Human Bronchial Epithelial Cell Transcriptome Changes in Response to Serum from Patients with Different Status of Inflammation
ConclusionThis simple model could be useful to characterize patient serum and epithelial cell properties. (Source: Lung)
Source: Lung - March 17, 2024 Category: Respiratory Medicine Source Type: research

Circulating Osteopontin Predicts Clinical and Radiological Response in First-Line Treatment of Advanced Non-Small Cell Lung Cancer
ConclusionBaseline levels of serum OPN is closely associated with performance status and short/long term outcomes in patients with advanced NSCLC, which are candidate to pembrolizumab-based regimens. As upfront biomarker of senescence, OPN may pave the way for future studies focusing on senescence patterns in NSCLC. (Source: Lung)
Source: Lung - March 13, 2024 Category: Respiratory Medicine Source Type: research

Pressure Support Ventilation Versus T-piece as Spontaneous Breathing Trials for Extubation of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials
ConclusionAlthough PSV in SBTs exhibits superior extubation success, consistent weaning protocols warrant further exploration through additional studies. (Source: Lung)
Source: Lung - March 12, 2024 Category: Respiratory Medicine Source Type: research

Genetic Testing Goes Beyond Imaging and Histological Evaluation in Pleuroparenchymal Fibroelastosis
ConclusionDetecting anomalies in TBD-related or surfactant protein genes can significantly refine the diagnosis and treatment strategies for individuals with PPFE and other F-ILD. (Source: Lung)
Source: Lung - March 10, 2024 Category: Respiratory Medicine Source Type: research

Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study
ConclusionsApproximately 60% of chronic cough patients in specialist clinics may require antitussive drugs. While codeine benefits some, only a limited proportion (about 20%) of patients may experience rapid and significant improvement. This underscores the urgent need for new antitussive drugs to address these unmet clinical needs. (Source: Lung)
Source: Lung - February 27, 2024 Category: Respiratory Medicine Source Type: research

Association Between Time to First Cigarette Use and Urine Biomarkers of Tobacco Exposure in Adult Smokers
(Source: Lung)
Source: Lung - February 22, 2024 Category: Respiratory Medicine Source Type: research

Identification of Idiopathic Pulmonary Fibrosis and Prediction of Disease Severity via Machine Learning Analysis of Comprehensive Metabolic Panel and Complete Blood Count Data
ConclusionAnalysis of CMP and CBC data via proposed ML methodology offers the potential to distinguish IPF from CTD-ILD and predict severity on associated PFT with accuracy that meets or exceeds current clinical practice. (Source: Lung)
Source: Lung - February 20, 2024 Category: Respiratory Medicine Source Type: research

Missing Nuts and Bolts: Translating Pulmonary Fibrosis from Preclinical Murine Models to Human Clinical Trials
(Source: Lung)
Source: Lung - February 7, 2024 Category: Respiratory Medicine Source Type: research