Moringa oleifera L. Extracts as Bioactive Ingredients That Increase Safety of Body Wash Cosmetics.
Authors: Nizioł-Łukaszewska Z, Furman-Toczek D, Bujak T, Wasilewski T, Hordyjewicz-Baran Z Abstract The work attempts to obtain a multifunctional plant extract derived from Moringa tree leaves. Obtained results indicate a strong antioxidant potential of the tested extracts. It was shown that Moringa oleifera leaf extract is a rich source of flavonoid and phenolic compounds. Furthermore, it shows a strong antioxidant activity by scavenging free radicals. In vitro toxicity studies showed that the tested extracts in concentrations up to 5% showed a positive effect on cell proliferation and metabolism and may contrib...
Source: Dermatology Research and Practice - July 23, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Clinico-Epidemiological Profile and Treatment Pattern of Vitiligo in Selected Dermatological Clinics of Mekelle City, Northern Ethiopia.
Conclusion: The prevalence of vitiligo was found to be high. The clinico-epidemiological profile of vitiligo in Ethiopia was similar with that found globally. However, treatment options of vitiligo were very limited in Ethiopia. PMID: 32550844 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - June 21, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Risk of General Anesthesia in Pediatric Skin Procedures with Projection on Tumescent Anesthesia.
Conclusion: Dermatologist and pediatricians can safely do necessary procedures under general anaesthesia with the supervision of pediatric-trained anesthesiologists while considering other safety and risk precautions and the pediatric age group. PMID: 32550845 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - June 21, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Public Knowledge and Attitudes towards Vitiligo: A Survey in Mekelle City, Northern Ethiopia.
Authors: Tsadik AG, Teklemedhin MZ, Mehari Atey T, Gidey MT, Desta DM Abstract Background: The overall well-being, sense of stigmatization, and treatment outcome of persons with vitiligo are largely dependent on their social acceptance and this is linked with perception and attitude of this disease in a given population. Therefore, this study assessed the knowledge and attitude of the public towards vitiligo. Methods: A cross-sectional survey was carried out using a self-reported questionnaire distributed to adults living in Mekelle city, Northern Ethiopia from August to November 2019. Individuals who were 18 t...
Source: Dermatology Research and Practice - June 19, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial.
This study aimed to evaluate the efficacy of a combination of 1% nanocurcumin gel with 0.1% triamcinolone acetonide mouth rinse for oral lichen planus (OLP). Materials and Methods: This double-blind randomized clinical trial was conducted on 31 patients with erosive or ulcerative OLP. All patients received 0.1% triamcinolone mouth rinse and were then randomly divided into two groups for combination therapy with (I) %1 nanocurcumin gel or (II) placebo gel. The reticular-erosive-ulcerative (REU) score was calculated at baseline and at two and four weeks after the intervention. The changes in the mean REU score and the ef...
Source: Dermatology Research and Practice - June 12, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Prevalence and Clinical Characteristics of Aquagenic Pruritus among Medical and Pharmacy Students in Lom é (Togo).
Prevalence and Clinical Characteristics of Aquagenic Pruritus among Medical and Pharmacy Students in Lomé (Togo). Dermatol Res Pract. 2020;2020:8420123 Authors: Teclessou JN, Kombate K, Akakpo AS, Mouhari-Toure A, Zoua J, Kassang P, Saka B, Pitche P Abstract Objective: The aim of this study was to determine the prevalence and clinical characteristics of aquagenic pruritus (AP) in medical students in Lomé (Togo). Methods: This was a prospective and descriptive study conducted among medical students in Lomé from June 1st to August 30th, 2019. The data collection questionnaire was...
Source: Dermatology Research and Practice - June 12, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin ® with Marilex® in Pattern Hair Loss and Telogen Effluvium.
Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium. Dermatol Res Pract. 2020;2020:8125081 Authors: Wadstein J, Thom E, Gadzhigoroeva A Abstract Follicular proteoglycans are key players with structural, functional, and regulatory roles in the growth and cycling behaviour of the hair follicles. The expression pattern of specific proteoglycans is strongly correlated with follicular phase transitions, which further affirms their functional...
Source: Dermatology Research and Practice - May 20, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Cutaneous Lesions in Iranian Neonates and Their Relationships with Maternal-Neonatal Factors: A Prospective Cross-Sectional Study.
Authors: Firouzi H, Jalalimehr I, Ostadi Z, Rahimi S Abstract Cutaneous lesions are common in the neonatal period and mostly physiological, transient, and self-limited; uncommonly, they are pathological and require treatment and cooperation between neonatologists and dermatologists. Particular conditions, like prematurity, can influence the onset, type, and evolution of cutaneous manifestations. Of the several articles in the literature about skin findings in newborns, only a few were performed in Iran. We aimed to investigate dermatological findings in a sample of neonates within the first three days of life and t...
Source: Dermatology Research and Practice - May 20, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Marital Status and Survival in Patients Diagnosed with Melanoma.
Authors: Maas JA, Monreal AJ, Diaz EL, Castro G, Rodriguez de la Vega P, Varella M Abstract Introduction: Previous research suggests the presence of a spouse may considerably affect melanoma detection rates through more frequent examinations, better access to healthcare, and improved social support. Yet, the role of marital status on melanoma survival is currently unknown. The aim of this study is to assess whether marital status is associated with survival following melanoma diagnosis. Methods: We performed secondary analysis of data from all participants of the Florida Cancer Data System (FCDS) and included a...
Source: Dermatology Research and Practice - May 17, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients.
Conclusions: Current findings showed that rs1501299 of the ADIPOQ gene might be associated with changes in HDL level in acne patients following treatment with isotretinoin. PMID: 32411191 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - May 17, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Onychomycosis in Psoriatic Patients with Nail Disorders: Aetiological Agents and Immunosuppressive Therapy.
Authors: Alves NCPOP, Moreira TA, Malvino LDS, Rodrigues JJ, Ranza R, de Araújo LB, Pedroso RDS Abstract Psoriasis and psoriatic arthritis are chronic, relapsing, immune-based diseases. Psoriatic patients may have nail involvement in 50 to 80% of cases, and this may reach 85% in patients with joint disease, in spite of the fact that the relationship between psoriasis and onychomycosis is not well established. The aim of this study was to investigate the occurrence of onychomycosis in patients with nail disorders and diagnosis of psoriasis and psoriatic arthritis. This was a cross-sectional study in which 38 ...
Source: Dermatology Research and Practice - May 17, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Systemic Glutathione as a Skin-Whitening Agent in Adult.
Conclusions: Highest-evidence literatures showed that glutathione is not beneficial enough as a skin-whitening agent as it was only effective in some parts of the body and did not elicit long-lasting effects. However, its safety profiles in oral preparations were well tolerated. More researches regarding the time needed for skin color to return to its original state following drug withdrawal need to be conducted as it is yet to be discovered. PMID: 32373172 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - May 7, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Consensus on the Clinical Approach to Moderate-to-Severe Atopic Dermatitis in Spain: A Delphi Survey.
Conclusion: This study contributes a reference framework to the care of AD patients. There is no diagnostic test or biomarkers to direct treatment or to assess the severity of the disease, and many therapeutic challenges remain. PMID: 32318104 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - April 23, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Sunscreen Use among a Population of Saudi University Students.
Conclusion: Almost half of the population in the study use sunscreen. We have identified several areas of improper use of sunscreen. Increasing the awareness of effective sunscreen use in our community might be needed. PMID: 32256562 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - April 9, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Efficacy and Safety of Tracnil ™ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study.
In this study, we evaluate the efficacy of Tracnil™, a combination of myo-inositol with folic acid and vitamin D3, in resolving acne in overweight women of menstruation age displaying normal hormone levels. It is a single-arm study conducted at 2 centers including 33 women with acne, hirsutism, and menstrual irregularities. Acne and hirsutism were assessed by manual lesion count, modified Cook's scale, and modified Ferriman-Gallwey hirsutism score (mFGHS). Hormone levels and safety parameters were assessed throughout the study. Our results show that Tracnil™ monotherapy could drastically reduce acne-related les...
Source: Dermatology Research and Practice - April 9, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Long-Term Infliximab Treatment in Psoriasis Patients: A National Multicentre Retrospective Study.
Conclusion: We report the efficacy and safety of IFX maintained for up to 12 years in psoriasis patients. The long-term use of IFX was associated with a high BMI confirming the critical role of weight-based dosing for this drug. PMID: 32231699 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - April 3, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Prevalence and Clinical Characteristics of Alopecia Areata at a Tertiary Care Center in Saudi Arabia.
Conclusion: The overall prevalence of AA among a population of Saudi patients is 2.3%. AA prevalence is higher in pediatrics than adults. Common comorbid conditions include hypothyroidism, diabetes mellitus, and atopic diseases. PMID: 32231700 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - April 3, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Predictive Value of Positive Margins in Diagnostic Biopsies of Dysplastic Nevi.
We present this value along with PPVs from the very few existing similar studies. The quantified predictive value of positive margins in diagnostic biopsies is useful information for providers who must make decisions regarding the best treatment options for patients with DN. The low PPV of positive margins lends further evidence that DN of moderate severity or less may simply be monitored. PMID: 32180806 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - March 18, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Memory Buttons in Combination with Mobile Application-Induced Objective and Subjective Effects in Patients with Atopic Dermatitis.
Authors: Joergensen KM, Vestergaard C, Joergensen MS, Eiken A, Malmstedt-Miller M, Schultz ANØ, Deleuran M, Zibert JR Abstract Background: Atopic dermatitis (AD) is a chronic skin condition where nonadherence often results in lack of disease control. Objective: We wanted to determine whether the combination of an electronic memory button and a supportive application (app) would affect the Quality of Life and subjective and objective severity measures among AD patients over one month following the patient's normal schedules of treatment. Methods: A randomized, investigator-blinded, prospective observa...
Source: Dermatology Research and Practice - February 27, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Epidemiological and Clinical Profile of Dermatoses Observed in Chronic Hemodialysis Patients at the National Teaching Hospital (NTH-HKM) of Cotonou, Benin.
Conclusion: Cutaneous manifestations in hemodialysis patients were frequent and dominated by xerosis, pruritus, and alopecia. Factors associated with some of these dermatologic manifestations were seniority in hemodialysis, long duration of the hemodialysis session, and female gender. PMID: 32099542 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - February 27, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Skin and Soft Tissue Lesions in a District Hospital in Central Nigeria: A Histopathological Study.
Conclusion: Skin and soft tissue lesions are relatively common in our environment with majority being benign neoplastic lesion. PMID: 32089672 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - February 26, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Heat Shock Lipolysis: Radiofrequency Combined with Cryolipolysis for the Reduction of Localized Subcutaneous Fat.
Conclusion: In conclusion, combining RF with cryolipolysis in one single session is safe and effective. PMID: 32089673 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - February 26, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

The Role of Digital Fluorescence in Acne Vulgaris: Correlation of Ultraviolet Red Fluorescence with the Severity of Acne Vulgaris.
Conclusion: The severity of acne vulgaris has no correlation with spot counts and percentage area covered with UVRF. Digital fluorescence might be helpful in investigating further of the interrelated pathogenesis factors of acne. PMID: 31975991 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - January 26, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Two Functional TP53 Genetic Variants and Predisposition to Keloid Scarring in Caucasians.
Conclusions: Our results suggest the lack of association of rs1042522 and rs17878362 TP53 polymorphisms and their haplotypes or diplotypes with the susceptibility to keloid scarring in Polish patients. PMID: 31827503 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - December 14, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Prurigo in Children of Tropical Zone: Epidemiological, Clinical, and Etiological Characteristics in a Dermatology Department in Cotonou (Benin).
Conclusion: The main etiologies of prurigo in the study participants were PS, prurigo of Besnier, scabiosis, and HCLM. It affected with predilection the limbs of children of less than 5 years. Prurigo was almost always itchy and often evolved in an acute or chronic mode. PMID: 31781184 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - December 1, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Assessment of Serum Vitamin D Levels in Patients with Vitiligo in Jordan: A Case-Control Study.
Authors: Alshiyab DM, Al-Qarqaz FA, Heis LH, Muhaidat JM, Eddin WS, Atwan AA Abstract Background: Low vitamin D serum levels have been associated with many autoimmune disorders and several other skin diseases. Vitiligo is an autoimmune disease characterized by destruction of melanocytes by immune mechanisms. Melanocytes express vitamin D receptors, and their function can be affected by vitamin D status. Objectives: The main objective of this study is to compare vitamin D levels in patients with vitiligo vs normal population and whether vitamin D deficiency is associated with vitiligo. Methods: A case-contro...
Source: Dermatology Research and Practice - November 8, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Relationship between Hand Eczema Severity and Occupational Stress: A Cross-Sectional Study.
Conclusion: Although the link between the severity of eczema and atopy, wet work, and contact with irritants and allergens is well known, the relation remains questionable for other factors including stress. PMID: 31687011 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - November 8, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Superficial Morphea: Clinicopathological Characteristics and a Novel Therapeutic Outcome to Excimer Light Therapy.
Conclusion: Our results proposed that SM is a distinctive clinicopathological variant and not a stage in the spectrum of LS. The novel response of SM to excimer light and not for UVA1 therapy also suggests the different therapeutic outcome of SM from LS. Although SM has a significant association with DM and HCV infection, they seem not to affect the course of the disease. PMID: 31641348 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - October 25, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Prevalence of Dermatophytosis and Antifungal Activity of Ethanolic Crude Leaf Extract of Tetradenia riparia against Dermatophytes Isolated from Patients Attending Kampala International University Teaching Hospital, Uganda.
Authors: Kakande T, Batunge Y, Eilu E, Shabohurira A, Abimana J, Akinola SA, Muhwezi R, Sunusi Adam A, Kemuma Onkoba S, Almustapha Aliero A, Atuheire C, Kato CD, Ntulume I Abstract Dermatophyte infections are a global health problem but neglected in Uganda. This work aimed at determining prevalence of dermatophytosis and antifungal activity of ethanolic crude leaf extract of Tetradenia riparia against dermatophytes isolated from patients attending Kampala International University Teaching Hospital (KIU-TH), Uganda. A total of 100 samples of skin and nail scrapings were collected and processed using standard microsc...
Source: Dermatology Research and Practice - August 6, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Effectiveness of the Electromagnetic Shock Wave Therapy in the Treatment of Cellulite.
Authors: Modena DAO, Nogueira da Silva C, Delinocente TCP, Bianca de Araújo T, de Carvalho TM, Grecco C, Moreira RG, Campos G, de Souza JR, Michelini Guidi R Abstract In the past centuries, the human body was undervalued; nowadays, however, it is overvalued, and thus the manifestation of the dissatisfactions regarding the body has been increasing. Most of the time, these dissatisfactions are related to cellulite, which is most common in women. Its treatment is one of the challenges which encourage the development of new therapeutic modalities, among them the shockwave therapy. Objective. To evaluate the effi...
Source: Dermatology Research and Practice - July 20, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Position Statement on Secukinumab in the Management of Plaque Psoriasis: The Malaysian Perspective.
Authors: Johar A, Thevarajah S, Heng A, Chan LC, Ch'ng CC, Mohd Safdar NA, Muniandy P, Taib T, Tan WC, Tey KE Abstract Psoriasis is a chronic inflammatory skin disease affecting nearly 10% of dermatologic patients in Malaysia. Treatment options include topical agents and phototherapy as well as nonbiologic and biologic systemic therapy. Mild psoriasis can often be managed with topical agents. However, managing moderate to severe psoriasis is more challenging and may require systemic treatment with nonbiologics or biologics. Despite the availability of several biologics, there are many unmet clinical needs, which ma...
Source: Dermatology Research and Practice - June 20, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

The Clinical Effect of Oral Vitamin D2 Supplementation on Psoriasis: A Double-Blind, Randomized, Placebo-Controlled Study.
Conclusion: Oral vitamin D2 supplementation in patients with psoriasis increased the serum vitamin D level and significantly improved the treatment outcome without increasing adverse events. Trial Registration: This trial is registered with Thai Clinical Trials Registry TCTR20180613001. PMID: 31139214 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - May 31, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Radiotherapy for Melanoma: More than DNA Damage.
Authors: Rogers SJ, Puric E, Eberle B, Datta NR, Bodis SB Abstract Despite its reputation as a radioresistant tumour, there is evidence to support a role for radiotherapy in patients with melanoma and we summarise current clinical practice. Melanoma is a highly immunogenic tumour and in this era of immunotherapy, there is renewed interest in the potential of irradiation, not only as an adjuvant and palliative treatment, but also as an immune stimulant. It has long been known that radiation causes not only DNA strand breaks, apoptosis, and necrosis, but also immunogenic modulation and cell death through the inductio...
Source: Dermatology Research and Practice - May 11, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Gender Differences in Depression, Coping, Stigma, and Quality of Life in Patients of Vitiligo.
Authors: Sawant NS, Vanjari NA, Khopkar U Abstract Though vitiligo is one of the psychodermatological disorders which do not cause direct physical impairment, it is cosmetically disfiguring leading to serious psychological problems in daily life. We undertook this research to study patients of vitiligo the prevalence of depression, coping, stigma, and quality of life and comparison of the same in both genders. Patients diagnosed clinically as having vitiligo by consultant dermatologist were enrolled after informed consent and ethics approval. 156 patients were screened, of which 100 satisfying criteria were taken u...
Source: Dermatology Research and Practice - May 10, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Epidemiologic Trends of Viral Skin Infections in Egypt: A Cross-Sectional Hospital-Based Study.
The objective of this study was to determine the epidemiologic features of VSIs in patients attending a dermatology clinic in Egypt from June 2010 to May 2011. Patient's residence, occupation, housing data, and family history of similar conditions were recorded. Categorical data were recorded as frequencies and percentages and were compared by Chi square test. P value
Source: Dermatology Research and Practice - May 1, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Impact of Allergic Contact Dermatitis on the Quality of Life and Work Productivity.
Authors: Kalboussi H, Kacem I, Aroui H, El Maalel O, Maoua M, Brahem A, El Guedri S, Chatti S, Ghariani N, Mrizak N Abstract Background: Allergic contact dermatitis (ACD) is a common chronic skin disease that generates considerable public-health and socioeconomic costs. This disease affects the quality of life and the occupational activity of patients. Aims: To assess the quality of life (QOL) of patients with ACD and study the impact of this disease on their work productivity. Methods: This is a cross-sectional study carried out from January 2012 to December 2014. All patients diagnosed with ACD in the Der...
Source: Dermatology Research and Practice - April 4, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo.
Conclusion: Ocular and mucocutaneous sequelae are common in SJS/TEN survivors. Exposure to sulfadoxine and severity of acute ocular involvement are risk factors of ocular sequelae. PMID: 30838038 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - March 8, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Pattern of Dermatological Disease Encountered in a Hematology Ward: A Retrospective Analysis of Dermatology Consultation in a Hematology Ward in a Tertiary Care Center in Saudi Arabia.
Conclusion. Various dermatological disorders and cutaneous manifestations are observed in hematology inpatients with morbilliform drug eruption and graft versus host disease being the most common. PMID: 30733801 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - February 9, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Pentavalent Antimonials Combined with Other Therapeutic Alternatives for the Treatment of Cutaneous and Mucocutaneous Leishmaniasis: A Systematic Review.
Authors: Berbert TRN, de Mello TFP, Wolf Nassif P, Mota CA, Silveira AV, Duarte GC, Demarchi IG, Aristides SMA, Lonardoni MVC, Vieira Teixeira JJ, Silveira TGV Abstract The first choice drugs for the treatment of cutaneous and mucocutaneous leishmaniasis are pentavalent antimonials, sodium stibogluconate, or meglumine antimoniate. However, the treatment with these drugs is expensive, can cause serious adverse effects, and is not always effective. The combination of two drugs by different routes or the combination of an alternative therapy with systemic therapy can increase the efficacy and decrease the collateral e...
Source: Dermatology Research and Practice - January 26, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Effectiveness and Safety of Contrast Cryolipolysis for Subcutaneous-Fat Reduction.
Authors: Savacini MB, Bueno DT, Molina ACS, Lopes ACA, Silva CN, Moreira RG, Almeida S, Guidi RM, Sant'Ana E, Liebano RE Abstract Cryolipolysis is the noninvasive treatment of localized fat through cold-induced panniculitis. The purpose of the present study was to evaluate the safety and efficacy of contrast cryolipolysis for subcutaneous-fat reduction. Contrast cryolipolysis mixes the principles of conventional cryolipolysis and periods of heating in accordance with the contrast lipocryolysis process. Twenty-one subjects aged 34 ± 9 years were treated with contrast cryolipolysis in the regions of abdomen an...
Source: Dermatology Research and Practice - January 13, 2019 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Comparing the Efficacy of Triamcinolone Acetonide Iontophoresis versus Topical Calcipotriol/Betamethasone Dipropionate in Treating Nail Psoriasis: A Bilateral Controlled Clinical Trial.
Conclusion: Monthly TI has an equal efficacy compared to daily topical calcipotriol/betamethasone dipropionate. It can be used as a safe, easy, and compliant treatment for nail psoriasis. This study is registered under IRCT2017050233778N1. PMID: 30584420 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - December 27, 2018 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

A Real-Life Based Evaluation of the Effectiveness of Antibacterial Fabrics in Treating Atopic Dermatitis.
Conclusion: Considerable differences in the antibacterial effectiveness of conventional AD clothes were revealed. Under practical (dry) wear conditions, garments were unable to modify skin colonization with S. aureus, although effectiveness can be triggered by wetting the garments. Remnants of moisturising cream remain on the fibres after laundry. PMID: 30581460 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - December 26, 2018 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Investigation of Interleukin-27 in the Sera of Nonmelanoma Skin Cancer Patients.
In this study we observed that IL-27 serum levels were significantly higher in NMSC patients in comparison to healthy individuals (0.0134 versus 0.0008 ng/ml; P
Source: Dermatology Research and Practice - December 26, 2018 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Dermatophytosis: Prevalence of Dermatophytes and Non-Dermatophyte Fungi from Patients Attending Arsho Advanced Medical Laboratory, Addis Ababa, Ethiopia.
Conclusions: Failure to detect or isolate fungal pathogens in a large number of clinical samples revealed the limitation of clinical diagnosis in differentiating dermatophytosis from other skin infections demonstrating that clinical diagnosis should be coupled with laboratory methods. Recovery of large number of non-dermatophyte fungi along with dermatophytes in our study showed that non-dermatophyte fungi are emerging as important causes of dermatophytosis, warranting the implementation of intensive epidemiological studies of dermatophytosis across the country. PMID: 30402089 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - November 9, 2018 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Confocal Microscopy Predicts the Risk of Recurrence and Malignant Transformation of Mucocutaneous Neurofibromas in NF-1: An Observational Study.
Authors: Giudice G, Favia G, Tempesta A, Limongelli L, Vestita M Abstract From 2005 to 2010, 20 consecutive patients with fully manifested neurofibromatosis type 1 (NF1) underwent elective neurofibroma resection at our institution (Departments of Plastic Surgery and of Odontostomatology). Specimens were photographed under optical microscope and confocal laser scanning microscopy (CLSM) with ultra-high accuracy of detail, including depth of field. Patients were followed up for a minimum of 4 years and up to a maximum of 12 years, postsurgery. While all nonrecurring lesions showed intense fluorescence, six of the sev...
Source: Dermatology Research and Practice - October 3, 2018 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Histomorphometrical Study on Regional Variation in Distribution of Sweat Glands in Buffalo Skin.
Authors: Debbarma D, Uppal V, Bansal N, Gupta A Abstract The study was conducted on skin of 24 buffaloes collected from slaughter house. The skin tissues were collected from dorsal, lateral, and ventral parts of head, neck, thorax, abdomen, and tail regions and fixed in 10% neutral buffered formalin. The tissues were processed for paraffin blocks preparation by acetone benzene schedule. The paraffin sections of 5-6 μm were cut with rotary microtome and stained with hematoxylin and eosin. The sweat glands in buffaloes were of saccular and simple coiled tubular type. Most of the sweat glands were associated...
Source: Dermatology Research and Practice - September 8, 2018 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Whole Genome Sequencing in an Acrodermatitis Enteropathica Family from the Middle East.
We report a family from Tabuk, Saudi Arabia, previously screened for Acrodermatitis Enteropathica (AE), in which two siblings presented with typical features of acral dermatitis and a pustular eruption but differing severity. Affected members of our family carry a rare genetic variant, p.Gly512Trp in the SLC39A4 gene which encodes a zinc transporter; disease is thought to result from zinc deficiency. Similar mutations have been reported previously; however, the variable severity within cases carrying the p.Gly512Trp variant and in AE overall led us to hypothesise that additional genetic modifiers may be contributing to the...
Source: Dermatology Research and Practice - September 5, 2018 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Autologous Fat Grafting in the Treatment of Facial Scleroderma.
In this study, we aimed to assess the safety and efficacy of autologous fat grafting in the face of patients with systemic sclerosis. We enrolled 16 SSc patients suffering from facial sclerosis and limited mouth opening capacity. Autologous fat injection ranging from 15 to 40 ml was administered per patient, based on their face morphology. The patients were evaluated at baseline and 3 months after fat injection. Evaluations included mouth opening capacity, mouth handicap in systemic sclerosis (MHISS), Rodnan skin sclerosis score, skin biophysical properties using a sensitive biometrologic device with the assessment of cuta...
Source: Dermatology Research and Practice - August 31, 2018 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Cutaneous Tuberculosis: Clinicopathologic Arrays and Diagnostic Challenges.
This article revises the current scenario of the disease's physiopathology and underscores clinicopathological challenges, due to multifaceted presentations of cutaneous tuberculosis, in the diagnosis. PMID: 30111996 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - August 18, 2018 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Experience with Treating Lentigo Maligna with Definitive Radiotherapy.
Authors: Fogarty GB, Hong A, Economides A, Guitera P Abstract Lentigo maligna (LM) is a form of melanoma in situ that occurs on exposed, sun-damaged skin; LM can progress to invasive melanoma. Conventional surgical treatment is the preferred management option as it is usually a one-treatment episode and generates a histopathology report that records completion of excision. Some patients may not be surgical candidates due to comorbidities, patient preference, impact on function, and cosmesis or they have failed surgery with a positive margin. Other therapies, including radiotherapy (RT) and topical medicines, may th...
Source: Dermatology Research and Practice - August 15, 2018 Category: Dermatology Tags: Dermatol Res Pract Source Type: research