Implementation and outcome of an electronic tool for detection of paracetamol overdose in a tertiary care hospital
In this study, the performance of such an e-agent developed to detect paracetamol overdosing was analyzed.Setting Swiss tertiary care hospital.Method All patients  ≥ 18 years old who had documented paracetamol administration in the used clinical information system during 2017 were retrospectively screened for an absolute and relative overdosing of paracetamol (>  4 g and >  60 mg/kg/24 h, respectively). This was compared with the patients for which the e-agent had, during the same period, prospectively made an alert for absolute or relative overdosing or for a...
Source: International Journal of Clinical Pharmacy - October 29, 2020 Category: Drugs & Pharmacology Source Type: research

Discharge prescription optimization by emergency medicine pharmacists in an academic emergency department in the United States
This study was conducted in an academic medical center ED.Methods: This was a retrospective observational study of patients discharged with prescriptions from the ED over two months. EM pharmacists reviewed discharge prescriptions and provided drug therapy recommendations. Two independent reviewers rated the clinical significance of interventions. High risk criteria were proposed a priori and included in a multivariable logistic regression analysis to identify variables independently associated with pharmacist intervention.Main Outcome Measure The primary outcome measure was the rate, type, and clinical significance of int...
Source: International Journal of Clinical Pharmacy - October 29, 2020 Category: Drugs & Pharmacology Source Type: research

Knowledge of stroke and medication adherence among patients with recurrent stroke or transient ischemic attack in Indonesia: a multi-center, cross-sectional study
AbstractBackgroundThere is a limited data in Indonesia regarding the stroke knowledge and medication adherence among stroke survivors.ObjectiveTo assess the level of stroke knowledge and medication adherence along with their relationship among stroke survivors.SettingTwo tertiary-care hospitals in Surabaya, East Java, Indonesia.MethodsA prospective, cross-sectional study was conducted among 215 stroke survivors. Stroke Knowledge Test and the Morisky Green Levine Adherence Scale questionnaires were used to evaluate stroke knowledge and medication adherence, respectively. Binary logistic regression was performed to assess th...
Source: International Journal of Clinical Pharmacy - October 29, 2020 Category: Drugs & Pharmacology Source Type: research

Awareness about barriers to medication adherence in cardiovascular patients and strategies used in clinical practice by Portuguese clinicians: a nationwide study
Conclusions Clinicians seem well informed about the importance of medication adherence and aware of problems encountered in practice. Limited time during medical appointment may be a barrier for better patient support. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - October 26, 2020 Category: Drugs & Pharmacology Source Type: research

Drug survival of infliximab and adalimumab in inflammatory bowel disease
(Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - October 21, 2020 Category: Drugs & Pharmacology Source Type: research

Real-life data of survival and reasons for discontinuation of biological disease-modifying drugs ‘in’ rheumatoid arthritis
Conclusion Among the biological disease-modifying antirheumatic drugs being used for long periods, infliximab had greater time of use. Most drug suspensions (64%) were due to primary or secondary inefficacy. Number of discontinuations due to clinical and laboratory adverse effects for each drug was analyzed, and these data should be confirmed by other real-life studies. Knowledge of what is happening in real life is essential to health professionals, who need to be aware of the most common adverse effects and to health managers, who aim for greater cost-effectiveness in the choice of medications. (Source: International Jou...
Source: International Journal of Clinical Pharmacy - October 21, 2020 Category: Drugs & Pharmacology Source Type: research

Off-label antibiotic use among paediatric in-patients: a mixed-method prospective study at a tertiary hospital in southwestern Uganda
Conclusion Off-label frequency of administration was the major category of off-label drug use, while off-label dose was the minor category. Age was a significant factor for off-label antibiotic prescription, with infants receiving the highest number of off-label prescriptions. Attending physicians identified several justifiable circumstances that warrant off-label antibiotic use and support emerging “well-founded” off-label uses of antibiotics in different paediatric age groups. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - October 18, 2020 Category: Drugs & Pharmacology Source Type: research

Venous thromboembolism prophylaxis in patients undergoing knee replacements: comparison of real-world outcomes
Conclusion The results suggest aspirin to be as effective as apixaban in preventing venous thromboembolism and readmission. Apixaban usage decreased with a corresponding increase in Aspirin use. The impact of obesity and length of hospital stay need further investigations. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - October 18, 2020 Category: Drugs & Pharmacology Source Type: research

Creating clinical pharmacy capacity in Namibia: a collaboration to establish a post-graduate pharmacy degree programme
AbstractNamibia has previously relied on external training of pharmacists but began in-country training in 2011. In response to an identified need for postgraduate clinical pharmacy development and training in the country, a Master ’s degree was set up at the University of Namibia in 2016. The country has a considerable health burden of HIV and TB as well as a shortage of healthcare professionals. A UK clinical diploma model was adapted to meet the specific needs of the country and wider region, ensuring students could acces s the course over a sparsely populated, but large geographical spread, in addition to providi...
Source: International Journal of Clinical Pharmacy - October 15, 2020 Category: Drugs & Pharmacology Source Type: research

Clinical, economic, and organizational impact of pharmacists ’ interventions in a cognitive-behavioral unit in France
Conclusions The present study shows that the pharmacist may detect a high number of drug related problems with significant clinical relevance during medication review in a cognitive-behavioral unit. Describing and identifying significant pharmaceutical interventions in cognitive-behavioral unit patients allow us to better understand and improve clinical practice in this population. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - October 14, 2020 Category: Drugs & Pharmacology Source Type: research

Prognostic factors for patients with heparin-induced thrombocytopenia: a systematic review
ConclusionsPatient comorbidities, presence of HIT-related thromboembolism on admission and shorter anticoagulant therapy were found to be negative prognostic factors. Thrombocythemia on admission, patients age and gender did not influence the overall outcome. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - October 12, 2020 Category: Drugs & Pharmacology Source Type: research

Validation and psychometric properties of the self-efficacy for Appropriate Medication Use Scale in elderly Chinese patients
Conclusions This study presented a Chinese version of the self-efficacy for Appropriate Medication Use Scale with psychometrically sound properties that will enable pharmacists, nurses and physicians to prospectively evaluate the impact of medication self-efficacy on a variety of health outcomes in elderly patients with type 2 diabetes. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - October 12, 2020 Category: Drugs & Pharmacology Source Type: research

A possible effect of montelukast on neurological aging examined by the use of register data
Conclusion The present data suggest that montelukast may alleviate degenerative neurological changes associated with human aging. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - October 9, 2020 Category: Drugs & Pharmacology Source Type: research

Levels of tacrolimus after treatment for chronic hepatitis C with direct antiviral agents in solid organ transplant recipients
AbstractBackground and objective The main objective was to evaluate the impact of Hepatitis C Virus treatment with direct-acting antiviral agents on tacrolimus blood levels in recipients of kidney and heart allografts.Method We analysed Hepatitis C Virus infected adult patients who received tacrolimus as immunosuppressive maintenance therapy and received direct-acting antiviral agents treatment in a tertiary hospital with solid transplant multidisciplinary program in Madrid, Spain. Liver and renal function, tacrolimus dose and blood levels were analysed before and 12  weeks after the end of treatment.Results We identi...
Source: International Journal of Clinical Pharmacy - October 9, 2020 Category: Drugs & Pharmacology Source Type: research

Implementation of mouth rinsing after use of inhaled corticosteroids in Australia
AbstractBackground: Clinical guidelines recommend that patients using inhaled corticosteroids should rinse their mouth following inhalation. There is however, a paucity of research regarding patient implementation of this recommendation and the impact it has on the occurrence of adverse effects.Objective: The aim of this study was to determine how well patients implement mouth rinsing after using inhaled corticosteroids in practice and their understanding of the rationale, information sources and the impact of mouth rinsing on adverse effects.Setting: Australians aged 18  years and over with a diagnosis of asthma and/...
Source: International Journal of Clinical Pharmacy - October 7, 2020 Category: Drugs & Pharmacology Source Type: research

Validation of an instrument to measure adherence to type 2 diabetes management
Conclusion The proposed instrument, which includes factors that measure adherence in type 2 diabetes mellitus patient ’s management, using the transtheoretical model of behaviour change to simultaneously identify patient motivation to change their lifestyle, is valid and reliable. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - October 6, 2020 Category: Drugs & Pharmacology Source Type: research

Patients satisfaction with free healthcare pharmaceutical services in Sierra Leone: a national cross-sectional study
AbstractBackground Patient satisfaction is a critical construct of quality of pharmaceutical care in that it reflects whether a given service is meeting patients ’ expectations and consistent with their values. The government of Sierra Leone in 2010 introduced a free healthcare policy, which includes free pharmaceutical services for under-five children, lactating mothers, and pregnant women at all governments hospitals nationawide.Objectives The main objective of this study is to evaluate patient ’s satisfaction with the pharmaceutical services received from public hospitals implementing the free healthcare pol...
Source: International Journal of Clinical Pharmacy - October 5, 2020 Category: Drugs & Pharmacology Source Type: research

Community pharmacists ’ knowledge and practice regarding malaria and its treatment in Sudan: a cross-sectional survey
Conclusion Inadequate knowledge and irrational antimalarials dispensing practices were reported among the community pharmacists in Khartoum State. Although training was a significant predictor of pharmacists ’ knowledge regarding malaria and its treatment, health authorities were not providing regular training for the practicing pharmacists. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - October 5, 2020 Category: Drugs & Pharmacology Source Type: research

Pharmaceutical Care Network Europe (PCNE) drug-related problem classification version 9.00: German translation and validation
Conclusions This study provides a German translation of the PCNE classification for drug related problems of approximately similar consistency as the international version. It hence can be considered to classify drug-related problems in German speaking countries. Patient cases need to be more specific in future validations, feasibility and layout of the classification system need to improve. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - October 5, 2020 Category: Drugs & Pharmacology Source Type: research

Co-trimoxazole induced hyperkalemia and potassium monitoring in hospitalized patients
This study aimed to determine average serum potassium rise after administration of intravenous co-trimoxazole in hospitalized patients, compared to intravenous ceftriaxone. This study also aimed to determine adherence to Dutch guidelines by measuring the incidence of serum potassium monitoring in these patients.Setting Data was collected retrospectively from patients in five departments of the Canisius Wilhelmina Hospital, a teaching hospital in Nijmegen, the Netherlands.Method Data was collected and compared from patients that received intravenous co-trimoxazole (n  = 66) and intravenous ceftriaxone (n&thins...
Source: International Journal of Clinical Pharmacy - October 5, 2020 Category: Drugs & Pharmacology Source Type: research

Pharmacist review of high-risk haematology outpatients to improve appropriateness of antifungal prophylaxis
AbstractBackground Patients with haematological malignancies are at high risk of invasive fungal infections. However, there is a lack of information about the utilisation of the recommended Australian antifungal prophylaxis guidelines in haematology outpatients.Objective To assess the impact of a weekly pharmacist review of high-risk adult haematology outpatients on the utilisation of appropriate antifungal prophylaxis.Setting Outpatient cancer centre, tertiary referral hospital in Sydney, Australia.Method A 3-month pre-and post-interventional study was conducted. A retrospective audit was conducted to obtain baseline util...
Source: International Journal of Clinical Pharmacy - October 2, 2020 Category: Drugs & Pharmacology Source Type: research

Potentially inappropriate medications involved in drug –drug interactions at hospital discharge in Croatia
Conclusion A very high incidence of DDIs in elderly patients and a high incidence of PIMs involved in DDIs was determined at hospital discharge. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 30, 2020 Category: Drugs & Pharmacology Source Type: research

A qualitative process evaluation of the introduction of procalcitonin testing as an antimicrobial stewardship intervention
Conclusion This process evaluation provides a detailed analysis of the implementation of procalcitonin testing as an antimicrobial stewardship intervention. The positive findings of this process evaluation and feasibility study should be built upon and a full randomised controlled trial and economic evaluation should be conducted in a variety of hospital settings to confirm the effectiveness of procalcitonin as an antimicrobial stewardship intervention. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 30, 2020 Category: Drugs & Pharmacology Source Type: research

Exploring the use of extended release opioids at shortened dosing intervals in people with chronic pain and high risk medication or substance use
This study took place in the Interprofessional Pain and Addiction Recovery Clinic, a specialty ambulatory clinic at the Centre for Addiction and Mental Health in Toronto, Canada for adults with chronic pain and a diagnosis or suspicion of substance use disorder.Method This was a retrospective cross-sectional study. Data were collected from records of patients with assessments completed in the years 2012 –2017 (n  =  210).Main outcome measure Proportion of patients using extended release opioids at shortened intervals.Results Sixty-one percent of individuals using extended release opioids (n  = &t...
Source: International Journal of Clinical Pharmacy - September 29, 2020 Category: Drugs & Pharmacology Source Type: research

The effect of medication related clinical decision support at the time of physician order entry
Conclusion Implementation of advanced algorithms that take patient characteristics into account and are shown directly to the physician during order entry, result in an increased guideline adherence. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 28, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of the safety and efficacy of low-dose rasburicase in critically ill children with haematological malignancies
Conclusion Low-dose rasburicase is effective and may be an acceptable choice for critically ill children with haematological malignancies. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 23, 2020 Category: Drugs & Pharmacology Source Type: research

The therapeutic effects of traditional chinese medicine on COVID-19: a narrative review
Conclusion TCMs have been widely used in the treatment of COVID-19 in China. The unique properties of TCM compounds allow TCMs to have a role in the management of COVID-19. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 23, 2020 Category: Drugs & Pharmacology Source Type: research

Pharmaceutical opioids utilisation by dose, formulation, and socioeconomic status in Queensland, Australia: a population study over 22  years
Conclusion The dispensing of opioids increased significantly in Queensland. There was a positive relationship between the increased dispensing of opioids and locations of lower socioeconomic status. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 22, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of a trough-only extrapolated area under the curve vancomycin dosing method on clinical outcomes
Conclusion Extrapolated-AUC24 dosing was associated with less nephrotoxicity without an increase in treatment failures for bloodstream infections compared to conventional dosing. Further investigation is warranted to determine the relationship between extrapolated-AUC24 dosing and clinical failures. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 22, 2020 Category: Drugs & Pharmacology Source Type: research

Meta-analysis of clinical trials to assess denosumab over zoledronic acid in bone metastasis
Conclusion Overall, denosumab showed superiority in delaying the first and subsequent SREs, and hence seems to be a promising choice for managing bone metastases in both solid tumors and MM. However, it can induce a higher incidence of ONJ and hypocalcaemia, but these are preventable and manageable effects. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 21, 2020 Category: Drugs & Pharmacology Source Type: research

Health-related stakeholders ’ perceptions of clinical pharmacy services in Qatar
Conclusion Health-related stakeholders in Qatar have positive perceptions of current clinical pharmacy services and support the expansion of pharmacist ’s roles. However, service development needs to consider the issues of patient and public awareness and initially target institutionalised healthcare settings. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 21, 2020 Category: Drugs & Pharmacology Source Type: research

Identifying patients with metformin associated lactic acidosis in the emergency department
AbstractBackground Metformin associated lactic acidosis (MALA) is a serious adverse event with a high mortality rate of 30 –50%. Early recognition of MALA and timely starting treatment may reduce its morbidity and mortality.Objective The aim of this study was to explore clinical parameters to identify patients with MALA in patients with suspected sepsis induced lactic acidosis in the emergency department ED.Setting A retrospective single centre study was conducted at the Deventer Teaching Hospital in the Netherlands.Method Patients with lactate concentration  >  4.0 mmol/l admitted at the ED bet...
Source: International Journal of Clinical Pharmacy - September 21, 2020 Category: Drugs & Pharmacology Source Type: research

Opportunistic screening of cardiovascular disease risk factors in community pharmacies in Nigeria: a cross-sectional study
Conclusion Opportunistic screening for CVD risk factors is possible in community pharmacies and has the ability to detect previously undiagnosed risk factors. This community pharmacy based model could serve as a cost-effective approach to primary prevention of CVD. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 21, 2020 Category: Drugs & Pharmacology Source Type: research

Impact of community pharmacist-led intensive education on the control of serum phosphate levels in haemodialysis patients
Conclusion Community pharmacist-led education focusing on phosphate binders affects short- and long-term management of serum phosphate levels in patients receiving haemodialysis, especially the patients whose levels were initially high. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 20, 2020 Category: Drugs & Pharmacology Source Type: research

The incidence, risk factors, and outcomes of acute kidney injury in the intensive care unit in Sudan
Conclusion The major significant predictors for the development of acute kidney injury in the intensive care unit were: sepsis; hypovolemia; chronic cardiovascular diseases; age  >  60 years; diabetes mellitus; hypertension; and renal replacement therapy. Sepsis and hypovolemia were common etiologies for acute kidney injury post-admission to the intensive care unit. Acute kidney injury was associated with increased length of hospital stay and a very high absolute mortality rate. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 19, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluating the impact of various medication safety risk reduction strategies on medication errors in an Australian Health Service
AbstractBackground Medication errors remain the second common type of preventable incidents reported in Australian hospitals contributing to a significant morbidity and mortality to the society.Objectives The primary objective was to evaluate the impact of multiple patient-centred and system redesign strategies on medication errors across an Australian Health service. The secondary aim is to assess the impact of these strategies on patients ‘satisfaction.Methods Multiple patient centred and system redesign stratrgies were implemented to reduce medication errors across a 450 bed Australian hospital through optimising ...
Source: International Journal of Clinical Pharmacy - September 19, 2020 Category: Drugs & Pharmacology Source Type: research

Redundant medication use during acute exacerbation of chronic obstructive pulmonary disease in hospitalized patients
AbstractBackground Few clinical studies have evaluated redundant therapy during an exacerbation of chronic obstructive pulmonary disease in hospitalized patients, but clinical practice guidelines endorse this practice.Objective The aim of this study is to measure the frequency of redundant therapy and explore its association with clinical outcomes, adverse effects, and cost among adults hospitalized with acute exacerbation of chronic obstructive pulmonary disease.Setting Six hospitals within an academic health system in the United States.Method A retrospective cohort study of adults with a principal diagnosis of acute exac...
Source: International Journal of Clinical Pharmacy - September 19, 2020 Category: Drugs & Pharmacology Source Type: research

Allergic rhinitis characterization in community pharmacy customers: a cross-sectional study
Conclusions The findings of this study showed that the estimated prevalence of allergic rhinitis seems to be apparently lower in Guarda than that found in the general Portuguese population. From the data, some patients showed uncontrolled allergic rhinitis symptoms, strengthening the importance of the role of intervention by a health professional. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 19, 2020 Category: Drugs & Pharmacology Source Type: research

Risk of developing hypertension after hormone therapy for prostate cancer: a nationwide propensity score-matched longitudinal cohort study
This study aimed to investigate the risk of subsequent hypertension in patients undergoing androgen deprivation therapy for prostate cancer.Setting Data of 10,843 patients with prostate cancer were retrospectively collected from the Longitudinal Health Insurance Database of Taiwan. The institutional review board of Kaohsiung Medical University Hospital approved our study.Method In propensity score matching, 3001 patients with prostate cancer aged ≥ 40 years who underwent androgen deprivation therapy were included in the study cohort (androgen deprivation therapy-ever), and 3001 patients wi...
Source: International Journal of Clinical Pharmacy - September 19, 2020 Category: Drugs & Pharmacology Source Type: research

Community pharmacists ’ preparedness to intervene with concerns around prescription opioids: findings from a nationally representative survey
Conclusion Considering specific factors such as gender and years of practice to help target pharmacist training may lead to increased comfort in discussing concerns related to prescription opioids, which in turn may improve communication with prescribers and patients. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 19, 2020 Category: Drugs & Pharmacology Source Type: research

Dipeptidyl peptidase-4 inhibitors and risk of venous thromboembolism: data mining of FDA adverse event reporting system
ConclusionOur analysis found no association between dipeptidyl peptidase-4 inhibitors and venous thromboembolism risk, while moderate to strong signals of portal vein thrombosis, splenic vein thrombosis, mesenteric vein thrombosis risks were observed. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 19, 2020 Category: Drugs & Pharmacology Source Type: research

Potentially inappropriate medications in Chinese older adults: a comparison of two updated Beers criteria
AbstractBackground Beers criteria have been into the mainstay to characterize the potentially inappropriate medication since its first publication, but the recent version, Beers 2019, is yet to be validated by clinical studies nationally.Objective To identify the prevalence and the predictors of potentially inappropriate medications in hospitalized geriatric patients based on the Beers 2019 and 2015 criteria.Setting Nanjing Drum Tower Hospital, a 3000-bed tertiary care teaching hospital in China.Method We conducted a cross-sectional study from July 1, 2018 to December 31, 2018. Data from all hospitalized patients aged &thi...
Source: International Journal of Clinical Pharmacy - September 12, 2020 Category: Drugs & Pharmacology Source Type: research

Pharmacists views on participating in New Zealand ’s community pharmacy anticoagulation management service: a mixed-methods study
Conclusions Overall, pharmacists have favourable experiences of and attitudes towards CPAMS and strongly supported its wider implementation. Promoting the benefits and addressing the barriers highlighted in this study may lead to wider implementation of CPAMS. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 12, 2020 Category: Drugs & Pharmacology Source Type: research

Dose –response of intravenous calcium in the surgical intensive care unit
Conclusion We observed that change in iCa level after initial calcium dose depended on the baseline iCa. Our full and simplified model excluding two outliers predicted 76.9% and 75.6% of the variation in iCa response, respectively. If validated in other settings this model could be utilized to provide more accurate calcium dosing. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 11, 2020 Category: Drugs & Pharmacology Source Type: research

Medications and the risk of falls among older people in a geriatric centre in Nigeria: a cross-sectional study
Conclusion The prevalence of falls was high and being a woman  ≥ 60 years is a major risk factor for falling. Interventions to decrease falls in older patients by drug modification and deprescribing of FRIDs and ODs might reduce fall-related injuries. Thus, a multidisciplinary approach is essential for intervention to reduce the risk of falls and improve therapeutic outcomes among older patients. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Source Type: research

Prevention of anthracycline-induced cardiotoxicity: a systematic review and network meta-analysis
Conclusions The amount of left ventricular ejection fraction used by cardiac agents in anthracycline-based chemotherapy was reduced to a lesser extent. The effective and ineffective drugs were spironolactone and metoprolol, respectively. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Source Type: research

A cost analysis study of the implementation of fixed-dosing of monoclonal antibodies in the Netherlands Cancer Institute
Conclusion Fixed-dosing resulted in substantial savings in health care costs. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Source Type: research

Unintended consequences of United States chronic pain guidelines
AbstractIn 2015, the United States of America (USA) Department of Health and Human Services (HHS) released an issue brief that addressed opioid addiction, opioid overdoses, and opioid-related deaths as a public health concern within the country. After collaboration with state and stakeholder organizations, the HHS identified three target initiatives aimed to mitigate the negative consequences of opioid use within the USA. One initiative included implementation of guidelines to help reduce inappropriate opioid prescribing with a goal to reduce morbidity and mortality. The aim of this commentary is to discuss the misapplicat...
Source: International Journal of Clinical Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Source Type: research

The effect of an inpatient geriatric stewardship on drug-related problems reported by patients after discharge
AbstractBackground Drug-related problems after discharge are common among older adults with polypharmacy. Medication review during hospitalization has been proposed as one solution. Inpatient medication review is often based on clinical records only. An obstacle is the lack of insight into the outpatient history. Therefore, a geriatric stewardship was designed and involved an inpatient medication review by a hospital pharmacist and geriatrician based on (I) clinical records to draft initial recommendations, (II) consultations with primary care providers (general practitioner and community pharmacist) to discuss the hospita...
Source: International Journal of Clinical Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Source Type: research

Discontinuation of antipsychotics treatment for elderly patients within a specialized behavioural unit: a retrospective review
This study aims to examine the relationship between high dose antipsychotic (greater than 62  mg chlorpromazine equivalent daily dose) and antipsychotics discontinuation in hospitalized dementia patients.Setting Specialized Dementia Behavioral Health Program in Hamilton, Ontario, Canada.Method A retrospective chart review was completed from August to December of 2019. A univariate logistic regression model was applied to antipsychotic doss (in chlorpromazine equivalent) and antipsychotic discontinuation outcome at 60  days (Narayan and Nishtala in Eur J Clin Pharmacol 73(12):1665–1672, 2017). A multivariant...
Source: International Journal of Clinical Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Source Type: research