Association of Gas Diffusing Capacity of the Lung for Carbon Monoxide with Cardiovascular Morbidity and Survival in a Disadvantaged Clinical Population
ConclusionLowDLCO,KCO, andVA measurements are associated with cardiovascular disease prevalence. As risk factors of all-cause mortality, they are more sensitive than spirometry even among patients with no diagnosed respiratory disease. (Source: Lung)
Source: Lung - October 22, 2022 Category: Respiratory Medicine Source Type: research
Narrowing the Differential Diagnosis of Cystic Lesions in Smokers with Expiratory CT Acquisition Using the Cyst-Airway Communication Hypothesis
AbstractThe aim of this study was to assess percentage respiratory changes ( δ) in the size of pulmonary cysts of different smoking-related etiologies. Retrospectively, we measured the cystic lesions due to histopathological-confirmed honeycombing from interstitial pulmonary fibrosis, pulmonary Langerhans cell histiocytosis (PLCH), and paraseptal emphysema, using paired ins piratory and expiratory CT scans. In a sample of 72 patients and 216 lesions, the mean diameter of PLCH and honeycombing decreased during expiration (PLCH,δ = 60.9%;p = 0.001; honeycombing,δ = 47.5%;p = 0.014). Conversely, paraseptal ...
Source: Lung - October 22, 2022 Category: Respiratory Medicine Source Type: research
Association of Gas Diffusing Capacity of the Lung for Carbon Monoxide with Cardiovascular Morbidity and Survival in a Disadvantaged Clinical Population
ConclusionLowDLCO,KCO, andVA measurements are associated with cardiovascular disease prevalence. As risk factors of all-cause mortality, they are more sensitive than spirometry even among patients with no diagnosed respiratory disease. (Source: Lung)
Source: Lung - October 22, 2022 Category: Respiratory Medicine Source Type: research
Narrowing the Differential Diagnosis of Cystic Lesions in Smokers with Expiratory CT Acquisition Using the Cyst-Airway Communication Hypothesis
AbstractThe aim of this study was to assess percentage respiratory changes ( δ) in the size of pulmonary cysts of different smoking-related etiologies. Retrospectively, we measured the cystic lesions due to histopathological-confirmed honeycombing from interstitial pulmonary fibrosis, pulmonary Langerhans cell histiocytosis (PLCH), and paraseptal emphysema, using paired ins piratory and expiratory CT scans. In a sample of 72 patients and 216 lesions, the mean diameter of PLCH and honeycombing decreased during expiration (PLCH,δ = 60.9%;p = 0.001; honeycombing,δ = 47.5%;p = 0.014). Conversely, paraseptal ...
Source: Lung - October 22, 2022 Category: Respiratory Medicine Source Type: research
Poly I:C Exacerbates Airway Inflammation and Remodeling in Cigarette Smoke-Exposed Mice
ConclusionPoly I:C could promote airway inflammation and remodeling in CS-induced COPD mice probably by NF- κB and MAPK signaling. (Source: Lung)
Source: Lung - October 21, 2022 Category: Respiratory Medicine Source Type: research
Adding (Viral) Insult to (Smoke) Injury may Prolong COPD Changes After Smoking Cessation
(Source: Lung)
Source: Lung - October 21, 2022 Category: Respiratory Medicine Source Type: research
Poly I:C Exacerbates Airway Inflammation and Remodeling in Cigarette Smoke-Exposed Mice
ConclusionPoly I:C could promote airway inflammation and remodeling in CS-induced COPD mice probably by NF- κB and MAPK signaling. (Source: Lung)
Source: Lung - October 21, 2022 Category: Respiratory Medicine Source Type: research
Adding (Viral) Insult to (Smoke) Injury may Prolong COPD Changes After Smoking Cessation
(Source: Lung)
Source: Lung - October 21, 2022 Category: Respiratory Medicine Source Type: research
Different Impacts of Blood and Sputum Eosinophil Counts on Lung Function and Clinical Outcomes in Asthma: Findings from the COREA Cohort
ConclusionEOS-S and EOS-B contribute differently to the clinical outcomes and should be taken into account independently to improve asthma care. (Source: Lung)
Source: Lung - October 20, 2022 Category: Respiratory Medicine Source Type: research
Hypersensitivity Pneumonitis With and Without Autoimmune Features: A Clinical Comparative Analysis
ConclusionPatients with HPAF had a higher echocardiographic probability of pulmonary hypertension as compared to patients with non-HPAF HP. The clinical characteristics and outcomes did not differ between the two groups and concomitant autoimmunity among the HP group did not portend a poorer prognosis. (Source: Lung)
Source: Lung - October 18, 2022 Category: Respiratory Medicine Source Type: research
Gut –lung Microbiota Interactions in Chronic Obstructive Pulmonary Disease (COPD): Potential Mechanisms Driving Progression to COPD and Epidemiological Data
AbstractThis paper focuses on the gut –lung axis in the context of Inflammatory Bowel Disease (IBD) and Chronic Obstructive Pulmonary Disease (COPD), highlighting the key role played by microbial dysbiosis and the impact of environmental and genetic factors on the innate and acquired immune system and on chronic inflammation in the in testinal and pulmonary tracts. Recent evidence indicates that Antigen-Presenting Cells (APCs) perform regulatory activity influencing the composition of the microbiota. APCs (macrophages, dendritic cells, B cells) possess membrane receptors known as Pattern Recognition Receptors (PRRs), a c...
Source: Lung - October 14, 2022 Category: Respiratory Medicine Source Type: research
Impact of Biologic Therapy on the Small Airways Asthma Phenotype
AbstractThe small airways dysfunction (SAD) asthma phenotype is characterised by narrowing of airways < 2 mm in diameter between generations 8 and 23 of the bronchial tree. Recently, this has become particularly relevant as measurements of small airways using airway oscillometry for example, are strong determinants of asthma control and exacerbations in moderate-to-severe asthma. The small airways can be assessed using spirometry as forced expiratory flow rate between 25 and 75% of forced vital capacity (FEF25 –75) and has been deemed more accurate in detecting small airways dysfunction than forced expiratory v...
Source: Lung - October 14, 2022 Category: Respiratory Medicine Source Type: research
