Coenzyme Q10 in COPD: An Unexplored Opportunity?
Authors: Zozina VI, Covantev S, Kukes VG, Corlateanu A Abstract COPD represents a major cause of mortality and morbidity worldwide, is linked to systemic inflammation and tends to coexist with a variety of comorbidities. Inflammation, oxidative stress and protease-antiprotease imbalance represent the pathogenic triad of COPD. Even though oxidative stress and mitochondrial dysfunction is a well-studied phenomenon in COPD and there is a variety of studies that aim to counteract its effect, there is limited data available on the use of coenzyme Q10 in COPD. The aim of the current review is to analyze the current data ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 16, 2021 Category: Respiratory Medicine Tags: COPD Source Type: research

Baseline Characteristics of Subjects with Chronic Obstructive Pulmonary Disease Associated to the Improvement in Activities of Daily Living after Exercise Training.
In conclusion, the baseline variables that best predict the improvement of individuals after exercise training are TGlittre and LCADL, showing that subjects with significant functional impairment are more likely to clinically significantly improve their ADLs. PMID: 33427517 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 13, 2021 Category: Respiratory Medicine Tags: COPD Source Type: research

Bacterial and Viral Infection in Patients Hospitalized for Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Implication for Antimicrobial Management and Clinical Outcome.
The objectives of this study were first to evaluate the prevalence of pathogens associated to these episodes by combining conventional bacteriology and multiplex viral and bacterial PCR assays in sputum specimens, and second to determine whether C-reactive protein (CRP) value and clinical outcome could be influenced by the type of microbial agent(s) recovered from these samples. A cohort of 84 Tunisian patients hospitalized at the emergency room for AECOPD was investigated prospectively for the semi-quantitative detection of bacteria by conventional culture (the threshold of positivity was of 107 CFU/ml) and for the detect...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 30, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Adherence to GOLD Recommendations among Swiss Pulmonologists and General Practitioners.
This study confirms that discordance of real-world prescription patterns with international guidance is frequent. Further educational efforts are required to improve adherence to COPD management recommendations. PMID: 33342309 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 23, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Follow-up with Telemedicine in Early Discharge for COPD Exacerbations: Randomized Clinical Trial (TELEMEDCOPD-Trial).
In conclusion follow-up via a telemedicine program in early discharge after hospitalization is as effective as conventional home follow up, being the cost of either strategy not significantly different. PMID: 33307857 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 15, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Lung Deposition Using the Respimat ® Soft Mist™ Inhaler Mono and Fixed-Dose Combination Therapies: An In Vitro/In Silico Analysis.
Lung Deposition Using the Respimat® Soft Mist™ Inhaler Mono and Fixed-Dose Combination Therapies: An In Vitro/In Silico Analysis. COPD. 2020 Dec 11;:1-10 Authors: Ciciliani AM, Denny M, Langguth P, Voshaar T, Wachtel H Abstract Tiotropium and olodaterol are mainstay treatments for chronic obstructive pulmonary disease (COPD) and yield important clinical improvements, especially when used in fixed-dose combination. Whilst previous studies have shown consistent delivery of tiotropium to the lungs with the Respimat® inhaler, no such study has been carried out for olodaterol or the components...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 13, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Adiponectin is Associated with Neutrophils to Lymphocyte Ratio in Patients with Chronic Obstructive Pulmonary Disease.
Authors: Perrotta F, Nigro E, Pafundi PC, Polito R, Nucera F, Scialò F, Caramori G, Bianco A, Daniele A Abstract Disproportionate systemic inflammation in chronic obstructive pulmonary disease (COPD) is associated with declining lung functions and comorbidities. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have emerged as valuable markers of the systemic inflammation in COPD. Adiponectin (Acpr30) circulates in serum as complexes of different molecular weight (HMW, MMW, LMW) with multifaceted metabolic and anti-inflammatory properties implicated in airway pathophysiology. We aim...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 13, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Is the Symptom of Cough in Chronic Obstructive Pulmonary Disease Important?
Authors: Niu S, Wang S, Xu X, Yu L Abstract Chronic obstructive pulmonary disease (COPD) is a common disease and a significant burden worldwide. The clinical symptoms of this disease include progressive dyspnea, cough, expectoration, and wheezing, among others. At present, the primary focus has been on reducing the frequency of acute exacerbations and improving lung function and dyspnea symptoms, and limited attention has been paid to cough and expectoration symptoms, which may be associated with a decrease in lung function, more acute exacerbations, and hospitalizations. Therefore, this outcomes in patients with C...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 13, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Timing of Pulmonary Rehabilitation in Readmitted Patients with Severe Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial.
Authors: Güell-Rous MR, Morante-Vélez F, Flotats-Farré G, Paz-Del Río LD, Closa-Rusinés C, Ouchi-Vernet D, Segura-Medina M, Bolíbar-Ribas I Abstract Early pulmonary rehabilitation (PR), started during hospitalization or within the first month after discharge, has been shown to reduce exacerbations and improve health-related-quality of life (HRQoL) and exercise capacity. However, no randomized clinical trials (RCT) have compared the efficacy of PR started during hospitalization (DHPR) to PR initiated one month post-hospitalization (PHPR). We conducted an RCT to compare DHPR to...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 10, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

The Gini Coefficient: A New Approach to Assess Physical Activity Inequality in COPD.
Authors: Hirata RP, Oliveira JM, Schneider LP, Bertoche MP, Rodrigues LAL, Rodrigues A, Mantoani LC, Hernandes NA, Pitta F, Furlanetto KC Abstract Increasing physical activity (PA) is a complex and challenging task in patients with chronic obstructive pulmonary disease (COPD). However, some questions are raised regarding the evaluation of PA in these patients: Have all aspects of PA evaluation in patients with COPD already been explored in the scientific literature and clinical practice? What is the clinical importance of assessing PA inequality? PA inequality is defined as the Gini coefficient (Ginicoef) of the PA...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 28, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Disproportionally Impaired Diffusion Capacity Relative to Airflow Limitation in COPD.
This study tested whether a disproportionally impaired DLCO relative to FEV1 (FEV1 z-score>-3 and DLCO z-score≤-3) is a common functional COPD phenotype associated with distinct clinical and structural features and the prognosis of two cohorts. The cross-sectional analyses of the Korea COPD Subgroup Study (KOCOSS) cohort (multicenter study in Korea) included 743 males with COPD whose DLCO was available. The cross-sectional and longitudinal analyses of the Kyoto University Cohort (single-center study in Japan) included 195 males with COPD who were prospectively followed for 10 years. A disproportionally impaire...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 24, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Oscillometry as a Predictor of Exercise Tolerance in COPD.
Authors: Yamamoto A, Shirai T, Hirai K, Tanaka Y, Watanabe H, Endo Y, Shimoda Y, Suzuki T, Noguchi R, Mochizuki E, Sakurai S, Saigusa M, Akamatsu T, Shishido Y, Akita T, Morita S, Asada K Abstract The usefulness of the oscillometry, known as forced oscillation technique, for predicting exercise tolerance in subjects with COPD is unknown. To test the hypothesis, we investigated whether oscillometry could predict a 6-minute walking distance (6MWD)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 17, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

A Systematic Review of the Use of Physiological Tests Assessing the Acute Response to Treatment During Exacerbations of COPD (with a Focus on Small Airway Function).
Authors: Alobaidi NY, Almeshari M, Stockley JA, Sapey E, Edgar RG Abstract Exacerbations are prevalent in Chronic Obstructive Pulmonary Disease (COPD) patients and associated with poor clinical outcomes. Currently, there is a lack of sensitive and specific tools that can objectively identify exacerbations and assess their progress or treatment response. FEV1 is often reported as a study outcome, but it has significant limitations. Studies have suggested that small airways measures might provide physiological biomarkers during exacerbations. Therefore, this study was done to assess which physiological tests of small...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 17, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

The Effects of Endobronchial Coil Therapy on Right Ventricular Functions.
Authors: Kilic ID, Ugurlu E, Sevgican CI, Yigit N, Cetin N, Sen G, Kaya D Abstract Lung hyperinflation is an important therapeutic target in symptomatic emphysema patients. Endobronchial therapies that reduce end-expiratory lung volume are increasingly being used in advanced cases. However, there is paucity of data regarding the effects of these therapies on the heart functions. The aim of this study is to evaluate the right ventricular functions before and after the procedure in patients who underwent endobronchial coil therapy (EBCT). Patients who were between 18 and 80 years of age and scheduled for EBCT ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 11, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

One Year Change in 6-Minute Walk Test Outcomes is Associated with COPD Prognosis.
This study aimed to examine whether change in 6MWD and desaturation in 1 year were risk factors for later mortality, lung function decline and number of exacerbations. A total of 295 COPD patients performed 6MWT at baseline and 1 year later in the Bergen COPD cohort study 2006-2011. They were clinically examined and interviewed at annual visits. Mortality information was collected from the Norwegian Cause of Death Registry in 2015. We performed cox regression for mortality outcomes, linear mixed effect models for lung function, and negative binomial regression for exacerbations. Patients who desaturated in both 6MWT...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 11, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Coding of COPD Exacerbations and the Implications on Clinical Practice, Audit and Research.
Authors: Echevarria C, Steer J, Bourke SC Abstract International Classification of Disease 10 (ICD-10) codes record hospital admissions. We aimed to measure the accuracy of COPD exacerbation (ECOPD) codes and examine coding practices for COPD exacerbation. Prospective screening and ICD-10 codes were used to identify potential ECOPD within the DECAF internal validation cohort. Two coding searches were performed. The first search identified patients with an ECOPD discharge code, and a second, broad search was developed to identify all clinically confirmed ECOPD. 717 of 1,122 (64%) patients with an ECOPD code had conf...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 11, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Diagnostic Ability of Impulse Oscillometry in Diagnosis of Chronic Obstructive Pulmonary Disease.
Authors: Chaiwong W, Namwongprom S, Liwsrisakun C, Pothirat C Abstract The diagnosis of chronic obstructive pulmonary disease (COPD) mainly relies on spirometry. Due to the complexity of spirometry, easier-to-do impulse oscillometry (IOS) has been introduced as a complementary approach to conventional pulmonary function testing. Therefore, this study aimed to assess the efficacy of the diagnostic ability of IOS for diagnosing chronic obstructive pulmonary disease (COPD). This cross-sectional study was conducted at the Lung Health Center, Chiang Mai University, Thailand, between June 2019 and January 2020. IOS and s...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 1, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

What is the Impact of Outreach Services on Medication Adherence for COPD Patients? A Systematic Review.
Authors: Marron E, Patton D, O'Connor T, Moore Z, Murray B, Nugent LE Abstract Chronic obstructive pulmonary disease (COPD) patients have been known to have poor medication adherence rates. The purpose of this systematic review was to assess if outreach services could impact on medication compliance rates. CINAHL, Medline, Clinical Key and Cochrane library were all searched electronically along with grey literature for all eligible studies conducted on COPD patients in a non-acute hospital setting. Systematic review methodology was followed for data selection, extraction and risk of bias, validity testing and data ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - October 28, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Comprehensive Cluster Analysis for COPD Including Systemic and Airway Inflammatory Markers.
Authors: Zahraei HN, Guissard F, Paulus V, Henket M, Donneau AF, Louis R Abstract Chronic obstructive pulmonary disease (COPD) is a complex, multidimensional and heterogeneous disease. The main purpose of the present study was to identify clinical phenotypes through cluster analysis in adults suffering from COPD. A retrospective study was conducted on 178 COPD patients in stable state recruited from ambulatory care at University hospital of Liege. All patients were above 40 years, had a smoking history of more than 20 pack years, post bronchodilator FEV1/FVC
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - October 25, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Reliability and Validity of Patient-Reported, Rater-Based, and Hybrid Physical Activity Assessments in COPD: A Systematic Review.
Authors: Gore S, Chindam T, Goldberg A, Huang MH, Shoemaker M, Blackwood J Abstract Selecting valid and reliable PA assessments in chronic obstructive pulmonary disease (COPD) is crucial to ensure that the information obtained is accurate, valuable, and meaningful. The purpose of this systematic review was to compare the validity and reliability among PA assessments in COPD. An electronic database search of PubMed and CINAHL was completed in December 2019 using MeSH terms on physical activity, COPD, validation, and questionnaires. Transparency in reporting was assessed with the STrengthening the Reporting of OBserv...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - October 21, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Asthma-COPD Overlap (ACO) PRO-CON Debate. ACO: Call Me by My Name.
Authors: Miravitlles M PMID: 33043715 [PubMed - in process] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - October 14, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Asthma COPD Overlap PRO-CON Debate. ACO: The Mistaken Term.
Authors: Papi A PMID: 33043716 [PubMed - in process] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - October 14, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

The Correlation of Sit-to-Stand Tests with COPD Assessment Test and GOLD Staging Classification.
This study was conducted on a sample of 42 COPD subjects with patient history, COPD assessment test (CAT) and spirometry. 5STST performance time and the number 30s-STST repetitions showed differences of statistical significance in COPD subjects considered to be more symptomatic and in subjects with high risk of future exacerbations. Both STSTs correlated significantly with forced expiratory volume in one second % predicted (FEV1%), CAT, number of acute exacerbations in the past year and number of hospitalized exacerbations in the past year. STST performance correlates significantly with items of the CAT questionnaire that ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - October 9, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Predictors of NIV Treatment in Patients with COPD Exacerbation Complicated by Respiratory Acidaemia.
Authors: Echevarria C, Steer J, Hartley T, Lane N, Bourke SC Abstract Non-invasive ventilation (NIV) treatment decisions are poorly understood for patients with COPD exacerbation complicated by acute hypercapnic respiratory failure and respiratory acidaemia (ECOPD-RA). We identified 420 NIV-eligible patients from the DECAF study cohorts admitted with an ECOPD-RA. Using bivariate and multivariate analyses, we examined which indices were associated with clinicians' decisions to start NIV, including whether the presence of pneumonia was a deterrent. Admitting hospital, admission from institutional care, partial pressu...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - October 2, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Enhancing Confidence and Coping with Stigma in an Ambiguous Interaction with Primary Care: A Qualitative Study of People with COPD.
This study's aim was to explore how people with COPD experience COPD-related interactions with healthcare professionals in primary care, and how these interactions influence their self-management and how they cope with their disease. Interviews were performed with eight women and five men with COPD, and grounded theory guided data collection and analysis. The analysis resulted in a theoretical model and the core category (Re)acting in an ambiguous interaction, representing a dynamic process in which healthcare priorities, healthcare professionals' attitudes and participants' personal emotions were important for the partici...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 29, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

S100A9/CD163 Expression in Circulating Classical Monocytes in Chronic Obstructive Pulmonary Disease.
This study aimed to determine the influence of cigarette smoking and COPD on the cellular phenotype of circulating monocytes. Thirty-two patients with COPD and 36 healthy volunteers (n = 17 and 19 in nonsmokers and smokers with normal lung functions, respectively) were enrolled in this study. The expression of two cell surface markers, pro-inflammatory-related S100A9 and anti-inflammatory-related CD163, on classical monocytes was analyzed by flow cytometry. The percentage of CD14strongCD16- classical monocytes in circulating monocytes showed no difference among the three groups. The percentage of S100A9+, S10...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 25, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

The Identification and Cost of Acute Chronic Obstructive Pulmonary Disease Exacerbations in a United States Population Healthcare Claims Database.
Authors: Stanford RH, Engel-Nitz NM, Bancroft T, Essoi B Abstract Almost half of chronic obstructive pulmonary disease (COPD) exacerbations are estimated to be inaccurately reported by patients, inconsistently recorded in medical records, or not measured due to coding errors inherent to administrative claims. This retrospective observational study aimed to develop an algorithm capable of detecting acute COPD exacerbations (AECOPD) in healthcare claims and estimate costs associated with AECOPD over a 12-month period. Commercial and Medicare Advantage healthcare plan members (≥40 years old) with evidence of...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 25, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

COPD Maintenance Therapy with Tiotropium/Olodaterol Compared with Tiotropium: An Analysis in the Absence of Additional ICS Therapy.
Authors: Calverley PMA, Hoz A, Xue W, Ferguson GT, Miravitlles M Abstract The American Thoracic Society guidelines recommend long-acting β2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) dual bronchodilation over LAMA or LABA monotherapy as maintenance therapy for patients with chronic obstructive pulmonary disease suffering from dyspnea or exercise intolerance. Previous studies, which included patients receiving background inhaled corticosteroids (ICS), have shown the benefits of dual bronchodilation over monotherapy. This analysis aimed to confirm the benefits of LAMA/LABA over LAMA alone, without a...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 18, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Obstructive Sleep Apnea Increases the Prevalence of Hypertension in Patients with Chronic Obstructive Disease.
Authors: Hu W, Zhao Z, Wu B, Shi Z, Dong M, Xiong M, Jiang Y, Liu D, Li H, Hu K Abstract Whether there are increased rates of chronic diseases associated with the combination of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) overlap syndrome (OVS) has not been determined. The purpose of this study was to assess the prevalence of five comorbidities in COPD and OVS patients. A total of 968 patients with confirmed COPD were included in this study. Participants were requested to fill out a questionnaire involving their basic information and medical history. All subjects underwent one ove...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 11, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Telemedicine in COPD: An Overview by Topics.
Authors: Barbosa MT, Sousa CS, Morais-Almeida M, Simões MJ, Mendes P Abstract COPD is a major cause of morbidity and mortality worldwide and carries a huge and growing economic and social burden. Telemedicine might allow the care of patients with limited access to health services and improve their self-management. During the COVID-19 pandemic, patient's safety represents one of the main reasons why we might use these tools to manage our patients. The authors conducted a literature search in MEDLINE database. The retrieval form of the Medical Subject Headings (Mesh) was ((Telemedicine OR Tele-rehabilitation O...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 9, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

PredictAAT: Accounting for Inflammation in the Diagnosis of Alpha 1 Antitrypsin Deficiency.
Authors: Kueppers F Abstract Alpha 1 antitrypsin deficiency (AATD) is a rarely diagnosed hereditary condition characterized by low alpha 1 antitrypsin (AAT) levels, which can lead to early-onset emphysema due to accelerated degradation of lung tissue. Similar to C-reactive protein (CRP), AAT is an acute phase reactant, meaning that blood levels rise in response to inflammation, injury or infection. Testing AAT levels is essential in the diagnosis of AATD; however, the presence of inflammation at the time of AATD testing can provide a false 'normal' level reading of the patient's baseline AAT levels. Researchers fro...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 1, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

New Mexico Female Miners Have Lower Odds for COPD than Their Male Counterparts.
Authors: Assad N, Sen P, Shore X, Myers O, Armstrong E, Cook LS, Sood A Abstract Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity among miners. There is an increasing number of women in the mining industry and the differences in their risk for COPD compared to men miners are not understood. Our objective is to compare the odds for COPD between male and female miners. Using cross-sectional data from the Mining Dust in the United States (MiDUS) Cohort, that included New Mexico miners between 1989 and 2018, we compared the odds for airflow obstruction or chronic bronchitis between women...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 26, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Decreased Bone Type I Collagen in the Early Stages of Chronic Obstructive Pulmonary Disease (COPD).
Authors: Junqueira JJM, Lourenço JD, da Silva KR, Cervilha DAB, da Silveira LKR, Correia AT, Silva LEF, Teodoro WR, Tibério IFLC, Barbosa AP, Lopes FDTQDS Abstract Smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD) and is known to have deleterious effects on bone metabolism. However, the effects on bone collagen matrix during the development of COPD are unclear. The aim of this study was to evaluate the temporal effect of cigarette smoke exposure on bone type I collagen during COPD development in a cigarette smoke-induced model. C57BL/6 mice were alloca...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 22, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Test-Retest Reliability of Handgrip Strength in Patients with Chronic Obstructive Pulmonary Disease.
Authors: Karagiannis C, Savva C, Korakakis V, Matheou I, Adamide T, Georgiou A, Xanthos T Abstract The purpose of this study was to investigate the intra-rater reliability and agreement of handgrip strength (HGS) measurement using a hydraulic hand dynamometer in patients with chronic obstructive pulmonary disease (COPD). A sample of 19 COPD patients (18 males and 1 female; mean ± SD age, 66.9 ± 6.3 years) was evaluated using a hand dynamometer by the same rater in two different testing sessions with a 7-d interval. During each session, patients were asked to exert th...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 22, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Description of Participation in Daily and Social Activities for Individuals with COPD.
This study described the participation in daily and social activities and the perceived barriers and facilitators to participation of individuals with chronic obstructive pulmonary disease (COPD). Individuals, recruited from outpatient clinics, responded to a survey on their participation in, and barriers and facilitators towards, 26 daily and social activities, divided into 3 categories: (1) physical activity and movement (PAM); (2) self-care; and (3) social engagement. For each activity, chi-square analyses were used to examine participation differences by individuals': quartiles of airflow obstruction [percent predicted...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 20, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

A Lay Health Worker Intervention to Increase Uptake and Completion of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease: Assessing Fidelity of Intervention Delivery.
We present here the feasibility of assessment, and the fidelity of delivery of LHW support achieved for COPD patients referred for PR. LHWs, volunteer COPD patients experienced in PR, received training in the intervention including communication skills, confidentiality and behaviour change techniques (BCTs). Interactions between LHWs and patients were recorded, transcribed and coded for delivery style and BCTs. Inter-rater agreement on the coding of delivery style and BCTs was high at>84%. LHWs built rapport and communicated attentively in over 80% of interactions. LHWs most consistently delivered BCTs concerning inform...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 19, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

The Importance of Reference Centers and Registries for Rare Diseases: The Example of Alpha-1 Antitrypsin Deficiency.
Authors: Miravitlles M, Nuñez A, Torres-Durán M, Casas-Maldonado F, Rodríguez-Hermosa JL, López-Campos JL, Calle M, Rodríguez E, Esquinas C, Barrecheguren M Abstract Alpha-1 antitrypsin deficiency (AATD) is a rare and underdiagnosed disease that is associated with the development of liver disease in adults and children and pulmonary emphysema in adults. Several studies have shown that there is limited knowledge about the disease and its diagnosis among health care providers, and there is an important inequity in the access to specialized care and appropriate treatment across Europ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 16, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Decreased Risk of COPD Exacerbations in Obese Patients.
Authors: Smulders L, van der Aalst A, Neuhaus EDET, Polman S, Franssen FME, van Vliet M, de Kruif MD Abstract Survival in chronic obstructive pulmonary disease (COPD) is enhanced in obese patients, which is called the obesity paradox. Despite some theories, the precise mechanism remains unclear. Since COPD exacerbations play a major role in COPD survival, this study aimed to stratify patients into BMI classes and investigate exacerbation frequency, time to readmission and survival in patients hospitalized with a COPD exacerbation. Therefore, patients hospitalized with an exacerbation of COPD were categorized into B...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 13, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Genetic Polymorphisms of CYP2C9/CYP2C19 in Chronic Obstructive Pulmonary Disease.
In this study, a total of 821 subjects were recruited which include 313 COPD cases and 508 healthy controls. Seven SNPs of CYP2C9/CYP2C19 were selected for genotyping. The odds ratios (ORs) and 95% confidence interval (95% CI) were calculated using logistic regression analysis to evaluate the association between COPD risk and CYP2C9/CYP2C19 polymorphisms. Our study showed that A allele of rs9332220 in CYP2C9 was associated with reducing COPD risk (OR = 0.64, 95% CI = 0.43-0.94, p = 0.021). And rs111853758 G allele carrier could significantly decrease 0.35-fold COPD risk comp...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 13, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Relationship between Distress Related to Caregiver Burden and Physical Activity in Informal Caregivers of Patients with COPD.
This study aimed to explore the relationship between distress and PA in informal caregivers of patients with COPD, and the influence of caregivers' (age, sex) and patients' (age, sex, lung function) characteristics and caregiving duration on this relationship. A cross-sectional study was conducted with 50 caregivers (62.7 ± 9.8 years, 88% female; 78% caring for a spouse/partner; 38% caring>40 h/week; patients' FEV1=45.2 ± 21.3% predicted). Data collection comprised questions related to the caregiving context, distress related to caregiving burden assessed with the ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 13, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Multiple Gene Expression Dataset Analysis Reveals Toll-Like Receptor Signaling Pathway is Strongly Associated With Chronic Obstructive Pulmonary Disease Pathogenesis.
Authors: Dhamodharan P, Arumugam M Abstract Chronic obstructive pulmonary disease is a complex pulmonary disease that causes airflow obstruction in humans. To identify the core genes in COPD pathogenesis, seven diverse microarray datasets (GSE475, GSE1122, GSE1650, GSE3212, GSE8823, GSE37768, and GSE22148) were downloaded from the gene expression omnibus database. All the datasets were analyzed independently with the R/Bioconductor package to screen the differentially expressed genes (DEGs). The gene ontology and pathway enrichment analysis were performed for the acquired DEGs using DAVID (Database for Annotation, ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 13, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Prevalence and Characteristics of Undiagnosed COPD in Adults 40 Years and Older - Reports from the Tunisian Population-Based Burden of Obstructive Lung Disease Study.
This study aimed to investigate the underdiagnosis of COPD and its determinants based on the Tunisian Burden of Obstructive Lung Disease study. We collected information on respiratory history symptoms and risk factors for COPD. Post-bronchodilator (Post-BD) FEV1/FVC 
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 13, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence.
This study aimed to investigate whether the pharmacological SIRT1 activator SRT2104 protects against AECII senescence in rats with emphysema. Our findings confirmed that SRT2104 administration reduced the pathological characteristics of emphysema and improved lung function parameters, including pulmonary resistance, pulmonary dynamic compliance, and peak expiratory flow. Moreover, SRT2104 treatment upregulated the expression of surfactant proteins A and C, SIRT1, and forkhead box O 3a (FoxO3a), decreased senescence-associated-β-galactosidase (SA-β-gal) activity, increased SIRT1 deacetylase activity, and downregul...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 31, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Inspiratory Muscle Training Potentiates the Beneficial Effects of Proportional Assisted Ventilation on Exertional Dyspnea and Exercise Tolerance in COPD: A Proof-of-Concept Randomized and Controlled Trial.
Authors: Koch R, Augusto TRL, Ramos AG, Müller PT Abstract During pulmonary rehabilitation, a subset of subjects with COPD requires adjunct therapy to achieve high-intensity training. Both noninvasive ventilation (NIV) and inspiratory muscle training (IMT) are available to assist these subjects. We aimed to prime the respiratory muscles before NIV with IMT, anticipating additive effects for maximal exercise tolerance (T lim) and dyspnea/leg fatigue relief throughout the exercise as primary outcomes. Changes in the respiratory pattern were secondary outcomes. COPD subjects performed a total of four identical co...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 23, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

The COVID-19 Pandemic Confronts the Motivation Fallacy within Pulmonary Rehabilitation Programs.
Authors: Karloh M, Sousa Matias T, Fleig Mayer A Abstract Social distancing and quarantines have been implemented worldwide to reduce the spread of Coronavirus Disease (COVID-19). However, social distancing has had far-reaching health consequences, considering that the COVID-19 pandemic has exposed people to the hazard of physical inactivity and sedentary behavior. For patients with Chronic Obstructive Pulmonary Disease (COPD), which is one of the main diseases at risk for COVID-19, the impact is even greater since outpatient pulmonary rehabilitation (PR) programs are temporarily closed. More than ever, patients' b...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 14, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Daily Impact of COPD in Younger and Older Adults: Global Online Survey Results from over 1,300 Patients.
Authors: Dekhuijzen PNR, Hass N, Liu J, Dreher M Abstract The daily impact of chronic obstructive pulmonary disease (COPD) on younger patients is often underappreciated. To assess this, we investigated the disease burden experienced by younger and older patients. A panel of questions was developed in conjunction with the European Federation of Allergy and Airways Diseases Patients' Associations and Boehringer Ingelheim. The online survey was conducted by Instar Research. Data were collected from eight countries in Europe, plus China, Japan and the United States. All patients were receiving COPD maintenance therapy....
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 10, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Risk of Pneumonia with Different Inhaled Corticosteroids in COPD Patients: A Meta-Analysis.
Authors: Zhang Q, Li S, Zhou W, Yang X, Li J, Cao J Abstract ICS are anti-inflammatory agents which have been suggested to benefit people with worsening symptoms of COPD, by improving lung function, reducing exacerbation of disease, and enhancing overall quality of life. This systematic review and meta-analysis explored the association of the risk of pneumonia in COPD patients that were undergoing treatment using ICS alone or together with LABAs or LAMAs. PubMed, Cochrane Library and EMBASE were systematically searched through August 1, 2019; only double-blinded randomized controlled trials were eligible for this s...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 10, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

The Relationship between Self-Efficacy, Functional Exercise Capacity and Physical Activity in People with COPD: A Systematic Review and Meta-Analyses.
Authors: Selzler AM, Moore V, Habash R, Ellerton L, Lenton E, Goldstein R, Brooks D Abstract The purpose of this study was to investigate the strength of the relationships between self-efficacy and (i) functional exercise capacity and (ii) physical activity in chronic obstructive pulmonary disease (COPD), and whether self-efficacy assessment type (i.e., COPD symptoms, exercise-task, exercise-barrier, general, falls) and physical activity assessment type (i.e., self-report vs. objective) are moderators. A systematic search of COPD and self-efficacy concepts was conducted using eight databases from inception to 23 Ja...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 9, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Validity and Responsiveness of the Glittre-ADL Test without a Backpack in People with Chronic Obstructive Pulmonary Disease.
Authors: Mendes LPS, Parreira VF, Spencer LM, Vieira DSR, Alison JA Abstract The Glittre-ADL test assesses the functional capacity for activities of daily living of people with chronic obstructive pulmonary disease (COPD). In the test, a weighted backpack is worn (2.5 kg for women and 5.0 kg for men). The differential in weight between men and women is not common in other tests of exercise capacity and may limit the comparison of the test between sexes. The primary aim of this study was to validate the Glittre-ADL test performed without the backpack in people with COPD. Forty participants with mild to...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 1, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Alveolar Macrophage Phenotype and Compartmentalization Drive Different Pulmonary Changes in Mouse Strains Exposed to Cigarette Smoke.
Authors: De C.o G, Cavarra E, Bartalesi B, Lungarella G, Lucattelli M Abstract COPD can manifest itself with different clinical phenotypes characterized by different disease progression and response to therapy. Although a remarkable number of studies have been carried out, little is known about the mechanisms underlying phenotypes that could guide the development of viable future therapies. Several murine strains mirror some human phenotypes after smoke exposure. It was of interest to investigate in these strains whether different pattern of activation of macrophages, and their distribution in lungs, is associated ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 1, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research