Benefits and Risks of Inhaled Corticosteroid Treatment in Patients with Chronic Obstructive Pulmonary Disease Classified by Blood Eosinophil Counts
AbstractBackgroundChronic obstructive pulmonary disease (COPD) typically includes neutrophilic airway inflammation and eosinophilic inflammation in some cases. Inhaled corticosteroid (ICS) suppresses eosinophilic inflammation of the airway and reduces acute exacerbation (AE). The present study investigated the relationship between ICS and AE in patients with COPD classified by blood eosinophil counts.MethodsOverall, 244 patients with COPD were retrospectively evaluated between 2014 and 2017 and classified into two groups based on blood eosinophil counts ( ≥ 300/μL and
Source: Lung - October 17, 2020 Category: Respiratory Medicine Source Type: research

Influence of Cystic Fibrosis-Related Diabetes on Mental Health in Adults: A Single-Center Study
ConclusionWe show a significant association between CFRD and selected diagnoses of depression in a cohort of adult patients. (Source: Lung)
Source: Lung - October 16, 2020 Category: Respiratory Medicine Source Type: research

Postoperative Adverse Events are Associated with Oncologic Recurrence Following Curative-intent Resection for Lung Cancer
AbstractBackgroundUp to 50% of patients suffer short-term postoperative adverse events (AEs) and metastatic recurrence in the long-term following curative-intent lung cancer resection. The association between AEs, particularly infectious in nature, and disease recurrence is controversial. We sought to evaluate the association of postoperative AEs on risk of developing recurrence and recurrence-free survival (RFS) following curative-intent lung resection surgery.MethodsAll lung cancer resections at a single institution (January 2008 –July 2015) were included, with prospective collection of AEs using the Thoracic Morbi...
Source: Lung - October 9, 2020 Category: Respiratory Medicine Source Type: research

The St. George ’s Respiratory Questionnaire in Pulmonary Sarcoidosis
AbstractRationaleThe Saint George ’s Respiratory Questionnaire (SGRQ) is a frequently used tool to assess health status in pulmonary disease patients. However, its performance characteristics in sarcoidosis patients are not well characterized.MethodsData from a clinical trial of 138 symptomatic adults with sarcoidosis were used to examine the performance characteristics of SGRQ. Data were available at both baseline and week 24. Other assessments included FVC, FEV1, ATS dyspnea score, Borg ’s CR 10 dyspnea score, 6-min walk distance (6MWD), and Short Form-36 Physical Component Summary (SF-36 PCS) score.ResultsBa...
Source: Lung - September 25, 2020 Category: Respiratory Medicine Source Type: research

Are Serum Interleukin 6 and Surfactant Protein D Levels Associated with the Clinical Course of COVID-19?
ConclusionIn addition to IL-6, which has an important role in predicting course and planning treatment in COVID-19, SP-D may be a novel pneumoprotein that can be used in the clinical course, follow-up, and possibly in future treatments. (Source: Lung)
Source: Lung - September 11, 2020 Category: Respiratory Medicine Source Type: research

Moderate or Severe Impairment in Pulmonary Function is Associated with Mortality in Sarcoidosis Patients Infected with SARS ‑CoV‑2
ConclusionModerate or severe impairment in pulmonary function is associated with mortality in sarcoidosis patients infected with SARS ‑CoV‑2. (Source: Lung)
Source: Lung - September 10, 2020 Category: Respiratory Medicine Source Type: research

Objective Assessment of Cough: An Early Marker of Response to Biological Therapies in Asthma?
The objective assessment of chronic cough has been enhanced by the development of ambulatory cough monitoring systems. Mepolizumab has been demonstrated to reduce exacerbations in eosinophilic asthmatics long-term. We evaluate the utility of objective cough count as an outcome measure in severe eosinophilic asthma treated with mepolizumab. Consecutive, consenting patients initiated on treatment with mepolizumab had a 24-h cough count recorded at baseline; this was repeated at 1, 3 and 6  months. Asthma control questionnaire (ACQ) scores and exacerbation frequency were also recorded. The mean 24-h cough count in 11 sub...
Source: Lung - September 9, 2020 Category: Respiratory Medicine Source Type: research

What is the Role of Over 100 Excipients in Over the Counter (OTC) Cough Medicines?
AbstractMost medicines are white bitter powders that are formulated as tablets and capsules but cough medicines are an exception where the taste and appearance of the medicine are more important to the patient than the pharmacology of the active ingredient. Excipients are generally defined as any ingredient in a medicine other than the active ingredient. In most medicines excipients play a supportive role in delivering the medicine, but in the case of cough medicines, excipients have more important and complex roles and they can also be the main active ingredient of the cough medicine as menthol, glycerol, and sugars, whic...
Source: Lung - September 4, 2020 Category: Respiratory Medicine Source Type: research

Quantitative Pectoralis Muscle Area is Associated with the Development of Lung Cancer in a Large Lung Cancer Screening Cohort
AbstractBackgroundStudies have demonstrated an inverse relationship between body mass index (BMI) and the risk of developing lung cancer. We conducted a retrospective cohort study evaluating baseline quantitative computed tomography (CT) measurements of body composition, specifically muscle and fat area in a large CT lung screening cohort (CTLS). We hypothesized that quantitative measurements of baseline body composition may aid in risk stratification for lung cancer.MethodsPatients who underwent baseline CTLS between January 1st, 2012 and September 30th, 2014 and who had an in-network primary care physician were included....
Source: Lung - September 4, 2020 Category: Respiratory Medicine Source Type: research

Comparison of Clinical Measures Among Interstitial Lung Disease (ILD) Patients with Usual Interstitial Pneumonia (UIP) Patterns on High-Resolution Computed Tomography
AbstractPurposeIdiopathic Pulmonary Fibrosis is a progressive and fatal interstitial lung disease (ILD) characterized by a typical radiographic or histologic usual interstitial pneumonia (UIP) pattern.  In 2018, diagnostic categories of UIP based on computed tomography patterns were revised by the Fleischner Society. The study aimed to describe differences in comorbidities and spirometry in ILD patients that were characterized by high-resolution computed tomography (HRCT) images as having a typic al, probable, indeterminate, and alternative diagnosis of UIP.MethodsWe retrospectively studied 80 ILD patients from 2017 t...
Source: Lung - September 4, 2020 Category: Respiratory Medicine Source Type: research

Utility of Bronchoalveolar Lavage and Transbronchial Biopsy in Patients with Interstitial Lung Disease
ConclusionOur study suggests clinical features that may assist with patient selection for bronchoscopy. We suggest bronchoscopy in patients with identified antigen or an HRCT that is consistent with a non-IPF diagnosis. Appropriate patient selection for bronchoscopy may improve ILD diagnostic confidence and avoid potential complications from more invasive and higher risk procedures. (Source: Lung)
Source: Lung - August 31, 2020 Category: Respiratory Medicine Source Type: research

Blood Cell Count Derived Inflammation Indexes in Patients with Idiopathic Pulmonary Fibrosis
ConclusionsIn conclusion, our data indicate significant alterations of combined blood cell count indexes of inflammation in IPF. (Source: Lung)
Source: Lung - August 24, 2020 Category: Respiratory Medicine Source Type: research

Correction to: Don ’t Drive Blind: Driving Pressure to Optimize Ventilator Management in ECMO
The original version of this article unfortunately contained a mistake. The spelling of the Hitoshi Hirose name was incorrect. It was corrected in this erratum. (Source: Lung)
Source: Lung - August 19, 2020 Category: Respiratory Medicine Source Type: research

Toll-Like Receptor-4-Mediated Inflammation is Involved in Intermittent Hypoxia-Induced Lung Injury
AbstractPurposeIntermittent hypoxia (IH) is a recognized risk factor for multiple organs damage, resulting in lung injury. Its pathophysiology is still poorly understood. Toll-like receptor 4 (TLR4) signaling plays a critical role in host immune response to invading pathogen and non-infectious tissue injury. The role of TLR4-mediated inflammation in IH-induced lung injury was investigated in this study.MethodsLean adult male TLR4-deficient (TLR4−/−) mice and their controls (C57BL/6 mice) were exposed to either IH (FiO2 6 –8% for 25 s, 150 s/cycle, 8 h/day) or air (normoxic mice) for 6 ...
Source: Lung - August 11, 2020 Category: Respiratory Medicine Source Type: research

Connective Tissue Disease-Related Interstitial Lung Disease: Prevalence, Patterns, Predictors, Prognosis, and Treatment
AbstractInterstitial lung disease is a common pulmonary manifestation of connective tissue diseases and results in significant morbidity and mortality. Although all connective tissue diseases are linked by underlying autoimmunity, there is significant variability in the presentation and clinical course of interstitial lung disease associated with the different types of connective tissue diseases. In this paper, we review the prevalence, patterns, predictors, and prognosis of interstitial lung disease secondary to the most common forms of connective tissue diseases. We have also highlighted the available evidence regarding ...
Source: Lung - August 10, 2020 Category: Respiratory Medicine Source Type: research

Change in Dynamic Hyperinflation After Bronchoscopic Lung Volume Reduction in Patients with Emphysema
In this study, we investigated the effect of BLVR compared to standard of care (SoC) on dynamic hyperinflation.MethodsDynamic hyperinflation was induced by a manually paced tachypnea test (MPT) and was defined by change in inspiratory capacity (IC) measured before and after MPT. Static and dynamic hyperinflation measurements were performed both at baseline and 6  months after BLVR with endobronchial valves or coils (treatment group) or SoC (control group).ResultsEighteen patients underwent BLVR (78% female, 57 (43 –67) years, FEV1 25(18 –37) %predicted, residual volume 231 (182–376) %predicted). Thir...
Source: Lung - July 23, 2020 Category: Respiratory Medicine Source Type: research

Don ’t Drive Blind: Driving Pressure to Optimize Ventilator Management in ECMO
AbstractIntroductionDriving pressure (DP) while on ECMO has been studied in acute respiratory distress syndrome (ARDS) but no studies exist in those on ECMO without ARDS. We aimed to study association of mortality with DP in all patients on ECMO and compare change in DP before and after initiation of ECMO.MethodsConsecutive patients placed on ECMO either veno-arterial ECMO or veno-venous ECMO between August 2010 and February 2017 were reviewed. The outcomes were compared based on DP before and after ECMO initiation.ResultsA total of 192 patients were included: 68 (35%) had ARDS while 124 (65%) did not. There were 70 indivi...
Source: Lung - July 22, 2020 Category: Respiratory Medicine Source Type: research

Risk Factors for Cytomegalovirus Reactivation in Lung Transplant Recipients
We examined risk factors that may have contributed to Cytomegalovirus (CMV) reactivation among patients who underwent lung transplantation (LTx).MethodsWe reviewed medical records of patients who underwent LTx at a tertiary healthcare hospital in South Korea between January 2013 and May 2017. We excluded patients who died within the first year after LTx and those lost to follow-up. CMV reactivation was defined as the detection of CMV titers above 3000 copies/ml regardless of specific symptoms after prophylaxis cessation.ResultsOf 89 patients included, 39 (43.8%) developed CMV reactivation. Of those 39 patients, 16 (41.0%) ...
Source: Lung - July 21, 2020 Category: Respiratory Medicine Source Type: research

Mepolizumab and Benralizumab in Severe Eosinophilic Asthma: Preliminary Results of a Proteomic Study
AbstractBenralizumab and mepolizumab are new therapies for severe eosinophilic asthma. They are both humanized IgG antibodies, targeting the IL ‐5 receptor and IL‐5, respectively, suppressing the corresponding pathways. No specific biomarkers have been proposed to evaluate treatment response to benralizumab or mepolizumab. The aim of this proteomic study was to compare serum protein profiles of patients with severe eosinophilic asthma b efore and after anti‐IL5 or anti‐IL5R therapies. Proteomic analysis highlighted 22 differently abundant spots. Among the proteins identified, CAYP1, A1AT and A2M expression was si...
Source: Lung - July 19, 2020 Category: Respiratory Medicine Source Type: research

Negative Lymph Node Count Predicts Survival of Resected Non-small Cell Lung Cancer
AbstractPurposeThe purpose of this study was to explore the association between the negative lymph node (NLN) count and survival, as well as compare the prognostic value of the positive lymph node (PLN) count, lymph node ratio (the PLN count/total lymph nodes examined, LNR), and NLN count in patients with non-small cell lung cancer (NSCLC).MethodsWe identified patients diagnosed with NSCLC between 2005 and 2011 from the Surveillance, Epidemiology, and End Results database. Outcomes of interest were lung cancer-specific survival (LCSS) and overall survival (OS). Cases were divided into several groups based on the PLN count,...
Source: Lung - July 17, 2020 Category: Respiratory Medicine Source Type: research

Guidelines for the Treatment of Pulmonary Arterial Hypertension
AbstractPulmonary arterial hypertension (PAH) is a rare form of pulmonary hypertension characterized by a progressive obliterative vasculopathy of the distal pulmonary arterial circulation that usually leads to right ventricular failure and death. Over the last 25  years, more than a dozen drugs representing five drug classes have been developed and approved for the treatment of this devastating disease. Due to the small number of patients afflicted by PAH, most health care providers have little experience with its management. To address this gap in medical knowledge, treatment guidelines have been developed by profes...
Source: Lung - July 14, 2020 Category: Respiratory Medicine Source Type: research

Association Between Serum S100A8/S100A9 Heterodimer and Pulmonary Function in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
AbstractBackgroundMany studies have indicated that S100A8 and S100A9 may be involved in the development and progression of chronic obstructive pulmonary disease (COPD). However, there has been no clinical study analyzing the role of the serum S100A8/S100A9 heterodimer in COPD patients. The aim of this study was to analyze the correlation of the serum S100A8/S100A9 heterodimer with pulmonary function in COPD patients during acute exacerbation (AE-COPD) based on a cross-sectional study.MethodsA total of 131 AE-COPD patients and matched healthy subjects were recruited. Pulmonary function, arterial blood gas values, and serum ...
Source: Lung - July 12, 2020 Category: Respiratory Medicine Source Type: research

P2X3-Receptor Antagonists as Potential Antitussives: Summary of Current Clinical Trials in Chronic Cough
AbstractCough is among the most common complaints for which patients worldwide seek medical attention. In a majority of patients with chronic cough (defined as cough of greater than 8  weeks’ duration), successful management results from a thorough evaluation and treatment of underlying causes. In a subgroup of patients, however, cough proves refractory to therapeutic trials aimed at known reversible causes of chronic cough. Such patients are appropriately termed as having ref ractory chronic cough. At present, safe and effective medications are lacking for this challenging patient population. Currently availabl...
Source: Lung - July 12, 2020 Category: Respiratory Medicine Source Type: research

Pulmonary Arteriovenous Malformations in Non-hereditary Hemorrhagic Telangiectasia Patients: An 18-Year Retrospective Study
ConclusionsNon-HHT PAVMs occur more commonly in females, are most commonly simple and single, and have lower lobe predominance and a high rate of neurologic complications. Potential predisposing risk factors were identified in about 40% of the cases. Clinicians should be aware of the risk of PAVM development in patients with history of chest trauma, congenital heart disease, lung infection/abscess, and thoracic surgery. (Source: Lung)
Source: Lung - July 8, 2020 Category: Respiratory Medicine Source Type: research

High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections —A Single-Center Experience with 536 Consecutive Patients Over 17 Years
AbstractPurposePleural infections are associated with significant inflammation, long hospitalizations, frequent comorbidities, and are often treated operatively —all of which are consequential risk factors for thrombo-embolic complications. However, their occurrence following the treatment of pleural infection is still unknown. The aim of the study was to ascertain the early and long-term occurrence of thrombo-embolic events in patients treated for pleura l infections.MethodsThe study included all patients that were treated for pleural infections in Tampere University Hospital between January 2000 and December 2016. ...
Source: Lung - June 29, 2020 Category: Respiratory Medicine Source Type: research

Reply to: Understanding the Role of Regulatory T Cells in Non-asthmatic Eosinophilic Bronchitis
(Source: Lung)
Source: Lung - June 29, 2020 Category: Respiratory Medicine Source Type: research

Understanding the Role of Regulatory T Cells in Non-asthmatic Eosinophilic Bronchitis
(Source: Lung)
Source: Lung - June 29, 2020 Category: Respiratory Medicine Source Type: research

Determining Static Hyperinflation in Patients with Severe Emphysema: Relation Between Lung Function Parameters and Patient-Related Outcomes
AbstractBackgroundBronchoscopic lung volume reduction techniques are minor invasive treatment modalities for severely hyperinflated emphysema patients. The severity of static lung hyperinflation determines eligibility and success rate for these treatments. However, it is not exactly known what parameter should be used to optimally reflect hyperinflation. Commonly used parameters are residual volume (RV) and the RV/Total lung capacity (TLC) ratio. Other parameters reflecting hyperinflation are Inspiratory Capacity/TLC and forced vital capacity.ObjectivesTo define which of these function parameters is the most optimal reflec...
Source: Lung - June 27, 2020 Category: Respiratory Medicine Source Type: research

Radiologic Characteristics of Non-tuberculous Mycobacteria Infection in Patients with Bronchiectasis
AbstractIntroductionNon-tuberculous mycobacteria pulmonary disease (NTM-pd) commonly complicates bronchiectasis. However, clinical and radiological features of NTM-pd and bronchiectasis are very similar. We aimed to develop a radiologic prediction tool for bronchiectasis to identify NTM-pd.MethodsWe reviewed clinical, laboratory and radiological data in patients with bronchiectasis. Radiologic features on CT scans and the individual components of the Bhalla scoring system were compared between people with and without NTM-pd. Logistic regression and receiver-operating curve (ROC) analysis were performed to predict NTM-pd.Re...
Source: Lung - June 25, 2020 Category: Respiratory Medicine Source Type: research

Advances in Targeted Therapy for Progressive Fibrosing Interstitial Lung Disease
AbstractProgressive fibrosing interstitial lung disease (PF-ILD) has been redefined as a new clinical syndrome that shares similar genetics, pathophysiology, and natural history to idiopathic pulmonary fibrosis (IPF). IPF is the most common form of idiopathic interstitial pneumonias, which is progressive in nature and is associated with significant mortality. Therapies targeting an inflammatory and/or immune response have not been consistently effective or well tolerated in patients with IPF. The two antifibrotic drugs approved for IPF treatment, nintedanib and pirfenidone, have been shown to reduce lung function decline i...
Source: Lung - June 25, 2020 Category: Respiratory Medicine Source Type: research

Newer Biological Agents in the Treatment of Severe Asthma: Real-World Results from a Tertiary Referral Center
AbstractPurpose To determine the efficacy of IL-5 inhibitory therapy in severe, refractory asthma in a real-world clinical setting from a tertiary referral center.MethodsA retrospective chart review of patients with severe asthma treated with IL-5 biologic therapy for  ≥ 6 months at Mayo Clinic in Rochester, Minnesota between January 1, 2013 and August 31, 2019.ResultsOver the study period, we identified 63 patients with a mean age of 54 who received an IL-5 inhibitor for  ≥ 6 months. A total of 55 patients received mepolizumab, 2 received benralizumab, and 9 patients received both. Pati...
Source: Lung - June 23, 2020 Category: Respiratory Medicine Source Type: research

The Relationship Between Cough Reflex Sensitivity and Exacerbation Frequency in Chronic Obstructive Pulmonary Disease
AbstractBackgroundCough is predictive of exacerbations of chronic obstructive pulmonary disease (COPD). Little is known about cough reflex sensitivity during exacerbation of COPD and whether it is associated with exacerbation frequency. This pilot study aimed to investigate cough reflex sensitivity during and following recovery from exacerbation of COPD, and its association with the frequency of future exacerbations. In addition, the repeatability of cough reflex sensitivity in stable COPD was investigated.MethodsTwenty participants hospitalised with exacerbation of COPD underwent inhaled capsaicin challenge during exacerb...
Source: Lung - June 18, 2020 Category: Respiratory Medicine Source Type: research

Chronic Hepatitis C Virus Infection is Associated with an Increased Risk of Lung Cancer: A Systematic Review and Meta-analysis
ConclusionsThe current study demonstrated that chronic HCV infection is significantly associated with a 1.94-fold increased risk of developing lung cancer. However, further studies are still needed to investigate if this association is causative. (Source: Lung)
Source: Lung - June 3, 2020 Category: Respiratory Medicine Source Type: research

A Cross-sectional Study of Hospital Performance on ICU Utilization Practices for Patients with Chronic Obstructive Pulmonary Disease
ConclusionsHospital characteristics, including quality metrics, are associated with variability in ICU utilization for COPD patients, with higher ICU utilization seen for lower performing hospitals. (Source: Lung)
Source: Lung - June 2, 2020 Category: Respiratory Medicine Source Type: research

Increased Th17  and Th22 Cell Percentages Predict Acute Lung Injury in Patients with Sepsis
This study was conducted to investigate the percentages of Th22 and Th17 cells in the peripheral blood of septic patients with and without acute lung injury (ALI) and their clinical significance.MethodsA total of 479 patients were divided into non-ALI and ALI groups. The percentages of Th22 and Th17 cells and the levels of interleukin 22 (IL-22), 6 (IL-6), and 17 (IL-17) were determined. Receiver operating characteristic curve analysis was performed to assess the diagnostic value of Th22 and Th17 cells to predict sepsis-induced ALI.ResultsThe lung  injury prediction score (LIPS), IL-6, IL-17, and IL-22 levels and the ...
Source: Lung - May 26, 2020 Category: Respiratory Medicine Source Type: research

The Significance of Controlling Nutritional Status (CONUT) Score as a Novel Prognostic Parameter in Small Cell Lung Cancer
AbstractPurposeThe immuno-nutritional status is closely related to the prognosis in many cancers. Controlling nutritional status (CONUT) score is a new parameter that reflects the immuno-nutritional status and is prognostic in some cancers. However, the prognostic significance of the CONUT score in small cell lung cancer (SCLC) is unknown. We aimed to demonstrate the prognostic significance of the CONUT score in patients with SCLC.MethodsTwo hundred sixteen patients who were followed up with SCLC were included in the study retrospectively. According to the receiver operating characteristic (ROC) curve analysis, the optimal...
Source: Lung - May 18, 2020 Category: Respiratory Medicine Source Type: research

Pulmonary Embolism in Acute Asthma Exacerbation: Clinical Characteristics, Prediction Model and Hospital Outcomes
ConclusionIt is important to consider acute PE, a potentially life-threatening event, in the setting of asthma exacerbation especially when other risk factors are present. (Source: Lung)
Source: Lung - May 17, 2020 Category: Respiratory Medicine Source Type: research

Fibrotic Hypersensitivity Pneumonitis: Diagnosis and Management
AbstractFibrotic hypersensitivity pneumonitis is a complex interstitial lung disease that is not entirely understood. In its chronic and fibrotic form, hypersensitivity pneumonitis is one of the main mimickers of idiopathic pulmonary fibrosis (IPF). Distinguishing between these two conditions is challenging but is of particular clinical relevance. Two approved therapies are available for IPF, and a considerable number of clinical trials are now exploring newer pharmacological options. This impressive research effort is a consequence of new pathogenetic understanding, updated diagnostic criteria and a long history of pharma...
Source: Lung - May 14, 2020 Category: Respiratory Medicine Source Type: research

Elevated Circulating CD4 + CD25 + CD127 −/low Regulatory T Cells in Patients with Non-asthmatic Eosinophilic Bronchitis
This study aimed to preliminarily explore the role of Tregs in NAEB by comparing circulating Tregs levels to asthma and healthy controls.MethodsFractional exhaled nitric oxide (FeNO), spirometry with bronchial provocation test, sputum induction and blood routine test were performed in all subjects. Peripheral blood mononuclear cells were used to detect the Tregs (CD4+CD25+CD127−/low) by flow cytometry. Relationship between the levels of circulating Tregs and clinical indexes was also observed.ResultsA total of 15 patients with NAEB, 20 patients with asthma and 11 healthy controls were included. The absolute numbers o...
Source: Lung - May 3, 2020 Category: Respiratory Medicine Source Type: research

Prevalence and Mortality of Pulmonary Hypertension in ESRD: A Systematic Review and Meta-analysis
ConclusionsEchocardiographic evidence of PH is common among ESRD patients undergoing dialysis and associated with increased mortality. Identification of those patients with evidence of pulmonary hypertension on transthoracic echocardiography may warrant further evaluation and treatment. (Source: Lung)
Source: Lung - May 3, 2020 Category: Respiratory Medicine Source Type: research

COPD Assessment Test Changes from Baseline Correlate with COPD Exacerbations: A Longitudinal Analysis of the DACCORD Observational Study
AbstractPurposeA number of analyses have shown the immediate impact of COPD exacerbations on health status. However, none evaluated the long-term correlation between health status and the occurrence of exacerbations.MethodsDACCORD is an observational study in patients with COPD recruited across Germany following initiation or change in COPD maintenance medication. Data collected include COPD Assessment Test (CAT) total score on entry and after 1 and 2 years, and the occurrence of exacerbations. We analysed the correlation between change from baseline in CAT total score and exacerbations, after excluding patients who exacer...
Source: Lung - May 3, 2020 Category: Respiratory Medicine Source Type: research

A Randomized, Controlled, Pilot Study of CPAP for Patients with Chronic Cough and Obstructive Sleep Apnea
ConclusionTreatment of comorbid OSA in patients with chronic cough improved cough quality of life measures following treatment of OSA with CPAP in this pilot study. Larger studies to understand this association and unravel mechanisms of CPAP benefit in chronic cough need to be undertaken.Clinical Trial Registration NCT03172130 (Source: Lung)
Source: Lung - April 29, 2020 Category: Respiratory Medicine Source Type: research

Obesity Predicts Treatment Response to Proton Pump Inhibitor Therapy in Patients with Chronic Cough
This study aims to describe treatable traits of chronic cough and the response to pump proton inhibitor (PPI) therapy in this sub-group of patients.MethodsA retrospective, observational study was performed in patients with chronic cough in a French University Hospital. Characteristics of chronic cough were analyzed for obese (N = 112) and non-obese (N = 355) patients. Refractory cough was estimated at 6 and 12 months.ResultsThe 3 main treatable traits associated with chronic cough in obese patients and non-obese patients were gastroesophageal reflux disease (GERD), asthma, and upper airway ...
Source: Lung - April 29, 2020 Category: Respiratory Medicine Source Type: research

Risk of Future Type 2 Diabetes Mellitus in Patients Developing Steroid-Induced Hyperglycemia During Hospitalization for Chronic Obstructive Pulmonary Disease Exacerbation
ConclusionsOur study suggests that patients without T2DM with acute exacerbation of COPD who develop steroid-induced hyperglycemia in response to systemic corticosteroid treatment have an increased risk for developing future IGT or T2DM. Bigger studies are needed to support our findings since results drawn from our study have the limitations of smaller sample size (wider confidence interval) in a single center. (Source: Lung)
Source: Lung - April 27, 2020 Category: Respiratory Medicine Source Type: research

Age-Dependent Progression in Lung Pathophysiology can be Prevented by Restoring Fatty Acid and Ceramide Imbalance in Cystic Fibrosis
ConclusionOur results demonstrate a progressive age-dependent decline in lung function inCftr KO mice. Treatment with LAU-7b corrects the lipid imbalance observed in the aging KO and WT mice and, more importantly, inhibits the age-dependent deterioration in lung physiology and histopathology. (Source: Lung)
Source: Lung - April 17, 2020 Category: Respiratory Medicine Source Type: research

The Utility of Diaphragm Ultrasound in Reducing Time to Extubation
AbstractPurposePrediction of optimal timing for extubation of mechanically ventilated patients is challenging. Ultrasound measures of diaphragm thickness or diaphragm dome excursion have been used to aid in predicting extubation success or failure. The aim of this study was to determine if incorporating results of diaphragm ultrasound into usual ICU care would shorten the time to extubation.MethodsWe performed a prospective, randomized, controlled study at three Brown University teaching hospitals. Included subjects underwent block randomization to either usual care (Control) or usual care enhanced with ultrasound measurem...
Source: Lung - April 12, 2020 Category: Respiratory Medicine Source Type: research

Cardio-Pulmonary Changes After Bronchoscopic Lung Volume Reduction with Endobronchial One-Way Valves
AbstractIntroductionTo evaluate the cardio-pulmonary hemodynamics changes before and after valve treatment, and their correlation with lobe volume reduction.MethodsThis retrospective multicentre study included consecutive patients undergoing bronchoscopic valve treatment for heterogeneous emphysema. In addition to standard functional evaluation, patients underwent cardiac evaluation by Doppler trans-thoracic echocardiography. The difference in respiratory and cardio-pulmonary hemodynamics indexes before and 3-month after the procedure, and their relationship with changes in lobar volume were evaluated.ResultsSeventy-seven ...
Source: Lung - April 6, 2020 Category: Respiratory Medicine Source Type: research

Incidence and Risk of Pneumococcal Pneumonia in Adults with Distinct Underlying Medical Conditions: A Population-Based Study
ConclusionOld age, immunocompromising conditions and chronic pulmonary/respiratory disease are major risk factors for pneumococcal pneumonia in adults. Our data underline the need for better prevention strategies in these persons. (Source: Lung)
Source: Lung - April 5, 2020 Category: Respiratory Medicine Source Type: research

Quantitative CT Evidence of Airway Inflammation in WTC Workers and Volunteers with Low FVC Spirometric Pattern
DiscussionWTC workers with spirometric low FVC have higher QCT-measured WAP compared to those with normal spirometries, but did not differ in distal airway and emphysema measurements, independently of obesity, smoking, and other covariates. (Source: Lung)
Source: Lung - March 31, 2020 Category: Respiratory Medicine Source Type: research

Correlations Between Serum Decoy Receptor 3 and Airflow Limitation and Quality of Life in Male Patients with Stable Stage and Acute Exacerbation of COPD
AbstractPurposeSerum decoy receptor 3 (DcR3) level increases in chronic inflammatory diseases. The present study aimed to examine serum DcR3 and IL-6 levels in male patients with stable chronic obstructive pulmonary disease (COPD) and acute exacerbation of the disease and correlations between these markers and airflow limitation.MethodsWe measured serum DcR3 and IL-6 levels in 60 COPD patients [30 stable COPD (SCOPD), and 30 acute exacerbation of COPD (AECOPD)], and 30 control subjects and assessed their correlations with airflow limitation according to the COPD stage indicated by the global initiative for chronic obstruct...
Source: Lung - March 23, 2020 Category: Respiratory Medicine Source Type: research