An Artificial Intelligence Platform for the Radiologic Diagnosis of Pulmonary Sarcoidosis: An Initial Pilot Study of Chest Computed Tomography Analysis to Distinguish Pulmonary Sarcoidosis from a Negative Lung Cancer Screening Scan
ConclusionThis AL/DL model shows promise to distinguish sarcoidosis from alternative pulmonary conditions using minimal radiologic data. (Source: Lung)
Source: Lung - November 14, 2023 Category: Respiratory Medicine Source Type: research
Recurrent Cough in the Elderly: A Forgotten Entity
ConclusionThe risk factors and consequences of recurrent and isolated chronic cough were comparable. Recurrent cough seems beneficial to address in cough evaluation. (Source: Lung)
Source: Lung - November 14, 2023 Category: Respiratory Medicine Source Type: research
An Artificial Intelligence Platform for the Radiologic Diagnosis of Pulmonary Sarcoidosis: An Initial Pilot Study of Chest Computed Tomography Analysis to Distinguish Pulmonary Sarcoidosis from a Negative Lung Cancer Screening Scan
ConclusionThis AL/DL model shows promise to distinguish sarcoidosis from alternative pulmonary conditions using minimal radiologic data. (Source: Lung)
Source: Lung - November 14, 2023 Category: Respiratory Medicine Source Type: research
A Clinical Decision Tool for Risk Stratifying Patients with Systemic Sclerosis-Related Pulmonary Hypertension
AbstractWe devised a scoring system to identify patients with systemic sclerosis (SSc) at risk for pulmonary hypertension (PH) and predict all-cause mortality. Using 7 variables obtained via pulmonary function testing, echocardiography, and computed tomographic chest imaging, we applied the score to a retrospective cohort of 117 patients with SSc. There were 60 (51.3%) who were diagnosed with PH by right heart catheterization. Using a scoring threshold ≥ 0, our decision tool predicted PH with a sensitivity, specificity, and accuracy of 0.87 (95% CI 0.75, 0.94), 0.74 (95% CI 0.60, 0.84), and 0.80 (95% CI 0.72, 0.87),...
Source: Lung - November 13, 2023 Category: Respiratory Medicine Source Type: research
Inhibition of Prostaglandin-Degrading Enzyme 15-PGDH Mitigates Acute Murine Lung Allograft Rejection
ConclusionOur study provides new insights into the role of 15-PGDH in acute lung rejection and highlights the therapeutic potential of inhibiting 15-PGDH for enhancing graft survival. The accumulation of PGE2 and modulation of CD8+ T-cell responses represent potential mechanisms underlying the benefits of 15-PGDH inhibition in this model. Our findings provide impetus for further exploring 15-PGDH as a target for improving lung transplantation outcomes. (Source: Lung)
Source: Lung - November 7, 2023 Category: Respiratory Medicine Source Type: research
Assessment and Management of Cough in Idiopathic Pulmonary Fibrosis: A Narrative Review
AbstractIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal disease with an unknown cause. It is characterized by symptoms such as cough and breathlessness, which significantly impact patients ’ quality of life. Cough, in particular, has emerged as a burdensome symptom for individuals with IPF. The etiology of cough in IPF patients is believed to be complex, involving factors related to the disease itself, such as increased sensitivity of cough nerves, lung structural changes, inflammat ion, and genetic factors, as well as comorbidities and medication effects. Unfortunately, effective treatment optio...
Source: Lung - November 7, 2023 Category: Respiratory Medicine Source Type: research
Inhibition of Prostaglandin-Degrading Enzyme 15-PGDH Mitigates Acute Murine Lung Allograft Rejection
ConclusionOur study provides new insights into the role of 15-PGDH in acute lung rejection and highlights the therapeutic potential of inhibiting 15-PGDH for enhancing graft survival. The accumulation of PGE2 and modulation of CD8+ T-cell responses represent potential mechanisms underlying the benefits of 15-PGDH inhibition in this model. Our findings provide impetus for further exploring 15-PGDH as a target for improving lung transplantation outcomes. (Source: Lung)
Source: Lung - November 7, 2023 Category: Respiratory Medicine Source Type: research
Assessment and Management of Cough in Idiopathic Pulmonary Fibrosis: A Narrative Review
AbstractIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal disease with an unknown cause. It is characterized by symptoms such as cough and breathlessness, which significantly impact patients ’ quality of life. Cough, in particular, has emerged as a burdensome symptom for individuals with IPF. The etiology of cough in IPF patients is believed to be complex, involving factors related to the disease itself, such as increased sensitivity of cough nerves, lung structural changes, inflammat ion, and genetic factors, as well as comorbidities and medication effects. Unfortunately, effective treatment optio...
Source: Lung - November 7, 2023 Category: Respiratory Medicine Source Type: research
Predictive Value of CT Biomarkers in Lung Transplantation Survival: Preliminary Investigation in a Diverse, Underserved, Urban Population
ConclusionPre-transplantation CT biomarkers had predictive value in lung transplant survival and varied by sex. The absence of sarcopenia in women, lower visceral fat attenuation and area in men, and higher vertebral body density in both sexes predicted survival in our diverse, urban population. (Source: Lung)
Source: Lung - November 2, 2023 Category: Respiratory Medicine Source Type: research
Prognostic Impact of Cancer Inflammation Prognostic Index for Non-small Cell Lung Cancer
ConclusionCIPI was a significant factor for RFS in NSCLC patients treated surgically, even in those with pathological stage I disease. SUVmax was also a significant factor for RFS and overall survival in NSCLC patients treated surgically, and for RFS in patients with pathological stage I NSCLC.Trial RegistrationThe Institutional Review Board of Kanazawa Medical University approved the protocol of this retrospective study (Approval Number: I392), and written informed consent was obtained from all patients. (Source: Lung)
Source: Lung - October 31, 2023 Category: Respiratory Medicine Source Type: research
Feasibility and Utility of a Smartphone Application-Based Longitudinal Cough Monitoring in Chronic Cough Patients in a Real-World Setting
ConclusionMonitoring cough frequency longitudinally for at least one week may be feasible. The substantial day-to-day variability in objective cough frequency highlights the need for continuous monitoring. Grasping the implications of daily cough variability is crucial in both clinical practice and clinical trials. (Source: Lung)
Source: Lung - October 13, 2023 Category: Respiratory Medicine Source Type: research
