Chronic Obstructive Pulmonary Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

PTP1B Attenuates the Progression of COPD by Suppressing the SHP-2/Src/ERK1/2/NLRP3 Signaling Pathway
CONCLUSION: Our findings suggest that macrophage intracellular tyrosine phosphatase PTP1B plays a critical role in delaying COPD progression by targeting the SHP-2/Src/ERK1/2/NLRP3 signaling pathway, underscoring its potential as a therapeutic target in COPD management.PMID:38639633 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Hui Wang Hao Zhang Wei Yuan Source Type: research

The Role of SHP2 in Advancing COPD: Insights into Oxidative Stress, Endoplasmic Reticulum Stress, and Pyroptosis
CONCLUSIONS: SHP2 promotes COPD progression by inducing oxidative stress, endoplasmic reticulum stress, and pyroptosis.PMID:38639622 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Haidong Ding Rina Wu Source Type: research

Can blood eosinophil count be used as a predictive marker for the severity of COPD and concomitant cardiovascular disease? The relationship with the 2023 Version of the Global Initiative for Chronic Obstructive Lung Disease Staging
CONCLUSIONS: The results of our study indicate a strong relationship between eosinophils and cardiovascular events in COPD subjects, particularly in subjects at high risk of exacerbations and cardiovascular complications.PMID:38639517 | DOI:10.26355/eurrev_202404_35906 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: F Bozku ş A Samur O Yaz ıcı Source Type: research

Differences in Healthcare Utilization at the End of Life: a Comparison Study of Three Progressive Lung Diseases
1. Understand differences in healthcare and palliative care utilization across lung cancer, COPD, and idiopathic pulmonary fibrosis.2. Identify potential areas of unmet palliative care needs in patients with different non-cancer lung diseases. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Angela Suen, Kara E. Bischoff, Ashwin Kotwal, Rebecca Sudore, Erica Farrand Source Type: research

Heat-Induced Secretion of Heat Shock Proteins 70 and 90 Does not Affect the Expression of the Glucocorticoid Receptor in Primary Airway Cells in COPD
ConclusionsThe results of this study indicate that primary airway cells from COPD patients respond differently to heat exposure and extracellular HSP70 or HSP90 than cells from asthma patients regarding the expression of GR and this may explain the reduced response to glucocorticoids in patients with COPD.Trial Registration: ISRCTN11017699 (Source: Lung)
Source: Lung - April 19, 2024 Category: Respiratory Medicine Source Type: research

Structural Lung Disease and Clinical Phenotype in Bronchiectasis Patients: The EMBARC CT Study
CONCLUSION: Patients with bronchiectasis have highly heterogeneous type and extent of structural lung abnormalities. Strong relationships between radiological disease and clinical features suggest CT analysis may be a useful tool for clinical phenotyping.PMID:38635862 | DOI:10.1164/rccm.202311-2109OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 18, 2024 Category: Intensive Care Authors: Angelina L P Pieters Tjeerd van der Veer Jennifer J Meerburg Eleni-Rosalina Andrinopoulou Menno M Vd Eerden Pierluigi Ciet Stefano Aliberti Pierre-Regis Burgel Megan L Crichton Amelia Shoemark Pieter C Goeminne Michal Shteinberg Michael R Loebinger Charle Source Type: research

The Application of Diaphragm Ultrasound in Chronic Obstructive Pulmonary Disease: A Narrative Review
This article aims to review the structural measurement and functional evaluation methods through the use of diaphragmatic ultrasound and relevant research on its application in clinical practice for COPD patients. Thus, it serves to provide valuable insights for clinical monitoring of diaphragm function in COPD patients, facilitating early clinical intervention and aiding in the recovery of diaphragm function.PMID:38634575 | DOI:10.1080/15412555.2024.2331202 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 18, 2024 Category: Respiratory Medicine Authors: Heng Mu Qunxia Zhang Source Type: research

Clinical utilization of airway inflammatory biomarkers in the prediction and monitoring of clinical outcomes in patients with chronic obstructive pulmonary disease
Expert Rev Mol Diagn. 2024 Apr 18. doi: 10.1080/14737159.2024.2344777. Online ahead of print.ABSTRACTINTRODUCTION: Chronic obstructive pulmonary disease (COPD) accounts for 545 million people living with chronic respiratory disorders and is the third leading cause of morbidity and mortality around the world. COPD is a progressive disease, characterized by episodes of acute worsening of symptoms such as cough, dyspnea, and sputum production.AREAS COVERED: Airway inflammation is a prominent feature of COPD. Chronic airway inflammation results in airway structural remodeling and emphysema. Persistent airway inflammation is a ...
Source: Expert Review of Molecular Diagnostics - April 18, 2024 Category: Laboratory Medicine Authors: Dina Yehia Clarus Leung Don D Sin Source Type: research

Bronchiectasis not due to cystic fibrosis
Med Clin (Barc). 2024 Apr 17:S0025-7753(24)00145-3. doi: 10.1016/j.medcli.2024.01.023. Online ahead of print.ABSTRACTBronchiectasis is a clinical-radiological condition composed of irreversible bronchial dilation due to inflammation and infection of the airways, which causes respiratory symptoms, usually productive cough and infectious exacerbations. Bronchiectasis can have multiple causes, both pulmonary and extrapulmonary, and its clinical presentation is very heterogenous. Its prevalence is unknown, although up to 35-50% of severe COPD and 25% of severe asthma present them, so their underdiagnosis is evident. Chronic ba...
Source: Medicina Clinica - April 18, 2024 Category: General Medicine Authors: Rosa Gir ón Rafael Golpe Miguel Ángel Martínez-García Source Type: research

Structural Lung Disease and Clinical Phenotype in Bronchiectasis Patients: The EMBARC CT Study
CONCLUSION: Patients with bronchiectasis have highly heterogeneous type and extent of structural lung abnormalities. Strong relationships between radiological disease and clinical features suggest CT analysis may be a useful tool for clinical phenotyping.PMID:38635862 | DOI:10.1164/rccm.202311-2109OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 18, 2024 Category: Respiratory Medicine Authors: Angelina L P Pieters Tjeerd van der Veer Jennifer J Meerburg Eleni-Rosalina Andrinopoulou Menno M Vd Eerden Pierluigi Ciet Stefano Aliberti Pierre-Regis Burgel Megan L Crichton Amelia Shoemark Pieter C Goeminne Michal Shteinberg Michael R Loebinger Charle Source Type: research

Development and application of a deep learning-based comprehensive early diagnostic model for chronic obstructive pulmonary disease
CONCLUSION: We developed and implemented a data fusion strategy to construct a state-of-the-art COPD diagnostic model integrating deep learning features, radiomics features, and questionnaire variables. Our data fusion strategy proved effective, and the model can be easily deployed in clinical settings.TRIAL REGISTRATION: Not applicable. This study is NOT a clinical trial, it does not report the results of a health care intervention on human participants.PMID:38637823 | PMC:PMC11027407 | DOI:10.1186/s12931-024-02793-3 (Source: Respiratory Care)
Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Zecheng Zhu Shunjin Zhao Jiahui Li Yuting Wang Luopiao Xu Yubing Jia Zihan Li Wenyuan Li Gang Chen Xifeng Wu Source Type: research