Chronic Obstructive Pulmonary Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Optimizing Pharmacotherapy Management of COPD: Don't Miss the Forest for the Trees
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202402-0338VP. Online ahead of print.NO ABSTRACTPMID:38626371 | DOI:10.1164/rccm.202402-0338VP (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Jean Bourbeau Mohit Bhutani Paul Hernandez Erika Penz Darcy D Marciniuk Source Type: research

Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
CONCLUSIONS: A novel multi-layer network analysis is able to identify clinically relevant COPD patient communities. Patients with similarly low FEV1 and emphysema can have molecularly distinct small airways and immune response patterns, indicating that different endotypes can lead to similar clinical presentation.PMID:38626356 | DOI:10.1164/rccm.202303-0500OC (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Nuria Olvera Jon S ánchez-Valle Iker N úñez-Carpintero Joselyn Rojas-Quintero Guillaume Noell Sandra Casas-Recasens Alen Faiz Philip Hansbro Angela Guirao Rosalba Lepore Davide Cirillo Alvar Agust í Francesca Polverino Alfonso Valencia Rosa Faner Source Type: research

Identifying COPD patients with poor health status and low exercise tolerance through the five-repetition sit-to-stand test and modified Medical Research Council Dyspnea Score
CONCLUSIONS: COPD patients with concurrent conditions have worse clinical status. The diagnostic model developed to discriminate these patients shows good internal validation.PMID:38627182 | DOI:10.1016/j.ejim.2024.03.032 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - April 16, 2024 Category: Internal Medicine Authors: Roberto Bernab éu-Mora Silvana Loana Oliveira-Sousa Francesc Medina-Mirapeix Mariano Gacto-S ánchez Group of Investigation SAQ_COPD Source Type: research

Optimizing Pharmacotherapy Management of COPD: Don't Miss the Forest for the Trees
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202402-0338VP. Online ahead of print.NO ABSTRACTPMID:38626371 | DOI:10.1164/rccm.202402-0338VP (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Jean Bourbeau Mohit Bhutani Paul Hernandez Erika Penz Darcy D Marciniuk Source Type: research

Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
CONCLUSIONS: A novel multi-layer network analysis is able to identify clinically relevant COPD patient communities. Patients with similarly low FEV1 and emphysema can have molecularly distinct small airways and immune response patterns, indicating that different endotypes can lead to similar clinical presentation.PMID:38626356 | DOI:10.1164/rccm.202303-0500OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Nuria Olvera Jon S ánchez-Valle Iker N úñez-Carpintero Joselyn Rojas-Quintero Guillaume Noell Sandra Casas-Recasens Alen Faiz Philip Hansbro Angela Guirao Rosalba Lepore Davide Cirillo Alvar Agust í Francesca Polverino Alfonso Valencia Rosa Faner Source Type: research

Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: Role of mitochondrial damage
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 16. doi: 10.1152/ajplung.00362.2023. Online ahead of print.ABSTRACTChronic exposure to environmental hazards causes airway epithelial dysfunction, primarily impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of airway epithelial function subsequently leads to exaggerated airway inflammation and remodeling, the main features of chronic obstructive pulmonary disease (COPD). Mitochondrial damage has been identified as one of the mechanisms of airway abnormalities in COPD, which is closely related to airway inflammation and airflow limitation. In ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 16, 2024 Category: Cytology Authors: Qinglan He Peijun Li Lihua Han Chen Yang Meiling Jiang Yingqi Wang Xiaoyu Han Yuanyuan Cao Xiaodan Liu Weibing Wu Source Type: research

Alleviatory Role of < em > Panax Notoginseng < /em > Saponins in Modulating Inflammation and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease: mechanisms and Implications
This study delves into the therapeutic potential and mechanistic underpinnings of Panax notoginseng Saponins (PNS) in alleviating inflammation and pulmonary vascular remodeling in a COPD rat model. Symmap and ETCM databases provided Panax notoginseng-related target genes, and the CTD and DisGeNET databases provided COPD-related genes. Intersection genes were subjected to protein-protein interaction analysis and pathway enrichment to identify downstream pathways. A COPD rat model was established, with groups receiving varying doses of PNS and a Roxithromycin control. The pathological changes in lung tissue and vasculature w...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 16, 2024 Category: Respiratory Medicine Authors: Yanan Hu Qiuyang Fan Bo Qiao Ou Xu Bijun Lv Niping Han Xiaomei Zhang Source Type: research

Neutrophil/Lymphocyte Ratio as a Predictive Biomarker of NIV Failure in AECOPD: The Unveiled Facts [Letter]
Int J Chron Obstruct Pulmon Dis. 2024 Apr 11;19:905-906. doi: 10.2147/COPD.S465448. eCollection 2024.NO ABSTRACTPMID:38623318 | PMC:PMC11018122 | DOI:10.2147/COPD.S465448 (Source: Pain Physician)
Source: Pain Physician - April 16, 2024 Category: Anesthesiology Authors: Dipasri Bhattacharya Antonio M Esquinas Mohanchandra Mandal Source Type: research

Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: Role of mitochondrial damage
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 16. doi: 10.1152/ajplung.00362.2023. Online ahead of print.ABSTRACTChronic exposure to environmental hazards causes airway epithelial dysfunction, primarily impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of airway epithelial function subsequently leads to exaggerated airway inflammation and remodeling, the main features of chronic obstructive pulmonary disease (COPD). Mitochondrial damage has been identified as one of the mechanisms of airway abnormalities in COPD, which is closely related to airway inflammation and airflow limitation. In ...
Source: Am J Physiol Lung Ce... - April 16, 2024 Category: Respiratory Medicine Authors: Qinglan He Peijun Li Lihua Han Chen Yang Meiling Jiang Yingqi Wang Xiaoyu Han Yuanyuan Cao Xiaodan Liu Weibing Wu Source Type: research

Optimizing Pharmacotherapy Management of COPD: Don't Miss the Forest for the Trees
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202402-0338VP. Online ahead of print.NO ABSTRACTPMID:38626371 | DOI:10.1164/rccm.202402-0338VP (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Jean Bourbeau Mohit Bhutani Paul Hernandez Erika Penz Darcy D Marciniuk Source Type: research

Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
CONCLUSIONS: A novel multi-layer network analysis is able to identify clinically relevant COPD patient communities. Patients with similarly low FEV1 and emphysema can have molecularly distinct small airways and immune response patterns, indicating that different endotypes can lead to similar clinical presentation.PMID:38626356 | DOI:10.1164/rccm.202303-0500OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Nuria Olvera Jon S ánchez-Valle Iker N úñez-Carpintero Joselyn Rojas-Quintero Guillaume Noell Sandra Casas-Recasens Alen Faiz Philip Hansbro Angela Guirao Rosalba Lepore Davide Cirillo Alvar Agust í Francesca Polverino Alfonso Valencia Rosa Faner Source Type: research

Intercostal Muscle Function During Noninvasive Ventilation and Acute Hypercapnic Respiratory Failure
CONCLUSIONS: There is a positive relation between intercostal muscle TF measured by ultrasound and NIV failure, even after adjusting for APACHE II and SOFA scores.PMID:38626952 | DOI:10.4187/respcare.11676 (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Mira ç Öz Serhat Erol Fatma Arslan Ayd ın Çiledağ Ak ın Kaya Source Type: research