Methotrexate Polyglutamate Concentrations as a Possible Predictive Marker for Effectiveness of Methotrexate Therapy in Patients with Sarcoidosis: A Pilot Study
ConclusionThese results suggest a relation between MTXPG(n) concentrations and the anti-inflammatory effect in patients with sarcoidosis. Further prospective validation is warranted, but if measuring MTXPG concentrations could predict treatment effect of MTX this would be a step in the direction of personalized medicine. (Source: Lung)
Source: Lung - November 16, 2023 Category: Respiratory Medicine Source Type: research
Pulmonary Function and Quality of Life in Adults with Cystic Fibrosis
ConclusionAdvancing our understanding of patient-centered markers of quality of life, rather than focusing on pulmonary function alone, may help identify novel interventions to improve quality of life in this patient population. (Source: Lung)
Source: Lung - November 16, 2023 Category: Respiratory Medicine Source Type: research
Lung Cancer in Never Smokers: Delving into Epidemiology, Genomic and Immune Landscape, Prognosis, Treatment, and Screening
AbstractLung cancer in never smokers (LCINS) represents a growing and distinct entity within the broader landscape of lung malignancies. This review provides a comprehensive overview of LCINS, encompassing its epidemiologic trends, risk factors, distinct genomic alterations, clinical outcomes and the ongoing initiative aimed at formulating screening guidelines tailored to this unique population. As LCINS continues to gain prominence, understanding its intricate genomic landscape has become pivotal for tailoring effective therapeutic strategies. Moreover, LCINS does not meet the criteria for lung cancer screening as per the...
Source: Lung - November 16, 2023 Category: Respiratory Medicine Source Type: research
Methotrexate Polyglutamate Concentrations as a Possible Predictive Marker for Effectiveness of Methotrexate Therapy in Patients with Sarcoidosis: A Pilot Study
ConclusionThese results suggest a relation between MTXPG(n) concentrations and the anti-inflammatory effect in patients with sarcoidosis. Further prospective validation is warranted, but if measuring MTXPG concentrations could predict treatment effect of MTX this would be a step in the direction of personalized medicine. (Source: Lung)
Source: Lung - November 16, 2023 Category: Respiratory Medicine Source Type: research
Pulmonary Function and Quality of Life in Adults with Cystic Fibrosis
ConclusionAdvancing our understanding of patient-centered markers of quality of life, rather than focusing on pulmonary function alone, may help identify novel interventions to improve quality of life in this patient population. (Source: Lung)
Source: Lung - November 16, 2023 Category: Respiratory Medicine Source Type: research
MMP19 Variants in Familial and Sporadic Idiopathic Pulmonary Fibrosis
ConclusionsMMP19 variants were identified in familial or sporadic IPF, thus providing a potential new clue into IPF pathogenesis. (Source: Lung)
Source: Lung - November 16, 2023 Category: Respiratory Medicine Source Type: research
Lung Cancer in Never Smokers: Delving into Epidemiology, Genomic and Immune Landscape, Prognosis, Treatment, and Screening
AbstractLung cancer in never smokers (LCINS) represents a growing and distinct entity within the broader landscape of lung malignancies. This review provides a comprehensive overview of LCINS, encompassing its epidemiologic trends, risk factors, distinct genomic alterations, clinical outcomes and the ongoing initiative aimed at formulating screening guidelines tailored to this unique population. As LCINS continues to gain prominence, understanding its intricate genomic landscape has become pivotal for tailoring effective therapeutic strategies. Moreover, LCINS does not meet the criteria for lung cancer screening as per the...
Source: Lung - November 16, 2023 Category: Respiratory Medicine Source Type: research
MMP19 Variants in Familial and Sporadic Idiopathic Pulmonary Fibrosis
ConclusionsMMP19 variants were identified in familial or sporadic IPF, thus providing a potential new clue into IPF pathogenesis. (Source: Lung)
Source: Lung - November 16, 2023 Category: Respiratory Medicine Source Type: research
Recurrent Cough in the Elderly: A Forgotten Entity
ConclusionThe risk factors and consequences of recurrent and isolated chronic cough were comparable. Recurrent cough seems beneficial to address in cough evaluation. (Source: Lung)
Source: Lung - November 14, 2023 Category: Respiratory Medicine Source Type: research
An Artificial Intelligence Platform for the Radiologic Diagnosis of Pulmonary Sarcoidosis: An Initial Pilot Study of Chest Computed Tomography Analysis to Distinguish Pulmonary Sarcoidosis from a Negative Lung Cancer Screening Scan
ConclusionThis AL/DL model shows promise to distinguish sarcoidosis from alternative pulmonary conditions using minimal radiologic data. (Source: Lung)
Source: Lung - November 14, 2023 Category: Respiratory Medicine Source Type: research
Recurrent Cough in the Elderly: A Forgotten Entity
ConclusionThe risk factors and consequences of recurrent and isolated chronic cough were comparable. Recurrent cough seems beneficial to address in cough evaluation. (Source: Lung)
Source: Lung - November 14, 2023 Category: Respiratory Medicine Source Type: research
An Artificial Intelligence Platform for the Radiologic Diagnosis of Pulmonary Sarcoidosis: An Initial Pilot Study of Chest Computed Tomography Analysis to Distinguish Pulmonary Sarcoidosis from a Negative Lung Cancer Screening Scan
ConclusionThis AL/DL model shows promise to distinguish sarcoidosis from alternative pulmonary conditions using minimal radiologic data. (Source: Lung)
Source: Lung - November 14, 2023 Category: Respiratory Medicine Source Type: research
A Clinical Decision Tool for Risk Stratifying Patients with Systemic Sclerosis-Related Pulmonary Hypertension
AbstractWe devised a scoring system to identify patients with systemic sclerosis (SSc) at risk for pulmonary hypertension (PH) and predict all-cause mortality. Using 7 variables obtained via pulmonary function testing, echocardiography, and computed tomographic chest imaging, we applied the score to a retrospective cohort of 117 patients with SSc. There were 60 (51.3%) who were diagnosed with PH by right heart catheterization. Using a scoring threshold ≥ 0, our decision tool predicted PH with a sensitivity, specificity, and accuracy of 0.87 (95% CI 0.75, 0.94), 0.74 (95% CI 0.60, 0.84), and 0.80 (95% CI 0.72, 0.87),...
Source: Lung - November 13, 2023 Category: Respiratory Medicine Source Type: research
