Screening for atrial fibrillation in care homes using pulse palpation and the AliveCor Kardia Mobile ® device: a comparative cross-sectional pilot study
ConclusionThis study has shown a need for AF screening in care homes and that elements of the PDAF screening protocol are transferable in this setting. Early diagnosis and treatment of AF are essential to reduce the risk of stroke in this population. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 27, 2023 Category: Drugs & Pharmacology Source Type: research

Accuracy in patient-reported adverse drug reactions and their recognition: a mixed-methods study
ConclusionPromoting the causality assessment tool for use by patients in collaboration with healthcare professionals is likely to enhance patients' ability to correctly identify ADRs and ultimately contribute to increased medication safety. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 27, 2023 Category: Drugs & Pharmacology Source Type: research

Discrepancies among equations to estimate the glomerular filtration rate for drug dosing decision making in aged patients: a cross sectional study
ConclusionClinically relevant differences in GFR estimation were observed among different equations, potentially impacting drug dose adjustments. However, discrepancies were not considered significant when comparing patient-adjusted and BSA-normalized versions of the equations, particularly for patients with BSA close to the average. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 27, 2023 Category: Drugs & Pharmacology Source Type: research

Screening for atrial fibrillation in care homes using pulse palpation and the AliveCor Kardia Mobile ® device: a comparative cross-sectional pilot study
ConclusionThis study has shown a need for AF screening in care homes and that elements of the PDAF screening protocol are transferable in this setting. Early diagnosis and treatment of AF are essential to reduce the risk of stroke in this population. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 27, 2023 Category: Drugs & Pharmacology Source Type: research

Management of iron deficiency in women of childbearing age with oral iron intolerance: a prospective, randomised, controlled trial of three doses of an iron-whey-protein formulation
ConclusionUndiagnosed iron deficiency is common in women of childbearing age with a history of intolerance to oral iron and iron-whey-protein microspheres can improve adherence, GI tolerability, iron stores, haemoglobin and energy levels in these women.Clinical trial registration Clinicaltrials.gov identifier (registration includes full trial protocol): NCT04778072. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 26, 2023 Category: Drugs & Pharmacology Source Type: research

The prevalence of hepatic and thyroid toxicity associated with imatinib treatment of chronic myeloid leukaemia: a systematic review
ConclusionHigh frequency of mild and severe hepatotoxicity, associated with imatinib in CML patients, was reported in the published literature. Low numbers of mild and manageable thyroid toxicity events were reported. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 26, 2023 Category: Drugs & Pharmacology Source Type: research

Management of iron deficiency in women of childbearing age with oral iron intolerance: a prospective, randomised, controlled trial of three doses of an iron-whey-protein formulation
ConclusionUndiagnosed iron deficiency is common in women of childbearing age with a history of intolerance to oral iron and iron-whey-protein microspheres can improve adherence, GI tolerability, iron stores, haemoglobin and energy levels in these women.Clinical trial registration Clinicaltrials.gov identifier (registration includes full trial protocol): NCT04778072. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 26, 2023 Category: Drugs & Pharmacology Source Type: research

The prevalence of hepatic and thyroid toxicity associated with imatinib treatment of chronic myeloid leukaemia: a systematic review
ConclusionHigh frequency of mild and severe hepatotoxicity, associated with imatinib in CML patients, was reported in the published literature. Low numbers of mild and manageable thyroid toxicity events were reported. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 26, 2023 Category: Drugs & Pharmacology Source Type: research

Real-world data of atezolizumab in patients with previously treated locally advanced or metastatic urothelial bladder cancer
ConclusionIn a real-world population with previously treated mUBC, atezolizumab seems to provide clinically relevant benefit, which is even higher for patients with ECOG 0 –1 and without liver metastases, with an acceptable safety profile. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 19, 2023 Category: Drugs & Pharmacology Source Type: research

The effectiveness of ibandronate in reducing the risk of nonvertebral fractures in women with osteoporosis: systematic review and meta-analysis of observational studies
ConclusionResults suggest that once-monthly 150  mg oral ibandronate may be as effective as other oral bisphosphonates in reducing the risk of nonvertebral fractures. However, uncertainty associated to the small number of included studies, which are characterized by heterogeneous demographics and methodologies, precluded definitive conclusions. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 19, 2023 Category: Drugs & Pharmacology Source Type: research

What do emergency department pharmacist practitioners know and understand about patient safeguarding? A qualitative study
ConclusionWhile Emergency Department Pharmacist Practitioners interviewed were aware of  the safeguarding process, there were some misconceptions as to the roles of different healthcare workers in this process. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 19, 2023 Category: Drugs & Pharmacology Source Type: research

Real-world data of atezolizumab in patients with previously treated locally advanced or metastatic urothelial bladder cancer
ConclusionIn a real-world population with previously treated mUBC, atezolizumab seems to provide clinically relevant benefit, which is even higher for patients with ECOG 0 –1 and without liver metastases, with an acceptable safety profile. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 19, 2023 Category: Drugs & Pharmacology Source Type: research

The effectiveness of ibandronate in reducing the risk of nonvertebral fractures in women with osteoporosis: systematic review and meta-analysis of observational studies
ConclusionResults suggest that once-monthly 150  mg oral ibandronate may be as effective as other oral bisphosphonates in reducing the risk of nonvertebral fractures. However, uncertainty associated to the small number of included studies, which are characterized by heterogeneous demographics and methodologies, precluded definitive conclusions. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 19, 2023 Category: Drugs & Pharmacology Source Type: research

What do emergency department pharmacist practitioners know and understand about patient safeguarding? A qualitative study
ConclusionWhile Emergency Department Pharmacist Practitioners interviewed were aware of  the safeguarding process, there were some misconceptions as to the roles of different healthcare workers in this process. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 19, 2023 Category: Drugs & Pharmacology Source Type: research

Assessing safety concerns of interstitial lung disease associated with antibody-drug conjugates: a real-world pharmacovigilance evaluation of the FDA adverse event reporting system
ConclusionThis real-world study highlights high safety signals of interstitial lung disease associated with antibody-drug conjugates. Clinicians should be aware of these safety concerns and risk factors and implement early identification measures for their patients. Future research should prioritize comprehensively exploring the relationship between antibody-drug conjugates and lung diseases. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 15, 2023 Category: Drugs & Pharmacology Source Type: research