Prevalence and Severity Distribution of Type 2 Inflammation-Related Comorbidities Among Patients with Asthma, Chronic Rhinosinusitis with Nasal Polyps, and Atopic Dermatitis
AbstractThis observational study assessed the prevalence of co-existing type 2 inflammatory conditions [T2Cs; asthma, atopic dermatitis (AD), allergic rhinitis, and chronic rhinosinusitis with nasal polyps (CRSwNP)] in patients with moderate-to-severe (M/S) type 2 asthma, M/S CRSwNP, or M/S AD, in the real-world setting. Data from 761 physicians in the US and EUR5 were sourced from Adelphi Disease-Specific Programmes covering patients with M/S asthma (n = 899), M/S CRSwNP (n = 683), and M/S AD (n = 1497). At least one T2C was identified in 66%, 69%, and 46% of M/S asthma, M/S CRSwNP, and M/S AD cohorts, respect...
Source: Lung - February 20, 2023 Category: Respiratory Medicine Source Type: research
Canadian Health Care Professionals ’ Familiarity with Chronic Cough Guidelines and Experiences with Diagnosis and Management: A Cross-Sectional Survey
ConclusionThis survey of Canadian physicians demonstrates low uptake of recent advances in chronic cough diagnosis, disease categorization, and pharmacologic management. Canadian physicians also report unfamiliarity with guideline-recommended therapies, including centrally acting neuromodulators for refractory or unexplained chronic cough. This data highlights the need for educational programs and collaborative care models on chronic cough in primary and specialist care. (Source: Lung)
Source: Lung - February 18, 2023 Category: Respiratory Medicine Source Type: research
SIRT1 as a Potential Therapeutic Target for Chronic Obstructive Pulmonary Disease
AbstractChronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease characterized by irreversible airflow obstruction and lung function decline. It is well established that COPD represents a major cause of morbidity and mortality globally. Due to the substantial economic and social burdens associated with COPD, it is necessary to discover new targets and develop novel beneficial therapies. Although the pathogenesis of COPD is complex and remains to be robustly elucidated, numerous studies have shown that oxidative stress, inflammatory responses, cell apoptosis, autophagy, and aging are invo...
Source: Lung - February 15, 2023 Category: Respiratory Medicine Source Type: research
Fatigue in Patients with Sarcoidosis in Denmark
ConclusionIn Denmark, fatigue was frequent in patients with sarcoidosis. The majority of patients had mild disease at diagnosis and were older but lower at Scadding stage at diagnosis compared to previous cohorts. (Source: Lung)
Source: Lung - February 11, 2023 Category: Respiratory Medicine Source Type: research
Tiotropium in Patients with Bronchiectasis: A Prospective Cohort Study
ConclusionIn conclusion, prospective cohort study showed that tiotropium effectively ameliorated the annual decline in the FEV1, with a lower-risk rate of moderate exacerbations and prolonging the time to the first-time severe exacerbation in patients with bronchiectasis and airflow limitation. (Source: Lung)
Source: Lung - February 7, 2023 Category: Respiratory Medicine Source Type: research
Bronchodilators in bronchiectasis: we urgently need more trials
(Source: Lung)
Source: Lung - February 7, 2023 Category: Respiratory Medicine Source Type: research
Tiotropium in Patients with Bronchiectasis: A Prospective Cohort Study
ConclusionIn conclusion, prospective cohort study showed that tiotropium effectively ameliorated the annual decline in the FEV1, with a lower-risk rate of moderate exacerbations and prolonging the time to the first-time severe exacerbation in patients with bronchiectasis and airflow limitation. (Source: Lung)
Source: Lung - February 7, 2023 Category: Respiratory Medicine Source Type: research
Bronchodilators in bronchiectasis: we urgently need more trials
(Source: Lung)
Source: Lung - February 7, 2023 Category: Respiratory Medicine Source Type: research
Early Exacerbation Relapse is Increased in Patients with Asthma and Bronchiectasis (a Post hoc Analysis)
ConclusionThe clinical response to treatment was similar but patients with coexisting asthma were at increased risk of early relapse within 14 days of stopping intravenous antibiotic therapy. Clinical Trial Registration: NCT02047773. (Source: Lung)
Source: Lung - February 6, 2023 Category: Respiratory Medicine Source Type: research
The Effect of Heparin Full-Dose Anticoagulation on Survival of Hospitalized, Non-critically Ill COVID-19 Patients: A Meta-analysis of High Quality Studies
ConclusionOur meta-analysis of high-quality multicenter RCTs suggests that full-dose anticoagulation with heparin or low molecular weight heparin reduces all-cause mortality in hospitalized non-critically ill COVID-19 patients.Study registration: PROSPERO, review no. CRD42022348993.Graphical Abstract (Source: Lung)
Source: Lung - February 4, 2023 Category: Respiratory Medicine Source Type: research
