Adherence to Long-Term Follow-Up of Patients with Life-Threatening, Inhaled Synthetic Cannabinoids-Associated Coagulopathy in Chicago
We report on 3 poisoned patients who reside in underserved, socioeconomically disadvantaged neighborhoods of Chicago that were admitted and treated successfully at two inner-city, tertiary care hospitals in Chicago. The patients were discharged from the hospitals on daily long-term high-dose oral vitamin K1 (VK1), provided free of charge. However, 2 patients were lost to follow-up prior to safe discontinuation of oral VK1 therapy. The third patient was treated and followed successfully for 7  months when VK1 was discontinued. We conclude that prolonged oral VK1 therapy and follow-up of acute, life-threatening LAAR poi...
Source: Lung - April 19, 2019 Category: Respiratory Medicine Source Type: research

Effects of Ongoing Feedback During a 12-Month Maintenance Walking Program on Daily Physical Activity in People with COPD
AbstractThis multi-centred, randomised controlled trial explored the effects of adding ongoing feedback to a 12-month unsupervised maintenance walking program, on daily physical activity (PA) in people with chronic obstructive pulmonary disease. Participants were randomised to either an intervention group (IG) or a usual care group (UCG). During the maintenance program, the IG received ongoing feedback (telephone calls,  biofeedback provided via pedometer and progressive goal setting) and the UCG received no feedback. The SenseWear® Pro3 Armband was used to measure PA. Of the 86 participants {IG =&thin...
Source: Lung - April 15, 2019 Category: Respiratory Medicine Source Type: research

Improved False-Positive Rates and the Overestimation of Unintended Harm from Lung Cancer Screening
ConclusionFalse-positive rates in lung cancer screening programs continue to decline with improved radiologic expertise. Additionally, false-positive reporting overestimates the risk of unintended harm from further investigative procedures as only a percentage of positive findings are generally considered for tissue diagnosis (i.e., Lung-RADS category 4). (Source: Lung)
Source: Lung - April 12, 2019 Category: Respiratory Medicine Source Type: research

Real-Life Experience with Selexipag as an Add-On Therapy to Oral Combination Therapy in Patients with Pulmonary Arterial or Distal Chronic Thromboembolic Pulmonary Hypertension: A Retrospective Analysis
ConclusionsEarly initiation of triple oral combination therapy including selexipag in PAH/CTEPH with intermediate risk factor profile may help to stabilize functional class, exercise performance, and pulmonary hemodynamics in a real-life setting and potentially improves quality of life. Whether these beneficial effects can be truly attributed to the addition of selexipag should be addressed in future randomized controlled trials. (Source: Lung)
Source: Lung - April 8, 2019 Category: Respiratory Medicine Source Type: research

Correction to: The Burden of Sarcoidosis Symptoms from a Patient Perspective
The original version of this article unfortunately contained a mistake in coauthor's given name. The abbreviated given name"M.D." for coauthor M.D.P. Elfferich's name has been inadvertently deleted during the production process. (Source: Lung)
Source: Lung - April 8, 2019 Category: Respiratory Medicine Source Type: research

Screening for Myositis Antibodies in Interstitial Lung Disease
(Source: Lung)
Source: Lung - April 5, 2019 Category: Respiratory Medicine Source Type: research

Thoracic Hyper-IgG4-Related Disease Mimicking Malignant Pleural Mesothelioma
We report a rare case of a IgG4-related disease presenting with recurrent pleural effusion, pleural thickness and multiple mediastinal lymphadenopathies and no involvement of other extrathoracic organs. A 65-year-old man with a previous asbestos exposure presented with cough and pain discomfort. A large right pleural effusion was detected and evacuated (siero-haematic liquid). With the suspicious of a pleural mesothelioma, a CT-scan before and a18F-FDG PET/CT-scan later were performed revealing multiple pleural thickenings and multiple mediastinal lymphadenopathies with radiotracer uptake. EBUS-TBNA EBUS-TBNA did not resul...
Source: Lung - April 2, 2019 Category: Respiratory Medicine Source Type: research

A New Diagnosis-Specific Survival Score for Patients to be Irradiated for Brain Metastases from Non-small Cell Lung Cancer
AbstractIntroductionPersonalized treatment helps one achieve optimal outcomes in patients with non-small cell lung cancer (NSCLC). Understanding patients ’ survival prognoses in a palliative situation like intracerebral metastases is critical. A new survival score, the WBRT-30-NSCLC, was developed for patients with intracerebral metastases from NSCLC.MethodsEight factors were investigated in 157 patients receiving 10  × 3 Gy of whole-brain radiotherapy (WBRT) including age, gender, Karnofsky performance score (KPS), interval from diagnosis of NSCLC to WBRT, pre-WBRT systemic treatment, primar...
Source: Lung - March 29, 2019 Category: Respiratory Medicine Source Type: research

Reply To: A Comment on Helicobacter pylori and Lung Transplant Outcome:  Is Serology the Ideal Diagnostic Approach?
(Source: Lung)
Source: Lung - March 21, 2019 Category: Respiratory Medicine Source Type: research

Pulmonary Acinus: Understanding the Computed Tomography Findings from an Acinar Perspective
AbstractThe lung acinus is the most distal portion of the airway responsible for the gas exchange. The normal acini are not visible on conventional computed tomography (CT), but the advent of micro-CT improved the understanding of the microarchitecture of healthy acini. The comprehension of the acinar architecture is pivotal for the understanding of CT findings of diseases that involve the acini. Centriacinar emphysema, for example, presents as round areas of low attenuation due to the destruction of the most central acini with compensatory enlargement of proximal acini due to alveolar wall destruction. In pulmonary fibros...
Source: Lung - March 21, 2019 Category: Respiratory Medicine Source Type: research

Identification of Active Sarcoidosis Using Chitotriosidase and Angiotensin-Converting Enzyme
ConclusionsThe algorithm involving CHITO, hs-CRP, and ACE could be a suitable strategy for differentiation between sarcoidosis activity/remission status. (Source: Lung)
Source: Lung - March 19, 2019 Category: Respiratory Medicine Source Type: research

Physical Inactivity in Pulmonary Sarcoidosis
AbstractPurposeReduced physical activity in many chronic diseases is consistently associated with increased morbidity. Little is known about physical activity in sarcoidosis. The aim of this study was to objectively assess physical activity in patients with pulmonary sarcoidosis and investigate its relationship with lung function, exercise capacity, symptom burden, and health status.MethodsPhysical activity was assessed over one week in 15 patients with pulmonary sarcoidosis and 14 age-matched healthy controls with a tri-axial accelerometer (ActivPal ™) and the International Physical Activity Questionnaire (IPAQ). Al...
Source: Lung - March 19, 2019 Category: Respiratory Medicine Source Type: research

Nutritional Status in Childhood as a Prognostic Factor in Patients with Cystic Fibrosis
AbstractIntroductionThere is a strong association between cystic fibrosis and malnutrition, mainly because of the higher energy needs combined with lower intake. There is also a well-established correlation between good nutritional status and better lung function. To date, however, there are no studies examining nutritional status in childhood and adult lung function. To respond to this need, this innovative study explored the long-term correlations between nutritional status in childhood and lung function in adulthood for the same patient population.MethodsA retrospective patient file study was conducted to identify putat...
Source: Lung - March 18, 2019 Category: Respiratory Medicine Source Type: research

Gene Variants, mRNA and NOD1/2 Protein Levels in Tunisian Childhood Asthma
AbstractIntroductionAsthma is a common respiratory childhood disease that results from an interaction between genetic, environmental and immunologic factors. The implication of nucleotide-binding and oligomerization domain 1 and 2 (NOD1/CARD4, NOD2/CARD15) was highlighted in many inflammatory diseases.MethodsIn this case-control study, we analyzed the association of three NOD2 polymorphisms and one NOD1 variant, in 338 Tunisian asthmatic children and 425 healthy Controls, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We also assessed NOD1 and NOD2 mRNA and protein levels by qRT...
Source: Lung - March 14, 2019 Category: Respiratory Medicine Source Type: research

The Economic Effect of Early Management in Patients with Early Chronic Obstructive Pulmonary Disease: Results from a Population-Based Nationwide Survey
ConclusionPatients with early COPD, even those with FEV1 ≥ 80, need regular follow-up for early management and disease control as well as for reducing the socioeconomic burden of the disease. (Source: Lung)
Source: Lung - March 11, 2019 Category: Respiratory Medicine Source Type: research

Screening for Myositis Antibodies in Idiopathic Interstitial Lung Disease
AbstractPurposeInternational guidelines recommend screening for connective tissue disease (CTD) with autoantibodies when evaluating patients with idiopathic interstitial lung disease (ILD). Idiopathic inflammatory myositis comprises of a subgroup of CTD diagnosed with myositis antibodies (MA), often presenting with ILD. Our aim was to evaluate the utility of MA screening in patients with idiopathic ILD.MethodsA retrospective analysis was conducted on patients referred with idiopathic ILD to a tertiary centre ILD clinic who were screened for MA. Patients with known or suspected CTD were excluded. Descriptive statistics, uni...
Source: Lung - March 5, 2019 Category: Respiratory Medicine Source Type: research

Bronchoscopic Brushing from Central Lung Cancer —Next Generation Sequencing Results are Reliable
In this study, 50 consecutive subjects with suspected central lung cancer underwent bronchoscopic brushing (31 males, median age 70, 5 never smokers). Histological results were: NSCLC/SCLC/low-grade-NET/granulation tissue in 36/8/2/4 cases. Next generation sequencing (NGS) was feasible in 62% of tumor-positive brush smear samples. In 78% of these cases, NGS displayed identical results compared to histology samples, in 22% NGS from brush smears detected specific mutations, whereas DNA quality from forceps biopsy was insufficient for NGS analysis. Sensitivity, specificity, positive predictive value, negative predictive value...
Source: Lung - March 1, 2019 Category: Respiratory Medicine Source Type: research

Soluble Urokinase-Type Plasminogen Activator Receptor and Arterial Stiffness in Patients with COPD
AbstractIntroductionSoluble urokinase-type plasminogen activator receptor (suPAR) is upregulated by inflammation and plays a role in the pathogenesis of atherosclerosis. Chronic obstructive pulmonary disease (COPD) is associated with enhanced systemic inflammation and increased risk for atherosclerosis, however, studies analysing the circulating suPAR levels in COPD are contradictory. The aim of the study was to investigate plasma suPAR concentrations together with markers of arterial stiffness in COPD.Materials and MethodsTwenty-four patients with COPD and 18 non-COPD, control subjects participated in the study. Plasma su...
Source: Lung - February 28, 2019 Category: Respiratory Medicine Source Type: research

Inpatient Prevalence, Expenditures, and Comorbidities of Sarcoidosis: Nationwide Inpatient Sample 2013 –2014
AbstractPurposeTo investigate inpatient prevalence, expenditures, and comorbidities of hospitalized patients with sarcoidosis in the USA.MethodsPatients with sarcoidosis were identified within the Nationwide Inpatient Sample (NIS) database for the years 2013 and 2014 using the respective ICD-9 diagnostic code. Data on patient and hospital characteristics, comorbidities, total hospital costs, and total hospitalization charges were collected. A propensity-matched cohort of patients without sarcoidosis from the same database was created and used as comparators for the analysis of comorbidities.ResultsA cohort of 78,055 patien...
Source: Lung - February 23, 2019 Category: Respiratory Medicine Source Type: research

Unusual Etiology of Cough: Giant Pleural Lipoma
(Source: Lung)
Source: Lung - February 20, 2019 Category: Respiratory Medicine Source Type: research

Using a Dedicated Interventional Pulmonology Practice Decreases Wait Time Before Treatment Initiation for New Lung Cancer Diagnoses
ConclusionsCompared to prior reports from international and United States cohorts, obtaining a tissue biopsy diagnosis through a gatekeeper interventional pulmonology practice decreases median delay from abnormal imaging to treatment initiation. This finding has the potential to positively impact patient outcomes and requires further evaluation. (Source: Lung)
Source: Lung - February 19, 2019 Category: Respiratory Medicine Source Type: research

The Burden of Sarcoidosis Symptoms from a Patient Perspective
ConclusionSarcoidosis patients in Denmark, Germany and the Netherlands present with similar self-reported symptoms, organ-related as well as non-specific, non-organ related. Fatigue (90%) and symptoms associated with SFN (86%) were highly prevalent in all three countries. (Source: Lung)
Source: Lung - February 16, 2019 Category: Respiratory Medicine Source Type: research

Investigation of Urinary Sestrin2 in Patients with Obstructive Sleep Apnea
AbstractBackgroundObstructive sleep apnea (OSA) is a disease seriously threatening individual health, which results in serious complications such as hypertension and stroke. These complications are associated with oxidative stress triggered by intermittent hypoxia in OSA. Sestrin2 is a crucial factor involved in oxidative stress. The goal of this study was to investigate if a relationship exists between OSA and Sestrin2.MethodsWe prospectively enrolled 71 subjects, and 16 patients of them with severe OSA completed 4  weeks of nasal continuous positive airway pressure (nCPAP) therapy. We measured and compared the conce...
Source: Lung - February 15, 2019 Category: Respiratory Medicine Source Type: research

The Inflammatory Effect of Iron Oxide and Silica Particles on Lung Epithelial Cells
ConclusionsWhile previous studies have suggested that iron may augment silica-induced inflammation, we saw no evidence of this in human epithelial cells. We found that alveolar epithelial cells produce pro-inflammatory cytokines in response to iron oxide particles, suggesting that previous in vivo observations are due to the alveolar response to these particles. (Source: Lung)
Source: Lung - February 14, 2019 Category: Respiratory Medicine Source Type: research

Proof of Concept: Very Rapid Tidal Breathing Nasal Nitric Oxide Sampling Discriminates Primary Ciliary Dyskinesia from Healthy Subjects
AbstractIntroductionNasal nitric oxide (nNO) is extremely low in individuals with primary ciliary dyskinesia (PCD) and is recommended as part of early workup. We investigated whether tidal breathing sampling for a few seconds was as discriminative between PCD and healthy controls (HC) as conventional tidal breathing sampling (cTB-nNO) for 20 –30 s.MethodsWe performed very rapid sampling of tidal breathing (vrTB-nNO) for 2, 4 and 6  s, respectively. Vacuum sampling with applied negative pressure (vrTB-nNOvac; negative pressure was applied by pinching the sampling tube) for
Source: Lung - February 14, 2019 Category: Respiratory Medicine Source Type: research

Degradation of Lung Protective Angiotensin Converting Enzyme-2 by Meconium in Human Alveolar Epithelial Cells: A Potential Pathogenic Mechanism in Meconium Aspiration Syndrome
AbstractBackgroundPancreatic digestive enzymes present in meconium might be responsible for meconium-induced lung injury. The  local Renin Angiotensin System plays an important role in lung injury and inflammation. Particularly, angiotensin converting enzyme-2 (ACE-2) has been identified as a protective lung enzyme against the insult. ACE-2 converts pro-apoptotic Angiotensin II to anti-apoptotic Angiotensin 1–7. However , the effect of meconium on ACE-2 has never been studied before.ObjectiveTo study the effect of meconium on ACE-2, and whether inhibition of proteolytic enzymes present in the meconium reverses i...
Source: Lung - February 13, 2019 Category: Respiratory Medicine Source Type: research

Pirfenidone Therapy for Familial Pulmonary Fibrosis: A Real-Life Study
ConclusionDifferent rate of progression was observed in patients with IPF and FPF on therapy with pirfenidone; our findings may not be due to lack of effectiveness of therapy, but to the different natural history and evolution of these two conditions. Pirfenidone was well tolerated by FPF and IPF patients. Specific unbiased randomized clinical trials on larger populations to validate our preliminary exploratory results are needed. (Source: Lung)
Source: Lung - February 13, 2019 Category: Respiratory Medicine Source Type: research

A Comment on Helicobacter pylori and Lung Transplant Outcome: Is Serology the Ideal Diagnostic Approach?
(Source: Lung)
Source: Lung - February 11, 2019 Category: Respiratory Medicine Source Type: research

The Amide Local Anesthetic Ropivacaine Attenuates Acute Rejection After Allogeneic Mouse Lung Transplantation
AbstractPurposeAcute allograft rejection after lung transplantation remains an unsolved hurdle. The pathogenesis includes an inflammatory response during and after transplantation. Ropivacaine, an amide-linked local anesthetic, has been shown to attenuate lung injury due to its anti-inflammatory effects. We hypothesized that the drug would also be able to attenuate acute rejection (AR) after allogeneic lung transplantation.MethodsAllogeneic, orthotopic, single left lung transplantation was performed between BALB/c (donors) and C57BL/6 (recipients) mice. Prior to explantation, lungs were flushed with normal saline with or w...
Source: Lung - February 9, 2019 Category: Respiratory Medicine Source Type: research

The Effect of Breathing Retraining Using Metronome-Based Acoustic Feedback on Exercise Endurance in COPD: A Randomized Trial
ConclusionsIn patients with COPD, breathing-retraining using a metronome-based acoustic feedback did not result in improved exercise endurance or decreased dynamic hyperinflation when compared to exercise-training alone.Trial registry: ClinicalTrials.gov; No.: NCT NCT01009099; URL:http://www.clinicaltrials.gov (Source: Lung)
Source: Lung - February 9, 2019 Category: Respiratory Medicine Source Type: research

Association Between Serum Lipid Profile and Obstructive Respiratory Events During REM and Non-REM Sleep
AbstractPurposeObstructive sleep apnoea (OSA) represents a risk for dyslipidaemia. Obstructive respiratory events during rapid eye movement (REM) sleep are more strongly related to the development of hypertension and diabetes than in non-REM. However, the relationship between sleep phases and serum lipid profile is unclear. We aimed to analyse the relationship between obstructive respiratory events in REM and non-REM sleep as well as serum lipid profile.MethodsPolysomnography was performed in 94 adult subjects who did not take any lipid-modifying medications. Fasting venous blood sample was taken the following morning for ...
Source: Lung - February 2, 2019 Category: Respiratory Medicine Source Type: research

Methodological Concerns of a Recent Network Meta-analysis Assessing Biologics for Eosinophilic Asthma
(Source: Lung)
Source: Lung - January 31, 2019 Category: Respiratory Medicine Source Type: research

Prognostic Accuracy of Three COPD Classification Systems in Relation to Long-Term Mortality of COPD Patients: A Prospective Multicenter Study
AbstractRecent research showed group B patients express higher mortality compared to group C patients when GOLD A-D grouping is used. We aimed to compare the prognostic accuracy of three GOLD classification systems, I –IV (“pre-2011”), A-D (“2011–2016”) and A-D (“2017–present”) in relation to mortality, exacerbation risk, quality of life (QoL) assessment and specific treatments use in a real-life COPD cohort. We used the data of 720 patients from the Czech Multicenter Research Database of COPD. Four-year mortality and time-to-exacerbation using the GOLD “pre-2011&...
Source: Lung - January 29, 2019 Category: Respiratory Medicine Source Type: research

The Role of the Cerebellum in Control of Swallow: Evidence of Inspiratory Activity During Swallow
AbstractAnatomical connections are reported between the cerebellum and brainstem nuclei involved in swallow such as the nucleus tractus solitarius, nucleus ambiguus, and K ölliker-fuse nuclei. Despite these connections, a functional role of the cerebellum during swallow has not been elucidated. Therefore, we examined the effects of cerebellectomy on swallow muscle recruitment and swallow–breathing coordination in anesthetized freely breathing cats. Electromyograms were recorded from upper airway, pharyngeal, laryngeal, diaphragm, and chest wall muscles before and after complete cerebellectomy. Removal of the cer...
Source: Lung - January 24, 2019 Category: Respiratory Medicine Source Type: research

The Effects of Aging on Exhaled Nitric Oxide (FeNO) in a North African Population
ConclusionThe development and aging of the lung touched non-respiratory functions and so modified FeNO values in healthy North African subjects. (Source: Lung)
Source: Lung - January 14, 2019 Category: Respiratory Medicine Source Type: research

Concentration of Serum Vascular Endothelial Growth Factor (VEGF-D) and Its Correlation with Functional and Clinical Parameters in Patients with Lymphangioleiomyomatosis from a Brazilian Reference Center
AbstractIntroductionSerum vascular endothelial growth factor-D (VEGF-D) is a lymphangiogenic growth factor that is considered a valuable tool in the diagnosis of lymphangioleiomyomatosis (LAM). Previous studies have reported a wide variability in VEGF-D serum levels in LAM patients and it seems to be associated with pulmonary impairment and lymphatic involvement.MethodsWe conducted a cross-sectional study from 2009 to 2017 that evaluated VEGF-D serum levels in a cohort of LAM patients who were never treated with mTOR inhibitors and compared them to healthy age-matched volunteers. Clinical and functional parameters were ass...
Source: Lung - January 8, 2019 Category: Respiratory Medicine Source Type: research

Predictors of Continuous Positive Airway Pressure Adherence in Patients with Obstructive Sleep Apnea
AbstractObstructive sleep apnea (OSA) is a common disease which impacts quality of life, mood, cardiovascular morbidity, and mortality. Continuous positive airway pressure (CPAP) is the first-line treatment for patients with moderate to severe OSA. CPAP ameliorates respiratory disturbances, leading to improvements in daytime sleepiness, quality of life, blood pressure, and cognition. However, despite the high efficacy of this device, CPAP adherence is often sub-optimal. Factors including: socio-demographic/economic characteristics, disease severity, psychological factors, and side-effects are thought to affect CPAP adheren...
Source: Lung - January 7, 2019 Category: Respiratory Medicine Source Type: research

Nanogold Assay Improves Accuracy of Conventional TB Diagnostics
ConclusionsOur study shows that TB nanogold assay is accurate, rapid, and holds the potential for use as an add-on initial test to improve accuracy of SSM and CXR in detecting patients of active pulmonary TB in developing countries. Future studies should involve larger sample size for further assessment of test accuracy. (Source: Lung)
Source: Lung - January 4, 2019 Category: Respiratory Medicine Source Type: research

Fractional Exhaled Nitric Oxide Measurements and Screening of Obstructive Sleep Apnea in a Sleep-Laboratory Setting: A Cross-Sectional Study
ConclusionsIn a sleep-lab setting, our findings suggest that FeNO measurements are inconsequential in the screening of OSA in adults. (Source: Lung)
Source: Lung - January 2, 2019 Category: Respiratory Medicine Source Type: research

8-Foot-Up-and-Go Test is Associated with Hospitalizations and Mortality in Idiopathic Pulmonary Fibrosis: A Prospective Pilot Study
AbstractPurposeTo assess the prognostic value of the 8-foot-up-and-go test (8-FUGT) in pilot cohort of patients with idiopathic pulmonary fibrosis (IPF).MethodsThirty-four patients with IPF (68  ± 8 years) underwent 8-FUGT at baseline and were followed for up to 40 months. Receiver operating characteristics and age-adjusted Cox hazard ratios (HR) were analyzed for 8-FUGT, hospitalizations, and mortality. Correlation coefficients were determined between 8-FUGT and other exercise test s.Results8-FUGT  ≥ 6.9 s was found to be associated with hospitalization (sensitivity&thi...
Source: Lung - January 2, 2019 Category: Respiratory Medicine Source Type: research

Role of Antigen Type in Survival in Chronic Hypersensitivity Pneumonitis
(Source: Lung)
Source: Lung - December 14, 2018 Category: Respiratory Medicine Source Type: research

Cytotoxic Natural Killer Subpopulations as a Prognostic Factor of Malignant Pleural Effusion
ConclusionsOur data suggest that both the PF/PB ratios of cytotoxic subpopulations CD57+ NK and CD16+ NK are useful as a prognostic factor of MPE. Other subpopulations (CD56 bright CD16 − and CD56 dim CD16− NK) could help to diagnose MPE. (Source: Lung)
Source: Lung - December 6, 2018 Category: Respiratory Medicine Source Type: research

Iftikhar and Colleagues Reply: Methodology Clarified
(Source: Lung)
Source: Lung - December 5, 2018 Category: Respiratory Medicine Source Type: research

Sigh Syndrome in Pediatric Asthma
(Source: Lung)
Source: Lung - December 3, 2018 Category: Respiratory Medicine Source Type: research

Pleural Effusions in Diffuse Large B-Cell Lymphoma: Clinical and Prognostic Significance
ConclusionsPEs are common in DLBCL and foreshadow a poor prognosis. (Source: Lung)
Source: Lung - November 30, 2018 Category: Respiratory Medicine Source Type: research

Effect of High Glucose on Human Alveolar Macrophage Phenotype and Phagocytosis of Mycobacteria
ConclusionAlteration in the expression of certain receptors may contribute to defective sentinel function of AMs, promoting susceptibility to TB in a diabetic host. Variability in cell surface marker expression under direct glucose exposure compared to exposure via co-culture reveals that cell signaling between endothelial cells and AMs may play a crucial role in the phenotypic expression of AMs. (Source: Lung)
Source: Lung - November 24, 2018 Category: Respiratory Medicine Source Type: research

Significant Delay in the Detection of Desaturation between Finger Transmittance and Earlobe Reflectance Oximetry Probes during Fiberoptic Bronchoscopy: Analysis of 104 Cases
AbstractPurposeThere is clinical significance to a delay in response time for detecting desaturation by pulse oximetry. Our aim in this study was to compare the response time of the reflectance and transmittance saturation probes during fiberoptic bronchoscopy (FOB) under monitored anesthesia care.MethodsA prospective study included 104 patients scheduled for FOB. Patients were monitored with transmittance (finger) and reflectance (ear) oximetry probes. The response time was evaluated during desaturation and resaturation. We also acquired blood tests for arterial oxygen saturation to assess the agreement with the oximetry ...
Source: Lung - November 24, 2018 Category: Respiratory Medicine Source Type: research

Helicobacter pylori Infection Does Not Impact on Lung Transplant Outcome
AbstractBackgroundHelicobacter pylori (HP) is a spiral, gram-negative, microaerophilic bacterium that colonises the human gastric mucosa and is associated with gastrointestinal and extragastrointestinal disorders. Since no data are yet available on HP infection in lung transplant patients, we evaluated the prevalence and impact of HP infection in a population of such patients.MethodsSixty-seven lung transplant patients were enrolled in the study (35 females and 32 males, age 48.4  ± 13.3 years), 54 underwent bilateral and 13 single lung transplant. Serum antibodies against HP and CagA were assayed...
Source: Lung - November 19, 2018 Category: Respiratory Medicine Source Type: research

The Effect of Using Different Types of Forceps in the Efficacy of Transbronchial Lung Biopsy
ConclusionsThe results of the study showed that using cupped forceps in performing TBBX had fewer complications (pneumothorax and bleeding) and a higher diagnostic yield in comparison with alligator forceps, but the difference did not reach a statistical significant value. (Source: Lung)
Source: Lung - November 15, 2018 Category: Respiratory Medicine Source Type: research

Prognostic Factors in Adult Patients with Non-Cystic Fibrosis Bronchiectasis
ConclusionsOlder age, lower FEV1 % of predicted, and lower MEP were independently linked to unfavorable outcomes. FACED and BSI were not accurate in predicting mortality in our cohort. (Source: Lung)
Source: Lung - November 14, 2018 Category: Respiratory Medicine Source Type: research