Whole Genome Sequencing in Advanced Lung Cancer can be Performed Using Diff-Quik Cytology Smears Derived from Endobronchial Ultrasound, Transbronchial Needle Aspiration (EBUS TBNA)
ConclusionsWGS of commonly collected Diff-Quik slides is feasible and their DNA yield can be predicted. (Source: Lung)
Source: Lung - July 5, 2023 Category: Respiratory Medicine Source Type: research

Collagen Type IV Alpha 5 Chain in Bronchiolitis Obliterans Syndrome After Lung Transplant: The First Evidence
ConclusionSerum concentrations of COL4A5 can be considered a good prognostic marker due to their association with survival and correlation with functional parameters. (Source: Lung)
Source: Lung - July 4, 2023 Category: Respiratory Medicine Source Type: research

Lactate Dehydrogenase and Hemorrhagic Stroke During Extracorporeal Membrane Oxygenation for COVID-19
ConclusionElevated LDH prior to ECMO cannulation is associated with a higher incidence of HS during  device support. LDH can risk stratify cases for impending cerebral bleeding during ECMO. (Source: Lung)
Source: Lung - July 4, 2023 Category: Respiratory Medicine Source Type: research

Collagen Type IV Alpha 5 Chain in Bronchiolitis Obliterans Syndrome After Lung Transplant: The First Evidence
ConclusionSerum concentrations of COL4A5 can be considered a good prognostic marker due to their association with survival and correlation with functional parameters. (Source: Lung)
Source: Lung - July 4, 2023 Category: Respiratory Medicine Source Type: research

Lactate Dehydrogenase and Hemorrhagic Stroke During Extracorporeal Membrane Oxygenation for COVID-19
ConclusionElevated LDH prior to ECMO cannulation is associated with a higher incidence of HS during  device support. LDH can risk stratify cases for impending cerebral bleeding during ECMO. (Source: Lung)
Source: Lung - July 4, 2023 Category: Respiratory Medicine Source Type: research

The Relationship Between Serum Angiotensin Converting Enzyme Level and the Decision to Escalate Treatment of Sarcoidosis
ConclusionsAlthough there was a strong correlation between sACE at the initial sarcoidosis clinic visit and subsequent treatment escalation of sarcoidosis, the predictive power was such that sACE is not adequately reliable to be used in isolation to make this determination. (Source: Lung)
Source: Lung - June 27, 2023 Category: Respiratory Medicine Source Type: research

Improved Survival of IPF patients Treated With Antifibrotic Drugs Compared With Untreated Patients
ConclusionThis large real-world study showed a survival benefit in IPFAF compared with IPFnon −AF. This especially holds true for patients with GAP stage II and III. (Source: Lung)
Source: Lung - June 21, 2023 Category: Respiratory Medicine Source Type: research

Multiple Correspondence Analysis and HLA-Associations of Organ Involvement in a Large Cohort of African-American and European-American Patients with Sarcoidosis
AbstractSarcoidosis is a systemic granulomatous disease with predominant pulmonary involvement and vast heterogeneity of clinical manifestations and disease outcomes. African American (AA) patients suffer greater morbidity and mortality. Using Multiple Correspondence Analysis, we identified seven clusters of organ involvement in European American (EA; n  = 385) patients which were similar to those previously described in a Pan-European (GenPhenReSa) and a Spanish cohort (SARCOGEAS). In contrast, AA (n = 987) had six, less well-defined and overlapping clusters with little similarity to the cluster identified in the ...
Source: Lung - June 15, 2023 Category: Respiratory Medicine Source Type: research

The Relationship Between Sarcoidosis Organ Involvement, Environment, Race, and Genetics: There ’s a Signal, But Fine Tuning Is Needed
(Source: Lung)
Source: Lung - June 15, 2023 Category: Respiratory Medicine Source Type: research

Multiple Correspondence Analysis and HLA-Associations of Organ Involvement in a Large Cohort of African-American and European-American Patients with Sarcoidosis
AbstractSarcoidosis is a systemic granulomatous disease with predominant pulmonary involvement and vast heterogeneity of clinical manifestations and disease outcomes. African American (AA) patients suffer greater morbidity and mortality. Using Multiple Correspondence Analysis, we identified seven clusters of organ involvement in European American (EA; n  = 385) patients which were similar to those previously described in a Pan-European (GenPhenReSa) and a Spanish cohort (SARCOGEAS). In contrast, AA (n = 987) had six, less well-defined and overlapping clusters with little similarity to the cluster identified in the ...
Source: Lung - June 15, 2023 Category: Respiratory Medicine Source Type: research

The Relationship Between Sarcoidosis Organ Involvement, Environment, Race, and Genetics: There ’s a Signal, But Fine Tuning Is Needed
(Source: Lung)
Source: Lung - June 15, 2023 Category: Respiratory Medicine Source Type: research

Static Respiratory System Compliance as a Predictor of Extubation Failure in Patients with Acute Respiratory Failure
ConclusionRC measured on the day of extubation is a promising physiological discriminant to potentially risk stratify patients with acute respiratory failure for extubation readiness. We recommend further validation studies in prospective cohorts. (Source: Lung)
Source: Lung - June 10, 2023 Category: Respiratory Medicine Source Type: research