Is Vimentin the Cause or Effect of Obstructive Sleep Apnea Development?
ConclusionIn this study, we observed significant positive correlations between plasma vimentin level and OSA severity, weight, AHI, and mean oxygen desaturation. Vimentin may have utility as a biomarker in the follow-up and treatment of OSA. (Source: Lung)
Source: Lung - February 22, 2020 Category: Respiratory Medicine Source Type: research

Nicorandil, a K ATP Channel Opener, Attenuates Ischemia –Reperfusion Injury in Isolated Rat Lungs
AbstractPurposeNicorandil is a hybrid between nitrates and KATP channel opener activators. The aim of this study was to evaluate the nicorandil ’s effects on ischemia–reperfusion (IR) lung injury and examine the mechanism of its effects.MethodsIsolated rat lungs were divided into 6 groups. In the sham group, the lungs were perfused and ventilated for 150  min. In the IR group, after perfusion and ventilation for 30 min, they were interrupted (ischemia) for 60 min, and then resumed for 60 min. In the nicorandil (N) + IR group, nicorandil 6 mg was added before ischemia (nico...
Source: Lung - February 21, 2020 Category: Respiratory Medicine Source Type: research

Lung Cancer in Young Patients: The Importance of Assessing Driver Mutations and Treatment Strategies
(Source: Lung)
Source: Lung - February 21, 2020 Category: Respiratory Medicine Source Type: research

Culturally Appropriate Outreach Specialist Respiratory Medical Care Improves the Lung Function of Children in Regional and Remote Queensland
ConclusionThe IROC model of care in regional and remote settings leads to significant lung function improvement in Indigenous children with asthma and bronchiectasis. (Source: Lung)
Source: Lung - February 20, 2020 Category: Respiratory Medicine Source Type: research

TLR5 Activation Exacerbates Airway Inflammation in Asthma
ConclusionTogether, our results reveal a novel genetic protective factor (TLR5 deficiency) and a novel environmental pollutant (microbial flagellin) that influence asthma severity. (Clinical trials NCT01688986 and NCT01087307). (Source: Lung)
Source: Lung - February 14, 2020 Category: Respiratory Medicine Source Type: research

Real-Life Study of Mepolizumab in Idiopathic Chronic Eosinophilic Pneumonia
ConclusionsIn this open-label retrospective study, treatment of ICEP with mepolizumab was associated with a reduction of relapses, OCS use, and the disappearance of lung infiltrates. (Source: Lung)
Source: Lung - February 12, 2020 Category: Respiratory Medicine Source Type: research

Effects of Transcutaneous Electrical Nerve Stimulation on Pain, Pulmonary Function, and Respiratory Muscle Strength After Posterolateral Thoracotomy: A Randomized Controlled Trial
AbstractPurposeTo evaluate the effects of transcutaneous electrical nerve stimulation (TENS) compared to placebo TENS and a control group on pain, pulmonary function, respiratory muscle strength, and analgesic medications in the postoperative period of thoracotomy in an Intensive care unit (ICU).MethodsPatients who had undergone posterolateral thoracotomy were randomly allocated to receive TENS during ICU stay, or placebo TENS, or into the control group. All groups received conventional physiotherapy. We analysed the intensity of pain, pulmonary function, respiratory muscle strength, and use of analgesia medications. Outco...
Source: Lung - February 8, 2020 Category: Respiratory Medicine Source Type: research

High Expression of CARM1 Inhibits Lung Cancer Progression by Targeting TP53 by Regulating CTNNB1
ConclusionOverexpression of CARM1 may inhibit the progression of LC by targeting TP53 via regulation CTNNB1. (Source: Lung)
Source: Lung - February 7, 2020 Category: Respiratory Medicine Source Type: research

High Systemic Immune-Inflammation Index (SII) Represents an Unfavorable Prognostic Factor for Small Cell Lung Cancer Treated with Etoposide and Platinum-Based Chemotherapy
AbstractPurposeSystemic immune-inflammation index (SII) has been demonstrated to be closely associated with prognosis of a series of solid tumors. However, its role in small cell lung cancer (SCLC) remains poorly understood. The present study aims to evaluate the prognostic significance of pretreatment SII in SCLC treated with etoposide and platinum-based chemotherapy.MethodsSixty hundred and fifty-three newly diagnosed SCLC patients were enrolled. The optimal cut-off values for SII and LDH (lactate dehydrogenase) were obtained by a receiver operating characteristic (ROC) curve analysis. Overall survival (OS) was assessed ...
Source: Lung - February 3, 2020 Category: Respiratory Medicine Source Type: research

Abstracts from the Seventh American Cough Conference
(Source: Lung)
Source: Lung - February 3, 2020 Category: Respiratory Medicine Source Type: research

Strategies for Young Pulmonary Faculty to Achieve Early Success
(Source: Lung)
Source: Lung - February 1, 2020 Category: Respiratory Medicine Source Type: research

Change in Serum Biomarker CA 15-3 as an Early Predictor of Response to Treatment and Survival in Hypersensitivity Pneumonitis
AbstractBackgroundHypersensitivity pneumonitis (HP) is an interstitial lung disease with a heterogeneous course of disease and treatment response. Cancer antigen 15-3 (CA 15-3), part of mucin 1, is believed to reflect epithelial cell injury and lung permeability and could be a potential biomarker for treatment response in HP.ObjectiveTo assess the value of CA 15-3 as a predictive biomarker in non-fibrotic and fibrotic HP during immunosuppressive therapy.DesignSerum levels of CA 15-3 and pulmonary function tests (PFTs) were retrospectively retrieved from 48 HP patients treated with prednisone or cyclophosphamide at initiati...
Source: Lung - January 28, 2020 Category: Respiratory Medicine Source Type: research

Chitotriosidase Activity in Plasma and COPD Exacerbations
ConclusionWhile mixed associations between chitotriosidase activity and clinical outcomes were seen, chitotriosidase activity could be a predictor of future exacerbations in patients with a history of  ≥ 1 exacerbation in the past  12 months. (Source: Lung)
Source: Lung - January 25, 2020 Category: Respiratory Medicine Source Type: research

Falsely Accused? Insufficient Evidence to Conclude that Sitagliptin is a Cause of Chronic Cough
(Source: Lung)
Source: Lung - January 24, 2020 Category: Respiratory Medicine Source Type: research

Discriminating Between Non-Specific Interstitial Pneumonia and Idiopathic Pulmonary Fibrosis at Early Stages: When CPET is Enough?
(Source: Lung)
Source: Lung - January 24, 2020 Category: Respiratory Medicine Source Type: research

Obstructive Sleep Apnea Severity and the Risk of Occupational Injury: A Prospective Observational Cohort
ConclusionsIn this prospective study, OSA severity was independently associated with an increased risk of OI. (Source: Lung)
Source: Lung - January 21, 2020 Category: Respiratory Medicine Source Type: research

Is Metrnl an Adipokine İnvolved in the Anti-inflammatory Response to Acute Exacerbations of COPD?
ConclusionThe high Metrnl level in COPD exacerbations and active smoking may be important in balancing the inflammatory response. However, plasma Metrnl levels were found to be lower in COPD patients with comorbidities. (Source: Lung)
Source: Lung - January 20, 2020 Category: Respiratory Medicine Source Type: research

Resveratrol Attenuates Intermittent Hypoxia-Induced Lung Injury by Activating the Nrf2/ARE Pathway
AbstractPurposeObstructive sleep apnea (OSA) is associated with lung injury. As a novel pathophysiological hallmark of OSA, chronic intermittent hypoxia (CIH) enhances apoptosis. The present study aims to evaluate the effect of resveratrol (Res) on CIH-induced lung apoptosis and inflammation in a rat model of CIH.MethodsRats were randomly allocated to normoxia (control), CIH, and CIH  + Res groups (n = 10 in each group). The CIH exposure duration was 12 weeks. Rats in the CIH + Res group were additionally administered Res (50 mg kg–1 d–1). Inflammato...
Source: Lung - January 20, 2020 Category: Respiratory Medicine Source Type: research

Ranking Self-reported Gastrointestinal Side Effects of Pharmacotherapy in Sarcoidosis
ConclusionThe current study ranked the gastrointestinal side effects associated with pharmacotherapy in sarcoidosis patients. Pharmacotherapy does have multiple gastrointestinal side effects. The strongest association between a reported side effect and drug use was that of weight gain associated with increased appetite among prednisone users. It would therefore be useful for future research to look further into dietary interventions to counter these side effects and reduce their burden. (Source: Lung)
Source: Lung - January 20, 2020 Category: Respiratory Medicine Source Type: research

Needle Aspiration Versus Closed Thoracostomy in the Treatment of Spontaneous Pneumothorax: A Meta-analysis
ConclusionsFor the treatment of SP, NA method could significantly decrease complication rate, operation rate, as well as hospital stay length, compared with the CT method. Subgroup analysis indicated that the use of CT method in SSP and PSP patients might increase the initial success rate. (Source: Lung)
Source: Lung - January 11, 2020 Category: Respiratory Medicine Source Type: research

Association of Serum TGF- β1 Levels with Different Clinical Phenotypes of Cystic Fibrosis Exacerbation
AbstractPurposeCystic Fibrosis (CF) is a multi-organ genetic disorder and Transforming Growth Factor (TGF- β1) is a modifier gene which modulates lung pathology in CF. There is great phenotypic variability among CF patients who even have similar genotype. The aim of the present study was to associate the serum levels of TGF-β1 with several clinical phenotypes of CF.MethodsThe diagnosed cases of CF were recruited and the blood sample was withdrawn at different time points: during exacerbation (n = 26), non-exacerbation (n = 9) and after antibiotic therapy (n = 11). The con...
Source: Lung - January 9, 2020 Category: Respiratory Medicine Source Type: research

Reduced Surfactant Contributes to Increased Lung Stiffness Induced by Rapid Inspiratory Flow
ConclusionRapidVI′ may contribute to ventilator induced lung injury (VILI) through reduced surfactant release and/or more rapid reuptake despite unchanged tidal stretch. (Source: Lung)
Source: Lung - January 8, 2020 Category: Respiratory Medicine Source Type: research

Ambulatory Transition from Parenteral Prostanoid to Inhaled Treprostinil in Patients with Pulmonary Arterial Hypertension
ConclusionFor select patients, transition from a parenteral prostanoid-based therapy to a combination regimen including inhaled treprostinil in the home setting appears safe and well tolerated. (Source: Lung)
Source: Lung - January 7, 2020 Category: Respiratory Medicine Source Type: research

Current Status and Future Directions of Chronic Cough in China
AbstractChronic cough is one of the most common complaints for which patients in China seek medical attention. However, there are no nationwide data on the prevalence and socioeconomic burden of chronic cough. Although approximately 50% of Chinese men smoke, the vast majority of patients presenting for evaluation of chronic cough are never smokers. An equal sex distribution and a middle-aged predominance have been observed in the Chinese chronic cough population, despite demonstration of a higher cough reflex sensitivity in females and older patients. The role of air pollution in the distinct age and sex distribution requi...
Source: Lung - January 7, 2020 Category: Respiratory Medicine Source Type: research

Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients
ConclusionsP-selectin expression relates to disease severity suggesting a pathophysiological role in endothelial cell activation. PSGL-1 levels are unaltered in OSA, suggesting an alternative activation pathway for P-selectin in OSA. (Source: Lung)
Source: Lung - January 2, 2020 Category: Respiratory Medicine Source Type: research

Evaluation of the Incidence of Chronic Thromboembolic Pulmonary Hypertension 1  Year After First Episode of Acute Pulmonary Embolism: A Cohort Study
ConclusionThe incidence of CTEPH observed in this study 1  year after the first episode of acute PE was approximately 6.9%. This incidence seems to be high in our population, and diagnostic and therapeutic strategies for the early identification of CTEPH are needed. (Source: Lung)
Source: Lung - January 2, 2020 Category: Respiratory Medicine Source Type: research

External Validation of a Survival Score for Limited-Stage Small Cell Lung Cancer Patients Treated with Chemoradiotherapy
AbstractPurposeIn order to personalize multimodal treatment regimens in limited-stage small cell lung cancer (LS-SCLC), a survival score for these patients was proposed. The aim of this study is to validate the score in an independent external patient cohort.MethodsWe collected data of 78 patients treated with chemoradiotherapy for LS-SCLC between 2004 and 2015. The survival score was calculated by independent prognostic factors: gender, Karnofsky performance status, tumor substage, and hemoglobin level before treatment. Scoring points were derived from 2-year survival rates divided by 10 and the values for each prognostic...
Source: Lung - January 2, 2020 Category: Respiratory Medicine Source Type: research

Effect of Anti-IL5, Anti-IL5R, Anti-IL13 Therapy on Asthma Exacerbations: A Network Meta-analysis
ConclusionBenralizumab, dupilumab, mepolizumab, and reslizumab are all associated with decreased asthma exacerbations in patients with eosinophilic asthma, with no significant inter-drug differences. (Source: Lung)
Source: Lung - January 1, 2020 Category: Respiratory Medicine Source Type: research

Point of Care Portable Spirometry in the Diagnosis and Treatment of Inpatients with Chronic Obstructive Pulmonary Disease
AbstractIntroductionSpirometry is required to accurately diagnose chronic obstructive pulmonary disease (COPD). Following an acute exacerbation, it is recommended that spirometry be performed after a delay of 4 –6 weeks to allow stability and a measure of ‘baseline’ lung function. However, poor attendance at these appointments can occur, leading to an inability to confirm the diagnosis of COPD or assess the severity of airflow obstruction. Portable spirometry (PS) is a proven surrogate device that m ay provide a convenient method to address these issues. The purpose of this study was to compare PS va...
Source: Lung - January 1, 2020 Category: Respiratory Medicine Source Type: research

Lung Ultrasound for the Diagnosis and Management of Acute Respiratory Failure
AbstractFor critically ill patients with acute respiratory failure (ARF), lung ultrasound (LUS) has emerged as an indispensable tool to facilitate diagnosis and rapid therapeutic management. In ARF, there is now evidence to support the use of LUS to diagnose pneumothorax, acute respiratory distress syndrome, cardiogenic pulmonary edema, pneumonia, and acute pulmonary embolism. In addition, the utility of LUS has expanded in recent years to aid in the ongoing management of critically ill patients with ARF, providing guidance in volume status and fluid administration, titration of positive end-expiratory pressure, and ventil...
Source: Lung - January 1, 2020 Category: Respiratory Medicine Source Type: research

Is There Value in Repeating Inhaled Nitric Oxide Vasoreactivity Tests in Patients with Pulmonary Arterial Hypertension?
ConclusionsPulmonary vascular reactivity to inhaled NO might decrease over time; however, there is great variability among patients. The use of PDE5-inh at first RHC and number of PAH-specific treatments by the second RHC were associated with an improvement in pulmonary vasoreactivity over time. (Source: Lung)
Source: Lung - January 1, 2020 Category: Respiratory Medicine Source Type: research

Are the Effects of High-Intensity Exercise Training Different in Patients with COPD Versus COPD+Asthma Overlap?
ConclusionHigh-intensity exercise training generates similar benefits in patients with COPD regardless of whether presenting asthma overlap or not. (Source: Lung)
Source: Lung - December 23, 2019 Category: Respiratory Medicine Source Type: research

Increased E / A Ratio is a Risk Factor for the Formation of Pleural Effusion in Heart Failure
AbstractPurposePleural effusion is a common finding in patients with congestive heart failure (CHF). The pathogenesis of pleural effusion in heart failure is multifactorial. However, the role of right and left ventricular function assessed by ECHO cardiogram has not been studied. Therefore, we explored the association between right and left ventricular parameters on echocardiogram in patients with heart failure with and without pleural effusion diagnosed using CT scan of chest.MethodsA case –control study was utilized to explore the objectives. Using strict exclusion criteria, patients admitted with a single diagnosi...
Source: Lung - December 18, 2019 Category: Respiratory Medicine Source Type: research

Abnormal Lung Clearance Index in Cystic Fibrosis Screen Positive, Inconclusive Diagnosis (CFSPID) Children with Otherwise Normal FEV 1
AbstractIn preschool children with cystic fibrosis (CF), lung clearance index (LCI) is a sensitive test to detect early lung disease. Some children with CF screen positive, inconclusive diagnosis (CFSPID) may in time develop clinical features of CF. LCI has not been studied in CFSPID children. LCI and spirometry were performed in preschool age children with CF, CFSPID, and non-CF healthy controls (HCs) during two visits. Fifty-four preschool age children (HCn = 18, CFSPIDn = 17, and CFn = 19) were tested. Mean LCI from the CFSPID group was not statistically different from HC (p&thi...
Source: Lung - December 16, 2019 Category: Respiratory Medicine Source Type: research

The Powerful Placebo Effect in Cough: Relevance to Treatment and Clinical Trials
AbstractInterest in the placebo effect of medicines has developed from the use of placebo treatments as controls in clinical trials into a whole new area of research around how placebos fit into a psychosocial model of therapeutics. The large placebo effect associated with cough medicines is both a problem and an opportunity for researchers: a problem for clinical trials on new actives as the active must beat the large placebo effect, and an opportunity for harnessing the placebo effect to produce effective cough medicines without any pharmacologically active ingredient. This review discusses the mechanisms associated with...
Source: Lung - December 13, 2019 Category: Respiratory Medicine Source Type: research

Screening for Bronchoscopic Lung Volume Reduction: Reasons for Not Receiving Interventional Treatment
ConclusionBLVR is a therapeutic option for highly selected patients. In our cohort, one in four could be treated. These data highlight the limitations of BLVR under real-life conditions. (Source: Lung)
Source: Lung - December 12, 2019 Category: Respiratory Medicine Source Type: research

Obstructive Sleep Apnea in School-Aged Children Presented with Nocturnal Enuresis
AbstractObjectivesWe aimed to detect obstructive sleep apnea (OSA) among school-age children presented with nocturnal enuresis (NE) and to identify the possible risk factors for OSA in them.MethodsSixty-six children aged  >  5–16 years presented with NE were enrolled in the study. Children with urinary tract anatomical abnormalities or infection, intellectual disabilities, genetic syndromes, psychological issues, and diabetes mellitus were excluded. They were clinically examined, scored using sleep clinical record score (SCR), and subjected for full-night polysomnogram (PSG). Children with obstr...
Source: Lung - December 11, 2019 Category: Respiratory Medicine Source Type: research

Effect of Using a Wheeled Walker on Physical Activity and Sedentary Time in People with Chronic Obstructive Pulmonary Disease: A Randomised Cross-Over Trial
ConclusionThese data demonstrated that, when provided to selected patients with COPD, WWs increased daily step count.Clinical trial registration number: ACTRN12609000332224. (Source: Lung)
Source: Lung - December 11, 2019 Category: Respiratory Medicine Source Type: research

Risk of Readmission and Mortality Following Hospitalization with Hypercapnic Respiratory Failure
ConclusionsHospitalization for HRF is associated with a high morbidity and mortality. Our observation that home oxygen use was associated with increased mortality suggests that oxygen use could be a risk factor for death in patients with HRF. (Source: Lung)
Source: Lung - December 11, 2019 Category: Respiratory Medicine Source Type: research

Positive Airway Pressure Adherence in Patients with Obstructive Sleep Apnea with Schizophrenia
ConclusionsPAP adherence and usage is not significantly different among patients with schizophrenia compared to matched controls. Therefore, schizophrenia does not appear to influence CPAP compliance. (Source: Lung)
Source: Lung - December 10, 2019 Category: Respiratory Medicine Source Type: research

The Impact of Interleukin (IL)-33 Gene Polymorphisms and Environmental Factors on Risk of Asthma in the Iranian Population
ConclusionThis study revealed that both IL-33 SNPs were associated with an increased risk of asthma. The rs1342326 was associated with atopic, mild and adult-onset asthma and a higher level of eosinophils in peripheral blood. However, rs3939286 was more frequent in moderate and severe asthma. Moreover, rs3939286 was associated with non-atopic and childhood-onset asthma. (Source: Lung)
Source: Lung - December 9, 2019 Category: Respiratory Medicine Source Type: research

Lung T-Cell Profile Alterations are Associated with Bronchiolitis Obliterans Syndrome in Cystic Fibrosis Lung Transplant Recipients
AbstractThe contribution of T-cells after lung transplant (LTx) remains controversial with no current consensus of their role concerning chronic lung allograft dysfunction. Using flow cytometry to assess T-cell subsets of bronchoalveolar lavage fluid (BALF) in 16 cystic fibrosis (CF) LTx recipients, we identified a decline in CD4+ T-cell frequency and an increase in CD8+ T-cell frequency in patients who developed severe bronchiolitis obliterans syndrome (BOS) (N = 10) when comparing baseline (6 months post-LTx) and follow-up (most recent bronchoscopy—clinical or surveillance per protocol). Comparin...
Source: Lung - December 5, 2019 Category: Respiratory Medicine Source Type: research

Is Asthma and COPD Overlap Syndrome Weather and Environment Sensitive?
(Source: Lung)
Source: Lung - December 4, 2019 Category: Respiratory Medicine Source Type: research

The CALIPER-Revised Version of the Composite Physiologic Index is a Better Predictor of Survival in IPF than the Original Version
AbstractCALIPER is a computer-based quantitative algorithm to accurately characterize and quantify pulmonary fibrosis, and a revised version of composite physiologic index (CPI) has been developed against this new algorithm. The prognostic capabilities of the original and CALIPER-revised versions of CPI were compared in a cohort of 185 patients with IPF prospectively followed in 2 centers. CALIPER-revised CPI was a significant risk factor towards lung transplant  (LTx)-free survival, with enhanced hazard ratio (5.68) compared to the original CPI (5.36). Accuracy of LTx-free survival was substantially improved with CAL...
Source: Lung - December 2, 2019 Category: Respiratory Medicine Source Type: research

Chloride Conductance, Nasal Potential Difference and Cystic Fibrosis Pathophysiology
AbstractPurposeCystic fibrosis (CF) is a multisystem genetic disease caused by dysfunction of the epithelial anionic channel Cystic Fibrosis Transmembrane conductance Regulator (CFTR). Decreased mucociliary clearance because of thickened mucus is part of the pulmonary disease pathophysiology. It is controversial if the thickened  airway surface liquid (ASL) is caused by the deficient chloride secretion and excessive sodium (through ENaC) and water hyperabsorption from the periciliar fluid or by the lack of bicarbonate secretion with relative acidification of the ASL. Correlations between the magnitude of in vivo chlor...
Source: Lung - November 16, 2019 Category: Respiratory Medicine Source Type: research

Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy)
ConclusionsThe observed phenotype suggests that Daisy cells are a good model of human macrophages with a phenotype similar to human alveolar macrophages. (Source: Lung)
Source: Lung - November 16, 2019 Category: Respiratory Medicine Source Type: research

Controlled Delivery of 80  mg Aerosol Furosemide Does Not Achieve Consistent Dyspnea Relief in Patients
ConclusionsHigh dose controlled delivery aerosol furosemide was not statistically different from saline placebo at reducing exercise-induced dyspnea. However, a clinically meaningful improvement was noted in some patients. (Source: Lung)
Source: Lung - November 15, 2019 Category: Respiratory Medicine Source Type: research

The Role of Noninvasive Endpoints in Predicting Long-Term Outcomes in Pulmonary Arterial Hypertension
ConclusionAssessment of 6MWD, FC, and BNP/NT-proBNP provides low-cost, efficient, and noninvasive means of predicting long-term health and economic outcomes in patients with PAH. (Source: Lung)
Source: Lung - November 13, 2019 Category: Respiratory Medicine Source Type: research

Effects of Expiratory Muscle Training and Air Stacking on Peak Cough Flow in Individuals with Parkinson ’s Disease
AbstractThe purpose of this study was to investigate the effects of air stacking (AS) and an expiratory muscle training (EMT) program to increase voluntary and reflex peak cough flow (PCF) in individuals with Parkinson ’s disease. Participants were allocated to the control (n = 11), EMT (n = 11), or EMT + AS group (n = 11). All groups performed EMT (5 sets of 5 repetitions), 6 times a week for 2 months. The control group used a fixed resistance, EMT plus AS and EMT groups used a progressively increased resistance. The EMT plus AS group additionally performe...
Source: Lung - November 12, 2019 Category: Respiratory Medicine Source Type: research

The Phagocytosis of Blood Leukocytes from Cystic Fibrosis Patients is not Impaired in General
AbstractImpaired phagocytosis ofPseudomonas aeruginosa was found in isolated monocytes of peripheral blood of cystic fibrosis patients, but not in their neutrophils, as reported some years ago. In the present study, we analysed the phagocytic capacity of peripheral blood neutrophils and monocytes of cystic fibrosis patients and of healthy controls. Phagocytosis was determined using a commercial phagocytosis “in whole blood” assay on the basis of fluorescence-labelled opsonizedEscherichia coli bacteria and flow cytometry. Venous blood of cystic fibrosis patients and of healthy controls was collected and the phag...
Source: Lung - November 9, 2019 Category: Respiratory Medicine Source Type: research