Multiple Correspondence Analysis and HLA-Associations of Organ Involvement in a Large Cohort of African-American and European-American Patients with Sarcoidosis
AbstractSarcoidosis is a systemic granulomatous disease with predominant pulmonary involvement and vast heterogeneity of clinical manifestations and disease outcomes. African American (AA) patients suffer greater morbidity and mortality. Using Multiple Correspondence Analysis, we identified seven clusters of organ involvement in European American (EA; n = 385) patients which were similar to those previously described in a Pan-European (GenPhenReSa) and a Spanish cohort (SARCOGEAS). In contrast, AA (n = 987) had six, less well-defined and overlapping clusters with little similarity to the cluster identified in the ...
Source: Lung - June 15, 2023 Category: Respiratory Medicine Source Type: research
The Relationship Between Sarcoidosis Organ Involvement, Environment, Race, and Genetics: There ’s a Signal, But Fine Tuning Is Needed
(Source: Lung)
Source: Lung - June 15, 2023 Category: Respiratory Medicine Source Type: research
Multiple Correspondence Analysis and HLA-Associations of Organ Involvement in a Large Cohort of African-American and European-American Patients with Sarcoidosis
AbstractSarcoidosis is a systemic granulomatous disease with predominant pulmonary involvement and vast heterogeneity of clinical manifestations and disease outcomes. African American (AA) patients suffer greater morbidity and mortality. Using Multiple Correspondence Analysis, we identified seven clusters of organ involvement in European American (EA; n = 385) patients which were similar to those previously described in a Pan-European (GenPhenReSa) and a Spanish cohort (SARCOGEAS). In contrast, AA (n = 987) had six, less well-defined and overlapping clusters with little similarity to the cluster identified in the ...
Source: Lung - June 15, 2023 Category: Respiratory Medicine Source Type: research
The Relationship Between Sarcoidosis Organ Involvement, Environment, Race, and Genetics: There ’s a Signal, But Fine Tuning Is Needed
(Source: Lung)
Source: Lung - June 15, 2023 Category: Respiratory Medicine Source Type: research
Static Respiratory System Compliance as a Predictor of Extubation Failure in Patients with Acute Respiratory Failure
ConclusionRC measured on the day of extubation is a promising physiological discriminant to potentially risk stratify patients with acute respiratory failure for extubation readiness. We recommend further validation studies in prospective cohorts. (Source: Lung)
Source: Lung - June 10, 2023 Category: Respiratory Medicine Source Type: research
Efficacy and Safety of Eliapixant in Refractory Chronic Cough: The Randomized, Placebo-Controlled Phase 2b PAGANINI Study
ConclusionEliapixant demonstrated efficacy and a favorable taste tolerability profile in RCC. However, a drug-induced liver injury contributed to intensified liver monitoring in clinical trials with eliapixant and discontinuation of the entire development program in all indications by Bayer AG.Trial RegistrationClinicalTrials.gov identifier NCT04562155; registered September 18, 2020. (Source: Lung)
Source: Lung - June 1, 2023 Category: Respiratory Medicine Source Type: research
Cyclophilin D Contributes to Airway Epithelial Mitochondrial Damage in Chronic Obstructive Pulmonary Disease
ConclusionThese data suggest that CypD signaling pathway is involved in the pathogenesis of COPD and provide a potential therapeutic target for COPD. (Source: Lung)
Source: Lung - June 1, 2023 Category: Respiratory Medicine Source Type: research
Activated CYPD in COPD: Filling in the Puzzle of how Perturbed Epithelial Respiration Leads to Disturbed Respiratory Function
(Source: Lung)
Source: Lung - June 1, 2023 Category: Respiratory Medicine Source Type: research
Efficacy and Safety of Eliapixant in Refractory Chronic Cough: The Randomized, Placebo-Controlled Phase 2b PAGANINI Study
ConclusionEliapixant demonstrated efficacy and a favorable taste tolerability profile in RCC. However, a drug-induced liver injury contributed to intensified liver monitoring in clinical trials with eliapixant and discontinuation of the entire development program in all indications by Bayer AG.Trial RegistrationClinicalTrials.gov identifier NCT04562155; registered September 18, 2020. (Source: Lung)
Source: Lung - June 1, 2023 Category: Respiratory Medicine Source Type: research
Cyclophilin D Contributes to Airway Epithelial Mitochondrial Damage in Chronic Obstructive Pulmonary Disease
ConclusionThese data suggest that CypD signaling pathway is involved in the pathogenesis of COPD and provide a potential therapeutic target for COPD. (Source: Lung)
Source: Lung - June 1, 2023 Category: Respiratory Medicine Source Type: research
Activated CYPD in COPD: Filling in the Puzzle of how Perturbed Epithelial Respiration Leads to Disturbed Respiratory Function
(Source: Lung)
Source: Lung - June 1, 2023 Category: Respiratory Medicine Source Type: research
Clinical Relevance of Staphylococcus aureus Nasal Colonization and Staphylococcal Enterotoxin-Specific IgE Sensitization in Late-Onset Asthma
In conclusion, SA nasal colonization and SE-IgE sensitization may synergistically affect disease severity in late-onset asthmatics. (Source: Lung)
Source: Lung - May 30, 2023 Category: Respiratory Medicine Source Type: research
