Successful treatment of severe splenic lymphoma ‑associated hemophagocytic syndrome by splenectomy and subsequent chemotherapy: A case report
Oncol Lett. 2024 Mar 22;27(5):222. doi: 10.3892/ol.2024.14355. eCollection 2024 May.ABSTRACTHemophagocytic lymphohistiocytosis (HLH) represents a fatal immunopathology derived from excessive inflammatory reactions. In particular, lymphoma-associated hemophagocytic syndrome (LAHS) is associated with a dismal prognosis. The current study presented a challenging case of splenic LAHS. A 71-year-old man presented with fatigue and anorexia. Laboratory test results revealed anemia, thrombocytopenia, lactate dehydrogenase elevation and markedly elevated levels of ferritin (6,210 ng/ml) and soluble interleukin 2 receptor (sIL-2R; 1...
Source: Oncology Letters - April 9, 2024 Category: Cancer & Oncology Authors: Hideyuki Masui Maki Shindo Yuta Inoue Maki Sugiyama Atsushi Ueda Takero Shindo Kae Okoshi Koichi Kinoshita Source Type: research
Giant Cell Arteritis
Klin Monbl Augenheilkd. 2024 Apr 9. doi: 10.1055/a-2252-3371. Online ahead of print.ABSTRACTGiant cell arteritis (GCA) is the most common primary vasculitis and is associated with potential bilateral blindness. Neither clinical nor laboratory evidence is simple and unequivocal for this disease, which usually requires rapid and reliable diagnosis and therapy. The ophthalmologist should consider GCA with the following ocular symptoms: visual loss or visual field defects, transient visual disturbances (amaurosis fugax), diplopia, eye pain, or new onset head or jaw claudication. An immediate ophthalmological examination with s...
Source: Klinische Monatsblatter fur Augenheilkunde - April 9, 2024 Category: Opthalmology Authors: Thomas Ness Bernhard N ölle Source Type: research
Systemic and Bilateral Severe Ocular Toxoplasmosis Resembling Autoimmune Phenomena: A Case Report
CONCLUSION AND IMPORTANCE: This case underscores the importance of ruling out an infectious etiology in all cases of uveitis. Additionally, it alerts clinicians to the possibility that elevated positive autoantibodies may result from a severe inflammatory reaction caused by pathogens rather than an autoimmune or autoinflammatory disease, particularly in instances of poor treatment response or atypical clinical presentation.PMID:38592492 | DOI:10.1080/09273948.2024.2336605 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 9, 2024 Category: Allergy & Immunology Authors: Sofia Romero-Santos Daniela Parra-Tanoux Carlos Cifuentes-Gonz ález Juliana Mu ñoz-Ortiz Germ án Mejía-Salgado Alejandra de-la-Torre Source Type: research
Successful treatment of severe splenic lymphoma ‑associated hemophagocytic syndrome by splenectomy and subsequent chemotherapy: A case report
Oncol Lett. 2024 Mar 22;27(5):222. doi: 10.3892/ol.2024.14355. eCollection 2024 May.ABSTRACTHemophagocytic lymphohistiocytosis (HLH) represents a fatal immunopathology derived from excessive inflammatory reactions. In particular, lymphoma-associated hemophagocytic syndrome (LAHS) is associated with a dismal prognosis. The current study presented a challenging case of splenic LAHS. A 71-year-old man presented with fatigue and anorexia. Laboratory test results revealed anemia, thrombocytopenia, lactate dehydrogenase elevation and markedly elevated levels of ferritin (6,210 ng/ml) and soluble interleukin 2 receptor (sIL-2R; 1...
Source: Oncology Letters - April 9, 2024 Category: Cancer & Oncology Authors: Hideyuki Masui Maki Shindo Yuta Inoue Maki Sugiyama Atsushi Ueda Takero Shindo Kae Okoshi Koichi Kinoshita Source Type: research
Giant Cell Arteritis
Klin Monbl Augenheilkd. 2024 Apr 9. doi: 10.1055/a-2252-3371. Online ahead of print.ABSTRACTGiant cell arteritis (GCA) is the most common primary vasculitis and is associated with potential bilateral blindness. Neither clinical nor laboratory evidence is simple and unequivocal for this disease, which usually requires rapid and reliable diagnosis and therapy. The ophthalmologist should consider GCA with the following ocular symptoms: visual loss or visual field defects, transient visual disturbances (amaurosis fugax), diplopia, eye pain, or new onset head or jaw claudication. An immediate ophthalmological examination with s...
Source: Klinische Monatsblatter fur Augenheilkunde - April 9, 2024 Category: Opthalmology Authors: Thomas Ness Bernhard N ölle Source Type: research
Systemic and Bilateral Severe Ocular Toxoplasmosis Resembling Autoimmune Phenomena: A Case Report
CONCLUSION AND IMPORTANCE: This case underscores the importance of ruling out an infectious etiology in all cases of uveitis. Additionally, it alerts clinicians to the possibility that elevated positive autoantibodies may result from a severe inflammatory reaction caused by pathogens rather than an autoimmune or autoinflammatory disease, particularly in instances of poor treatment response or atypical clinical presentation.PMID:38592492 | DOI:10.1080/09273948.2024.2336605 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 9, 2024 Category: Allergy & Immunology Authors: Sofia Romero-Santos Daniela Parra-Tanoux Carlos Cifuentes-Gonz ález Juliana Mu ñoz-Ortiz Germ án Mejía-Salgado Alejandra de-la-Torre Source Type: research
CT-guided lumbar facet cyst rupture and corticosteroid injection: technique, approach, and procedural and clinical success rates
ConclusionOur systematic approach to CT-guided LFC rupture is safe and has high technical and clinical success rates similar to prior studies. Since there are no definitive imaging features that determine rupture success, this procedure can almost always be attempted as a first-line treatment for LFC. (Source: Skeletal Radiology)
Source: Skeletal Radiology - April 9, 2024 Category: Radiology Source Type: research
Perioperative Intravenous Dexamethasone Use Is Not Associated with Periprosthetic Joint Infection or Wound Healing Complications Following Shoulder Arthroplasty
Perioperative intravenous (IV) dexamethasone is commonly used in lower extremity total joint arthroplasty to manage postoperative pain and nausea/vomiting, and recent studies have demonstrated that its use may lower rates of acute postoperative medical complications. However, there is limited information regarding the safety and efficacy of IV dexamethasone in patients undergoing total shoulder arthroplasty (TSA). Additionally, there is concern surrounding corticosteroid use prior to surgery as preoperative corticosteroid injections have been associated with adverse outcomes after TSA, including periprosthetic joint infect...
Source: Journal of Shoulder and Elbow Surgery - April 9, 2024 Category: Orthopaedics Authors: Ryan D. Freshman, Jacob L. Kotlier, Cory K. Mayfield, Amir Fathi, Aamir Ahmad, Christian Cruz, Joseph N. Liu, Frank A. Petrigliano Tags: Original Article Source Type: research
Evolution of radiation-induced dermatitis treatment
AbstractRadiation-induced skin damage (RID) is the most prevalent, significant side effect of radiotherapy (RT). Nearly 95% of patients experience moderate to severe skin reactions after receiving radiation therapy. However, criteria for acute radiation dermatitis (ARD) treatment remain unavailable. Topical agents with anti-inflammatory properties may protect the skin and facilitate tissue regeneration in patients with RID. Many of these topical agents function through nuclear factor kappa B pathway regulation. They either reduce the levels of inflammatory factors or elicit anti-inflammatory properties of their own, thus p...
Source: Clinical and Translational Oncology - April 9, 2024 Category: Cancer & Oncology Source Type: research
Current and emerging pharmacotherapies for cytokine release syndrome, neurotoxicity, and hemophagocytic lymphohistiocytosis-like syndrome due to CAR T cell therapy
Expert Opin Pharmacother. 2024 Apr 8. doi: 10.1080/14656566.2024.2340738. Online ahead of print.ABSTRACTINTRODUCTION: Chimeric antigen receptor (CAR) T cells have revolutionized treatment of multiple hematologic malignancies. Engineered cellular therapies now offer similar hope to transform management of solid tumors and autoimmune disease. However, toxicities can be serious and often require hospitalization.AREAS COVERED: We review the two chief toxicities of CAR T therapy, cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), and the rarer immune effector cell-associated hemo...
Source: Expert Opinion on Pharmacotherapy - April 8, 2024 Category: Drugs & Pharmacology Authors: Zandra E Walton Matthew J Frigault Marcela V Maus Source Type: research
Revolutionizing the Treatment of Idiopathic Pulmonary Fibrosis: From Conventional Therapies to Advanced Drug Delivery Systems
This article elaborates on the pathophysiology of IPF, its risk factors, and different advanced drug delivery systems for treating IPF. Although extensive preclinical data is available for these delivery systems, the clinical performance and scale-up studies would decide their commercial translation.PMID:38589751 | DOI:10.1208/s12249-024-02793-y (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 8, 2024 Category: Drugs & Pharmacology Authors: Sanskriti Singh Sarika Wairkar Source Type: research
Current and emerging pharmacotherapies for cytokine release syndrome, neurotoxicity, and hemophagocytic lymphohistiocytosis-like syndrome due to CAR T cell therapy
Expert Opin Pharmacother. 2024 Apr 8. doi: 10.1080/14656566.2024.2340738. Online ahead of print.ABSTRACTINTRODUCTION: Chimeric antigen receptor (CAR) T cells have revolutionized treatment of multiple hematologic malignancies. Engineered cellular therapies now offer similar hope to transform management of solid tumors and autoimmune disease. However, toxicities can be serious and often require hospitalization.AREAS COVERED: We review the two chief toxicities of CAR T therapy, cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), and the rarer immune effector cell-associated hemo...
Source: Expert Opinion on Pharmacotherapy - April 8, 2024 Category: Drugs & Pharmacology Authors: Zandra E Walton Matthew J Frigault Marcela V Maus Source Type: research
Revolutionizing the Treatment of Idiopathic Pulmonary Fibrosis: From Conventional Therapies to Advanced Drug Delivery Systems
This article elaborates on the pathophysiology of IPF, its risk factors, and different advanced drug delivery systems for treating IPF. Although extensive preclinical data is available for these delivery systems, the clinical performance and scale-up studies would decide their commercial translation.PMID:38589751 | DOI:10.1208/s12249-024-02793-y (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 8, 2024 Category: Drugs & Pharmacology Authors: Sanskriti Singh Sarika Wairkar Source Type: research
Maximum burn prevention practice versus conventional care after direct current cardioversion treatment: The BURN-PREVENTION trial
Development of cutaneous burns at the site of electrode placement is a known complication of the direct current (DC) cardioversion for atrial arrhythmias. While local cooling has been shown to mitigate burns,1 the effectiveness of weaker corticosteroid such as betamethasone has been less promising.2 This BURN-PREVENTION trial, a single-center, prospective, randomized, investigator-initiated, superiority trial, aimed to evaluate the efficacy of combining local cold application with clobetasol, a potent corticosteroid ointment, in preventing skin burns post-cardioversion. (Source: Heart Rhythm)
Source: Heart Rhythm - April 8, 2024 Category: Cardiology Authors: Reina Tonegawa-Kuji, Kenichiro Yamagata, Koshiro Kanaoka, Akinori Wakamiya, Yuko Y. Inoue, Koji Miyamoto, Yoshihiro Miyamoto, Eiji Kiyohara, Kengo Kusano Source Type: research
High Platelet Dose PRP May be the Nonoperative Treatment of Choice for Knee Osteoarthritis
Knee osteoarthritis (OA) affects 30% of individuals over 60 and 40% over 70 years old. The incidence of radiological knee OA is 373 per 10,000 person-years, but symptomatic knee OA registers as a considerably lower rate of 50 per 10,000 person-years. For symptomatic cases that are not candidates for surgical intervention, various treatment options include exercise, weight loss, pharmacological management, bracing, physical therapy, oral supplementation, and intra-articular injection with corticosteroids, hyaluronic acid, or orthobiologics such as platelet-rich plasma (PRP). (Source: Arthroscopy - Journal of Arthroscopic and Related Surgery)
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - April 8, 2024 Category: Surgery Authors: Erik Hohmann Tags: Editorial Commentary Source Type: research
