Chronic Obstructive Pulmonary Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
CONCLUSIONS: A novel multi-layer network analysis is able to identify clinically relevant COPD patient communities. Patients with similarly low FEV1 and emphysema can have molecularly distinct small airways and immune response patterns, indicating that different endotypes can lead to similar clinical presentation.PMID:38626356 | DOI:10.1164/rccm.202303-0500OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Nuria Olvera Jon S ánchez-Valle Iker N úñez-Carpintero Joselyn Rojas-Quintero Guillaume Noell Sandra Casas-Recasens Alen Faiz Philip Hansbro Angela Guirao Rosalba Lepore Davide Cirillo Alvar Agust í Francesca Polverino Alfonso Valencia Rosa Faner Source Type: research

Intercostal Muscle Function During Noninvasive Ventilation and Acute Hypercapnic Respiratory Failure
CONCLUSIONS: There is a positive relation between intercostal muscle TF measured by ultrasound and NIV failure, even after adjusting for APACHE II and SOFA scores.PMID:38626952 | DOI:10.4187/respcare.11676 (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Mira ç Öz Serhat Erol Fatma Arslan Ayd ın Çiledağ Ak ın Kaya Source Type: research

Optimizing Pharmacotherapy Management of COPD: Don't Miss the Forest for the Trees
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202402-0338VP. Online ahead of print.NO ABSTRACTPMID:38626371 | DOI:10.1164/rccm.202402-0338VP (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Jean Bourbeau Mohit Bhutani Paul Hernandez Erika Penz Darcy D Marciniuk Source Type: research

Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
CONCLUSIONS: A novel multi-layer network analysis is able to identify clinically relevant COPD patient communities. Patients with similarly low FEV1 and emphysema can have molecularly distinct small airways and immune response patterns, indicating that different endotypes can lead to similar clinical presentation.PMID:38626356 | DOI:10.1164/rccm.202303-0500OC (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Nuria Olvera Jon S ánchez-Valle Iker N úñez-Carpintero Joselyn Rojas-Quintero Guillaume Noell Sandra Casas-Recasens Alen Faiz Philip Hansbro Angela Guirao Rosalba Lepore Davide Cirillo Alvar Agust í Francesca Polverino Alfonso Valencia Rosa Faner Source Type: research

Identifying COPD patients with poor health status and low exercise tolerance through the five-repetition sit-to-stand test and modified Medical Research Council Dyspnea Score
CONCLUSIONS: COPD patients with concurrent conditions have worse clinical status. The diagnostic model developed to discriminate these patients shows good internal validation.PMID:38627182 | DOI:10.1016/j.ejim.2024.03.032 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - April 16, 2024 Category: Internal Medicine Authors: Roberto Bernab éu-Mora Silvana Loana Oliveira-Sousa Francesc Medina-Mirapeix Mariano Gacto-S ánchez Group of Investigation SAQ_COPD Source Type: research

Optimizing Pharmacotherapy Management of COPD: Don't Miss the Forest for the Trees
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202402-0338VP. Online ahead of print.NO ABSTRACTPMID:38626371 | DOI:10.1164/rccm.202402-0338VP (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Jean Bourbeau Mohit Bhutani Paul Hernandez Erika Penz Darcy D Marciniuk Source Type: research

Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
CONCLUSIONS: A novel multi-layer network analysis is able to identify clinically relevant COPD patient communities. Patients with similarly low FEV1 and emphysema can have molecularly distinct small airways and immune response patterns, indicating that different endotypes can lead to similar clinical presentation.PMID:38626356 | DOI:10.1164/rccm.202303-0500OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Nuria Olvera Jon S ánchez-Valle Iker N úñez-Carpintero Joselyn Rojas-Quintero Guillaume Noell Sandra Casas-Recasens Alen Faiz Philip Hansbro Angela Guirao Rosalba Lepore Davide Cirillo Alvar Agust í Francesca Polverino Alfonso Valencia Rosa Faner Source Type: research

Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: Role of mitochondrial damage
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 16. doi: 10.1152/ajplung.00362.2023. Online ahead of print.ABSTRACTChronic exposure to environmental hazards causes airway epithelial dysfunction, primarily impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of airway epithelial function subsequently leads to exaggerated airway inflammation and remodeling, the main features of chronic obstructive pulmonary disease (COPD). Mitochondrial damage has been identified as one of the mechanisms of airway abnormalities in COPD, which is closely related to airway inflammation and airflow limitation. In ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 16, 2024 Category: Cytology Authors: Qinglan He Peijun Li Lihua Han Chen Yang Meiling Jiang Yingqi Wang Xiaoyu Han Yuanyuan Cao Xiaodan Liu Weibing Wu Source Type: research

Alleviatory Role of < em > Panax Notoginseng < /em > Saponins in Modulating Inflammation and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease: mechanisms and Implications
This study delves into the therapeutic potential and mechanistic underpinnings of Panax notoginseng Saponins (PNS) in alleviating inflammation and pulmonary vascular remodeling in a COPD rat model. Symmap and ETCM databases provided Panax notoginseng-related target genes, and the CTD and DisGeNET databases provided COPD-related genes. Intersection genes were subjected to protein-protein interaction analysis and pathway enrichment to identify downstream pathways. A COPD rat model was established, with groups receiving varying doses of PNS and a Roxithromycin control. The pathological changes in lung tissue and vasculature w...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 16, 2024 Category: Respiratory Medicine Authors: Yanan Hu Qiuyang Fan Bo Qiao Ou Xu Bijun Lv Niping Han Xiaomei Zhang Source Type: research

Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: Role of mitochondrial damage
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 16. doi: 10.1152/ajplung.00362.2023. Online ahead of print.ABSTRACTChronic exposure to environmental hazards causes airway epithelial dysfunction, primarily impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of airway epithelial function subsequently leads to exaggerated airway inflammation and remodeling, the main features of chronic obstructive pulmonary disease (COPD). Mitochondrial damage has been identified as one of the mechanisms of airway abnormalities in COPD, which is closely related to airway inflammation and airflow limitation. In ...
Source: Am J Physiol Lung Ce... - April 16, 2024 Category: Respiratory Medicine Authors: Qinglan He Peijun Li Lihua Han Chen Yang Meiling Jiang Yingqi Wang Xiaoyu Han Yuanyuan Cao Xiaodan Liu Weibing Wu Source Type: research

Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease
Little is known about the relationships between human genetics and the airway microbiome. Deeply sequenced airway metagenomics, by simultaneously characterizing the microbiome and host genetics, provide a uniq... (Source: Respiratory Research)
Source: Respiratory Research - April 16, 2024 Category: Respiratory Medicine Authors: Jingyuan Gao, Yuqiong Yang, Xiaopeng Xiang, Huimin Zheng, Xinzhu Yi, Fengyan Wang, Zhenyu Liang, Dandan Chen, Weijuan Shi, Lingwei Wang, Di Wu, Shengchuan Feng, Qiaoyun Huang, Xueping Li, Wensheng Shu, Rongchang Chen & hellip; Tags: Research Source Type: research

Telephone Support for Copd Patients During COVID-19
Open Respir Arch. 2020 Jul-Sep;2(3):179-185. doi: 10.1016/j.opresp.2020.05.009. Epub 2020 Aug 17.ABSTRACTThe state of alarm declared by the Spanish government as the main measure for preventing contagion has involved a change in the clinical management of chronic patients. Although new communication technologies offer us many ways to establish direct but remote contact, the peculiarities of the COPD patient often mean that their healthcare is reduced to telephone calls. The challenge of caring for COPD patients is made even more complex when it has to be delivered over the phone. The interview must be conducted without exa...
Source: Respiratory Care - April 15, 2024 Category: Respiratory Medicine Authors: Jos é Luis Lopez-Campos Myriam Calle Borja G Cos ío Cruz Gonz ález Villaescusa Juan Luis Garc ía Rivero Alberto Fernandez Villar Juan Jose Soler Catalu ña Bernardino Alc ázar Source Type: research

Pulmonology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0613. Online ahead of print.ABSTRACTThe field of pulmonology saw significant advances in 2023. The publications highlighted in this article address advances and changes in practice related to asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pleural disorders, and sleep-disordered breathing. One article reviews data examining the efficacy of vaccination against respiratory syncytial virus, a respiratory viral illness that has had devastating effects globally. Four studies evaluate the role of various therapies in COPD, including dupilumab, ensifen...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Aram Karkar Sana Khan Rebecca O'Leary Albina Tyker Michael Unger Source Type: research

Does shortage of GPs matter? A cross-sectional study of practice population life expectancy
CONCLUSION: The number of GPs, continuity of care, and access in England are declining, and it is worrying that these features of general practice were positively associated with life expectancy.PMID:38621806 | DOI:10.3399/BJGP.2023.0195 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - April 15, 2024 Category: Primary Care Authors: Richard Baker Louis S Levene Christopher Newby George K Freeman Source Type: research