Analysis of inpatient and high-risk medicine pharmacist interventions associated with insulin prescribing for hospital inpatients with diabetes
Conclusion This study provides insights into pharmacist interventions for inpatients on insulin, showing that high-risk medicine pharmacists recorded most interventions. The classification of the insulin interventions into medicine optimisation and prescribing errors provides useful information for the training of prescribers in insulin management. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - July 11, 2021 Category: Drugs & Pharmacology Source Type: research

Clinical pharmacist consultant in primary care settings in Slovenia focused on elderly patients on polypharmacy: successful national program from development to reimbursement
AbstractClinical pharmacists in most primary care settings across Europe do not offer a reimbursed medication review service. This paper describes the development, implementation, and evaluation of a program in Slovenia that allows all general practitioners to refer patients to clinical pharmacists in primary care settings for a medication review. Between 2012 and 2015, the Health Insurance Institute of Slovenia proposed, funded and evaluated a pilot trial and recommended that the service be extended to all public health insurance beneficiaries in Slovenia. Following successful negotiations, the program (Pharmacist Consult...
Source: International Journal of Clinical Pharmacy - July 6, 2021 Category: Drugs & Pharmacology Source Type: research

Exploring pharmacist involvement in the discharge medicines reconciliation process and information transfer to primary care: an observational study
Conclusion Pharmacists undertaking a discharge medication reconciliation process significantly improves the quality of discharge summaries. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - July 5, 2021 Category: Drugs & Pharmacology Source Type: research

Pharmacists ’ involvement in COVID-19 vaccination across Europe: a situational analysis of current practice and policy
AbstractOne year since the emergence of the COVID-19 pandemic, rapid response measures have been implemented internationally to mitigate the spread of the virus. Following rapid and successful pre-clinical and human trials, several vaccines have been authorised for use across Europe through the European Medicines Agency and national regulatory authorities. Clinical trials have shown promising results including important reductions in disease severity, hospitalisation and mortality. In order to maximise the public health benefit of available vaccines, there is a pressing need to vaccinate a large proportion of the popula...
Source: International Journal of Clinical Pharmacy - July 3, 2021 Category: Drugs & Pharmacology Source Type: research

Clinical pharmacists in Dutch general practice: an integrated care model to provide optimal pharmaceutical care
ConclusionA clinical pharmacist in general practice proves a feasible integrated care model to improve the quality of drug therapy. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - July 3, 2021 Category: Drugs & Pharmacology Source Type: research

Direct oral anticoagulant-related medication incidents and pharmacists ’ interventions in hospital in-patients: evaluation using reason’s accident causation theory
Conclusion Prescribers ’ active failure rather than system errors (i.e. latent failures) contributed to the majority of DOAC-related incidents. Reinforcement of guideline adherence, prescriber education, harnessing pharmacists’ roles and mandating renal function information in prescriptions are likely to improve patie nt safety. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - July 2, 2021 Category: Drugs & Pharmacology Source Type: research

Development of innovative simulation teaching for advanced general practice clinical pharmacists
Conclusion. This innovative simulation evaluated as being of value to GPCPs in developing clinical confidence and competence when dealing with a variety of typical General Practice scenarios. Plans are underway to establish a Scottish Pharmacy Simulation Faculty which could support this training in each health board. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - July 1, 2021 Category: Drugs & Pharmacology Source Type: research

Barriers and facilitators to reducing anticholinergic burden: a qualitative systematic review
Conclusions This review identified important barriers and facilitators to anticholinergic burden reduction from healthcare provider perspectives which can inform implementation of such deprescribing interventions. Studies exploring patient and carer perspectives are presently absent but are required to ensure person-centeredness and feasibility of future interventions. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 25, 2021 Category: Drugs & Pharmacology Source Type: research

Defining clinical pharmacy and support activities indicators for hospital practice using a combined nominal and focus group technique
Conclusion A set of measurable KPIs was established to allow for benchmarking within and between Portuguese hospital Pharmacies and to elevate professional accountability and transparency. Future perspectives include the use of both cpKPIs and saKPIs on a national scale to identify the most efficient performances and areas of possible improvement. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 24, 2021 Category: Drugs & Pharmacology Source Type: research

A qualitative study of the views of healthcare professionals on providing vaccines information to patients
Conclusion The provision of vaccines information by HCPs to patients is multifactorial with participants mindful of patient autonomy and the HCP role to support vaccinations as a public health priority. Participants suggested that education and support on vaccines communication would enable them to support the vaccines uptake in their practice. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 21, 2021 Category: Drugs & Pharmacology Source Type: research

Exploring patients ’ pharmacy stories: an analysis of online feedback
Conclusions Online patient feedback highlighted factors important to patients when interacting with pharmacies and their staff. Medication supply was the primary topic of patient stories with waiting times and stock shortages being clear areas for improvement; however, accessibility, pharmacy services and advice were key strengths of the profession. Further research is needed to understand how online patient feedback can be used effectively to inform improvements in pharmacy services. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 19, 2021 Category: Drugs & Pharmacology Source Type: research

Timeliness of administration of amoxicillin-clavulanic acid and meropenem in a large tertiary care centre
AbstractBackground For amoxicillin-clavulanic acid and meropenem to be effective, concentrations must exceed the minimum inhibitory concentration of infecting pathogens.Objective To retrospectively evaluate time windows between both scheduled prescription and administration and reconstitution-preparation and end of administration of intravenous amoxicillin-clavulanic acid and meropenem prescriptions.Setting 37 hospital wards at a tertiary hospital, Belgium.Method All adult hospital stays with at least one amoxicillin-clavulanic acid or meropenem administration in 2018 were reviewed. Time windows were deemed acceptable if  
Source: International Journal of Clinical Pharmacy - June 17, 2021 Category: Drugs & Pharmacology Source Type: research

A theoretically informed, mixed-methods study of pharmacists ’ aspirations and readiness to implement pharmacist prescribing
AbstractBackground Studies have highlighted advancing clinical pharmacy practice in Qatar.Objective To explore pharmacists ’ aspirations and readiness to implement pharmacist prescribing.Setting Hamad Medical Corporation (HMC), the main provider of secondary and tertiary care.Method A sequential explanatory mixed-methods design. Questionnaire items were derived from the Consolidated Framework of Implementation Research (CFIR), in domains of: awareness/support; readiness; implementation; and facilitators and barriers. Following piloting, all pharmacists (n  = 554) were invited to participate. Questionnai...
Source: International Journal of Clinical Pharmacy - June 14, 2021 Category: Drugs & Pharmacology Source Type: research

Community pharmacists ’ perceptions on providing fall prevention services: a mixed-methods study
Conclusion Despite the complex decision-making process in medication-related fall prevention, community pharmacists are motivated and feel capable of providing fall prevention. Opportunities for pharmacists to provide fall prevention services should be enhanced, for example by implementing multidisciplinary agreements. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 13, 2021 Category: Drugs & Pharmacology Source Type: research

Understanding the role of hospice pharmacists: a qualitative study
Conclusion Barriers to the role of hospice pharmacist include time, access to role specific training, access to clinical information and complex medicines supply chains. The role would benefit from definition to ensure that hospices are able to use hospice pharmacists to their greatest potential. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 13, 2021 Category: Drugs & Pharmacology Source Type: research

Psychiatric disorders of the combination of levetiracetam either with lacosamide or perampanel: a retrospective cohort study
AbstractBackground The number of patients with epilepsy receiving perampanel or lacosamide as an add-on treatment following levetiracetam treatment has increased. Although levetiracetam causes psychiatric disorders, it is unclear whether they occur with the combined use of these antiepileptic drugs.Objective To determine the frequency of psychiatric disorders in patients received lacosamide or perampanel in combination with levetiracetam.Setting A single-center retrospective cohort study.Method Patients who received levetiracetam  + lacosamide or levetiracetam + perampanel were selected. Medical...
Source: International Journal of Clinical Pharmacy - June 13, 2021 Category: Drugs & Pharmacology Source Type: research

Abstracts of the European Society of Clinical Pharmacy International Workshop on Malabsorption and Malnutrition, A Challenge for Clinical Pharmacists, 26 –27 April 2021
(Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 13, 2021 Category: Drugs & Pharmacology Source Type: research

Defensive pharmacy practice: a gap in our understanding
AbstractDefensive practice is prevalent across healthcare disciplines and much study has been performed on this behaviour in medicine and nursing. However, little research has been carried out on defensive practice in pharmacy, despite its potential to increase healthcare costs, reduce quality of care and affect pharmacist job satisfaction. With a more litigious society emerging and greater level of regulation, the pharmacy profession shares many of the influences of defensive practice identified in other healthcare professions. As a result, pharmacists too may engage in defensive practice behaviours in order to protect th...
Source: International Journal of Clinical Pharmacy - June 13, 2021 Category: Drugs & Pharmacology Source Type: research

Logistics management provides greater efficiency, governance and compliance
AbstractDuring the 2020 Congress of the Italian Society of Hospital Pharmacy (Sifo 2020), there was a heated debate about whether it is more convenient to dispense healthcare directly in hospitals and public facilities, or indirectly, through the use of external private pharmacies. The former solution is called “direct dispensing” (DD), while the latter is called “dispensing on commission” (DPC). The strengths and advantages of DD over DPC are many: greater therapeutic appropriateness due to direct control of treatment plans, cost savings from external commissions, and greater clinical sharing of t ...
Source: International Journal of Clinical Pharmacy - June 13, 2021 Category: Drugs & Pharmacology Source Type: research

Editorial
(Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 13, 2021 Category: Drugs & Pharmacology Source Type: research

Survey on general practitioners ’ and pharmacists’ opinions regarding patient-initiated treatment of recurring urinary tract infections
AbstractBackground The Dutch general practitioners (GP) guideline for urinary tract infections (UTI) recommends patient-initiated treatment for women with recurring UTI. In countries other than the Netherlands, community pharmacists play a role in dispensing antibiotics for recurring UTI without preceding GP consultation.Objective To study GP and pharmacist opinions regarding the desirability of patient-initiated treatment, including potential pharmacist support for, and consequences of, facilitated access to antibiotics.Setting Dutch community pharmacies that cooperate with at least two GPs in their regional primary care ...
Source: International Journal of Clinical Pharmacy - June 10, 2021 Category: Drugs & Pharmacology Source Type: research

Evaluation of rivaroxaban-, apixaban- and dabigatran-associated hemorrhagic events using the FDA-Adverse event reporting system (FAERS) database
Conclusions Overall, we found a moderate signal of higher frequency of reporting hemorrhage in rivaroxban compared with dabigatran and decreased hemorrhagic event reporting in apixaban compared with dabigatran. While this potential signal has not been confirmed in clinical trials or observational studies, in clinical practice, attention should be paid to the risk of potential hemorrhage when the patients switch from apixaban to dabigatran or rivaroxban. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 9, 2021 Category: Drugs & Pharmacology Source Type: research

Residential Medication Management Reviews and continuous polypharmacy among older Australian women
Conclusion Polypharmacy was associated with receiving RMMRs and around two-thirds of women who are entitled to a RMMR never received one. There is potential to improve the use of medicines by increasing awareness of the service among eligible individuals, their carers and health care professionals. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 6, 2021 Category: Drugs & Pharmacology Source Type: research

Comparison of opioid prescribing upon hospital discharge in patients receiving tapentadol versus oxycodone following orthopaedic surgery
AbstractBackground The changing of opioids during the transition of care from hospital to home may be associated with harm.Objective To compare patients receiving tapentadol IR versus oxycodone IR following orthopaedic surgery during hospitalisation with regard to the changing of opioids at hospital discharge.Setting A major metropolitan tertiary referral hospital in Australia.Methods This is a retrospective cohort study. Participants included adult orthopaedic surgery patients receiving postoperative tapentadol IR or oxycodone IR during hospitalisation between 1 January 2018 and 30 June 2019.Main outcome measure The propo...
Source: International Journal of Clinical Pharmacy - June 5, 2021 Category: Drugs & Pharmacology Source Type: research

The value of domiciliary medication reviews: a thematic analysis of patient views
Conclusion For many patients, the domiciliary setting is preferred to traditional healthcare settings. Patients appreciated the time spent with them during a DMR and felt listened to. Informal carers felt reassured that the individual medication needs of their relative had been reviewed by an expert. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 3, 2021 Category: Drugs & Pharmacology Source Type: research

Evaluating the role and integration of general practice pharmacists in England: a cross-sectional study
Conclusion Practice pharmacists are fulfilling a wide range of clinical and non-clinical roles in England. Findings highlight relatively a satisfactory level of pharmacists ’ integration into practice and shed the light on their integration issues. These findings could be significant for the development of future roles of pharmacists in GP. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 2, 2021 Category: Drugs & Pharmacology Source Type: research

Pharmacists ’ experiences serving culturally and linguistically diverse patients in the Australian community pharmacy setting
Conclusion Pharmacist participants expressed being inadequately equipped to provide culturally competent care in the community setting and identified potential means by which such care may be delivered. Addressing identified barriers that hinder community pharmacists ’ capacity to engage in culturally competent practice can potentially improve provision of pharmaceutical care to culturally and linguistically diverse patients with low English proficiency. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 2, 2021 Category: Drugs & Pharmacology Source Type: research

Guiding axes for drug safety management of pharmacovigilance centres during the COVID-19 era
AbstractThe COVID-19 pandemic presents several challenges to the organisation and workflow of pharmacovigilance centres as a result of the massive increase in reports, the need for quick detection, processing and reporting of safety issues and the management of these within the context of lack of complete information on the disease. Pharmacovigilance centres permanently monitor the safety profile of medicines, ensuring risk management to evaluate the benefit-risk relationship. However, traditional pharmacovigilance approaches of spontaneous reporting, are not suitable in the context of a pandemic; the scientific community ...
Source: International Journal of Clinical Pharmacy - June 2, 2021 Category: Drugs & Pharmacology Source Type: research

A pharmacist-delivered smoking cessation program in Qatar: an exploration of pharmacists ’ and patients’ perspectives of the program
Conclusion The program was perceived to be beneficial in helping patients quit smoking, and it positively contributed to advancing pharmacist role. The study findings can guide future development of successful pharmacist ’ smoking cessation programs in Qatar. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 2, 2021 Category: Drugs & Pharmacology Source Type: research

Practical considerations when treating chronic hepatitis E in solid organ transplant recipients
AbstractHepatitis E virus (HEV) can lead to chronic infections in immunosuppressed patients. The use of ribavirin to treat chronic HEV has been well-established in case reports and guidelines. However, practical approaches to the use of this antiviral treatment in a post-transplant patient, including drug interactions, dosing adjustments, and monitoring parameters, are lacking. Thus, we present our real-world approach to the use of ribavirin to treat chronic HEV in a solid organ transplant recipient. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 1, 2021 Category: Drugs & Pharmacology Source Type: research

Superinfection associated with prolonged antibiotic use in non-ventilator associated hospital-acquired pneumonia
AbstractBackground Non-ventilator associated hospital-acquired pneumonia accounts for significant antibiotic use and is associated with a high rate of resistance emergence. However, the optimal duration of antibiotic treatment is uncertain, especially in cases of non-fermenting gram-negative bacilli.Objective To compare a short course (5 –7 days) to a prolonged course (10–14 days) of antibiotics for non-ventilator associated hospital-acquired pneumonia.Methods Data collected retrospectively on patients completed treatment in a Malaysian tertiary hospital from January 2017 till December 2018. Regressio...
Source: International Journal of Clinical Pharmacy - May 29, 2021 Category: Drugs & Pharmacology Source Type: research

Impact of pharmacy intervention on influenza vaccination acceptance: a systematic literature review and meta-analysis
Conclusion Pharmacists can play a significant role to improve patient treatment, adherence, and outcomes associated with influenza vaccines. Once pharmacy-based immunization is established, proactive involvement of is key to ensure successful program implementation and results. Expanding access for pharmacists and pharmacy intervention to provide vaccinations may increase vaccination acceptance and could be a valuable intervention in patient care. Additional studies should consider high-risk populations to inform optimal design and implementation strategies. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 28, 2021 Category: Drugs & Pharmacology Source Type: research

Advanced pharmacist practice: where is the United Kingdom in pursuit of this ‘ Brave New World ’?
AbstractPharmacy has developed many novel patient-facing roles across the globe, typically delivered through the lens of pharmaceutical care. The macro-level implementation of such interventions is, however, fraught with difficulty. At an individual-level, psychological barriers of pharmacists and their ability to deliver autonomous complex clinical care are key considerations. As the United Kingdom imminently plans to launch a new advanced pharmacist practice curriculum and credentialing process to support advanced skills development, this commentary discusses where progress to date has taken us and what other development...
Source: International Journal of Clinical Pharmacy - May 15, 2021 Category: Drugs & Pharmacology Source Type: research

Pharmacists in advanced clinical practice roles in emergency departments (PARED)
Conclusions Pharmacists can successfully train as ACP-p in this setting over a two-year period. This career transition needs careful management and clear structures. Training ACP-p is a useful way of enhancing skills and supporting clinical services to large numbers of patients. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 10, 2021 Category: Drugs & Pharmacology Source Type: research

Value of skin tests for managing allergic hypersensitivity reactions to platinum compounds
Conclusion ST helped physicians identify patients most susceptible to platinum derivative allergies and resume platinum-based therapy in many patients for whom no suitable therapeutic alternative was clinically acceptable. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 2, 2021 Category: Drugs & Pharmacology Source Type: research

Abstracts 12th PCNE working conference ‘Partnering for better patient outcomes: challenges and opportunities 3–6 February 2021, University of Basel, Switzerland (was held online)
(Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 30, 2021 Category: Drugs & Pharmacology Source Type: research

Association between reported medication adherence and health-related quality of life in adult patients with haemophilia
Conclusion We found that reported medication adherence can contribute to better health-related quality of life in patients with haemophilia. Since life with a chronic condition is demanding, it is an important finding that medication adherence to replacement therapy can improve life conditions for patients with haemophilia. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 29, 2021 Category: Drugs & Pharmacology Source Type: research

Vancomycin dosing and therapeutic drug monitoring practices: guidelines versus real-life
Conclusion Target attainment for vancomycin with current dosing regimens and TDM is poor in all age groups. Besides, human factors should not be ignored when aiming for optimal treatment. This study reflects an ongoing challenge in clinical practice and highlights the need for optimization of vancomycin dosing strategies and improvement of awareness of all health care professionals involved. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 28, 2021 Category: Drugs & Pharmacology Source Type: research

Pharmaceutical care program for ischemic stroke patients: a randomized controlled trial
Conclusion Pharmaceutical care programs can improve risk factor control for the secondary prevention of stroke recurrence in ischemic stroke patients. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 28, 2021 Category: Drugs & Pharmacology Source Type: research

Enhancing medication therapy in Parkinson's disease by establishing an interprofessional network including pharmacists
Conclusion A regional interprofessional PD network with pharmacists was established and new standards were established. Future research needs to measure the effects on patient outcomes. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 23, 2021 Category: Drugs & Pharmacology Source Type: research

Assessing the impact of virtual medication history technicians on medication reconciliation discrepancies
AbstractBackground To overcome resource limitations, Ascension hospitals have implemented a virtual pharmacy technician program to facilitate the completion of medication histories in select emergency departments.Objective This multicenter retrospective study aimed to assess the impact of taking a medication history virtually by pharmacy technicians on medication reconciliation accuracy in comparison to other clinicians.Setting Ascension Seton hospitals in Austin, Texas, United States.Method A retrospective chart review including patients above the age of 18, who were directly admitted from the emergency department between...
Source: International Journal of Clinical Pharmacy - April 19, 2021 Category: Drugs & Pharmacology Source Type: research

Multidisciplinary telephone conferences about medication therapy after discharge of older inpatients: a feasibility study
Conclusion Telephone conferences were only possible for half of the patients. The participating general practitioners, pharmacists and geriatricians expressed varied benefit and agreed that telephone conferences were mainly relevant for complex patients. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 13, 2021 Category: Drugs & Pharmacology Source Type: research

The integral role of the clinical pharmacist in drug-assisted intubation at a newly established children ’s major trauma center
We describe the implementation of this process in a new hospital, which was to become the designated children ’s trauma center for an entire country. Although the literature documents the use of pharmacists in emergency intubation, ours was a unique set of circumstances, where empowering the pharmacist in frontline clinical care provided additional quality assurance for rapid sequence induction and intuba tion in trauma. Medical simulation was a core part of socializing the advanced clinical practice role of pharmacy within the trauma team. It was our experience that the pharmacist helps to promote confidence and dec...
Source: International Journal of Clinical Pharmacy - April 13, 2021 Category: Drugs & Pharmacology Source Type: research

Burnout and the challenges facing pharmacists during COVID-19: results of a national survey
Conclusion Pharmacists are experiencing burnout, with work and psychosocial factors affecting them during COVID-19. Knowledge of this and that males experience more depersonalisation is valuable to inform advocacy and interventions to support pharmacists. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 13, 2021 Category: Drugs & Pharmacology Source Type: research

Psychotropic medicine beliefs, side effects and adherence in schizophrenia: a patient –caregiver dyad perspective
Conclusions This study highlights the need for patient-caregiver collaborations in decision-making relating to medication adherence in schizophrenia. Thus, in clinical practice, there is the need to recognize that caregivers are essential partners, and patient-caregiver views about psychotropic medications are critical in enhancing adherence for positive mental health outcomes. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 9, 2021 Category: Drugs & Pharmacology Source Type: research

Opioid prescribing and risk of drug-opioid interactions in older discharged patients with polypharmacy in Australia
AbstractBackground Opioids are commonly prescribed to managing chronic pain in older persons. However, these patients are often at risk of drug-opioid interactions due to polypharmacy.Objectives To identify the prevalence of opioid prescribing and drug-opioid interactions in poly-medicated older patients and factors associated with opioid prescribing.Setting Patients were included if they were admitted to the Royal Adelaide Hospital between September 2015 and August 2016, aged  ≥ 75 years and took ≥ 5 medications at discharge.Methods After ethics approval, data of were retrospectively...
Source: International Journal of Clinical Pharmacy - April 1, 2021 Category: Drugs & Pharmacology Source Type: research

Current status of opioid epidemic in the United Kingdom and strategies for treatment optimisation in chronic pain
AbstractThe increase in opioid prescriptions in the United States has been accompanied by an increase in misuse as well as overdose and toxicity related morbidity and mortality. However, the extent of the increased opioid use, including misuse in the United Kingdom, currently remains less debated. Recent studies in the United Kingdom have shown a rise in opioid use and attributed deaths, particularly in areas with higher deprivation. There are also large variations amongst the devolved nations; Scotland has the highest drug-related deaths and year-on-year increase within Europe. Better clinical guidelines that can enable p...
Source: International Journal of Clinical Pharmacy - April 1, 2021 Category: Drugs & Pharmacology Source Type: research

Opioids prescribing trend between 2013 and 2017 in the Lisbon and Tagus Valley region, Portugal
Conclusion The prescription of opioid drugs has increased approximately 1.5-fold over a 4  year period in the ambulatory care of one of the main health administrative regions in Portugal. This trend warrants monitoring and suggests the need for highlighting good practices for opioids prescribing. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 1, 2021 Category: Drugs & Pharmacology Source Type: research

Overview of this issue: “Pain management in an opioid crisis”
(Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 1, 2021 Category: Drugs & Pharmacology Source Type: research

Superior outcomes with Argatroban for heparin-induced thrombocytopenia: a Bayesian network meta-analysis
Conclusion Argatroban performed better overall for selected patients with HIT. Argatroban demonstrated the shortest hospitalization, and lowest rate of haemorrhages, thromboembolisms, and mortality compared to bivalirudin, lepirudin, desirudin, and danaparoid. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 28, 2021 Category: Drugs & Pharmacology Source Type: research