Management of Sarcoidosis-Associated Pulmonary Hypertension.
PMID: 32571775 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - June 22, 2020 Category: General Medicine Authors: Ho JQ, Kuschner WG Tags: Clin Med Res Source Type: research

Urine Antigen Testing is Equally Sensitive to B. dermatitidis and B. gilchristii Infections.
Abstract INTRODUCTION: Blastomycosis is endemic in Wisconsin with B. dermatitidis and B. gilchristii responsible for infections. Urine antigen testing is a non-invasive diagnostic method for blastomycosis with up to 93% test sensitivity. However, the test's sensitivity has not been evaluated with relationship to B. gilchristii infections. METHODS: We aimed to assess physician use of the urine antigen assay and its sensitivity to B. gilchristii and B. dermatitidis infections in a retrospective study. Culture confirmed clinical cases of blastomycosis from 2008-2016 were identified within Marshfield Clinic Healt...
Source: Clinical Medicine and Research - June 22, 2020 Category: General Medicine Authors: Laux KL, Anderson JL, Bentivenga SP, McBride JA, Sterkel A, Matkovic E, Gauthier GM, Meece JK Tags: Clin Med Res Source Type: research

Lipid Accumulation Product Index to Predict Metabolic Syndrome in People Living with HIV.
ás U Abstract BACKGROUND: Dyslipidemia and central obesity are the main components of metabolic syndrome (MS), which represent important risk factors for cardiovascular diseases in people living with HIV. The lipid accumulation product (LAP) index has been shown in studies as an efficient marker of MS in general adult population and its applicability in HIV-infected population is not discussed. We aimed to assess the accuracy of the LAP index to identify MS in people living with HIV. METHODS: It is a cross-sectional study with 141 HIV-infected patients on antiretroviral therapy, conducted in a referenc...
Source: Clinical Medicine and Research - April 27, 2020 Category: General Medicine Authors: Raposo MA, Guimarães NS, Tupinambás U Tags: Clin Med Res Source Type: research

Heart Failure with Preserve Ejection Fraction (HFpEF) and 30-Day Readmission.
The objective of this work was to investigate whether a specific type of heart failure (HFpEF or HFrEF) has a higher association to the rate of 30-day hospital readmission and compare their predictability with the two risk scores: HOSPITAL score and LACE index. DESIGN: Retrospective study from single academic center METHODS: Sample size included adult patients from an academic hospital in a two-year period (2015 - 2017). Exclusion criteria included death, transfer to another hospital, and unadvised leave from hospital. Baseline characteristics, Diagnosis-Related Group, and ICD diagnosis codes were obtained. Variables ...
Source: Clinical Medicine and Research - April 27, 2020 Category: General Medicine Authors: Regmi MR, Bhattarai M, Parajuli P, Garcia OEL, Tandan N, Ferry N, Cheema A, Chami Y, Robinson R Tags: Clin Med Res Source Type: research

Multimodal Intervention Approach Reduces Catheter-Associated Urinary Tract Infections (CAUTI) in a Rural Tertiary Care Center.
Abstract OBJECTIVE: To compare the catheter-associated urinary tract infections (CAUTI) standardized infection rate (SIR) before and after implementation of a multimodal intervention approach in a rural tertiary hospital. DESIGN: Before-after analysis of a multimodal intervention to evaluate primary outcomes of the incidence of inpatient CAUTI, the SIR for CAUTI, and number of urinary catheter days. SETTING: All inpatient departments of a rural 504-bed tertiary care facility in the Midwest. PARTICIPANTS: Patients admitted for in-patient care. INTERVENTIONS: A multimodal intervention composed of...
Source: Clinical Medicine and Research - April 27, 2020 Category: General Medicine Authors: Potugari BR, Umukoro PE, Vedre JG Tags: Clin Med Res Source Type: research

Suspected Neuro-invasive Powassan Virus Infection in a Pediatric Patient.
We present a suspected pediatric case of POWV infection in northern Wisconsin. PMID: 32060042 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - February 14, 2020 Category: General Medicine Authors: Koester TM, Timothy P, Meece JK, Osborn RA, Frost HM Tags: Clin Med Res Source Type: research

Clinical Outcomes of Various Management Strategies for Symptomatic Bradycardia.
Abstract OBJECTIVE: To determine clinical outcomes of various management strategies for reversible and irreversible causes of symptomatic bradycardia in the inpatient setting. DESIGN: Retrospective observational study. SETTING: Emergency Room and Inpatient. PARTICIPANTS: Patients presenting to the Emergency Department with symptomatic bradycardia. METHODS: We retrospectively reviewed electronic health records of 518 patients from 2 Mayo Clinic campuses (Rochester and Phoenix) who presented to the emergency department with symptomatic bradycardia (heart rate ≤50 beats/minute) from January 1, ...
Source: Clinical Medicine and Research - February 14, 2020 Category: General Medicine Authors: Abrich VA, Le RJ, Mulpuru SK, Friedman PA, Barsness GW, Cha YM, Lennon RJ, Lewis BR, Yang EH Tags: Clin Med Res Source Type: research

Inpatient Mortality and 30-Day Readmission Rates Associated with Troponin Testing in Patients without Acute Myocardial Infarction.
CONCLUSIONS: A higher inpatient mortality and 30-day readmission rates were found in patients with type 2 AMI compared to type 1 AMI group. PMID: 32060044 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - February 14, 2020 Category: General Medicine Authors: Widmer RJ, Wilson G, Haneke T, Lee M, Fan J, Davis A, Fry E, Kurian K, Urbanczyk J, Potter J, McMahon M, Rhodehouse B, Song JJ, Michel JB Tags: Clin Med Res Source Type: research

Physician Burnout, Engagement and Career Satisfaction in a Large Academic Medical Practice.
CONCLUSION: Engaged physicians have higher career satisfaction. There are many actionable ways to improve engagement. PMID: 31959669 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - January 20, 2020 Category: General Medicine Authors: Rao S, Ferris TG, Hidrue MK, Lehrhoff SR, Lenz S, Heffernan J, McKee KE, Del Carmen MG Tags: Clin Med Res Source Type: research

Cardiac Anomalies in Liveborn and Stillborn Monochorionic Twins.
CONCLUSIONS: Monochorionic twins, particularly those with TTT, are at increased risk for a spectrum of structural cardiac malformations which we suggest may be related to asymmetry of the inner cell mass resulting in a smaller poorly perfused twin. In severe cases, limited cardiac and circulatory development in the affected twin leads to acardia. In less severe cases, the smaller infant has deficient septal growth that sometimes results in ventricular septal defect. PMID: 31959670 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - January 20, 2020 Category: General Medicine Authors: McPherson E, Korlesky C, Hebbring S Tags: Clin Med Res Source Type: research

Mortality of Patients Requiring Escalation to Intensive Care within 24 Hours of Admission in a Mixed Medical-Surgical Population.
CONCLUSION: In a large retrospective study, surgical patients had increased 1-year mortality if they required escalation to the ICU within 24 hours of hospital admission. This result was not replicated in medical patients, possibly related to a burden of illness that could not be altered by earlier care. PMID: 31959671 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - January 20, 2020 Category: General Medicine Authors: Leong J, Madhok J, Lighthall GK Tags: Clin Med Res Source Type: research

Fact or Fable: The Truth About Physician Engagement and Burnout.
PMID: 31959672 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - January 20, 2020 Category: General Medicine Authors: Busari JO, Onitilo AA Tags: Clin Med Res Source Type: research

Reviewers: Volume 17, 2019.
Authors: PMID: 31792021 [PubMed - in process] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - December 1, 2019 Category: General Medicine Tags: Clin Med Res Source Type: research

Death Certification: Errors and Interventions.
CONCLUSION: This study reaffirms the importance of autopsy and autopsy pathologists in ensuring accurate and complete death certification. It also suggests that death certification errors may be more frequent than previously reported. We propose a method by which death certification errors can be classified in terms of increasing severity. By understanding the types of errors occurring on death certificates, academic institutions can work to improve certification accuracy. Better clinician education, coordination with autopsy pathologists, and implementation of a systematic approach to ensuring concordance of death certifi...
Source: Clinical Medicine and Research - October 9, 2019 Category: General Medicine Authors: Schuppener LM, Olson K, Brooks EG Tags: Clin Med Res Source Type: research

Beyond Hemoglobin: When and How to Work Up Possible Polycythemia Vera.
CONCLUSIONS: Readily accessible clinical and laboratory data can assist in considering a PV workup, and a possible diagnostic algorithm is presented. These preliminary findings warrant larger studies to develop a more formal PV-risk scoring system with optimal cutoffs and weighting. PMID: 31582417 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - October 3, 2019 Category: General Medicine Authors: Shaw G, Berg R Tags: Clin Med Res Source Type: research

First Report of Retroperitoneal Mucinous Cystadenoma in a Patient with Hirsutism.
Abstract Primary retroperitoneal mucinous cystadenomas (PRMC) are rare benign neoplasms with only 55 documented cases in the English literature so far. A 19-year-old female exhibited hirsutism and was found to have a cystic mass measuring 5.8 cm × 3.9 cm × 5.8 cm in the left retroperitoneum. During subsequent workup a high pre-operative value of dehydroepiandrosterone sulfate (DHEAS) was noted. The patient was referred to surgical oncology and underwent an uneventful laparoscopic cystectomy. Pathology classified the cyst as PRMC. Post-operatively, the patient's DHEAS levels normalized, though there was...
Source: Clinical Medicine and Research - October 3, 2019 Category: General Medicine Authors: Danen C, Leschke T, Bassi D, Sharma R Tags: Clin Med Res Source Type: research

Staphylococcus aureus Resistance Patterns in Wisconsin: 2018 Surveillance of Wisconsin Organisms for Trends in Antimicrobial Resistance and Epidemiology (SWOTARE) Program Report.
CONCLUSIONS: Several antimicrobial agents continue to demonstrate in vitro efficacy against clinical isolates of S. aureus (including MRSA) throughout Wisconsin, including three agents with recently-published susceptibility testing guidelines. However, continued surveillance efforts may be necessary in the Lake Winnebago, Southeast, and Southcentral regions to further assess higher rates of resistance to a number of antimicrobial agents. PMID: 31582419 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - October 3, 2019 Category: General Medicine Authors: Schulte RH, Munson E Tags: Clin Med Res Source Type: research

A Case of Isolated Unilateral Glossopharyngeal Nerve Palsy.
This article discusses the various etiologies and mechanisms of this rare condition. It is unique because of the nerve's location and relation to other structures. PMID: 31511240 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - September 11, 2019 Category: General Medicine Authors: Savarimuthu MK, Nair AK Tags: Clin Med Res Source Type: research

Hepatitis C Virus-associated Acalculous Cholecystitis and Review of the Literature.
We report on a patient who was first diagnosed with chronic Hepatic C infection and subsequently acalculous cholecystitis. PMID: 31511241 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - September 11, 2019 Category: General Medicine Authors: Wright WF, Palisoc K, Pinto CN, Lease JA, Baghli S Tags: Clin Med Res Source Type: research

GH-IGF1 Axis in Children with Cystic Fibrosis.
In this study we compared BMI, height, weight, IGF-I, GHBP and GHR gene expression values (evaluated by Chemiluminescent Immunometric assay; ELISA and Real time PCR respectively) in CF patients diagnosed through NBS (New born screening), or by symptoms (Late Diagnosis (LD)) and in healthy controls. RESULTS: BMI increased significantly in patients between the time of diagnosis and check-ups (p
Source: Clinical Medicine and Research - August 28, 2019 Category: General Medicine Authors: Pagani S, Bozzola E, Acquafredda G, Terlizzi V, Raia V, Maio F, Villani A, Bozzola M Tags: Clin Med Res Source Type: research

Neuropsychiatric Adverse Events from Topical Ophthalmic Timolol.
Abstract Timolol is a commonly-used topical antiglaucoma medication and has proven to be highly efficacious for most recipients. Among the reported adverse events, the neuropsychiatric spectrum has been cited, albeit for a small proportion of those treated. This review summarizes the cumulative published experience of such side effects and assesses the quality of evidence. As for other beta-blockers, whether orally or topically administered, various central nervous systems dysfunctions have been detailed in either case reports or larger patient series. The adverse event commonly resolves following drug termination...
Source: Clinical Medicine and Research - August 28, 2019 Category: General Medicine Authors: Cimolai N Tags: Clin Med Res Source Type: research

Tattoo Koebnerization and Severe Pulmonary Hypertension.
PMID: 31462539 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - August 28, 2019 Category: General Medicine Authors: Patel M, Ladak K Tags: Clin Med Res Source Type: research

Effectiveness of Standardized Patient in Abdominal Physical Examination Education: A Randomized, Controlled Trial.
Abstract INTRODUCTION: Simulation and virtual technologies currently are used to enhance basic and advanced nursing skills. Information on the use of simulation methods in the Iranian nursing education system, particularly regarding standardized patients (SP), is scarce. Hence, the present study aimed to evaluate the effect of using SP on the performance of Iranian nursing students in the physical examination of the abdomen. In addition, the SP method was compared with the purely lecture-based education method. METHODS: The present study was of a pre-test/post-test design carried out at the School of Nursing ...
Source: Clinical Medicine and Research - June 1, 2019 Category: General Medicine Authors: Jaberi A, Momennasab M Tags: Clin Med Res Source Type: research

Assessing Prognosis of Acute Coronary Syndrome in Recent Clinical Trials: A Systematic Review.
Abstract There is no recent comprehensive overview of contemporary clinical trials assessing short and long-term outcomes in patients with acute coronary syndrome (ACS). This paper reviews factors from recent clinical trials that influenced prognosis in patients with ACS. Cochrane and PubMed databases were screened systematically for clinical trials published in the English literature reporting on ACS prognosis. Two authors independently screened titles, abstracts, and full text. Studies meeting inclusion criteria evaluated the impact of modern practice on prognosis. In vitro and animal models studies, conference ...
Source: Clinical Medicine and Research - June 1, 2019 Category: General Medicine Authors: Ye F, Winchester D, Jansen M, Lee A, Silverstein B, Stalvey C, Khuddus M, Mazza J, Yale S Tags: Clin Med Res Source Type: research

Recognizing Poor Sleep Quality Factors During Oral Health Evaluations.
Abstract Oral health practitioners routinely perform oral health assessments for the dental patient to determine if oral disease is present. Systemic health is often a contributor to oral health concerns. One area in particular that has a direct effect on oral structures and oral health is poor sleep quality and open mouth breathing. Sleep is a fundamental process of the human body, which regulates core biological functions. Sleep quality reflects a person's ability to fall asleep, stay asleep, and enter into the various rejuvenating sleep cycles for the full duration. A person who does not obtain quality sleep ca...
Source: Clinical Medicine and Research - June 1, 2019 Category: General Medicine Authors: Schroeder K, Gurenlian JR Tags: Clin Med Res Source Type: research

Nivolumab-Associated Acute Demyelinating Encephalitis: A Case Report and Literature Review.
We present a 59-year-old Caucasian woman with a history of treatment-resistant, progressive, laryngeal squamous cell carcinoma. She received nivolumab and presented with gradual weakness, confusion, and progressive dyspnea. Magnetic resonance imaging of the head showed multifocal cerebral demyelination, primarily involving the parietal lobe. The diagnosis of acute demyelinating encephalitis was made. She improved dramatically after stopping nivolumab and receiving treatment with high-dose intravenous steroid and immunoglobin therapy. We conclude, from this case and literature review, that immune checkpoint inhibitor treatm...
Source: Clinical Medicine and Research - June 1, 2019 Category: General Medicine Authors: Zafar Z, Vogler C, Hudali T, Bhattarai M Tags: Clin Med Res Source Type: research

Cocaine-Induced Bronchospasm Mimicking Acute Asthma Exacerbation.
Abstract Cocaine can cause a myriad of changes in the lung, which can range from bronchoconstriction to destruction of the alveolar-capillary membrane and acute lung injury. Cocaine-induced bronchospasm is a diagnosis of exclusion that should be considered when the clinical presentation of acute hypoxic and hypercapneic respiratory failure cannot be explained by chronic obstructive pulmonary disease or asthma exacerbation, anaphylaxis to food or medications, exercise, or infection. Here, we present two patients with acute hypoxic and hypercapneic respiratory failure that was ultimately attributed to cocaine use sh...
Source: Clinical Medicine and Research - June 1, 2019 Category: General Medicine Authors: Zhou CY, Ricker M, Pathak V Tags: Clin Med Res Source Type: research

Prolongation of Second Twin's Delivery Until Term: A Rare Case of Delayed-Interval Delivery.
We report a case of delayed-interval delivery wherein prolongation of the second twin's delivery until term with a subsequent favorable infantile outcome. In this case, the stillbirth of the first twin occurred at 25 weeks' gestation. Prophylactic tocolysis was performed with ritodrine and magnesium sulfate, and a McDonald cerclage was performed 2 days after delivery of the first twin. Ampicillin and gentamicin were also administered for the purpose of prevention of intrauterine infection. No clinical sign of chorioamnionitis was found thereafter, and full term uneventful delivery was achieved. With this experience, we bel...
Source: Clinical Medicine and Research - June 1, 2019 Category: General Medicine Authors: Imachi Y, Hidaka N, Kai S, Hachisuga M, Kato K Tags: Clin Med Res Source Type: research

Contagious Horror: Infectious Themes in Fiction and Film.
Abstract Infectious diseases have been a preeminent part of literature since the earliest human writings. In particular, they have contributed greatly to the genre of horror-written or visual art intended to startle or scare. Horror fiction has emphasized infectious themes from the earliest Babylonian and Hebrew texts. In medieval times, stories of vampires and werewolves often had a contagious component, and pivotal works of Victorian horror centered around fear of infection and contamination. As film became prominent in the 20th Century, a strong emphasis on themes of plague and apocalypse developed. An analysis...
Source: Clinical Medicine and Research - June 1, 2019 Category: General Medicine Authors: Sartin JS Tags: Clin Med Res Source Type: research

Abdominal Physical Signs and Medical Eponyms: Part II. Physical Examination of Palpation, 1907-1926.
CONCLUSION: We describe brief historical background information about the physician who reported the sign, original description of the sign, and its clinical application and implication into today's medical practice. PMID: 31160480 [PubMed - in process] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - June 1, 2019 Category: General Medicine Authors: Rastogi V, Singh D, Tekiner H, Ye F, Mazza JJ, Yale SH Tags: Clin Med Res Source Type: research

Cardiac Dysfunction in Adult Patients with Traumatic Brain Injury: A Prospective Cohort Study.
CONCLUSIONS: Cardiac dysfunction occurs in patients after moderate to severe TBI, with mild to moderate reduction in left ventricular ejection fraction. Patients who developed cardiac dysfunction after TBI had a higher prevalence of diabetes mellitus and higher proportion of abnormalities in electrocardiograms. Development of cardiac dysfunction was not associated with adverse clinical outcomes. PMID: 30587559 [PubMed - in process] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - December 1, 2018 Category: General Medicine Authors: Venkata C, Kasal J Tags: Clin Med Res Source Type: research

Metastatic Prostate Cancer in a RAD51C Mutation Carrier.
Abstract A man, aged 61 years, with a history of hypogonadism and family history of cancer experienced persistent urinary difficulties with no visible prostate abnormalities. Laboratory testing and diagnostic imaging revealed a primary lesion in the prostate with lymph node involvement and multiple bone metastases. Treatment with androgen-deprivation therapy, 17,20-lyase inhibition, and bisphosphonates for 7 months was unsuccessful in preventing disease progression, but second-line chemotherapy and continued androgen-deprivation therapy improved prostate specific antigen levels. During the patient's second treatme...
Source: Clinical Medicine and Research - December 1, 2018 Category: General Medicine Authors: Potugari BR, Engel JM, Onitilo AA Tags: Clin Med Res Source Type: research

A Multidisciplinary Approach to Management of Bouveret Syndrome.
We describe a multidisciplinary approach to management of Bouveret Syndrome that could be adopted by healthcare systems with resources commonly found in facilities with a general urologist and gastroenterologist or general surgeon. Successful application of laser lithotripsy under endoscopic guidance sufficiently fractured the stone to allow for disimpaction and relief of the gastric outlet obstruction. PMID: 30587561 [PubMed - in process] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - December 1, 2018 Category: General Medicine Authors: Watson RS, Folkers TE, Van Every MJ Tags: Clin Med Res Source Type: research

Abdominal Physical Signs and Medical Eponyms: Movements and Compression.
CONCLUSION: These active and passive maneuvers of the abdomen, reported as medical signs, have variable performance in medical practice. The lack of diagnostic accuracy may be attributed to confounders such as the position of the organ, modification of the original technique, or lack of performance of the maneuver as originally intended. PMID: 30587562 [PubMed - in process] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - December 1, 2018 Category: General Medicine Authors: Rastogi V, Singh D, Tekiner H, Ye F, Mazza JJ, Yale SH Tags: Clin Med Res Source Type: research

Traction Diverticulum of the Small Bowel with Enterolith as a Cause of Intestinal Obstruction.
PMID: 30587563 [PubMed - in process] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - December 1, 2018 Category: General Medicine Authors: Gachabayov M, Orujova L, Kubachev K Tags: Clin Med Res Source Type: research

Subject Index: Volume 16, 2018.
Authors: PMID: 30587564 [PubMed - in process] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - December 1, 2018 Category: General Medicine Tags: Clin Med Res Source Type: research

Author Index: Volume 16, 2018.
Authors: PMID: 30587565 [PubMed - in process] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - December 1, 2018 Category: General Medicine Tags: Clin Med Res Source Type: research

Reviewers: Volume 16.
Authors: PMID: 30587566 [PubMed - in process] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - December 1, 2018 Category: General Medicine Tags: Clin Med Res Source Type: research

Abdominal Physical Signs and Medical Eponyms: Part I. Physical Examination of Palpation, 1876-1907.
CONCLUSION: We present brief historical background information about the physician who reported the sign, original description of the sign, and its clinical application and implication in today's medical practice. PMID: 30166497 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - August 30, 2018 Category: General Medicine Authors: Rastogi V, Singh D, Tekiner H, Ye F, Kirchenko N, Mazza JJ, Yale SH Tags: Clin Med Res Source Type: research

Infectious Mononucleosis and Lyme Disease as Confounding Diagnoses: A Report of 2 Cases.
We describe the clinical presentation of two children with confirmed early Lyme disease and features suggestive of infectious mononucleosis, including one case of probable Lyme and EBV co-infection. PMID: 30166498 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - August 30, 2018 Category: General Medicine Authors: Koester TM, Meece JK, Fritsche TR, Frost HM Tags: Clin Med Res Source Type: research

Effect of Near-Infrared Light Therapy Based on Acupoints on the Severity of Restless Legs Syndrome in Patients Undergoing Hemodialysis: A Single-Blind Randomized Controlled Trial.
Abstract INTRODUCTION: Restless legs syndrome (RLS) is a common disorder in hemodialysis patients. The present study was conducted to determine the effect of near-infrared (NIR) light therapy given to acupoints on the severity of RLS in patients undergoing hemodialysis. METHODS: This single-blind randomized controlled trial was performed on 60 hemodialysis patients with RLS. Participants who met the inclusion criteria were randomly assigned to an intervention group (n = 30) or a control group (n = 30). Data were collected using the International Restless Legs Syndrome Rating Scale (IRLSRS) and demographic inf...
Source: Clinical Medicine and Research - May 18, 2018 Category: General Medicine Authors: Mohammadi MM, Raygani AAV, Ghobadi A, Samadzadeh S, Salari N Tags: Clin Med Res Source Type: research

Treatment-Refractory Mania with Psychosis in a Post-Transplant Patient on Tacrolimus: A Case Report.
We report here a case of a 66 year old Caucasian female, previously diagnosed with Bipolar disorder who developed treatment refractory mania with psychotic feature after being on Tacrolimus (an immunosuppressive agent) after kidney transplantation. PMID: 29776917 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - May 18, 2018 Category: General Medicine Authors: Ithman M, Malhotra K, Bordoloi M, Singh G Tags: Clin Med Res Source Type: research

A Descriptive Study of Chlorhexidine as a Disinfectant in Cleft Palate Surgery.
CONCLUSIONS: This study demonstrated that 61 of the total of 113 pathogens isolated (54%), survived after 2 minutes of disinfecting the surgical and surrounding area with CHG, thus intensifying the chances of post-operative infection. PMID: 29724746 [PubMed - as supplied by publisher] (Source: Clinical Medicine and Research)
Source: Clinical Medicine and Research - May 3, 2018 Category: General Medicine Authors: Roode GJ, Bütow KW Tags: Clin Med Res Source Type: research

Flushing Disorders Associated with Gastrointestinal Symptoms: Part 1, Neuroendocrine Tumors, Mast Cell Disorders and Hyperbasophila.
Abstract Flushing is the subjective sensation of warmth accompanied by visible cutaneous erythema occurring throughout the body with a predilection for the face, neck, pinnae, and upper trunk where the skin is thinnest and cutaneous vessels are superficially located and in greatest numbers. Flushing can be present in either a wet or dry form depending upon whether neural-mediated mechanisms are involved. Activation of the sympathetic nervous system results in wet flushing, accompanied by diaphoresis, due to concomitant stimulation of eccrine sweat glands. Wet flushing is caused by certain medications, panic disord...
Source: Clinical Medicine and Research - April 12, 2018 Category: General Medicine Authors: Rastogi V, Singh D, Mazza JJ, Yang D, Parajuli D, Yale SH Tags: Clin Med Res Source Type: research

Flushing Disorders Associated with Gastrointestinal Symptoms: Part 2, Systemic Miscellaneous Conditions.
Abstract Flushing disorders with involvement of the gastrointestinal tract represent a heterogeneous group of conditions. In part 1 discussed were neuroendocrine tumors (NET), mast cell activation disorders (MCAD), and hyperbasophilia. In this section are covered the remaining flushing disorders which primarily or secondarily involves the gastrointestinal tract. This includes dumping syndrome, mesenteric traction syndrome, rosacea, hyperthyroidism and thyroid storm, anaphylaxis, panic disorders, paroxysmal extreme pain disorder, and food, alcohol and medications. With the exception of paroxysmal pain disorders, pa...
Source: Clinical Medicine and Research - April 12, 2018 Category: General Medicine Authors: Rastogi V, Singh D, Mazza JJ, Yang D, Parajuli D, Yale SH Tags: Clin Med Res Source Type: research

Beh çet's Disease: Pulmonary Aneurysm Resolution with Oral Therapy and HLA B72 Allele Association.
We report the case of a female patient who was diagnosed with a pulmonary artery aneurysm that was caused by Behçet's disease. The patient was initially diagnosed with community-acquired pneumonia and then pulmonary thromboembolism and aneurysm of the right pulmonary artery segmental branch was confirmed. The initial treatment consisted of anticoagulant drugs. After analysis of the family history and a positive pathergy test, the patient was diagnosed with Behçet's disease. Oral pharmacological treatment began with corticosteroids, cyclophosphamide, and anticoagulant suspension. The HLA B72 allele was identif...
Source: Clinical Medicine and Research - April 2, 2018 Category: General Medicine Authors: de Albuquerque Botura C, Bersani-Amado LE, Zacarias-Júnior AR, Boreli SD, Stecca NGG, da Rocha BA, Cuman RKN, Bersani-Amado CA Tags: Clin Med Res Source Type: research

Biologic Agent-Associated Cutaneous Adverse Events: A Single Center Experience.
Abstract Biologic agents are regarded as an effective treatment for a variety of autoimmune diseases. These drugs have an acceptable safety and tolerability profile, although an increasing number of autoimmune conditions have been reported with their use. Additionally, a variety of cutaneous diseases have been associated with their use. Here we report our experience of adverse cutaneous events with the use of biologic agents. An alternative explanation for patients presenting with adverse cutaneous events including drug interactions must be carefully investigated. PMID: 29610119 [PubMed - as supplied by publi...
Source: Clinical Medicine and Research - April 2, 2018 Category: General Medicine Authors: Sehgal R, Stratman EJ, Cutlan JE Tags: Clin Med Res Source Type: research

The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review.
Abstract Moisturizer is a major component of basic daily skin care, particularly in presence of epidermal barrier alteration and reduced epidermal water content. It is an important part of a dermatologist's strategy to maintain skin health as well as treating various dermatoses which co-exist with skin dryness, linked to impaired skin barrier function such as in atopic disorder as well as other types of dermatitis. Mastering the knowledge regarding action mechanism, application, dosage, adverse effects as well as specific clinical usage of moisturizers is must for a dermatologist, in order to support the capabilit...
Source: Clinical Medicine and Research - December 11, 2017 Category: General Medicine Authors: Purnamawati S, Satria B, Indrastuti N, Danarti R, Saefudin T Tags: Clin Med Res Source Type: research

Update on Electronic Dental Record and Clinical Computing Adoption Among Dental Practices in the United States.
Abstract The study sought to re-characterize trends and factors affecting electronic dental record (EDR) and technologies adoption by dental practices and the impact of the Health Information Technology for Economic and Clinical Health (HITECH) act on adoption rates through 2012. A 39-question survey was disseminated nationally over 3 months using a novel, statistically-modeled approach informed by early response rates to achieve a predetermined sample. EDR adoption rate for clinical support was 52%. Adoption rates were higher among: 1) younger dentists; 2) dentists ≤ 15 years in practice; 3) females; and 4) gr...
Source: Clinical Medicine and Research - December 11, 2017 Category: General Medicine Authors: Acharya A, Schroeder D, Schwei K, Chyou PH Tags: Clin Med Res Source Type: research

Recurrent Hemobilia Due to Right Hepatic Artery Pseudoaneurysm.
Abstract Hemobilia is a potentially life-threatening clinical issue in the etiology of which iatrogenesis is playing increasingly more immense role. Nowadays the most frequent etiology of hemobilia has shifted toward iatrogenesis owing to increasingly more frequent performance of liver procedures, either open or minimally invasive. Here we report a rare case of recurrent hemobilia after transarterial embolization. A 57-year-old male patient after cholecystectomy presented with Quincke's triad. CT revealed a pseudoaneurysm of the right hepatic artery. Transarterial embolization failed, hemobilia recurred. The patie...
Source: Clinical Medicine and Research - December 1, 2017 Category: General Medicine Authors: Gachabayov M, Kubachev K, Mityushin S, Zarkua N Tags: Clin Med Res Source Type: research