Real-World Effectiveness of Single-Inhaler Triple Therapy for COPD: Impact of Diabetes Comorbidity
COPD. 2024 Dec;21(1):2327345. doi: 10.1080/15412555.2024.2327345. Epub 2024 Mar 20.ABSTRACTType 2 diabetes is a frequent comorbidity in chronic obstructive pulmonary disease (COPD) patients, with the GOLD treatment recommendations asserting that the presence of diabetes be disregarded in the choice of treatment.In a cohort of COPD patients with frequent exacerbations, initiators of single-inhaler triple therapy or dual bronchodilators were compared on the incidence of COPD exacerbation and pneumonia over one year, adjusted by propensity score weighting and stratified by type 2 diabetes.The COPD cohort included 1,114 initia...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 21, 2024 Category: Respiratory Medicine Authors: Sophia Eilat-Tsanani Pierre Ernst Samy Suissa Source Type: research

Effectiveness of Aspirin on Major COPD Outcomes: A Prevalent New-User Design Observational Study
COPD. 2024 Dec;21(1):2317380. doi: 10.1080/15412555.2024.2317380. Epub 2024 Mar 14.ABSTRACTObservational studies that have reported an association between aspirin use in chronic obstructive pulmonary disease (COPD) with reductions in mortality and COPD exacerbations were shown to be affected by time-related biases. We assessed this association using a prevalent new-user study design that avoids these biases. We used the United Kingdom's Clinical Practice Research Datalink (CPRD) to form a cohort of patients with COPD. Aspirin initiators were matched on time and propensity score with nonusers during 2002-2018. The outcomes ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 14, 2024 Category: Respiratory Medicine Authors: Charles Khouri Sophie Dell'Aniello Pierre Ernst Samy Suissa Source Type: research

Knockdown of RTEL1 Alleviates Chronic Obstructive Pulmonary Disease by Modulating M1, M2 Macrophage Polarization and Inflammation
In conclusion, knockdown of RTEL1 promoted M1 and inhibited M2 macrophage polarization and inflammation to alleviate COPD.PMID:38420994 | DOI:10.1080/15412555.2024.2316607 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 29, 2024 Category: Respiratory Medicine Authors: He-Ping Xu Huan Niu Hong Wang Jie Lin Jin-Jian Yao Source Type: research

Understanding the Gaps in the Reporting of COPD Exacerbations by Patients: A Review
COPD. 2024 Dec;21(1):2316594. doi: 10.1080/15412555.2024.2316594. Epub 2024 Feb 29.ABSTRACTExacerbations of chronic obstructive pulmonary disease (COPD) are associated with loss of lung function, poor quality of life, loss of exercise capacity, risk of serious cardiovascular events, hospitalization, and death. However, patients underreport exacerbations, and evidence suggests that unreported exacerbations have similar negative health implications for patients as those that are reported. Whilst there is guidance for physicians to identify patients who are at risk of exacerbations, they do not help patients recognise and rep...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 29, 2024 Category: Respiratory Medicine Authors: Paul Jones Ashraf Alzaabi Alejandro Casas Herrera Mehmet Polatli Marcelo Fouad Rabahi Arturo Cortes Telles Bhumika Aggarwal Sudeep Acharya Abdelkader El Hasnaoui Chris Compton Source Type: research

Knockdown of RTEL1 Alleviates Chronic Obstructive Pulmonary Disease by Modulating M1, M2 Macrophage Polarization and Inflammation
In conclusion, knockdown of RTEL1 promoted M1 and inhibited M2 macrophage polarization and inflammation to alleviate COPD.PMID:38420994 | DOI:10.1080/15412555.2024.2316607 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 29, 2024 Category: Respiratory Medicine Authors: He-Ping Xu Huan Niu Hong Wang Jie Lin Jin-Jian Yao Source Type: research

Understanding the Gaps in the Reporting of COPD Exacerbations by Patients: A Review
COPD. 2024 Dec;21(1):2316594. doi: 10.1080/15412555.2024.2316594. Epub 2024 Feb 29.ABSTRACTExacerbations of chronic obstructive pulmonary disease (COPD) are associated with loss of lung function, poor quality of life, loss of exercise capacity, risk of serious cardiovascular events, hospitalization, and death. However, patients underreport exacerbations, and evidence suggests that unreported exacerbations have similar negative health implications for patients as those that are reported. Whilst there is guidance for physicians to identify patients who are at risk of exacerbations, they do not help patients recognise and rep...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 29, 2024 Category: Respiratory Medicine Authors: Paul Jones Ashraf Alzaabi Alejandro Casas Herrera Mehmet Polatli Marcelo Fouad Rabahi Arturo Cortes Telles Bhumika Aggarwal Sudeep Acharya Abdelkader El Hasnaoui Chris Compton Source Type: research