Core competencies for Australian pharmacists when supplying prescribed opioids: a modified Delphi study
Conclusion There was strong agreement by participants on what should be considered core competencies for Australian pharmacists in opioid supply. Given the large number of items identified, further research may help determine priorities for training and education. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 23, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of a collaborative care program for pulmonary hypertension patients: a multicenter randomized trial
Conclusion Including clinical pharmacists in the multidisciplinary care of hospitalized patients with pulmonary hypertension improved the outcome of drug-related problems and reduced the costs of related hospitalization. However, we observed no efficacy on medication errors, clinical outcomes or medication adherence.Clinical Trial Registration ClinicalTrials.gov Identifier NCT01038284. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 21, 2020 Category: Drugs & Pharmacology Source Type: research

The role of pharmacists in community education to promote responsible self-medication in Indonesia: an application of the spiral educational model
Conclusion Training based on the spiral model has the potential to be implemented in community training to improve self-medication literacy among the Indonesian public. Support from pharmacists as well as the relevant national and professional bodies is essential for successful implementation of the training. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 21, 2020 Category: Drugs & Pharmacology Source Type: research

Patient safety incidents involving transdermal opioids: data from the Danish Patient Safety Database
Conclusion This study has demonstrated that the administration of transdermal opioids is challenging and may cause harm, particularly in the primary care sector. To improve patient safety, optimized systems, including guidelines on drug management and the continuing education of healthcare personnel in transdermal opioid management, are necessary. These guidelines should preferably incorporate reminders and checklists, since the omission of doses was the most reported problem. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 19, 2020 Category: Drugs & Pharmacology Source Type: research

A survey of the European Society of Clinical Pharmacy members ’ research involvement, and associated enablers and barriers
Conclusion Study participants were highly active, interested, experienced, confident and positive regarding research. There is an opportunity for ESCP to harness these activities and provide support in the form of mentoring, education and training, and facilitating collaboration. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 19, 2020 Category: Drugs & Pharmacology Source Type: research

Mapping the characteristics of meta-analyses of pharmacy services: a systematic review
Conclusion: Poor conduction and reporting were observed in meta-analyses of pharmacy services, especially in those that favoured the pharmacist’s interventions. Reproducibility and transparency should be rigorously ensured by journal editors and peer-reviewers. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 19, 2020 Category: Drugs & Pharmacology Source Type: research

The effect of warfarin knowledge on anticoagulation control among patients with heart valve replacement
AbstractBackground Although novel oral anticoagulants have been applied into clinical practice, warfarin remains the only approved oral anticoagulant for heart valve replacement. Currently, an increasing number of Chinese clinical pharmacists provide patients with warfarin education. However, little research to date has been carried out to evaluate the relationship between warfarin knowledge level and anticoagulation control among patients with heart valve replacement.Objective To evaluate knowledge of warfarin and the relationship between knowledge level and anticoagulation control among patients with heart valve replacem...
Source: International Journal of Clinical Pharmacy - May 15, 2020 Category: Drugs & Pharmacology Source Type: research

Effect of a prospective audit with intervention and feedback on Clostridioides difficile infection management
AbstractBackground Clostridioides difficile infections are associated with morbidity and mortality in several countries. Their increasing incidence and frequent recurrence make them an urgent public health threat. The lack of adherence to international treatment guidelines forClostridioides difficile infections is a proven mortality risk factor.ObjectiveTo evaluate long-term prescribers ’ adherence to recommendations on the management ofClostridioides difficile infections and its impact on clinical outcomes after an educational andClostridioides difficile-prospective audit with intervention and feedback period.Settin...
Source: International Journal of Clinical Pharmacy - May 15, 2020 Category: Drugs & Pharmacology Source Type: research

Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China
Conclusion As of February 10, 2020, the symptoms of COVID-19 patients in Hunan province were relatively mild comparing to patients in Wuhan, the epicenter. We observed some treatment benefits with interferon- α2b and corticosteroid therapies but not with novaferon and antibiotic treatment in our study population. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 14, 2020 Category: Drugs & Pharmacology Source Type: research

Assessment of  direct oral anticoagulants administered as potentially inappropriate medications to elderly inpatients
This study analysed 315 patients aged  ≥ 65 years. The application of our evaluation criteria identified 155 (49.2%) instances of potentially inappropriate medications, comprising 5 different types of potentially inappropriate medications. Fifteen adverse drug reactions occurred in the study participants. The Pearson chi-square t est revealed significant differences in number of medications (p = 0.021) and creatinine clearance rate (p = 0.002) between potentially inappropriate medications and non-potentially inappropriate medications groups. In the binary logistic regressio...
Source: International Journal of Clinical Pharmacy - May 13, 2020 Category: Drugs & Pharmacology Source Type: research

Role ambiguity and role conflict and their influence on responsibility of clinical pharmacists in China
Conclusion This study shows that clinical pharmacists in China experience problems with role ambiguity and role conflict and it will affect their fulfilment of their responsibilities. We propose that corresponding policies and measures should be taken to alleviate role ambiguity and role conflict and improve clinical pharmacy service. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 13, 2020 Category: Drugs & Pharmacology Source Type: research

Potentially inappropriate medications for older adults in a primary healthcare unit in southern Brazil
Conclusion Among the older adult population studied, the prevalence of potentially anappropriate medication  is high, according to the four different classification criteria used. As a more specific tool, the agreement between Anticholinergic Risk Scale and other criteria was lower, but it can be an important complement to other lists. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 11, 2020 Category: Drugs & Pharmacology Source Type: research

Co-trimoxazole induced hyperkalemia and potassium monitoring in hospitalized patients
This study aimed to determine average serum potassium rise after administration of intravenous co-trimoxazole in hospitalized patients, compared to intravenous ceftriaxone. This study also aimed to determine adherence to Dutch guidelines by measuring the incidence of serum potassium monitoring in these patients.Setting Five departments of the Canisius Wilhelmina Hospital, a teaching hospital in Nijmegen, the Netherlands.Method Data was collected and compared from patients that received intravenous co-trimoxazole (n  = 66) and intravenous ceftriaxone (n = 132) in the period of November 2008&ndash...
Source: International Journal of Clinical Pharmacy - May 11, 2020 Category: Drugs & Pharmacology Source Type: research

Utilization pattern and side effect profile of oral anticonceptives: A community-based cross-sectional study among Saudi women
Conclusion: Saudi women had a high acceptance rate for oral anticonceptives as a legitimate method to prevent unintended pregnancy. This was associated with a modest degree of understanding about their risks and benefits. Pharmacists should provide up-to-date information and counsel patients about the use and side effects of oral anticonceptives. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 9, 2020 Category: Drugs & Pharmacology Source Type: research

Covid-19 and drug therapy, what we learned
AbstractCOVID-19, the disease associated in December 2019 with the novel coronavirus SARS-CoV-2, was observed for the first time in China and then spread worldwide becoming pandemic. Currently, there is still no licensed specific antiviral treatment for the human coronavirus disease and a vaccine will not be ready soon. However, based on experience from the use of other antiviral agents to treat similar virusses, some treatment options have been tried with some efficacy. Clinical trials for future therapies are still ongoing. In the meantime, prevention, control, active communication and investment in research are the only...
Source: International Journal of Clinical Pharmacy - May 7, 2020 Category: Drugs & Pharmacology Source Type: research

Use of amlodipine oral solution for the treatment of hypertension in children
Conclusion The results from the PK study and the acceptability assessment show that the amlodipine oral solution presented in this study offers an appropriate treatment option for young children. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 6, 2020 Category: Drugs & Pharmacology Source Type: research

Treatment of iron deficiency anemia with liposomal iron in inflammatory bowel disease: efficacy and impact on quality of life
AbstractBackground Anemia is a clinical condition frequently seen in patients with inflammatory bowel disease, which is responsible for a significant loss of quality of life.Objective To assess the efficacy and safety of using oral liposomal iron to treat iron deficiency anemia in inflammatory bowel disease patients, as well as assess the impact of this treatment on psychometric scores.Methods Patients with inactive/mildly active inflammatory bowel disease were screened for anemia in this  interventional pilot study conducted from November 2016 to March 2018. Patients with mild anemia were treated with oral liposomal ...
Source: International Journal of Clinical Pharmacy - May 5, 2020 Category: Drugs & Pharmacology Source Type: research

Drug-related problems in a general paediatric ward of a tertiary care hospital in Malaysia
AbstractBackground Drug-related problems are relatively common among hospitalised patients and may be detrimental to patients and even increase healthcare costs. Characterising drug-related problems allows remedial actions to be in place to minimise the frequency  and ensure higher medication safety for the patients involved. Currently, the incidence of drug-related problems among hospitalised paediatric patients in Malaysia is unknown.Objective To determine the incidence, types and intervention acceptance, as well as the risk factors associated with drug-related problems in a Malaysian general paediatric ward.Se...
Source: International Journal of Clinical Pharmacy - April 30, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of goserelin effectiveness based on assessment of inflammatory cytokines and symptoms in uterine leiomyoma
AbstractBackground Uterine leiomyoma is a benign tumour of the uterine smooth muscles associated with an elevated level of inflammatory cytokines. Goserelin, a synthetic gonadotropin-releasing hormone  analogue, suppresses the production of sex hormones and release of inflammatory cytokines in uterine leiomyoma cells.Objective The primary objective of this study was to find out the effectiveness of subcutaneous goserelin therapy on lowering serum levels of inflammatory cytokines and improving uterine leiomyoma-related symptoms in female patients diagnosed with uterine leiomyoma. The secondary objective was to assess t...
Source: International Journal of Clinical Pharmacy - April 29, 2020 Category: Drugs & Pharmacology Source Type: research

Effects of red blood cell concentrate transfusion on blood tacrolimus concentration
AbstractBackground Elevated blood concentration of tacrolimus is frequently observed following transfusion of red blood cell concentrate in patients after allogeneic hematopoietic stem cell transplantation.Objective The aim of this retrospective study was to clarify the effects of transfusion of red blood cell concentrate on the blood concentration of tacrolimus.Setting Chiba University Hospital in Japan.Method Fifty-two patients (aged 0 –65 years) receiving both tacrolimus and transfusion after allogeneic hematopoietic stem cell transplantation were enrolled. The ratio of measurement after transfusion to measur...
Source: International Journal of Clinical Pharmacy - April 28, 2020 Category: Drugs & Pharmacology Source Type: research

Impact of pharmacist interventions on medication errors in hospitalized pediatric patients: a systematic review and meta-analysis
Conclusion Pharmacist interventions are effective for reducing medication error rates in hospitalized pediatric patients. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 24, 2020 Category: Drugs & Pharmacology Source Type: research

Appropriateness of oral dosage form modification for aged care residents: a video-recorded observational study
Conclusion The  modification of oral dosage forms seems a common practice in aged care facilities in Queensland. However, some of these modifications do not comply with the requirements of good practice according to existing guidelines. Healthcare workers in aged care facilities need to be supported and upskil led with effective training to promote the best and safest practices of ODF modification. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 23, 2020 Category: Drugs & Pharmacology Source Type: research

Aspirin compared to enoxaparin or rivaroxaban for thromboprophylaxis following hip and knee replacement
Conclusion In daily clinical practice, extended aspirin regimen is at least as effective as modified rivaroxaban for preventing clinically important venous thromboembolism among patients undergoing hip or knee arthroplasty who are discharged from the hospital without complications. Aspirin can be considered a safe and effective agent in the prevention of venous thromboembolism after total hip or total knee replacement. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 23, 2020 Category: Drugs & Pharmacology Source Type: research

Impact of hospitalization on potentially inappropriate prescribing: a cross-sectional study in an acute geriatric hospital in Lithuania
Conclusion Potentially inappropriate prescribing is highly prevalent among older patients hospitalized in the studied setting in Lithuania and hospitalization had not reduced potentially inappropriate medications and potential prescribing omissions. There is a need for interventions aiming to reduce potentially inappropriate prescribing among elderly patients. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 22, 2020 Category: Drugs & Pharmacology Source Type: research

A scoping review of polypharmacy interventions in patients with stroke, heart disease and diabetes
Conclusions Existing polypharmacy interventions have some efficacy at improving a variety of patient and healthcare system outcomes. Increased frequency and duration of follow-up with patients led to significant improvements in quality of life, disease control and cost-savings in outpatient and in-patient settings. However, our analysis of the identified studies suggests low-quality evidence and significant knowledge gaps regarding patients with stroke and cardiometabolic multimorbidity. This signals a need for further high-quality research to both confirm these findings and include these other high-risk patient population...
Source: International Journal of Clinical Pharmacy - April 21, 2020 Category: Drugs & Pharmacology Source Type: research

Antibiotic de-escalation on internal medicine services with rounding pharmacists compared to services without
Conclusion This data shows that broad-spectrum antibiotics were de-escalated more frequently on medicine services with rounding pharmacists compared to services without pharmacists. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 17, 2020 Category: Drugs & Pharmacology Source Type: research

The views of Australian adults experiencing pain on the upscheduling of codeine-containing analgesics to ‘prescription only’
Conclusion This study showed there are mixed views, with some participants being unsure or not in favour of the codeine upscheduling, particularly based on qualitative responses. There is also opportunity in this space for healthcare providers to extend beyond standard practice and offer alternative pain management advice and support now that codeine is no longer available in Australian pharmacies without a prescription. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 16, 2020 Category: Drugs & Pharmacology Source Type: research

Effect of health professional intervention on adherence to statin use according to the cause of patient non-adherence
AbstractBackground Non-adherence is a problem that particularly affects those with chronic diseases. Studying causes for not following the treatment is necessary to choose the best intervention to improve non-adherence.Objective Analyze how the intentionality of non-adherence modulates the effects of professional intervention in patients with hypercholesterolemia.  Setting: Community pharmacies and primary care centres in Spain.Methods A  6-month randomized controlled trial was conducted in 46 community pharmacies and 50 primary care centres in Spain. Adherence to statin therapy was measured with the Morisky-Gree...
Source: International Journal of Clinical Pharmacy - April 16, 2020 Category: Drugs & Pharmacology Source Type: research

Community pharmacy sales of non-prescribed antibiotics in Riyadh, Saudi Arabia: a simulated patient study
AbstractBackground The increased dispensing of non-prescribed antibiotics increases the public health problem of antimicrobial resistance. In April 2018, the Saudi Ministry of Health reinforced the disciplinary regulations of banning pharmacies from selling antibiotics without a medical prescription.Objective To assess the rate of non-prescribed antibiotic sales by community pharmacies and compare it with the findings from our 2011 study.Setting Community pharmacies, Riyadh City, Saudi Arabia.MethodsA cross-sectional, simulated patient study was conducted between August and November 2018. Six simulated clinical scenarios w...
Source: International Journal of Clinical Pharmacy - April 16, 2020 Category: Drugs & Pharmacology Source Type: research

A clinical audit of oral anticoagulant therapy in aged care residents with atrial fibrillation
Conclusion Many residents with non-valvular AF and significant risk of stroke were not receiving oral anticoagulation despite a lack of documented reason for non-prescribing. Non-vitamin K antagonists were widely prescribed but dosing of these agents could still be improved. There remains a need to improve anticoagulant prescribing for aged care residents and optimise stroke prevention in this population. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 14, 2020 Category: Drugs & Pharmacology Source Type: research

Prevalence of anticholinergic burden and risk factors amongst the older population: analysis of insurance claims data of Korean patients
Conclusion This study showed that 1 in 4 older Koreans are exposed to high anticholinergic burden. The predictors identified in this research might assist pharmacists in early interventions for their patients. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 13, 2020 Category: Drugs & Pharmacology Source Type: research

The impact of a computerised decision support system on antibiotic usage in an English hospital
Conclusion The implementation of computerised decision support systems appears to influence the use of antibiotics by reducing their consumption. Further research is required to determine the specific features of computerised decision support systems, which influence increased higher adoption and uptake of this technology. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 11, 2020 Category: Drugs & Pharmacology Source Type: research

Exploring pharmacy ethics in developing countries: a scoping review
Conclusions: Findings of this literature review illuminated a gap in pharmacy ethics literacy in developing countries and variances in pharmacists ’ ethical attitudes in handling ethical dilemmas, as well as a lack of familiarity with ethical principles and codes of ethics. Pharmacists’ lack of respect for patients’ autonomy and pharmacists being prone to financial pressure were found to have a significant impact on pharmacy practice in most of developing countries. However, attempts are being made to rectify this gap by efforts to incorporate ethical and professional education in undergraduate curricula,...
Source: International Journal of Clinical Pharmacy - April 10, 2020 Category: Drugs & Pharmacology Source Type: research

Effects of generic exchange of solid oral dosage forms in neurological disorders: a systematic review
Conclusion While most reports were of poor quality, lamotrigine was the drug with the best available data. Summarizing the results of the available studies, pharmacokinetic parameters of antiepileptic drugs show low deviation. In contrast, data on clinical parameters are less consistent. Some studies found increased seizure frequencies and adverse-drug events, while others showed no complications. Adherence and patient satisfaction seemed to be impaired. In daily practice, generic exchange in epilepsy should be a carefully balanced decision, conducted with great caution. Further research is needed, especially regarding neu...
Source: International Journal of Clinical Pharmacy - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

Knowledge and practices of community pharmacists towards non-prescription dispensing of antibiotics in Northern Nigeria
Conclusion Non-prescription dispensing of antibiotics was common among community pharmacists despite awareness about its prohibition and implications. The malpractice was associated with number of years of community pharmacy experience. Confidence in knowledge of antibiotic therapy was the main reason community pharmacists dispensed antibiotics without prescription. Continuous pharmacy education and training on handling of antibiotics may help to reduce inappropriate practices among community pharmacists. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 8, 2020 Category: Drugs & Pharmacology Source Type: research

Aromatase inhibitors associated osteonecrosis of jaw: signal refining to identify pseudo safety signals
Conclusion Our study concluded that the signal generated for aromatase inhibitors associated Osteonecrosis of Jaw in FAERS database can be false positive. Careful background corrections with identification of those risk factors are imperative to exclude false positive results. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 8, 2020 Category: Drugs & Pharmacology Source Type: research

Association of combination opioid, benzodiazepine, and muscle relaxant usage with emergency department visits in a nationwide cohort in the United States
Conclusions Concurrent opioid and benzodiazepine use and opioid, benzodiazepine, and muscle relaxant use increased probability of emergency department  visit. Amplified efforts in surveillance, prescribing, and default follow-up for concurrent opioid, benzodiazepine, muscle relaxant use are needed to reduce this public health concern. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 7, 2020 Category: Drugs & Pharmacology Source Type: research

Gap between patient expectation and perception during pharmacist –patient communication at community pharmacy
This study analyzed responses of 460 participants who answered all items on the questionnaire. Most respondents agreed or strongly agreed that they want to share information with pharmacists. All items had significant gap between patient expectation and perception (p 
Source: International Journal of Clinical Pharmacy - April 7, 2020 Category: Drugs & Pharmacology Source Type: research

Genetic polymorphisms of high platelet reactivity in Chinese patients with coronary heart disease under clopidogrel therapy
This study was conducted in the Chinese People ’s Liberation Army (PLA) general hospital.Method: 578 patients with coronary heart disease undergoing percutaneous transluminal coronary intervention treatment were enrolled. They received dual antiplatelet therapy with aspirin (300  mg) plus clopidogrel (300 mg) over 24 h, or aspirin (100 mg/day) and clopidogrel (75 mg/day) over 3 days. Patients were divided into two groups according to the adenosine diphosphate inhibition rate. The follow-up lasted at least 12 months and adverse endpoint events were recorded.Main outcome measure: The singl...
Source: International Journal of Clinical Pharmacy - April 6, 2020 Category: Drugs & Pharmacology Source Type: research

Letter to the editor for a published article titled “The effect of online versus hospital warfarin management on patient outcomes: a systematic review and meta-analysis”
(Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 2, 2020 Category: Drugs & Pharmacology Source Type: research

Providing pharmacy services at cabin hospitals at the coronavirus epicenter in China
AbstractIn the Chinese coronavirus epicenter, Wuhan, 16 cabin hospitals were built to admit patients with confirmed coronavirus infection (COVID-19). These cabin hospitals serve the role of effectively quarantine and treat mild cases of patients infected with COVID-19. Each cabin hospital has pharmacists to provide services and pharmaceutical care to patients. Pharmacists also provide assistance to cabin hospitals through remote internet platforms across China. In this commentary, we describe pharmacy services at cabin hospitals to share our experiences with the international pharmacy community. (Source: International Jour...
Source: International Journal of Clinical Pharmacy - April 2, 2020 Category: Drugs & Pharmacology Source Type: research

Providing pharmacy services during the coronavirus pandemic
AbstractThe coronavirus disease 19 (COVID-19) is quickly spreading across China and globally. Pharmacy services are an important  pillar in public health to prevent and contain the COVID-19 pandemic. Chinese pharmacists have acted swiftly in the public health response in China, such as drafting professional service guidance to pharmacists and pharmacies, establishing emergency drug formularies, monitoring and resolving drug shortages, establishing remote pharmacy services to prevent human-to-human infections, providing event-driven pharmaceutical care, educating the public on infection prevention and disease managemen...
Source: International Journal of Clinical Pharmacy - March 28, 2020 Category: Drugs & Pharmacology Source Type: research

The role of clinical pharmacist trainees in medication reconciliation process at hospital admission
Conclusion Medication reconciliation performed by pharmacist trainees upon admission can reduce unintentional medication discrepancies. Patients taking 5 or more drugs and experiencing more than two chronic diseases were found to be particularly at risk. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 27, 2020 Category: Drugs & Pharmacology Source Type: research

Quality assessment and cost saving of renal dosing recommendation by clinical pharmacists at medical wards in Thailand
Conclusion Trained clinical pharmacists were able to provide high-quality recommendation on dosage adjustment in these patients in accordance to standard dosing guidelines. In addition, dosage adjustment also led to a significant direct cost saving and cost avoidance from prevention of adverse drug reactions. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 27, 2020 Category: Drugs & Pharmacology Source Type: research

Feasibility of an interprofessional collaborative osteoporosis screening programme in Malaysia
AbstractBackground Population screening for osteoporosis using bone mineral density scan is not feasible in Malaysia as this test is costly. Hence, there is a need to develop a more efficient method to screen for osteoporosis.Objectives To determine the feasibility of an interprofessional collaborative osteoporosis screening programme (IPC-OSP).Methods Postmenopausal women aged  ≥ 50 years, who had not been diagnosed with osteoporosis were recruited from a primary care clinic from June to August 2014. Patients were assessed for their osteoporosis risk and were counselled on prevention methods. Patient...
Source: International Journal of Clinical Pharmacy - March 27, 2020 Category: Drugs & Pharmacology Source Type: research

Tigecycline-induced coagulopathy: a literature review
(Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 27, 2020 Category: Drugs & Pharmacology Source Type: research

Abstracts 7th PCNE working symposium ‘Right questions, valid answers’. 6–8 February 2020, Egmond aan Zee, The Netherlands
(Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 18, 2020 Category: Drugs & Pharmacology Source Type: research

Impact of chemotherapy schedule modification on breast cancer patients: a single-centre retrospective study
ConclusionNonconformity to the chemotherapy schedule is common in clinical practice because of treatment complications, patients ’ social schedule conflicts, and facility administrative reasons. Cumulative delays of ≥ 14 days are likely to have negative prognostic effect on patient survival. Thus, the duration of the delays between cycles should be reduced whenever possible to achieve the maximum chemotherapeutic benef it. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 17, 2020 Category: Drugs & Pharmacology Source Type: research

Ketogenic diet: a pharmaceutical guide for the management of drug therapy in the pediatric population
AbstractFor a ketogenic diet to be effective, strict control of carbohydrate intake is paramount. Factors such as medications may upset this delicate balance. The aim of this commentary is to provide physicians who are  treating patients with a ketogenic diet, with a step-by-step guide. A list of unsuitable excipients was established. A flowchart with the title “Can this drug be prescribed to a patient following a ketogenic diet?” was then drafted. The first step is to determine the international nonpropriet ary name, dosage, form and composition. The amount of unsuitable excipients is calculated. Sui...
Source: International Journal of Clinical Pharmacy - March 17, 2020 Category: Drugs & Pharmacology Source Type: research

Risk of major bleeding in elderly patients with atrial fibrillation on direct oral anticoagulants: real world experience
AbstractBackground The efficacy and safety of direct oral anticoagulants is well established in patients with atrial fibrillation. However, data on their use in the oldest old patients ( ≥ 85 years), who have the highest risk of bleeding, is scarce.Objective The aim of this study was to evaluate the safety of direct oral anticoagulants in the oldest old patients with atrial fibrillation and assess the impact of age on major bleeding events.Setting Anticoagulation Clinic of the Department of Vascular Diseases, University Medical Centre Ljubljana, Slovenia.Methods From our single-centre prospective registry we...
Source: International Journal of Clinical Pharmacy - March 13, 2020 Category: Drugs & Pharmacology Source Type: research