General and Comparative Endocrinology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Irisin as an emerging target in the regulation of reproductive functions in health and disease
Gen Comp Endocrinol. 2024 Apr 19:114529. doi: 10.1016/j.ygcen.2024.114529. Online ahead of print.ABSTRACTGerm cells are highly conserved in the gonads, nurtured to either develop into a gamete or self-renew into a stem cell reserve. Preserving the germ cell pool and protecting the reproductive organs is essential for maintaining an individual's fertility. Several factors, including a sedentary lifestyle, pollutants, hormonal disruption, drugs, and a disease condition, have been shown to impair normal reproductive function. Irisin has recently been identified as an adipomyokine involved in modulating physiological functions...
Source: General and Comparative Endocrinology - April 21, 2024 Category: Endocrinology Authors: Sree Vaishnavi Nalla P Jayapradha None Lalruatmawii K Nandheeswari Pratik Naxine G Vigneshwaran Gaurav Rohilla Itishree Dubey Sapana Kushwaha Source Type: research
Kisspeptin administration may promote precopulatory behavior in male rats independently or supplementally to testosterone and contribute to proceptive behavior in female partners, reducing mating failure
In conclusion, kisspeptin may involve an as-yet-unidentified neural pathway in sexual desire independently of the HPG axis.PMID:38643848 | DOI:10.1016/j.ygcen.2024.114528 (Source: General and Comparative Endocrinology)
Source: General and Comparative Endocrinology - April 21, 2024 Category: Endocrinology Authors: Shota Yamamoto Ryosuke Arakaki Hiroki Noguchi Asuka Takeda Maimi Uchishiba Shuhei Kamada Ayuka Mineda Masafumi Kon Riyo Kinouchi Yuri Yamamoto Kanako Yoshida Takashi Kaji Nobuo Shinohara Takeshi Iwasa Source Type: research
Molecular characterization of GPR84 in domestic cats
This study aimed to present the molecular characterization of GPR84 in domestic cats. The deduced amino acid sequence of the feline GPR84 shows high sequence homology (83-89 %) with the orthologues from other mammalians by cDNA cloning of feline GPR84. Remarkably high mRNA expression was observed in the bone marrow by Q-PCR analysis. The inhibition of intracellular cAMP concentration was observed in cells transfected with feline GPR84 and treated with medium-chain fatty acids. Immunostaining of GPR84 and free fatty acid receptor 2 (FFAR2)/GPR43 in the bone marrow, where high mRNA expression was observed, showed reactions i...
Source: General and Comparative Endocrinology - April 19, 2024 Category: Endocrinology Authors: Ichiro Yamamoto Masaki Michishita Koki Fujita Tamami Sakai Noriyasu Sasaki Koh Kawasumi Source Type: research
Characterization of myoinhibitory peptide signaling system and its implication in larval metamorphosis and spawning behavior in Pacific abalone
In this study, we identified the MIP signaling system in the Pacific abalone Haliotis discus hannai (Hdh). Similar to the invertebrate MIPs, a total of eight paracopies of MIPs (named Hdh-MIP1 to Hdh-MIP8), harboring a WX5-7Wamide motif, except for Hdh-MIP2, were found in the Hdh-MIP precursor. Furthermore, we characterized a functional Hdh-MIPR, which responded to the Hdh-MIPs, except for Hdh-MIP2, possibly linked with the PKC/Ca2+ and PKA/cAMP signaling pathways. Hdh-MIPs delayed larval metamorphosis but increased the spawning behavior. These results suggest that the Hdh-MIP signaling system provides insights into the un...
Source: General and Comparative Endocrinology - April 15, 2024 Category: Endocrinology Authors: Sungwoo Park Mi Ae Kim Young Chang Sohn Source Type: research
Characterization of myoinhibitory peptide signaling system and its implication in larval metamorphosis and spawning behavior in Pacific abalone
In this study, we identified the MIP signaling system in the Pacific abalone Haliotis discus hannai (Hdh). Similar to the invertebrate MIPs, a total of eight paracopies of MIPs (named Hdh-MIP1 to Hdh-MIP8), harboring a WX5-7Wamide motif, except for Hdh-MIP2, were found in the Hdh-MIP precursor. Furthermore, we characterized a functional Hdh-MIPR, which responded to the Hdh-MIPs, except for Hdh-MIP2, possibly linked with the PKC/Ca2+ and PKA/cAMP signaling pathways. Hdh-MIPs delayed larval metamorphosis but increased the spawning behavior. These results suggest that the Hdh-MIP signaling system provides insights into the un...
Source: General and Comparative Endocrinology - April 15, 2024 Category: Endocrinology Authors: Sungwoo Park Mi Ae Kim Young Chang Sohn Source Type: research
Characterization of myoinhibitory peptide signaling system and its implication in larval metamorphosis and spawning behavior in Pacific abalone
In this study, we identified the MIP signaling system in the Pacific abalone Haliotis discus hannai (Hdh). Similar to the invertebrate MIPs, a total of eight paracopies of MIPs (named Hdh-MIP1 to Hdh-MIP8), harboring a WX5-7Wamide motif, except for Hdh-MIP2, were found in the Hdh-MIP precursor. Furthermore, we characterized a functional Hdh-MIPR, which responded to the Hdh-MIPs, except for Hdh-MIP2, possibly linked with the PKC/Ca2+ and PKA/cAMP signaling pathways. Hdh-MIPs delayed larval metamorphosis but increased the spawning behavior. These results suggest that the Hdh-MIP signaling system provides insights into the un...
Source: General and Comparative Endocrinology - April 15, 2024 Category: Endocrinology Authors: Sungwoo Park Mi Ae Kim Young Chang Sohn Source Type: research
Baseline and stress-induced steroid plasma levels and immune function vary annually and are associated with vocal activity in male toads (Rhinella icterica)
This study investigated annual variation in plasma corticosterone and testosterone levels, plasma bacterial killing ability (BKA), and neutrophil to lymphocyte ratio (NLR) in free-living male toads (Rhinella icterica). Toads were sampled in the field (baseline) and 1 h-post restraint over five months, and we considered the occurrence of vocal activity. Baseline corticosterone, testosterone, and BKA showed higher values during the reproductive period, specifically in calling male toads. The NLR was similar throughout the year, but higher values were observed in calling toads. Moreover, baseline NLR and BKA were positively c...
Source: General and Comparative Endocrinology - April 14, 2024 Category: Endocrinology Authors: Braz Titon Junior Adriana Maria Giorgi Barsotti Stefanny Christie Monteiro Titon Renata Ibelli Vaz Aymam Cobo de Figueiredo Ronyelle Vasconcelos-Teixeira Carlos A Navas Fernando Ribeiro Gomes Source Type: research
Baseline and stress-induced steroid plasma levels and immune function vary annually and are associated with vocal activity in male toads (Rhinella icterica)
This study investigated annual variation in plasma corticosterone and testosterone levels, plasma bacterial killing ability (BKA), and neutrophil to lymphocyte ratio (NLR) in free-living male toads (Rhinella icterica). Toads were sampled in the field (baseline) and 1 h-post restraint over five months, and we considered the occurrence of vocal activity. Baseline corticosterone, testosterone, and BKA showed higher values during the reproductive period, specifically in calling male toads. The NLR was similar throughout the year, but higher values were observed in calling toads. Moreover, baseline NLR and BKA were positively c...
Source: General and Comparative Endocrinology - April 14, 2024 Category: Endocrinology Authors: Braz Titon Junior Adriana Maria Giorgi Barsotti Stefanny Christie Monteiro Titon Renata Ibelli Vaz Aymam Cobo de Figueiredo Ronyelle Vasconcelos-Teixeira Carlos A Navas Fernando Ribeiro Gomes Source Type: research
The role of TGF- β signaling in muscle atrophy, sarcopenia and cancer cachexia
Gen Comp Endocrinol. 2024 Apr 10;353:114513. doi: 10.1016/j.ygcen.2024.114513. Online ahead of print.ABSTRACTSkeletal muscle, comprising a significant proportion (40 to 50 percent) of total body weight in humans, plays a critical role in maintaining normal physiological conditions. Muscle atrophy occurs when the rate of protein degradation exceeds protein synthesis. Sarcopenia refers to age-related muscle atrophy, while cachexia represents a more complex form of muscle wasting associated with various diseases such as cancer, heart failure, and AIDS. Recent research has highlighted the involvement of signaling pathways, inc...
Source: General and Comparative Endocrinology - April 11, 2024 Category: Endocrinology Authors: Xin-Qiang Lan Cheng-Jie Deng Qi-Quan Wang Li-Min Zhao Bao-Wei Jiao Yang Xiang Source Type: research
The role of TGF- β signaling in muscle atrophy, sarcopenia and cancer cachexia
Gen Comp Endocrinol. 2024 Apr 10;353:114513. doi: 10.1016/j.ygcen.2024.114513. Online ahead of print.ABSTRACTSkeletal muscle, comprising a significant proportion (40 to 50 percent) of total body weight in humans, plays a critical role in maintaining normal physiological conditions. Muscle atrophy occurs when the rate of protein degradation exceeds protein synthesis. Sarcopenia refers to age-related muscle atrophy, while cachexia represents a more complex form of muscle wasting associated with various diseases such as cancer, heart failure, and AIDS. Recent research has highlighted the involvement of signaling pathways, inc...
Source: General and Comparative Endocrinology - April 11, 2024 Category: Endocrinology Authors: Xin-Qiang Lan Cheng-Jie Deng Qi-Quan Wang Li-Min Zhao Bao-Wei Jiao Yang Xiang Source Type: research
The Role of TGF- β Signaling in Muscle Atrophy, Sarcopenia and Cancer Cachexia
Gen Comp Endocrinol. 2024 Apr 9:114513. doi: 10.1016/j.ygcen.2024.114513. Online ahead of print.ABSTRACTSkeletal muscle, comprising a significant proportion (40 to 50 percent) of total body weight in humans, plays a critical role in maintaining normal physiological conditions. Muscle atrophy occurs when the rate of protein degradation exceeds protein synthesis. Sarcopenia refers to age-related muscle atrophy, while cachexia represents a more complex form of muscle wasting associated with various diseases such as cancer, heart failure, and AIDS. Recent research has highlighted the involvement of signaling pathways, includin...
Source: General and Comparative Endocrinology - April 11, 2024 Category: Endocrinology Authors: Xin-Qiang Lan Cheng-Jie Deng Qi-Quan Wang Li-Min Zhao Bao-Wei Jiao Yang Xiang Source Type: research
Association of seasonal changes in circulating cortisol concentrations with the expression of cortisol biosynthetic enzymes and a glucocorticoid receptor in the blubber of common bottlenose dolphin
Gen Comp Endocrinol. 2024 Apr 7:114516. doi: 10.1016/j.ygcen.2024.114516. Online ahead of print.ABSTRACTCortisol is secreted from the adrenal cortex in response to stress, and its circulating levels are used as robust physiological indicators of stress intensity in various animals. Cortisol is also produced locally in adipose tissue by the conversion of steroid hormones such as cortisone, which is related to fat accumulation. Circulating cortisol levels, probably induced by cold stress, increase in cetaceans under cold conditions. However, whether cortisol production in subcutaneous adipose tissue is enhanced when fat accu...
Source: General and Comparative Endocrinology - April 9, 2024 Category: Endocrinology Authors: Miwa Suzuki Noriko Funasaka Yuki Sato Daiki Inamori Yurie Watanabe Miki Ozaki Masayuki Hosono Hideaki Shindo Keiko Kawamura Toshiyuki Tatsukawa Motoi Yoshioka Source Type: research
Association of seasonal changes in circulating cortisol concentrations with the expression of cortisol biosynthetic enzymes and a glucocorticoid receptor in the blubber of common bottlenose dolphin
Gen Comp Endocrinol. 2024 Apr 7:114516. doi: 10.1016/j.ygcen.2024.114516. Online ahead of print.ABSTRACTCortisol is secreted from the adrenal cortex in response to stress, and its circulating levels are used as robust physiological indicators of stress intensity in various animals. Cortisol is also produced locally in adipose tissue by the conversion of steroid hormones such as cortisone, which is related to fat accumulation. Circulating cortisol levels, probably induced by cold stress, increase in cetaceans under cold conditions. However, whether cortisol production in subcutaneous adipose tissue is enhanced when fat accu...
Source: General and Comparative Endocrinology - April 9, 2024 Category: Endocrinology Authors: Miwa Suzuki Noriko Funasaka Yuki Sato Daiki Inamori Yurie Watanabe Miki Ozaki Masayuki Hosono Hideaki Shindo Keiko Kawamura Toshiyuki Tatsukawa Motoi Yoshioka Source Type: research
Corrigendum to "The uterus masculinus of the Eurasian beaver (Castor fiber L.) - The appraisal of fast hormone regulation by membrane androgen and estrogen receptors involvement" [Gen. Comp. Endocrinol. 345 (2024) 114389]
Gen Comp Endocrinol. 2024 Apr 6:114502. doi: 10.1016/j.ygcen.2024.114502. Online ahead of print.NO ABSTRACTPMID:38584035 | DOI:10.1016/j.ygcen.2024.114502 (Source: General and Comparative Endocrinology)
Source: General and Comparative Endocrinology - April 7, 2024 Category: Endocrinology Authors: M Kotula-Balak G Lonc M Zarzycka J Tomiyasu K Knapczyk-Stwora B J P łachno A J Korzekwa J Kaczmarczyk I Krakowska Source Type: research
Corrigendum to "The uterus masculinus of the Eurasian beaver (Castor fiber L.) - The appraisal of fast hormone regulation by membrane androgen and estrogen receptors involvement" [Gen. Comp. Endocrinol. 345 (2024) 114389]
Gen Comp Endocrinol. 2024 Apr 6:114502. doi: 10.1016/j.ygcen.2024.114502. Online ahead of print.NO ABSTRACTPMID:38584035 | DOI:10.1016/j.ygcen.2024.114502 (Source: General and Comparative Endocrinology)
Source: General and Comparative Endocrinology - April 7, 2024 Category: Endocrinology Authors: M Kotula-Balak G Lonc M Zarzycka J Tomiyasu K Knapczyk-Stwora B J P łachno A J Korzekwa J Kaczmarczyk I Krakowska Source Type: research
