Triple Inhaler versus Dual Bronchodilator Therapy in COPD: Real-World Effectiveness on Mortality
COPD. 2021 Sep 21:1-9. doi: 10.1080/15412555.2021.1977789. Online ahead of print.ABSTRACTRandomized trials of triple therapy including an inhaled corticosteroid (ICS) for chronic obstructive pulmonary disease (COPD) reported remarkable benefits on mortality compared with dual bronchodilators, likely resulting from ICS withdrawal at randomization. We compared triple therapy with dual bronchodilator combinations on major COPD outcomes in a real-world clinical practice setting. We identified a cohort of COPD patients, age 50 or older, treated during 2002-2018, from the United Kingdom's Clinical Practice Research Datalink. Pat...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 21, 2021 Category: Respiratory Medicine Authors: Samy Suissa Sophie Dell'Aniello Pierre Ernst Source Type: research

Trends in Incidence, and Mortality of Acute Exacerbation of Chronic Obstructive Pulmonary Disease in the United States Emergency Department (2010-2018)
COPD. 2021 Sep 16:1-9. doi: 10.1080/15412555.2021.1979500. Online ahead of print.ABSTRACTLiterature regarding trends of incidence, mortality, and complications of acute exacerbation of chronic obstructive pulmonary disease (COPD) in the emergency departments (ED) is limited. What are trends of COPD exacerbation in ED? Data were obtained from the Nationwide Emergency Department Sample (NEDS) that constitutes a 20% sample of hospital-owned EDs and inpatient sample in the US. All ED encounters were included in the analysis. Complications of AECOPD were obtained by using ICD codes. Out of 1.082 billion ED encounters, 5,295,408...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 17, 2021 Category: Respiratory Medicine Authors: Paul L Nguyen Mohammed M Uddin Tanveer Mir Amir Khalil Neelambuj Regmi Amina Pervaiz Tanveer Hussain Mohammed Amir Babu Irfan Ullah Pragnesh Patel Prateek Lohia Ghulam Saydain Parvaiz A Koul Ayman O Soubani Source Type: research

Evaluation of Blood Markers at Admission for Predicting Community Acquired Pneumonia in Chronic Obstructive Pulmonary Disease
COPD. 2021 Sep 12:1-10. doi: 10.1080/15412555.2021.1976739. Online ahead of print.ABSTRACTAcute exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) and community acquired pneumonia (CAP) are two common acute attacks in COPD patients and it is not always easy to determine whether a COPD patient at admission has parenchymal infection or bronchial infection. Comprehensive comparison between AECOPD patients and CAP patients with COPD (COPD + CAP) can help us understand them better. We retrospectively collected the medical records of AECOPD and COPD + CAP patients. Systemic inflammation, eosinophilic inflammation, d...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 13, 2021 Category: Respiratory Medicine Authors: Shupei Gao Yifei Duan Jinqing Chen Jianmiao Wang Source Type: research

Frailty Assessment in a Stable COPD Cohort: Is There a COPD-Frail Phenotype?
COPD. 2021 Sep 9:1-8. doi: 10.1080/15412555.2021.1975670. Online ahead of print.ABSTRACTThe frailty syndrome increases the morbidity/mortality in older adults, and several studies have shown a higher prevalence of this syndrome in patients with Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to identify the characteristics of frail patients with COPD to define a new phenotype called "COPD-frail." We conducted a cross-sectional study in a cohort of patients with stable COPD, classified as either frail, pre-frail, or non-frail. Sociodemographic, clinical, and biochemical variables were compa...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 10, 2021 Category: Respiratory Medicine Authors: Elsa Naval Maria Cruz Gonz ález Sonia Girald ós Julia Calatayud Marc Jornet Inmaculada Lluch Maria Meseguer Juan Jos é Ruiz Cubillan Jos é Viña Francisco Jos é Tarazona-Santabalbina Source Type: research

Mechanisms of Exertional Dyspnea in Patients with Mild COPD and a Low Resting DL < sub > CO < /sub >
COPD. 2021 Sep 8:1-10. doi: 10.1080/15412555.2021.1932782. Online ahead of print.ABSTRACTPatients with mild chronic obstructive pulmonary disease (COPD) and lower resting diffusing capacity for carbon monoxide (DLCO) often report troublesome dyspnea during exercise although the mechanisms are not clear. We postulated that in such individuals, exertional dyspnea is linked to relatively high inspiratory neural drive (IND) due, in part, to the effects of reduced ventilatory efficiency. This cross-sectional study included 28 patients with GOLD I COPD stratified into two groups with (n = 15) and without (n = 13) DLCO less than ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 9, 2021 Category: Respiratory Medicine Authors: Matthew D James Devin B Phillips Amany F Elbehairy Kathryn M Milne Sandra G Vincent Nicolle J Domnik Juan P de Torres J Alberto Neder Denis E O'Donnell Source Type: research

Screening Tools for Depression and Anxiety in Patients with Chronic Obstructive Pulmonary Disease - A Systematic Review
COPD. 2021 Sep 5:1-7. doi: 10.1080/15412555.2021.1972091. Online ahead of print.ABSTRACTThe diagnosis of depression or anxiety is often difficult to establish in patients with Chronic Obstructive Pulmonary Disease (COPD) as many physical symptoms are shared. There is no consensus on a screening tool for depression and anxiety in patients with COPD. The aim of this systematic review is to review screening tools for depression and anxiety suitable for application among patients with COPD in the clinical setting. A systematic review was made using predefined search terms and eligibility criteria. Of 274 initially screened art...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 6, 2021 Category: Respiratory Medicine Authors: C H Larsen E Bendstrup M A Neergaard Source Type: research

Social Distancing among COPD Patients during the COVID-19 Pandemic - A Qualitative Study
COPD. 2021 Sep 5:1-8. doi: 10.1080/15412555.2021.1973981. Online ahead of print.ABSTRACTTo limit the ongoing COVID-19 pandemic, social distancing was introduced globally in the first half of 2020. COPD-patients were identified as a group at special risk in connection with the SARS-CoV-2 infection. Hence, social distancing has been important in this group of patients. However, little is known of the motives and consequences of social distancing in these vulnerable patients. The aim of this study was to explore the perspectives and experiences on social distancing among COPD-patients during the COVID-19 pandemic. Patients in...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 6, 2021 Category: Respiratory Medicine Authors: Kathrine Hoffmann Kusk Line Hust Storgaard Ulla M øller Weinreich Mette Gr ønkjaer Charlotte Brun Thorup Source Type: research

Screening Tools for Depression and Anxiety in Patients with Chronic Obstructive Pulmonary Disease - A Systematic Review
COPD. 2021 Sep 5:1-7. doi: 10.1080/15412555.2021.1972091. Online ahead of print.ABSTRACTThe diagnosis of depression or anxiety is often difficult to establish in patients with Chronic Obstructive Pulmonary Disease (COPD) as many physical symptoms are shared. There is no consensus on a screening tool for depression and anxiety in patients with COPD. The aim of this systematic review is to review screening tools for depression and anxiety suitable for application among patients with COPD in the clinical setting. A systematic review was made using predefined search terms and eligibility criteria. Of 274 initially screened art...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 6, 2021 Category: Respiratory Medicine Authors: C H Larsen E Bendstrup M A Neergaard Source Type: research

Social Distancing among COPD Patients during the COVID-19 Pandemic - A Qualitative Study
COPD. 2021 Sep 5:1-8. doi: 10.1080/15412555.2021.1973981. Online ahead of print.ABSTRACTTo limit the ongoing COVID-19 pandemic, social distancing was introduced globally in the first half of 2020. COPD-patients were identified as a group at special risk in connection with the SARS-CoV-2 infection. Hence, social distancing has been important in this group of patients. However, little is known of the motives and consequences of social distancing in these vulnerable patients. The aim of this study was to explore the perspectives and experiences on social distancing among COPD-patients during the COVID-19 pandemic. Patients in...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 6, 2021 Category: Respiratory Medicine Authors: Kathrine Hoffmann Kusk Line Hust Storgaard Ulla M øller Weinreich Mette Gr ønkjaer Charlotte Brun Thorup Source Type: research

A Systematic Review with Thematic Synthesis of the Experience of Hospitalization in People with Advanced Chronic Obstructive Pulmonary Disease
COPD. 2021 Sep 3:1-9. doi: 10.1080/15412555.2021.1971186. Online ahead of print.ABSTRACTHospital admissions are common for people with advanced chronic obstructive pulmonary disease (COPD). To provide effective, responsive care, it is important to understand how people experience hospitalization. The aim of this review was to explore the experience of hospitalization in people with advanced COPD, drawing from qualitative research data. Guided by a thematic synthesis approach, a systematic search of databases (n = 13) including PubMed, CINAHL, PsycINFO and ProQuest was undertaken from database inception to May 2020. Inclusi...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 3, 2021 Category: Respiratory Medicine Authors: Barathi Bakthavatsalu Catherine Walshe Jane Simpson Source Type: research

Characteristics of COPD Patients Prescribed ICS Managed in General Practice vs. Secondary Care
COPD. 2021 Sep 1:1-8. doi: 10.1080/15412555.2021.1970737. Online ahead of print.ABSTRACTInhaled corticosteroids (ICS) for COPD have been much debated. Our aim was to investigate characteristics of ICS prescribed COPD patients managed only in general practice compared to those also managed in secondary care. Participating general practitioners recruited patients with COPD (ICPC 2nd ed. code R95) currently prescribed ICS (ACT code R03AK and R03BA). Data on demographics, comorbidities, smoking habits, spirometry, dyspnea score and exacerbation history were retrieved from medical records. Logistic regression analysis was appli...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 2, 2021 Category: Respiratory Medicine Authors: Osman Savran Nina Godtfredsen Torben S ørensen Christian Jensen Charlotte Suppli Ulrik Source Type: research

Dysfunctional Bronchial Cilia Are a Feature of Chronic Obstructive Pulmonary Disease (COPD)
COPD. 2021 Sep 1:1-7. doi: 10.1080/15412555.2021.1963695. Online ahead of print.ABSTRACTImpaired mucociliary clearance may increase COPD exacerbation risk. We aimed to compare bronchial ciliary function and epithelial ultrastructure of COPD patients to healthy controls and explore its relationship to exacerbator phenotypes (frequent [FE] and infrequent [IFE] exacerbator). In this cross-sectional study, 16 COPD patients and 12 controls underwent bronchial brushings. Ciliary beat frequency (CBF) and dyskinesia index (DI; % of dyskinetic cilia) were assessed using digital high-speed video microscopy, and epithelial ultrastruc...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 1, 2021 Category: Respiratory Medicine Authors: Biju Thomas Mariko Siyue Koh Christopher O'Callaghan John Carson Allen Andrew Rutman Robert Anthony Hirst John Connolly Su Ying Low Ong Thun How Loo Chian Min Wan Teck Lim Lynette Lin Ean Oon Qixian He Oon Hoe Teoh Therese Sophie Lapperre Source Type: research

Prevalence and Newly Diagnosed Rates of Multimorbidity in Older Medicare Beneficiaries with COPD
This study updates existing literature with more current, generalizable findings of the substantial multimorbidity burden in medically complex older adults with COPD-necessary to inform patient-centered, multidimensional care.Supplemental data for this article is available online at https://doi.org/10.1080/15412555.2021.1968815 .PMID:34468243 | DOI:10.1080/15412555.2021.1968815 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 1, 2021 Category: Respiratory Medicine Authors: Tham T Le Danya M Qato Larry Magder Margr ét Bjarnadóttir Zafar Zafari Linda Simoni-Wastila Source Type: research

Ten Commandments for Randomized Trials of Pharmacological Therapy for COPD and Other Lung Diseases
We describe the concept of the counterfactual principle as it applies to the treatment of patients and to the randomized trial. We then present ten methodological tenets for the design and statistical aspects of randomized controlled trials evaluating the effectiveness of drugs used in the treatment of several respiratory diseases. They include eight study design and two statistical analysis principles: 1) Study question; 2) Intervention; 3) Study population; 4) Blinding; 5) Run-in period; 6) Follow-up; 7) Outcome; 8) Safety; 9) Intent-to-treat; 10) Covariate adjustment. These tenets are described using mainly examples fro...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 1, 2021 Category: Respiratory Medicine Authors: Samy Suissa Source Type: research

Frailty Impact during and after Pulmonary Rehabilitation
In conclusion, frail COPD patients have a higher potential to benefit from pulmonary rehabilitation, but a higher risk to have a steeper decline later.Supplemental data for this article is available online at https://doi.org/10.1080/15412555.2021.1967915 .PMID:34427156 | DOI:10.1080/15412555.2021.1967915 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 24, 2021 Category: Respiratory Medicine Authors: Panaiotis Finamore Simone Scarlata Anna Sofia Delussu Marco Traballesi Raffaele Antonelli Incalzi Alice Laudisio Source Type: research

< em > Community Participation by People with Chronic Obstructive Pulmonary Disease < /em >
COPD. 2021 Aug 23:1-8. doi: 10.1080/15412555.2021.1966761. Online ahead of print.ABSTRACTLittle is known regarding community participation in individuals with chronic obstructive pulmonary disease (COPD). The aim of this study was to explore community participation in individuals with COPD and to determine whether there is an association between community participation and activity-related outcome variables commonly collected during pulmonary rehabilitation assessment. We also sought to investigate which of these variables might influence community participation in people with COPD. Ninety-nine individuals with COPD were e...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 23, 2021 Category: Respiratory Medicine Authors: Carla Malaguti Anne E Holland Christine F McDonald Ajay Mahal Jennifer A Alison Catherine J Hill Paolo Zanaboni Paul O'Halloran Janet Bondarenko Heather Macdonald Kathryn Barker Hayley Crute Christie Mellerick Bruna Wageck Helen Boursinos Aroub Lahham Ama Source Type: research

Evaluation of the Level of Physical Activity and Muscle Strength of Quadriceps in Patients Hospitalized for E-COPD: A Longitudinal Study
The objectives of the present study were to assess the level of physical activity in daily life (PADL) and isometric muscle strength of the quadriceps in patients hospitalized for exacerbation of COPD and to verify changes after 3 months of hospital discharge. This is a longitudinal observational study that assessed the PADL level with an accelerometer, after 24 h of the hospitalization and the beginning of the drug treatment and assessed the quadriceps muscle strength with a manual dynamometer, after 72 h of hospitalization, in 32 patients with COPD (66 ± 7.61 years), in addition to repeating both assessments with ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 23, 2021 Category: Respiratory Medicine Authors: Bruna Shara Vidal de Oliveira Anna Claudia Leonardo Garbin Bueno Marcela Maria Carvalho Silva Juliano Ferreira Arcuri Val éria Amorim Pires Di Lorenzo Source Type: research

< em > Community Participation by People with Chronic Obstructive Pulmonary Disease < /em >
COPD. 2021 Aug 23:1-8. doi: 10.1080/15412555.2021.1966761. Online ahead of print.ABSTRACTLittle is known regarding community participation in individuals with chronic obstructive pulmonary disease (COPD). The aim of this study was to explore community participation in individuals with COPD and to determine whether there is an association between community participation and activity-related outcome variables commonly collected during pulmonary rehabilitation assessment. We also sought to investigate which of these variables might influence community participation in people with COPD. Ninety-nine individuals with COPD were e...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 23, 2021 Category: Respiratory Medicine Authors: Carla Malaguti Anne E Holland Christine F McDonald Ajay Mahal Jennifer A Alison Catherine J Hill Paolo Zanaboni Paul O'Halloran Janet Bondarenko Heather Macdonald Kathryn Barker Hayley Crute Christie Mellerick Bruna Wageck Helen Boursinos Aroub Lahham Ama Source Type: research

Evaluation of the Level of Physical Activity and Muscle Strength of Quadriceps in Patients Hospitalized for E-COPD: A Longitudinal Study
The objectives of the present study were to assess the level of physical activity in daily life (PADL) and isometric muscle strength of the quadriceps in patients hospitalized for exacerbation of COPD and to verify changes after 3 months of hospital discharge. This is a longitudinal observational study that assessed the PADL level with an accelerometer, after 24 h of the hospitalization and the beginning of the drug treatment and assessed the quadriceps muscle strength with a manual dynamometer, after 72 h of hospitalization, in 32 patients with COPD (66 ± 7.61 years), in addition to repeating both assessments with ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 23, 2021 Category: Respiratory Medicine Authors: Bruna Shara Vidal de Oliveira Anna Claudia Leonardo Garbin Bueno Marcela Maria Carvalho Silva Juliano Ferreira Arcuri Val éria Amorim Pires Di Lorenzo Source Type: research

Effectiveness of Aspirin in COPD: Biases in the Observational Studies
In conclusion, all observational studies reporting on the effectiveness of aspirin on major outcomes of COPD are affected by biases known to exaggerate the effectiveness of a drug. As these studies cannot be used to support a beneficial effect for aspirin in COPD, it would be premature to consider a randomized trial to investigate this question until methodologically rigorous studies are available.PMID:34396883 | DOI:10.1080/15412555.2021.1963696 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 16, 2021 Category: Respiratory Medicine Authors: Anirudh Bakshi Samy Suissa Source Type: research

Pulmonary Rehabilitation in the Management of Chronic Obstructive Pulmonary Disease among Asian Indians- Current Status and Moving Forward
COPD. 2021 Aug 12:1-6. doi: 10.1080/15412555.2021.1962267. Online ahead of print.ABSTRACTChronic Obstructive Pulmonary Disease (COPD) is a significant public health concern in India with high prevalence and associated disability, morbidity, mortality. The progression of COPD is not confined to the lungs but includes extrapulmonary involvement that reduces the functional capacity and quality of life. Pulmonary Rehabilitation (PR) is an evidence-based intervention, targeting multiple domains of pulmonary and extrapulmonary manifestations, and therefore, is recommended as an integral part of COPD management. The practical imp...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 12, 2021 Category: Respiratory Medicine Authors: Rohini Bhadra Shinjini Bhattacharya George A D'Souza Annemie M W J Schols Sucharita Sambashivaiah Source Type: research

Strategies to Prevent Readmissions to Hospital for COPD: A Systematic Review
COPD. 2021 Aug 11:1-13. doi: 10.1080/15412555.2021.1955338. Online ahead of print.ABSTRACTPatients with chronic obstructive pulmonary disease (COPD) experience high rates of hospital readmissions, placing substantial clinical and economic strain on the healthcare system. Therefore, it is essential to implement evidence-based strategies for preventing these readmissions. The primary objective of our systematic review was to identify and describe the domains of existing primary research on strategies aimed at reducing hospital readmissions among adult patients with COPD. We also aimed to identify existing gaps in the literat...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 11, 2021 Category: Respiratory Medicine Authors: Isobel Sharpe Meghan Bowman Andrew Kim Siddhartha Srivastava Matthew Jalink Don Thiwanka Wijeratne Source Type: research

Uptake of Clinical Prognostic Tools in COPD Exacerbations Requiring Hospitalisation
COPD. 2021 Aug 6:1-5. doi: 10.1080/15412555.2021.1959540. Online ahead of print.ABSTRACTClinical prognostic tools are used to objectively predict outcomes in many fields of medicine. Whilst over 400 have been developed for use in chronic obstructive pulmonary disease (COPD), only a minority have undergone full external validation and just one, the DECAF score, has undergone an implementation study supporting use in clinical practice. Little is known about how such tools are used in the UK. We distributed surveys at two time points, in 2017 and 2019, to hospitals included in the Royal College of Physicians of London nationa...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 6, 2021 Category: Respiratory Medicine Authors: Nicholas D Lane Sarah M Gillespie John Steer Stephen C Bourke Source Type: research

Genetic Evidence on the Association of Interleukin (IL)-1-Mediated Chronic Inflammation with Airflow Obstruction: A Mendelian Randomization Study
COPD. 2021 Aug 4:1-11. doi: 10.1080/15412555.2021.1955848. Online ahead of print.ABSTRACTPreclinical studies suggest interleukin (IL)-1α/β is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, recent trials of anti-IL-1 therapies showed limited benefit for COPD. To clarify, we primarily examined total and direct effects of IL-1 and its receptors/coreceptors/receptor antagonists (IL-1/IL-1Rs) on airflow obstruction (AO) using Mendelian randomization (MR), and secondarily explored reverse causation using bidirectional MR. We selected independent cis protein quantitative trait lo...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 5, 2021 Category: Respiratory Medicine Authors: Zhao Yang C Mary Schooling Man Ki Kwok Source Type: research

Serum MCP-1 and NGAL Play an Important Role in the Acute Inflammatory Event of Chronic Obstructive Pulmonary Disease
This study enrolled 97 COPD patients and 50 healthy controls. All participants received blood collection and lung function test and arterial blood gas measurements. The expression levels of serum NGAL and MCP-1 were measured by ELISA. The serum NGAL and MCP-1 levels of COPD with community-acquired pneumonia (COPD-CAP) patients were significantly higher than those of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients and healthy adults. The NGAL levels of the GOLD III and IV groups were significantly higher than those of the GOLD II group. Spearman correlation analysis showed a negative correlatio...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 30, 2021 Category: Respiratory Medicine Authors: Xing-Ru Chen Dao-Xin Wang Source Type: research