A Systematic Review and Meta-Analysis of Sputum Purulence to Predict Bacterial Infection in COPD Exacerbations.
Authors: Chen K, Pleasants KA, Pleasants RA, Beiko T, Washburn RG, Yu Z, Zhai S, Drummond MB Abstract The 2020 Global Initiative for Obstructive Lung Disease (GOLD) Report highlights the importance of sputum purulence in the decision to prescribe antibiotics for acute exacerbations. The purpose of this systematic review and meta-analysis was to evaluate the strength of literature supporting inclusion of sputum purulence in criteria utilized to evaluate if antimicrobials are indicated in acute COPD exacerbation. A total of 6 observational studies met inclusion criteria for this meta-analysis. Sputum purulence was de...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 28, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Changes in Oxyhemoglobin Concentration in the Prefrontal Cortex during Cognitive-Motor Dual Tasks in People with Chronic Obstructive Pulmonary Disease.
This study evaluated and compared cognitive and motor performance during dual tasks and related dorsolateral prefrontal cortex (PFC) changes in oxygenated hemoglobin (ΔO2Hb), a proxy measure of neural activity, in patients with COPD and age-matched healthy individuals. Participants performed three single tasks: (1) backwards spelling cognitive task; (2) 30 m preferred paced walk; (3) 30 m fast walk, and two dual tasks: (4) preferred paced walk + backwards spelling; (5) fast paced walk + backwards spelling. The ΔO2Hb from left and right dorsolateral PFC were measured usi...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 24, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

An Evaluation of Service Provision and Novel Strength Assessment on Patient Outcomes in a UK-Based Pulmonary Rehabilitation Setting.
This study's purpose was to (i) assess the impact of a 7-week pulmonary rehabilitation (PR) programme upon patient outcomes; incremental shuttle walk test (ISWT), COPD assessment tool (CAT), Clinical COPD Questionnaire (CCQ) and the Hospital Anxiety and Depression Scale (HADS); (ii) assess the impact of COPD severity on ISWT, psychological functioning and quality of life measures following PR; (iii) assess the feasibility of incorporating individually prescribed one repetition maximum (1RM) training loads into the existing strength training programme. Patients were people with COPD enrolled onto one of three versions (loca...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 20, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Analysis of Blood Biomarkers in Patients with Chronic Obstructive Pulmonary Disease (COPD) and with Asthma-COPD Overlap (ACO).
Authors: Gava G, Núñez A, Esquinas C, Sarasate M, Loeb E, Pirina P, Miravitlles M, Barrecheguren M Abstract Chronic obstructive pulmonary disease (COPD) is a heterogeneous entity with different clinical phenotypes, such as asthma-COPD overlap (ACO). The aim of this retrospective study was to compare routine blood biomarkers in patients with ACO and the remaning COPD phenotypes. Data were collected from stable COPD patients visited in during 2018, including C-reactive protein (CRP), fibrinogen, neutrophyl/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR).A total of 77 patients with COPD were i...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 10, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Incidence, Characteristics, and Outcomes of Acute Myocardial Infarction among Patients Admitted with Acute Exacerbation of Chronic Obstructive Lung Disease.
Authors: Alqahtani F, Welle GA, Elsisy MF, Kalra A, Alhajji M, Boubas W, Berzingi C, Alkhouli M Abstract The frequency, characteristics and outcomes of acute myocardial infarction (AMI) during exacerbation of chronic obstructive pulmonary disease (COPD) are unknown. Adult patients hospitalized with a principle diagnosis of acute COPD exacerbation were identified using retrospective analysis of the Nationwide Inpatient Sample (NIS) from 2003 to 2016. Patients were stratified into 2-groups with and without a secondary diagnosis of AMI. The study's endpoints were in-hospital morbidity, mortality, and resource utilizat...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 7, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

CD147 Promoted Epithelial Mesenchymal Transition in Airway Epithelial Cells Induced by Cigarette Smoke via Oxidative Stress Signaling Pathway.
In conclusion, CD147 promoted EMT in mice and HBE cells induced by cigarette smoke via oxidative stress signaling pathway. PMID: 32366134 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 7, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Clinical Outcomes and Inflammatory Responses of the Frequent Exacerbator in Pulmonary Rehabilitation: A Prospective Cohort Study.
Authors: Jenkins AR, Holden NS, Gibbons LP, Jones AW Abstract Frequent exacerbators of Chronic Obstructive Pulmonary Disease (COPD) is a distinct clinical phenotype characterised by systemic inflammation. Study objectives were to determine clinical outcomes of pulmonary rehabilitation in frequent exacerbators and the impact this has on the key surrogate markers of this phenotype. Eighty-five mild-very severe COPD patients (FEV1 pred, 52 ± 18%) were categorised as frequent (≥2 exacerbations per year, n = 50) or infrequent exacerbators (≤1 exacerbation per year, n =&thi...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 5, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

COPD Positive Screening with Spirometry Increases Motivation to Quit Tobacco Smoking in an Addiction Treatment Center.
Authors: Clergue-Duval V, Lair R, Lefebvre-Durel C, Barré T, Gautron MA, Mehtelli W, Bellivier F, Questel F, Vorspan F Abstract Providing an on-site immediate diagnosis of Chronic Obstructive Pulmonary Disease (COPD) and lung age in tobacco smokers could be a motivational tool for smoking cessation. Our aim was to investigate the effects of an abnormal spirometry results on motivational change and subsequent smoking cessation. We conducted a retrospective analysis of smoking status after 3 months of tobacco counseling. Patients were recruited in an addiction outpatient center. Spirometry results were ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 28, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Alpha-1 Antitrypsin Deficiency and Pregnancy.
Authors: Gaeckle NT, Stephenson L, Reilkoff RA Abstract Alpha-1 Antitrypsin Deficiency (A1AD) is a hereditary condition characterized by low levels of circulating alpha-antitrypsin (AAT) in plasma. It is the best understood genetic risk factor for the development of chronic obstructive pulmonary disease (COPD). The diagnosis of A1AD is under-recognized. While there is a significant heterogeneity in disease presentation in relation to the severity of symptoms and prognosis, it is not uncommon for young individuals, including pregnant women to already have moderate to advanced lung disease at the time of diagnosis. R...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 21, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

COPD Patients Have a Restricted Breathing Pattern That Persists with Increased Metabolic Demands.
Authors: Yentes JM, Fallahtafti F, Denton W, Rennard SI Abstract A healthy respiratory system has variability from breath-to-breath and patients with COPD (PwCOPD) have abnormal variability in breath cycles. The aim of this study was to determine if interbreath-interval and tidal-volume variability, and airflow regularity change as metabolic demands increase (seated, standing, and walking) in PwCOPD as compared to controls. Sixteen PwCOPD (64.3 ± 7.9 yr, 61.3 ± 44.1% FEV1%predicted) and 21 controls (60.2 ± 6.8 yr, 97.5 ±&thin...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 18, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Adding a Second Bronchodilator in COPD: A Meta-Analysis on the Risk of Specific Cardiovascular Serious Adverse Events of Tiotropium/Olodaterol Fixed-Dose Combination.
This study aimed to ascertain whether tiotropium/olodaterol (T/O) 5/5 μg fixed-dose combination (FDC) may modulate the risk of main cardiovascular outcomes in COPD patients enrolled in randomized controlled trials (RCTs). A meta-analysis (CRD42017070100) was performed by selecting RCTs reporting raw data from the ClinicalTrials.gov database concerning the impact of T/O 5/5 µg FDC vs. monocomponents on the occurrence of specific cardiovascular serious adverse events: arrhythmia, heart failure, myocardial infarction, and stroke. Data were reported as relative risk and 95% Confidence Interval, and the r...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 8, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Understanding the Knowledge Gap and Assessing Comfort Level among Healthcare Professionals Who Provide Inhaler Education.
Authors: Karle E, Patel TP, Zweig J, Krvavac A Abstract Inhaled medications play a pivotal role in the management of COPD and asthma. Provider knowledge and ability to teach various devices is paramount as poor inhaler technique directly correlates with worse disease control. The goal of our survey was to assess the knowledge and comfort level with various inhaled devices among providers involved in patient inhaler education. We constructed a 20-question survey consisting of a five-question Likert scale-based comfort assessment and a 15-question multiple-choice inhaler knowledge test that was distributed both inter...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 4, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Ratio of Maximal Inspiratory to Expiratory Flow Aids in the Separation of COPD from Asthma.
The objective of this study was to test the value of adding a maximal inspiratory manoeuvre to basic spirometry to differentiate COPD and BA. One hundred forty-three COPD patients and 142 BA patients had measurements of maximal inspiratory and expiratory flow during routine spirometry. Parameters from these tests were used to assess diagnostic accuracy using receiver-operating characteristic (ROC) analyses followed by logistic regression. The association of two independent parameters were analyzed using linear regression analyses. Results show that forced expiratory volume in one second/forced vital capacity (FEV1/FVC%)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 4, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Quercetin Attenuates Acute Lung Injury Caused by Cigarette Smoke Both In Vitro and In Vivo.
Authors: da Silva Araújo NP, de Matos NA, Leticia Antunes Mota S, Farias de Souza AB, Dantas Cangussú S, Cunha Alvim de Menezes R, Silva Bezerra F Abstract Cigarette smoke is highly toxic and is a major risk factor for airway inflammation, oxidative stress, and decline in lung function-the starting points for chronic obstructive pulmonary disease. Quercetin is a potent dietary antioxidant that displays anti-inflammatory activities. The goal of this study was to evaluate the effects of quercetin on reducing the redox imbalance and inflammation induced by short-term cigarette smoke exposure. In vitro, 2...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 4, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Patterns and Correlates of Sedentary Behaviour Accumulation and Physical Activity in People with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study.
This study aimed to quantify sedentary behaviour (SB), patterns of SB accumulation and physical activity (PA) in people with COPD, and to examine physiological and functional capacity correlates of total SB and patterns of SB accumulation. SB and PA were assessed continuously over seven days using thigh-worn accelerometery in people with COPD. Participants were regarded as "sedentary" if combined sitting/reclining time accounted for ≥70% of waking wear time. Differences in patterns of SB accumulation and PA were compared between "sedentary" and "non-sedentary" participants. Physiological an...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 29, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

COPD Patients' Experience of Long-Term Domestic Oxygen-Enriched Nasal High Flow Treatment: A Qualitative Study.
Authors: Storgaard LH, Weinreich UM, Laursen BS Abstract Little is known about chronic obstructive pulmonary disease (COPD) patients experience with home-based health treatments, which are currently rapidly evolving. A previous randomized controlled trial investigated the use of long-term oxygen enriched high flow nasal cannula (HFNC) treatment at home. The aim of this study was to explore COPD patients' experience using home HFNC treatment. Patients in this qualitative study were included from the previous RCT. All patients used long-term oxygen therapy and HFNC, the latter as a primarily nocturnal add-on. Data we...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 19, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

The Impact of Pulmonary Rehabilitation on Chronic Pain in People with COPD.
This study aimed to 1) determine the effect of PR on pain qualities, coping behavior and psychological symptoms in those with COPD and chronic pain; and 2) assess the impact of PR on exercise capacity and quality of life in individuals with COPD and chronic pain compared to those without pain. Patients with COPD and comorbidities enrolling in outpatient PR were assessed for chronic pain. Those with chronic pain completed the Brief Pain Inventory, Coping Strategies Questionnaire-24, Fear Avoidance Behavior Questionnaire and measures of anxiety and depression. Changes in HRQOL and 6-minute walk distance (6MWD) following PR w...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 6, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

A Simplified Screening Questionnaire for Detecting Severe OSA in Chronic Obstructive Airway Disease in Asian Population.
Authors: Wang TY, Tsai MH, Ni YL, Lin TY, Huang SY, Lo YL Abstract The aim of this study was to develop a simplified screening questionnaire to detect the existence of severe obstructive sleep apnea (OSA) in chronic obstructive pulmonary disease (COPD) patients to reduce mortality and hospitalization rates. Seventy-seven stable Asian COPD patients aged 69.2 ± 11.5 years were retrospectively analyzed into the development group. The simplified screening questionnaire was developed from factors identified from sleep surveys and demographic data to predict severe OSA. Receiver operating char...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 6, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Varenicline for Long Term Abstinence in Acute COPD- the Dilemma Continues.
Authors: Rathi V, Hadda V, Mittal S, Mohan A PMID: 32116036 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 4, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Fractional Exhaled Nitric Oxide is Associated with the Severity of Stable COPD.
Authors: Liu X, Zhang H, Wang Y, Lu Y, Gao Y, Lu Y, Zheng C, Yin D, Wang S, Huang K Abstract The value of fractional exhaled nitric oxide (FeNO) in patients with chronic obstructive pulmonary disease (COPD) remains unclear. We aimed to assess whether FeNO is a more valuable biomarker than blood eosinophil count for identifying clinical characteristics of COPD. Stable COPD patients (n = 390) were included and stratified by FeNO and blood eosinophil counts at recruitment. The demographic characteristics, lung functions, St George Respiratory Questionnaire (SGRQ), serum inhaled allergen-specific IgE and ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 4, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

High Flow Nasal Therapy Use in Patients with Acute Exacerbation of COPD and Bronchiectasis: A Feasibility Study.
Authors: Crimi C, Noto A, Cortegiani A, Campisi R, Heffler E, Gregoretti C, Crimi N Abstract The efficacy and feasibility of high flow nasal therapy (HFNT) use in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and bronchiectasis is unknown. We performed a single-center, single-arm prospective observational study in patients with AECOPD, documented bronchiectasis, pH ≥ 7.35, respiratory rate (RR) ≥ 26 breaths/minute despite receiving maximal medical treatment and oxygen via face mask up to 10 L/m. Patients received HFNT (Airvo 2, Fisher & Paykel) at a gas flow of ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 25, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Handgrip Strength Seems Not to Be Affected by COPD Disease Progression: A Longitudinal Cohort Study.
Authors: Kohlbrenner D, Sievi NA, Roeder M, Thurnheer R, Leuppi JD, Irani S, Frey M, Brutsche M, Brack T, Kohler M, Clarenbach CF Abstract Skeletal muscle dysfunction, functional exercise capacity impairment and reduced physical activity are characteristic features in patients with chronic obstructive pulmonary disease (COPD). Assessments addressing muscle strength of the upper limb, such as measurement of handgrip strength (HGS), are rarely performed and reported. We aimed to analyze the course of HGS and possible predictors of changes in HGS over time in COPD. Yearly assessments of various disease markers were pe...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 21, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Health Care Utilisation and Health Needs of People with Severe COPD in the Southern Region of New Zealand: A Retrospective Case Note Review.
We examined health care utilisation and needs of people with severe COPD in the low-population-density setting of the Southern Region of New Zealand (NZ). We undertook a retrospective case note review of patients with COPD coded as having an emergency department attendance and/or admission with at least one acute exacerbation during 2015 to hospitals in the Southern Region of NZ. Data were collected and analysed from 340 case notes pertaining to: demographics, hospital admissions, outpatient contacts, pulmonary rehabilitation, advance care planning and comorbidities. Geometric mean (95%CI) length of stay for hospital admis...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 11, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Prevalence of Airflow Obstruction as Measured by Spirometry, in Rural Southern Indian Adults.
This study assessed the prevalence of spirometry-defined airflow obstruction in Vellore, Tamil Nadu.A cross sectional survey was done in nine villages, among adults aged ≥30 years, where previous cardiovascular surveys had been conducted (1994, 2011). Population proportional to size sampling was used to select 20 clusters, with sampling from all streets proportional to the number of households. One person randomly selected per household was interviewed for symptoms and risk factors. A respiratory therapist performed pre and post bronchodilator spirometry on all, following American Thoracic Society criteria. Airfl...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 7, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

The Glittre ADL-Test Differentiates COPD Patients with and without Self-Reported Functional Limitation.
This study aims to analyze if difficulty to perform ADLs, as self-reported by patients with COPD, would reflect a worse Glittre ADL-test performance. In the first visit, patients were evaluated for clinical and nutritional status, spirometry, maximal cardiopulmonary exercise test on a treadmill. One week later, the patients performed two Glittre ADL-tests. Maximal voluntary ventilation (MVV) and the VEGlittre/MVV, VO2Glittre/VO2peak, and HRGlittre/HRpeak ratios were calculated to analyze the ventilatory, metabolic, and cardiac reserves. The London Chest Activity of Daily Living (LCADL) scale was only answered after the two...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 1, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Accuracy of WatchPAT for the Diagnosis of Obstructive Sleep Apnea in Patients with Chronic Obstructive Pulmonary Disease.
Authors: Jen R, Orr JE, Li Y, DeYoung P, Smales E, Malhotra A, Owens RL Abstract The co-existence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), termed the overlap syndrome (OVS), is associated with adverse outcomes that may be reversed with treatment. However, diagnosis is limited by the apparent need for in-laboratory polysomnography (PSG). WatchPAT is a portable diagnostic device that is validated for the diagnosis of OSA that might represent an attractive tool for the diagnosis of OVS.Subjects with established COPD were recruited from a general population. Subjects underwent ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 24, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Nasal High Flow Use in COPD Patients with Hypercapnic Respiratory Failure: Treatment Algorithm & Review of the Literature.
Nasal High Flow Use in COPD Patients with Hypercapnic Respiratory Failure: Treatment Algorithm & Review of the Literature. COPD. 2020 Jan 22;:1-11 Authors: Pantazopoulos I, Daniil Z, Moylan M, Gourgoulianis K, Chalkias A, Zakynthinos S, Ischaki E Abstract Nasal high flow (NHF) therapy has recently gained attention as a new respiratory support system and is increasingly being utilized in every day clinical practice. Recent studies suggest that it may also be effective in patients with hypercapnia and suggest NHF as a possible alternative for patients who cannot tolerate standard noninvasive ventilat...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 24, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Validity of the Medication Adherence Rating Scale for Adherence to Inhaled Corticosteroids among Older Adults with Asthma or Chronic Obstructive Pulmonary Disease.
Authors: Tangirala NC, O'Conor R, Wolf MS, Wisnivesky JP, Federman AD Abstract Regular use of inhaled corticosteroids (ICS) is the standard of care for patients with persistent asthma and chronic obstructive pulmonary disease (COPD). Adherence to ICS is measured using the 10-item Medication Adherence Report Scale (MARS), a self-reported medication adherence assessment. However, data on the validity of this measure are limited. Data were obtained from two cohort studies that examined the association of health literacy with self-management behaviors among adults ages 65 and older with asthma and adults ages 40 and ol...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 19, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Underutilization of Pulmonary Function Testing in Veterans Hospitalized for Chronic Obstructive Pulmonary Disease Exacerbation: Who are We Missing?
Authors: Bade BC, DeRycke EC, Skanderson M, Crothers K, Haskell S, Bean-Mayberry B, Cain HC, Brandt C, Bastian LA, Akgün KM Abstract Pulmonary function testing (PFT) is required to diagnose chronic obstructive pulmonary disease (COPD) but is completed for only 30-50% of patients with the disease. We determined patient factors associated with decreased likelihood for PFT acquisition (i.e. underutilization) in the United States Veterans Affairs (VA) health care system.We performed a retrospective analysis of Veterans who survived a VA-based COPD hospitalization between 2012 and 2015. COPD was identified using In...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 19, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Prevalence and Characteristics of Pain in Patients of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study in China.
Authors: Cheng W, Li X, Duan J, Zhou Z, Zhou A, Zhao Y, Zeng Y, Chen Y, Cai S, Chen P Abstract The purposes of this study were to: (1) study the prevalence of pain in patients with mild-to-very severe chronic obstructive pulmonary disease (COPD) in China; (2) compare the differences in pain characteristics between stable COPD and acute exacerbation of COPD (AECOPD); (3) explore the clinical associations with pain in those with COPD. This cross-sectional study was conducted in China from October 24, 2017, to January 11, 2019. A face-to-face interview was conducted to collect data. The Chinese version of the brief pa...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 19, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Protein Network Analysis Identifies Changes in the Level of Proteins Involved in Platelet Degranulation, Proteolysis and Cholesterol Metabolism Pathways in AECOPD Patients.
In conclusion, several potential plasma biomarkers for AECOPD were identified in this study. Further validation studies of these proteins may elucidate their roles in the development of AECOPD. PMID: 31920121 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 12, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Sleep Quality and Nocturnal Symptoms in a Community-Based COPD Cohort.
Authors: Shah A, Ayas N, Tan WC, Malhotra A, Kimoff J, Kaminska M, Aaron SD, Jen R Abstract Small studies have suggested that patients with chronic obstructive pulmonary disease (COPD) have poor sleep quality. Our aim was to examine the prevalence of subjective sleep-related complaints and predictors of poor sleep quality in a large community-based COPD cohort. We analyzed cross-sectional data on sleep questionnaire responses from the Canadian Cohort of Obstructive Lung Disease (CanCOLD) study, a population-based, prospective longitudinal cohort study across Canada. The cohort comprises a COPD group and two matched...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 12, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Determinants of Sedentary Behaviour in Individuals with COPD: A Qualitative Exploration Guided by the Theoretical Domains Framework.
This study reports the determinants, perceived by individuals with COPD, as being important for reducing ST. An in-depth understanding of this information is essential when planning an intervention to reduce ST. Fourteen individuals with COPD completed semi-structured one-on-one interviews, which were audio recorded and transcribed verbatim. Both the interview schedule and mapping of data items extracted from the interview transcripts were informed by the Theoretical Domains Framework (TDF). A total of 867 quotes were mapped to the 14 TDF domains. Seven of the fourteen domains were identified as being important determinant...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 9, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Effects of Lung Function-Related Genes and TSLP on COPD Phenotypes.
Authors: Yamada H, Hida N, Masuko H, Sakamoto T, Hizawa N Abstract A weighted genetic risk score (GRS) based on 16 SNPs implicated in reduced lung function in both Japanese and non-Japanese populations was previously associated with the onset of COPD and asthma. We here examine the genetic impact of this lung function GRS on specific COPD phenotypes. A cohort of Japanese COPD patients (N = 270) underwent lung function testing followed by genotyping with allele-specific arrays for 16 SNPs as well as expression quantitative trait loci at TSLP (rs2289276, rs3806933). Lung function GRS scoring and two-ste...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 9, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

COPD: Gaps in the GOLD Recommendations and Related Imperative Research Needs.
Authors: Sakhamuri S, Seemungal T Abstract The GOLD 2020 updates added more lucidity on the treatment of COPD. However, few diagnostic dilemmas still exist. Research is needed on the use of the CAT score in assessing symptoms for the diagnosis of COPD. Further work-up is needed on diagnostic instability of spirometry, and diagnostic role of the lower limit of normal (LLN) criteria, slow vital capacity (FEV1/VC), forced inspiratory vital capacity (FEV1/FIVC), and rapid FEV1 decline. Incorporating parameters of lung hyperinflation and exercise capacity in the COPD diagnostic criteria might add value in its diagnosis ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 8, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Effect of Early Initiation of Varenicline on Smoking Cessation in COPD Patients Admitted for Exacerbation: The Save Randomized Clinical Trial.
Authors: Le Mao R, Tromeur C, Paleiron N, Sanchez O, Gagnadoux F, Jouneau S, Magnan A, Hayem-Vannimenus C, Dansou A, Proust A, Dion A, Larhantec G, Brestec AL, Dewitte JD, Roche N, Leroyer C, Couturaud F Abstract Our main objective was to demonstrate that, in smoker patients hospitalised for Chronic Obstructive Pulmonary Disease (COPD) exacerbation, early initiation of varenicline during 12 weeks, combined with an intensive counselling, is associated with a higher continuous abstainers rate (CAR) at one year as compared to intensive counselling alone. In this multicenter, prospective, double-blind, randomise...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 20, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Emerging Treatments for COPD: Evidence to Date on Revefenacin.
Authors: Lal C, Khan A Abstract Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of death in the United States. Due to the substantial public health burden of COPD, there has been a lot of interest in developing new drug therapies, directed at improving the symptomatology and quality of life in COPD patients. Revefenacin is the first once daily nebulized long acting muscarinic antagonist for COPD treatment. It offers an advantage over other nebulized bronchodilators, as once daily administration may improve patient compliance. Revefenacin has a rapid onset of action, is long acting and signific...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 15, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Singing and Dancing as Modalities for Exercise Training in COPD.
Authors: Lewis A, Philip KE PMID: 31833425 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 15, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Association Between Dietary Nutrient Intake and Chronic Obstructive Pulmonary Disease Severity: A Nationwide Population-Based Representative Sample.
In conclusion, intake of carbohydrate, protein, fiber, thiamin, riboflavin, niacin, and vitamin C was associated with decreased severity of airway impairment in elderly men with COPD. Our results are in line with those of previous studies into the importance of nutritional status in airway disease. A longitudinal study is required to clarify the mechanisms underlying the association between dietary nutrient intake and COPD severity. PMID: 31833439 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 15, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Chronic Obstructive Pulmonary Disease as a Predictor of Cardiovascular Risk: A Case-Control Study.
Authors: Khanji MY, Stone IS, Boubertakh R, Cooper JA, Barnes NC, Petersen SE Abstract Chronic obstructive pulmonary disease (COPD) is a complex multi-morbid disorder with significant cardiac mortality. Current cardiovascular risk prediction models do not include COPD. We investigated whether COPD modifies future cardiovascular risk to determine if it should be considered in risk prediction models.Case-control study using baseline data from two randomized controlled trials performed between 2012 and 2015. Of the 90 eligible subjects, 26 COPD patients with lung hyperinflation were propensity matched for 10-year glob...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 15, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Acute Phase Proteins as Predictors of Survival in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease Requiring Mechanical Ventilation.
Authors: Sneh A, Pawan T, Randeep G, Anant M, Mani K, Hadda V, Madan K Abstract Few studies have tried to assess prognostic variables in chronic obstructive pulmonary disease (COPD) patients requiring mechanical ventilation (MV). We evaluated serum C reactive protein, (CRP) pre-albumin (PA) and transferrin (TR) levels in AE-COPD patients requiring MV as prognostic markers of in hospital mortality. 93 AE-COPD patients on MV were evaluated. Detailed clinical evaluation was done daily. Serum CRP & PA were measured on admission, 3rd, 8th and 16th day; TR was measured on admission, 8th and 16th day. Demographics, ba...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 12, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Improving the Efficiency of Randomized Trials: The DYNAGITO Example.
Authors: Suissa S Abstract A traditional principle of the randomized controlled trial is that the p-value comparing treatment groups should be computed from the simple crude data. This assumes that the size of the study is sufficiently large for an accurate and precise estimation of the difference between groups. There are situations where the accuracy and precision of the study can be improved by statistical adjustment for baseline covariates, including when the outcome is continuous and available at baseline. The European Medicines Agency (EMA) and the Food and Drug Administration (FDA) recommend covariate adjust...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Health Literacy and Medication Adherence in COPD Patients: When Caregiver Presence Is Not Sufficient.
In this study, we examined the potential mitigating role of caregiver support on the relationship between HL and adherence to COPD medications. We conducted a prospective observational study of adults with COPD and their caregivers. HL was assessed using the Short Test of Functional Health Literacy in Adults (S-TOFHLA) and COPD medication adherence was evaluated with the Medication Adherence Rating Scale (MARS). We also collected caregiver HL data for a subset of participants. We tested whether having a caregiver impacted the relationship between HL and medication adherence using cross-sectional data collected between 2011...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 23, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

The Association of Bone Mineral Density with Mortality in a COPD Cohort. The HUNT Study, Norway.
Authors: Vikjord SAA, Brumpton BM, Mai XM, Bhatta L, Vanfleteren L, Langhammer A Abstract In individuals with chronic obstructive pulmonary disease (COPD), the presence of comorbidities is associated with increased mortality risk. We wanted to study the association between bone mineral density (BMD) and mortality among individuals with COPD in a population-based cohort study. Participants were recruited from the second (1995-1997) and third (2006-2008) surveys of the HUNT Study and followed until February 2019. Hip and forearm BMD were included as continuous T-scores or categorized according to WHO criteria (normal...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 13, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Machine Learning-Based Prediction Models for 30-Day Readmission after Hospitalization for Chronic Obstructive Pulmonary Disease.
In this study using nationwide administrative data in Japan, machine learning models improved the prediction of 30-day readmission after COPD hospitalization compared with a conventional model.AbbreviationsADLactivities of daily livingCOPDchronic obstructive pulmonary diseaseCMSCenters for Medicare and Medicaid ServicesDPCDiagnosis Procedure CombinationICD-10-CMInternational Classification of Diseases, Tenth Revision, Clinical ModificationROCreceiver-operating-characteristic. PMID: 31709851 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 13, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Exercise Training Modalities for People with Chronic Obstructive Pulmonary Disease.
This article reviews the evidence for several exercise training modalities shown to be beneficial among individuals with COPD. These modalities include aerobic, resistance, nonlinear periodized, upper limb and balance training, as well as yoga, Tai Chi, inspiratory muscle training, whole body vibration training and neuromuscular electrical stimulation. The literature pertaining to each modality was critically reviewed, and information on the rationale, mechanism(s) of action (where known), benefits, and exercise prescription is described to facilitate easy implementation into clinical practice. PMID: 31684769 [PubMed -...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 8, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Assessment of Work of Breathing in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease.
Authors: Barrett NA, Hart N, Camporota L Abstract The assessment of the work of breathing (WOB) of patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) is difficult, particularly when the patient first presents with acute hypercapnia and respiratory acidosis. Acute exacerbations of COPD patients are in significant respiratory distress and noninvasive measurements of WOB are easier for the patient to tolerate. Given the interest in using alternative therapies to noninvasive ventilation, such as high flow nasal oxygen therapy or extracorporeal carbon dioxide removal, understanding the phy...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 8, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Phase II Study of Single/Repeated Doses of Acumapimod (BCT197) to Treat Acute Exacerbations of COPD.
In conclusion, repeated single-dose acumapimod showed a clinically relevant improvement in FEV1 over placebo at Day 8, along with consistent numerical differences in EXACT-PRO. These data can be used to determine dose regimens for a proof-of-clinical-concept trial. PMID: 31682162 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 6, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Nasal High Flow for Stable Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.
Authors: Bonnevie T, Elkins M, Paumier C, Medrinal C, Combret Y, Patout M, Muir JF, Cuvelier A, Gravier FE, Prieur G Abstract There is a growing body of evidence supporting the use of nasal high flow (NHF) to treat acute respiratory failure, particularly in Chronic Obstructive Pulmonary Disease (COPD) patients. Conversely, there are sparse data evaluating its effects in stable COPD patients. We identified randomized controlled trial comparing the effects of delivering air or oxygen via NHF, compared with delivering the same gas without NHF, in stable COPD patients through a systematic search using MEDLINE, CENTRAL,...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - October 29, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Prevalence, Contribution to Disease Burden and Management of Comorbid Depression and Anxiety in Chronic Obstructive Pulmonary Disease: A Narrative Review.
Authors: Zareifopoulos N, Bellou A, Spiropoulou A, Spiropoulos K Abstract Mental health issues such as depression and anxiety are common comorbidities of individuals suffering from chronic obstructive pulmonary disease (COPD), though they are frequently underdiagnosed and consequently undertreated. To that end we sought to identify the impact of co-morbid anxiety and depression in COPD patients and evaluate recent evidence regarding the management of such cases. A Pubmed search was conducted for relevant original articles with emphasis on the past 5 years. The studies we identified indicate that psychiatric ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - October 24, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research