Chronic Obstructive Pulmonary Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Impact of Using Pre- and Post-Bronchodilator Spirometry Reference Values in a Chinese Population
CONCLUSION: This study generated and applied pre- and post-bronchodilator spirometry reference values in a nationally representative Chinese adult population. Post-BD reference values may serve as an additional criterion in identifying individuals at risk for obstructive pulmonary diseases, its diagnostic and prognostic values should be further investigated.PMID:38687500 | DOI:10.1164/rccm.202308-1488OC (Source: Respiratory Care)
Source: Respiratory Care - April 30, 2024 Category: Respiratory Medicine Authors: Ke Huang Xueyan Han Zhaoyang Pan Jianying Xu Jianping Zhao Xiangyan Zhang Yuanlin Song Jian Kang Pixin Ran Yumin Zhou Huahao Shen Fuqiang Wen Kewu Huang Yahong Chen Yanfei Guo Guangliang Shan Sinan Wu Tianjia Guan Ting Yang Chen Wang Source Type: research

Impact of Using Pre- and Post-Bronchodilator Spirometry Reference Values in a Chinese Population
CONCLUSION: This study generated and applied pre- and post-bronchodilator spirometry reference values in a nationally representative Chinese adult population. Post-BD reference values may serve as an additional criterion in identifying individuals at risk for obstructive pulmonary diseases, its diagnostic and prognostic values should be further investigated.PMID:38687500 | DOI:10.1164/rccm.202308-1488OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 30, 2024 Category: Intensive Care Authors: Ke Huang Xueyan Han Zhaoyang Pan Jianying Xu Jianping Zhao Xiangyan Zhang Yuanlin Song Jian Kang Pixin Ran Yumin Zhou Huahao Shen Fuqiang Wen Kewu Huang Yahong Chen Yanfei Guo Guangliang Shan Sinan Wu Tianjia Guan Ting Yang Chen Wang Source Type: research

Does diet quality moderate the long-term effects of discrete but extreme PM < sub > 2.5 < /sub > exposure on respiratory symptoms? A study of the Hazelwood coalmine fire
Environ Res. 2024 Apr 27:119014. doi: 10.1016/j.envres.2024.119014. Online ahead of print.ABSTRACTIn 2014, a fire at an open cut coalmine in regional Victoria, Australia burned for 6 weeks. Residents of the nearby town of Morwell were exposed to smoke, which included high levels of fine particulate matter (PM2.5). We investigated whether the long-term effects of PM2.5 on respiratory health were moderated by diet quality. A cross-sectional analysis was conducted of data collected 8.5 years after the mine fire from 282 residents of Morwell and 166 residents from the nearby unexposed town of Sale. Primary outcomes were respir...
Source: Environmental Research - April 30, 2024 Category: Environmental Health Authors: Thara Govindaraju Martin Man Alice J Owen Matthew Carroll Brigitte M Borg Catherine L Smith Caroline X Gao David Brown David Poland Shantelle Allgood Jillian F Ikin Michael J Abramson Tracy A McCaffrey Tyler J Lane Source Type: research

The Roles of Neuropeptide Y in Respiratory Disease Pathogenesis via the Airway Immune Response
Acta Med Okayama. 2024 Apr;78(2):95-106. doi: 10.18926/AMO/66912.ABSTRACTThe lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). O...
Source: Acta Medica Okayama - April 30, 2024 Category: General Medicine Authors: Junko Itano Katsuyuki Kiura Yoshinobu Maeda Nobuaki Miyahara Source Type: research

Pulmonary Rehabilitation Reimbursement Challenges
Respir Care. 2024 Apr 30:respcare.11699. doi: 10.4187/respcare.11699. Online ahead of print.ABSTRACTPulmonary rehabilitation (PR) is a highly effective intervention for persons with chronic respiratory diseases, resulting in improvement in exercise capacity, dyspnea, health-related quality of life, mood, reduced hospitalization, and improved survival and cost savings post-COPD hospitalization. Despite demonstrated effectiveness, PR is underutilized in part due to lack of awareness, limited access, and inadequate PR reimbursement. Poor payment is a long-standing barrier to PR's financial stability and access. Addressing PR ...
Source: Rural Remote Health - April 30, 2024 Category: Rural Health Authors: Chris Garvey Source Type: research

Systematic Chemical Analysis of Crude Glycan Isolates from the Seven‑herb Decoction Quanzhenyiqitang with Anti-COPD Activity
Chem Biodivers. 2024 Apr 30:e202400277. doi: 10.1002/cbdv.202400277. Online ahead of print.ABSTRACTThe classical Chinese Medicine prescription, Quanzhenyiqitang (QZYQT), containing seven tonic herbs (Shudi, Dangshen, Maidong, Baizhu, Niuxi, Fuzi, and Wuweizi) is clinically used to treat chronic obstructive pulmonary disease (COPD). Although there are studies on the pharmacological effects of QZYQT, little attention has been paid to its active carbohydrate ingredients. We performed a systematic chemical analysis of the crude glycan isolates from the seven-herb decoction (GI-QZYQT) after confirming its anti-COPD activity. GI...
Source: Chemistry and Biodiversity - April 30, 2024 Category: Biochemistry Authors: Lingchong Wang Xiaoxian Yu Shiting Dai Longchao Dai Ran Ao Dapeng Zhang Source Type: research

Dyspnea and Quality of Life Improvements with Management of Comorbid Obstructive Sleep Apnea in Chronic Lung Disease
Obstructive sleep apnea (OSA) has emerged as a significant and prevalent comorbidity associated with chronic lung diseases, including chronic obstructive pulmonary disease, asthma, and interstitial lung diseases. These overlap syndromes are associated with worse patient-reported outcomes (sleep quality, quality of life measures, mental health) than each condition independently. Observational studies suggest that patients with overlap syndrome who are adherent to positive airway pressure therapy report improved quality of life, sleep quality, depression, and daytime symptoms. Screening for and management of OSA in patients ...
Source: Sleep Medicine Clinics - April 30, 2024 Category: Sleep Medicine Authors: Kori Ascher, Shirin Shafazand Source Type: research

GSE245259 The soluble factor milieu in IPF and in COPD exacerbations dysregulates epithelial differentiation
Contributors : Rosa K Kortekaas ; Kerstin E Geillinger-K ästle ; Janette K Burgess ; Reinoud GosensSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD), epithelial abnormalities are present including bronchiolization and alveolar cell death and dysfunction. As epithelial progenitor cells are directed by their microenvironment, we hypothesized that changes in the microenvironment disrupt normal epithelial growth and differentiation. We therefore mimicked the soluble factor microenvironment in IPF using...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Relationship between lactate-to-albumin ratio and 28-day mortality in patients with exacerbation of chronic obstructive pulmonary disease admitted to the Intensive Care Unit
ConclusionLAR is a rational and easily accessible marker, which is remarkably associated with 28-day mortality in ICU patients with AECOPD. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 30, 2024 Category: Research Source Type: research

The Effects of Alpha Linolenic Acid (Omega-3 Fatty Acid) on Tobacco Craving Intensity, Withdrawal Symptoms and Biochemical Markers in Tobacco Users
This study was registered at Clinical Trial Registry-India (http://www.ctri.nic.in) with reference no. CTRI202202040681 and was performed in accordance with the Declaration of Helsinki principles. (Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - April 30, 2024 Category: Biochemistry Source Type: research

Cancers, Vol. 16, Pages 1734: Treatment Strategies for Non-Small-Cell Lung Cancer with Comorbid Respiratory Disease; Interstitial Pneumonia, Chronic Obstructive Pulmonary Disease, and Tuberculosis
aba Takashi Ogura Non-small cell lung cancer (NSCLC) patients are often complicated by other respiratory diseases, including interstitial pneumonia (IP), chronic obstructive pulmonary disease (COPD), and pulmonary tuberculosis (TB), and the management of which can be problematic. NSCLC patients with IP sometimes develop fatal acute exacerbation induced by pharmacotherapy, and the establishment of a safe treatment strategy is desirable. For advanced NSCLC with IP, carboplatin plus nanoparticle albumin-bound paclitaxel is a relatively safe and effective first-line treatment option. Although the safety of immune checkpo...
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: Ryota Otoshi Satoshi Ikeda Taichi Kaneko Shinobu Sagawa Chieri Yamada Kosumi Kumagai Asami Moriuchi Akimasa Sekine Tomohisa Baba Takashi Ogura Tags: Review Source Type: research

Cellular Senescence in Lung Cancer: Molecular Mechanisms and Therapeutic Interventions
Ageing Res Rev. 2024 Apr 26:102315. doi: 10.1016/j.arr.2024.102315. Online ahead of print.ABSTRACTLung cancer stands as the primary contributor to cancer-related fatalities worldwide, affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC), accounts for 80-85% and SCLC accounts for 10-15% of cases. NSCLC subtypes include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Smoking, second-hand smoke, radon gas, asbestos, and other pollutants, genetic predisposition, and COPD are lung cancer risk factors. On the other hand, stresses such as DNA damage, telomere shortening, and ...
Source: Cell Research - April 28, 2024 Category: Cytology Authors: Saurav Kumar Jha Gabriele De Rubis Shankar Raj Devkota Yali Zhang Radhika Adhikari Laxmi Akhileshwar Jha Kunal Bhattacharya Samir Mehndiratta Gaurav Gupta Sachin Kumar Singh Nisha Panth Kamal Dua Philip M Hansbro Keshav Raj Paudel Source Type: research

Cellular Senescence in Lung Cancer: Molecular Mechanisms and Therapeutic Interventions
Ageing Res Rev. 2024 Apr 26:102315. doi: 10.1016/j.arr.2024.102315. Online ahead of print.ABSTRACTLung cancer stands as the primary contributor to cancer-related fatalities worldwide, affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC), accounts for 80-85% and SCLC accounts for 10-15% of cases. NSCLC subtypes include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Smoking, second-hand smoke, radon gas, asbestos, and other pollutants, genetic predisposition, and COPD are lung cancer risk factors. On the other hand, stresses such as DNA damage, telomere shortening, and ...
Source: Ageing Research Reviews - April 28, 2024 Category: Genetics & Stem Cells Authors: Saurav Kumar Jha Gabriele De Rubis Shankar Raj Devkota Yali Zhang Radhika Adhikari Laxmi Akhileshwar Jha Kunal Bhattacharya Samir Mehndiratta Gaurav Gupta Sachin Kumar Singh Nisha Panth Kamal Dua Philip M Hansbro Keshav Raj Paudel Source Type: research

Neutrophil Extracellular Traps and Respiratory Disease
J Clin Med. 2024 Apr 19;13(8):2390. doi: 10.3390/jcm13082390.ABSTRACTExtracellular traps made by neutrophils (NETs) and other leukocytes such as macrophages and eosinophils have a key role in the initial immune response to infection but are highly inflammatory and may contribute to tissue damage. They are particularly relevant to lung disease, with the pulmonary anatomy facilitating their ability to fully extend into the airways/alveolar space. There has been a rapid expansion in the number of published studies demonstrating their role in a variety of important respiratory diseases including chronic obstructive pulmonary d...
Source: Clinical Lung Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Paul T King Lovisa Dousha Source Type: research