causes.PMID:38652711 | DOI:10.12659/AJCR.943420 (Source: Pain Physician)
Source: Pain Physician - April 23, 2024 Category: Anesthesiology Authors: M ădălina Ștefania Vulcan Andrei-Daniel Dragne Camelia Georgeta Badea Source Type: research
Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways
CONCLUSIONS: Distinct immunologic ircAE endotypes suggest actionable targets for precision medicine-based interventions.PMID:38652814 | DOI:10.1158/1078-0432.CCR-23-3431 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 23, 2024 Category: Cancer & Oncology Authors: Mario E Lacouture Elena Goleva Neil Shah Veronica Rotemberg Lukas Kraehenbuehl Kwami F Ketosugbo Taha Merghoub Tara Maier Alexander Bang Stephanie Gu Trina Salvador Andrea P Moy Taras Lyubchenko Olivia Xiao Clifton F Hall Evgeny Berdyshev James Crooks Rya Source Type: research
A systematic review of randomised controlled trials on topical nasal steroids
CONCLUSIONS: BDP nasal spray is one of the most frequently prescribed INC for rhinitis and rhinosinusitis. Treatment with BDP resulted in significant and clinically meaningful improvements in nasal symptoms associated with AR and CRS. BDP is well tolerated, and the safety profile is similar to that of placebo in most patients. These results, in conjunction with the significant benefit reported in subjects with CRS and AR, provide convincing evidence of the overall effectiveness of BDP for the treatment of the full spectrum of sinonasal disease.PMID:38651550 | PMC:PMC11042551 | DOI:10.14639/0392-100X-N2745 (Source: Acta Oto...
Source: Acta Otorhinolaryngologica Italica - April 23, 2024 Category: ENT & OMF Authors: Chiara Zeroli Armela Gorica Giulia Monti Paolo Giocondo Maria Castelnuovo Maurizio Bignami Alberto Macchi Source Type: research
Acute Myopic Shift after a Single Dose of Acetazolamide: A Case Report and Review of the Literature
We report the case of a 32-year-old male who presented with an acute myopic shift as a result of uveal effusion following a single administration of 250 mg acetazolamide. The drug was discontinued and following cycloplegia and topical steroid therapy, we observed progressive deepening of the anterior chamber, reopening of the iridocorneal angle, and complete resolution of the myopic shift after 5 days. A literature review since 1956 identified 23 cases, including ours, which developed a myopic shift after a median time of 24 h (3 - 24) following a median dose of 500 mg (125 - 1000) acetazolamide, with about a third complic...
Source: Klinische Monatsblatter fur Augenheilkunde - April 23, 2024 Category: Opthalmology Authors: Eirini Kaisari Hana Abouzeid Laurent Magnin Melanie Boeuf Evangelia Gkaragkani Ann Schalenbourg Thomas J Wolfensberger Pierre-Fran çois Kaeser Source Type: research
A systematic review of randomised controlled trials on topical nasal steroids
CONCLUSIONS: BDP nasal spray is one of the most frequently prescribed INC for rhinitis and rhinosinusitis. Treatment with BDP resulted in significant and clinically meaningful improvements in nasal symptoms associated with AR and CRS. BDP is well tolerated, and the safety profile is similar to that of placebo in most patients. These results, in conjunction with the significant benefit reported in subjects with CRS and AR, provide convincing evidence of the overall effectiveness of BDP for the treatment of the full spectrum of sinonasal disease.PMID:38651550 | PMC:PMC11042551 | DOI:10.14639/0392-100X-N2745 (Source: Acta Oto...
Source: Acta Otorhinolaryngologica Italica - April 23, 2024 Category: ENT & OMF Authors: Chiara Zeroli Armela Gorica Giulia Monti Paolo Giocondo Maria Castelnuovo Maurizio Bignami Alberto Macchi Source Type: research
