A Randomized Controlled Trial of Noninvasive Ventilation with Pressure Support Ventilation and Adaptive Support Ventilation in Acute Exacerbation of COPD: A Feasibility Study.
Authors: Sehgal IS, Kalpakam H, Dhooria S, Aggarwal AN, Prasad KT, Agarwal R Abstract Whether the use of adaptive support ventilation (ASV) during noninvasive ventilation (NIV) is as effective as pressure support ventilation (PSV) remains unknown. In this exploratory study, we compared the delivery of NIV with PSV vs. ASV. We randomized consecutive subjects with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) to receive NIV either with the PSV or the ASV mode. The primary outcome was NIV failure (endotracheal intubation, re-institution of NIV within 48 h of discontinuation or mortality)....
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - June 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Consequences of Changing the GOLD Reports (2007-2011-2017) on the Treatment Regimen of Patients with COPD.
Authors: Brożek GM, Nowak M, Zejda JE, Jankowski M, Lawson J, Pierzchała W Abstract Detailed treatment regimens for patients with chronic obstructive pulmonary disease (COPD) were developed by the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Every few years the method of classification of COPD severity and the treatment recommendations are significantly revised. The aim of this study was to determine the clinical implications of changing GOLD reports (2007-2011-2017) and the impact that these changes would have on pharmacological treatment regimens of patients with COPD. A group of 500 randomly ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - June 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Airflow Obstruction and Cardio-metabolic Comorbidities.
Authors: Triest FJJ, Studnicka M, Franssen FME, Vollmer WM, Lamprecht B, Wouters EFM, Burney PGJ, Vanfleteren LEGW Abstract Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction and often co-exists with cardiovascular disease (CVD), hypertension and diabetes. This international study assessed the association between airflow obstruction and these comorbidities. 23,623 participants (47.5% males, 19.0% current smokers, age: 55.1 ± 10.8 years) in 33 centers in the Burden of Obstructive Lung Disease (BOLD) initiative were included. 10.4% of subjects had airflow obstruc...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 29, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Blood Eosinophil Counts, Withdrawal of Inhaled Corticosteroids and Risk of COPD Exacerbations and Mortality in the Clinical Practice Research Datalink (CPRD).
Authors: Oshagbemi OA, Franssen FME, van Kraaij S, Braeken DCW, Wouters EFM, Maitland-van der Zee AH, Driessen JHM, de Vries F Abstract Although recently introduced in the pharmacological treatment algorithm of chronic obstructive pulmonary disease (COPD), there is a need for more data supporting the use of blood eosinophil counts as a biomarker to guide inhaled corticosteroids (ICS) therapy. The aim of this study was to evaluate the risk of moderate and/or severe exacerbations and all-cause mortality in a large primary care population after withdrawal of ICS compared to continued users stratified by elevated blood...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 25, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

The Integrative Physiology of Exercise Training in Patients with COPD.
Authors: Neder JA, Marillier M, Bernard AC, James MD, Milne KM, O'Donnell DE Abstract Supervised exercise training (EXT) as part of pulmonary rehabilitation is arguably the most effective intervention for improving exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). In the current review, we focus on the physiological rationale for EXT and the expected physiological benefits that can be achieved in patients who can be exposed to sufficiently high training stimuli. Thus, after a brief consideration of the mechanisms of exercise limitation and their sensory consequences, we expose the po...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 18, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Development of a Nomogram to Predict the Risk of 30-Day Re-Exacerbation for Patients Hospitalized for Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
Authors: Hu WP, Lhamo T, Liu D, Hang JQ, Zhang FY, Zuo YH, Zeng YY, Zhang J Abstract Acute exacerbation (AE) is the main cause of increased disability and mortality for patients with Chronic Obstructive Pulmonary Disease (COPD). Short-term re-exacerbation after discharge is common for in-hospital patients with AECOPD. Thus, we aimed to design a scoring system to effectively predict the 30-day re-exacerbation using simple and easily accessible variables. We retrospectively enrolled 686 cases hospitalized for AECOPD in two Chinese hospitals from 2005 to 2017. A variety of parameters were collected like demographics, ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 18, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Mammalian Target of Rapamycin: Is It Relevant to COPD Pathogenesis or Treatment?
Authors: Pasini E, Flati V, Comini L, Olivares A, Bertella E, Corsetti G, Vitacca M Abstract The mammalian target of rapamycin (mTOR) signalling pathway regulates fundamental metabolic processes such as inflammation, autophagy and apoptosis, all of which influence cell fate. Recent experimental data suggest that mTOR signalling is involved in many diseases, including lung diseases, but with contrasting data. Overexpression of mTOR and its signalling proteins have been linked to lung cell senescence and development of emphysema, pulmonary hypertension and inflammation. On the other hand, mTOR inhibitors, as rapamyci...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 8, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Outdoor Walking Training Compared To Cycle Ergometer Training in Severe COPD: A Randomized Controlled Feasibility Trial.
In conclusion, the study design and the OWT are feasible. Health-related quality of life improved in the OWT group compared to the CT group after three weeks' inpatient rehabilitation. A minimum of 46 participants is needed for a RCT. Trial registration: www.who.int/trialsearch DRKS00010977. PMID: 31056954 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 8, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Physical Inactivity and Sedentarism among COPD Patients: What About Dynamic Hyperinflation?
Authors: Boutou AK PMID: 31044625 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 3, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Recovery Following Acute Exacerbations of Chronic Obstructive Pulmonary Disease - A Review.
Authors: Wageck B, Cox NS, Holland AE Abstract Acute exacerbations are associated with disease progression, hospital admission and death in people with chronic obstructive pulmonary disease (COPD). The detrimental outcomes associated with acute exacerbations highlights a need to understand the time course of recovery following acute exacerbation of COPD (AECOPD) so that effective and timely interventions can be provided. The aim of this narrative review was to describe the natural recovery in physiology, symptoms and function following AECOPD. Substantial recovery of lung function and airway inflammation occurs in ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 3, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Low Body Mass Index Is Associated with Higher Odds of COPD and Lower Lung Function in Low- and Middle-Income Countries.
Authors: Grigsby MR, Siddharthan T, Pollard SL, Chowdhury M, Rubinstein A, Miranda JJ, Bernabe-Ortiz A, Alam D, Kirenga B, Jones R, van Gemert F, Checkley W Abstract The relationship of body mass index (BMI) with lung function and COPD has been previously described in several high-income settings. However, few studies have examined this relationship in resource-limited settings where being underweight is more common. We evaluated the association between BMI and lung function outcomes across 14 diverse low- and middle-income countries. We included data from 12,396 participants aged 35-95 years and used multivariable...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 1, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

The COPD Comorbidome in the Light of the Degree of Dyspnea and Risk of Exacerbation.
Authors: Figueira Gonçalves JM, García Bello MÁ, Martín Martínez MD, Pérez Méndez LI, García-Talavera I, García Hernández S, Díaz Pérez D, Bethencourt Martín N Abstract The BODE group designed a bubble chart, analogous to the solar system, which depicts the prevalence of each disease and its association with mortality and called it a "comorbidome". Although this graph was used to represent mortality and, later, the risk of needing hospital admission, it was not applied to visualize the association between a set of c...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 1, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Correction.
Authors: PMID: 30961400 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 11, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Clinical Decision Support System: A Pragmatic Tool to Improve Acute Exacerbation of COPD Discharge Recommendations.
Authors: Epstein D, Barak-Corren Y, Isenberg Y, Berger G Abstract Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with significant mortality, morbidity and increased risk for further exacerbations. Therefore, appropriate measures for prevention of further exacerbations should be initiated before discharge. Unfortunately, this opportunity for treatment review and change in disease course is often missed. We designed a decision support tool to automatically generate discharge recommendations for COPD patients based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD)...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 6, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Socioeconomic circumstances and incidence of chronic obstructive pulmonary disease (COPD) in an urban population in Sweden.
Authors: Borné Y, Ashraf W, Zaigham S, Frantz S Abstract The association between socioeconomic circumstances and incidence of chronic obstructive pulmonary disease (COPD) was investigated in an urban population in Sweden. The study included all 40-89 year-old inhabitants in Malmö, Sweden (N = 117,479) without previous hospitalization due to COPD, who were followed over 14 years for COPD related hospital admissions. The Malmö Preventive Project (MPP) cohort (n = 27,358) with information on biological and lifestyle factors was also used to study the association between soc...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 30, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Bacterial Colonization in COPD Patients Admitted to a Rehabilitation Respiratory Unit and Impact on Length of Stay: A Real-Life Study.
Authors: Vitacca M, Marino S, Comini L, Fezzardi L, Paneroni M Abstract Bacterial colonization is a well-known phenomenon in acute care, but scant information is available regarding the rehabilitation setting. We retrospectively analyzed, in COPD patients admitted to a Respiratory Rehabilitative unit in 2010, the number of cultures requested, of positive cultures, and of cultures showing multiple drug resistant (MDR) organisms. We also compared hospital admissions (HA) with versus without positive cultures and with versus without MDR and investigated which baseline variables may predict length of stay (LOS)> 30 ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 23, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Right Heart Catheterization During Exercise in Patients with COPD-An Overview of Clinical Results and Methodological Aspects.
Authors: Ewert R, Heine A, Bollmann T, Müller-Heinrich A, Gläser S, Opitz CF Abstract While right heart catheterization (RHC) at rest is the gold standard to assess pulmonary hemodynamics in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH), the invasive measurement of exercise hemodynamics is less well established in this group. Since exercise hemodynamics are increasingly recognized as important clinical information in patients with PH, our goal was to review the literature in this field to provide a basis for clinical use, further studies, and future recommendat...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 23, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

The Association between Chronic Obstructive Pulmonary Disease and Coronary Artery Disease in Patients Undergoing Coronary Angiography.
Authors: Hong Y, Graham MM, Southern D, McMurtry MS Abstract Chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) are leading causes of morbidity and mortality. There are conflicting results regarding the association between COPD and CAD. We sought to measure the association between COPD and angiographically diagnosed CAD in a population-based cohort. We performed a retrospective analysis using data from the Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH), a prospectively collected registry capturing all patients undergoing coronary angiography in Al...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 23, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Pulmonary Rehabilitation does not Improve Objective Measures of Sleep Quality in People with Chronic Obstructive Pulmonary Disease.
Authors: Cox NS, Pepin V, Burge AT, Hill CJ, Lee AL, Bondarenko J, Moore R, Nicolson C, Lahham A, Parwanta Z, McDonald CF, Holland AE Abstract Abnormal sleep duration is associated with poor health. Upwards of 50% of people with chronic obstructive pulmonary disease (COPD) report poor sleep quality. The effect of pulmonary rehabilitation on self-reported sleep quality is variable. The aim of this study was to assess the effect of pulmonary rehabilitation on objectively measured sleep quality (via actigraphy) in people with COPD. Sleep quality was assessed objectively using the SenseWear Armband (SWA, BodyMedia, Pit...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 20, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study.
Authors: Almagro P, Martínez-Camblor P, Miravitlles M, Rodríguez-Carballeira M, Navarro A, Lamprecht B, Ramirez-Garcia Luna AS, Kaiser B, Alfageme I, Casanova C, Esteban C, Soler-Cataluña JJ, de-Torres JP, Celli BR, Marin JM, Ter Riet G, Sobradillo P, Lange P, Garcia-Aymerich J, Anto JM, Turner AM, Han MK, Langhammer A, Sternberg A, Leivseth L, Bakke P, Johannessen A, Oga T, Cosío B, Ancochea J, Echazarreta A, Roche N, Burgel PR, Sin DD, Puhan MA, Soriano JB, 3CIA collaboration Abstract The CODEX index was developed and validated in patients hospitalized for COPD exacerbation to predict ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Predictors of New Airway Obstruction - An 11 Year's Population-Based Follow-Up Study.
Authors: Vasankari T, Härkänen T, Kainu A, Sääksjärvi K, Mattila T, Jousilahti P, Laitinen T Abstract In the present study we aimed to investigate the incidence and predictors of spirometry based airway obstruction in a representative population-based sample. Altogether 3,863 subjects, 1,651 males and 2,212 females aged ≥30 years had normal spirometry in year 2000. Fifty-three percent of them were never and 23% current smokers. A re-spirometry was performed 11 years later. Several characteristics, such as level of education, use of alcohol, physical activity, diet using Alterna...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Functional Electrical Stimulation Changes Muscle Oxygenation in Patients with Chronic Obstructive Pulmonary Disease During Moderate-Intensity Exercise: A Secondary Analysis.
Authors: Prieur G, Combret Y, Bonnevie T, Gravier FE, Robledo Quesada A, Quieffin J, Lamia B, Medrinal C Abstract We previously showed that functional electrical stimulation during cycle ergometry (FES-cycling) increased oxygen consumption (VO2), indicating that metabolism during exercise was increased. However, the effects on muscle oxygenation have never been studied. The aim of this secondary analysis was to analyse changes in muscle oxygenation during an FES-cycling session. Eight patients with chronic obstructive pulmonary disease who were participating in a pulmonary rehabilitation programme were enrolled. Ea...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Beta-Blockers in COPD: A Methodological Review of the Observational Studies.
Authors: Suissa S, Ernst P Abstract The use of beta-blockers in patients with chronic obstructive pulmonary disease (COPD) has received much attention. Several observational studies reported important reductions in mortality and exacerbations with these drugs, but the extent of bias in these studies is unclear. Nevertheless, the large ongoing randomized trial (βLOCK-COPD) was initiated specifically to evaluate these effects. We searched the literature to identify all observational studies investigating the effectiveness of beta-blockers in COPD patients on major outcomes, including death and COPD exacerbation....
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

A Palliative Approach is Adopted for Many Patients Dying in Hospital with Chronic Obstructive Pulmonary Disease.
This study aimed to determine if symptom palliation or a palliative approach were delivered during the final hospital admission in which death occurred. Retrospective medical record audits were completed at two Australian hospitals, with all patients who died from COPD over 12 years between 1 January 2004 and 31 December 2015 included. Of 343 patients included, 217 (63%) were male with median age 79 years (IQR 71.4-85.0). Median respiratory function: FEV1 0.80L (42% predicted), FVC 2.02L (73% predicted) and DLco 9 (42% predicted). 164 (48%) used domiciliary oxygen. Sixty (18%) patients accessed specialist palliative care a...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Successful Ageing with COPD: Physical and Psychosocial Adaption to Functional Decline.
Authors: Southwell PJ, Crockett J, Burton D, Gullifer J Abstract There is considerable research regarding the adaption to functional decline associated with advanced (Stage IV) Chronic Obstructive Pulmonary Disease (COPD). This research has, however, primarily focused on physical and interventional strategies to manage disease progression and symptom burden, as opposed to the psychosocial strategies. To address this paucity, the current research explored the psychosocial strategies people with Stage IV COPD use to maintain quality of life towards the end of life. Eleven older people with Stage IV COPD living in reg...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Sedentary Behaviour and Physical Inactivity in Patients with Chronic Obstructive Pulmonary Disease: Two Sides of the Same Coin?
Authors: Schneider LP, Furlanetto KC, Rodrigues A, Lopes JR, Hernandes NA, Pitta F Abstract Despite the growing interest in sedentarism, there is no available information on the profile of patients with COPD according to sedentary behaviour (SB) and with a detailed analysis of minute-by-minute bouts. Hence, the aims of this study were to quantify the time spent in SB, light activities and moderate-to-vigorous physical activities (MVPA) and to verify the relationship of MVPA and SB in individuals with COPD, as well as to identify the profile of those physically (in)active and (non)-sedentary. A cross-sectional study...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Prediction of COPD and Related Events Improves by Combining Spirometry and the Single Breath Nitrogen Test.
Authors: Olofson J, Bake B, Bergman B, Ullman A, Svärdsudd K Abstract Chronic obstructive pulmonary disease (COPD) develops in small airways. Severity of small airway pathology relates to progression and mortality. The present study evaluated the prediction of COPD of a validated test for small airway disease, i.e. a slope of the alveolar plateau of the single breath nitrogen test (N2-slope). The N2-slope, spirometry, age, smoking habits, and anthropometric variables at baseline were obtained in a population-based sample (n = 592). The cohort was followed for first COPD events (first hospital adm...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Comparative Effectiveness of Two Tiotropium Formulations: A Retrospective Cohort Study.
This study confirms the findings observed in the TIOSPIR trial in a more heterogeneous population that included patient subgroups with severe respiratory disease and unstable COPD. PMID: 30822243 [PubMed - in process] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Oxidized Alpha-1-Antitrypsin as a Potential Biomarker Associated with Onset and Severity of Chronic Obstructive Pulmonary Disease in Adult Population.
In conclusion, serum level of OxyA1AT would be potentially good biomarker for the assessment of harmful effect of smoking to the onset and severity of COPD. Also, clinical significance of OxyA1AT as prognostic biomarker could be useful in assessing the effectiveness of antioxidant therapy for COPD and emphysema. Suitable and inexpensive laboratory method for determination of OxyA1AT is additional benefit for the introduction of OxyA1AT into routine clinical practice for diagnosis and monitoring of COPD. PMID: 30822244 [PubMed - in process] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Association Between Chronic Obstructive Pulmonary Disease and Type 2 Diabetes: A Systematic Review and Meta-Analysis.
CONCLUSION: This systemic review and meta-analyses showed that the association between COPD and T2D might be influenced by the diagnostic method and should be further investigated in studies using diagnostic definition according to guidelines. Nevertheless, physicians should be aware of comorbidities in COPD patients. PMID: 30822245 [PubMed - in process] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Observational Studies in COPD: Summary of Guidance for Authors.
Authors: Suissa S, Sotgiu G, Brusasco V PMID: 30822246 [PubMed - in process] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Quality of Care Delivered to Veterans with COPD Exacerbation and the Association with 30-Day Readmission and Death.
We examined whether patients received six guideline recommended care items including short-acting bronchodilators, corticosteroids, antibiotics, positive-pressure ventilation (in cases of acute hypercarbic respiratory failure), chest imaging, and arterial blood gas measurement. Our primary outcome was all-cause hospital readmission or death within 30 days. Overall quality of care was not significantly associated with readmission or death (acute care aOR 0.98; 95% CI 0.87-1.11; ICU aOR 0.89; 95% CI 0.71-1.13). Delivery of corticosteroids and antibiotics was associated with reduced odds of readmission and death (aOR 0.7...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

National Survey on the Management of Adult Bronchiectasis in Belgium.
Authors: Schoovaerts K, Lorent N, Goeminne P, Aliberti S, Dupont L Abstract The increasing prevalence and incidence of bronchiectasis leads to a substantial health care burden. Quality standards for the management of bronchiectasis were formulated by the British Thoracic Society following publication of guidelines in 2010. They can be used as a benchmark for quality of care. It is, however, unclear how and whether they apply outside of the UK. Between May and November 2017, we conducted an online survey among respiratory physicians caring for adult bronchiectasis patients in Belgium. About 186 cases were submitted ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 24, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Perspectives on End-of-Life Treatment among Patients with COPD: A Multicenter, Cross-sectional Study in Japan.
Authors: Fuseya Y, Muro S, Sato S, Sato A, Tanimura K, Hasegawa K, Uemasu K, Hamakawa Y, Takahashi Y, Nakayama T, Sakai N, Fukui M, Kita H, Mio T, Mishima M, Hirai T Abstract Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality. Since patients with severe COPD may experience exacerbations and eventually face mortality, advanced care planning (ACP) has been increasingly emphasized in the recent COPD guidelines. We conducted a multicenter, cross-sectional study to survey the current perspectives of Japanese COPD patients toward ACP. "High-risk" COPD patients and their attending physi...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 24, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Practical Guide to the Identification and Diagnosis of Asthma-COPD Overlap (ACO).
We describe how to recognise and diagnose ACO based on a recently proposed Spanish algorithm and by the analysis of three clinical cases of patients with COPD. The diagnosis of ACO is based on the diagnosis of COPD (chronic airflow obstruction in an adult with significant smoking exposure), in addition to a current diagnosis of asthma and/or signficant eosinophilia. PMID: 30789039 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 24, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Assessment of Self-Management Treatment Needs Among COPD Helpline Callers.
Authors: Mathew AR, Guzman M, Bridges C, Yount S, Kalhan R, Hitsman B Abstract Telephone quitlines are an effective population-based strategy for smoking cessation, particularly among individuals with tobacco-related diseases such as chronic obstructive pulmonary disease (COPD). Expanding quitline services to provide COPD-focused self-management interventions is potentially beneficial; however, data are needed to identify specific treatment needs in this population. We conducted a telephone-based survey (N = 5,772) to examine educational needs, behavioral health characteristics, and disease-related in...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 24, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

The role of physical activity in the context of pulmonary rehabilitation.
Authors: Blondeel A, Demeyer H, Janssens W, Troosters T Abstract Pulmonary rehabilitation is an important treatment for patients with chronic obstructive pulmonary disease (COPD). Although this intervention leads to large and clinically meaningful improvements in exercise capacity and quality of life, the effect of pulmonary rehabilitation on physical activity is controversial. Physical activity is lower in patients with COPD as compared to healthy age-matched controls and it is related to important health outcomes (e.g. increased risk of mortality and hospitalization). It is an important goal for rehabilitation pr...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 6, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum.
This study sought to test the relative utility of spontaneous sputum (SS) versus the reasonably noninvasive induced sputum (IS) samples for measurement of mucus hydration. SS and IS samples were collected over a 2-day study interval. Sputum was induced with escalating inhaled nebulized 3-5% hypertonic saline. Viscous portions of the samples ("plugs") were utilized for percent solids and total mucin analyses. Cytokines, nucleotides/nucleosides and cell differentials were measured in plugs diluted into 0.1% Sputolysin. Overall, 61.5% of chronic bronchitis (CB) subjects produced a SS sample and 95.2% an IS sample. T...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 6, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Palliative Care Provision for Patients with Advanced Chronic Obstructive Pulmonary Disease: A Systematic Integrative Literature Review.
Authors: Fusi-Schmidhauser T, Riglietti A, Froggatt K, Preston N Abstract Although chronic obstructive pulmonary disease (COPD) is recognized as being a life-limiting condition with palliative care needs, palliative care provision is seldom implemented. The disease unpredictability, the misconceptions about palliative care being only for people with cancer, and only relevant in the last days of life, prevent a timely integrated care plan. This systematic review aimed to explore how palliative care is provided in advanced COPD and to identify elements defining integrated palliative care. Eight databases, including M...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 6, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Prevalence of Comorbid Chronic Obstructive Pulmonary Disease in Individuals Suffering from Schizophrenia and Bipolar Disorder: A Systematic Review.
Authors: Zareifopoulos N, Bellou A, Spiropoulou A, Spiropoulos K Abstract The disease burden associated with schizophrenia and bipolar disorder is substantial, with affected individuals having a shorter life expectancy and a high risk of severe physical comorbid conditions. These individuals are more likely to smoke and have a longer smoking history compared to the general population. Furthermore, use of antipsychotic drugs has also been linked to active smoking. Chronic obstructive pulmonary disease (COPD) is a respiratory condition affecting elderly individuals with a long smoking history, so it would be expected...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 6, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Adenosine Metabolism in COPD: A Study on Adenosine Levels, 5'-Nucleotidase, Adenosine Deaminase and Its Isoenzymes Activity in Serum, Lymphocytes and Erythrocytes.
Authors: Singh Patidar B, Meena A, Kumar M, Menon B, Rohil V, Kumar Bansal S Abstract Adenosine is a signaling molecule which is produced in high concentrations during airway inflammation. Airway inflammation is a characteristic feature of COPD. Therefore, the current study was designed to evaluate the changes in adenosine metabolism in COPD and correlate these changes with severity of the disease. The study was conducted on 50 healthy controls (25 healthy non-smokers and 25 healthy smokers) and 46 COPD patients (21 moderate, 15 severe and 10 very severe). The patients were sub-divided into moderate, severe and ver...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 22, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

The Role of Cardiopulmonary Exercise Testing (CPET) in Pulmonary Rehabilitation (PR) of Chronic Obstructive Pulmonary Disease (COPD) Patients.
Authors: Stringer W, Marciniuk D Abstract Chronic obstructive pulmonary disease (COPD) is a common multisystem inflammatory disease with ramifications involving essentially all organ systems. Pulmonary rehabilitation is a comprehensive program designed to prevent and mitigate these disparate systemic effects and improve patient quality of life, functional status, and social functioning. Although initial patient assessment is a prominent component of any pulmonary rehabilitation (PR) program, cardiopulmonary exercise testing (CPET) is not regularly performed as a screening physiologic test prior to PR in COPD patien...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 1, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Spirometric instability - another hurdle in achieving real-world COPD diagnostic criteria?
Authors: Boppana LKT, Sakhamuri S, Seemungal T Abstract Globally, mortality, morbidity and the economic burden of chronic obstructive pulmonary disease (COPD) are on the rise. In addition, its diagnosis continues to pose challenges to the physicians, which is compounded further by its new feature "spirometric instability." Based on the findings from the two recent observational studies, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommended repeat spirometry for the individuals with a fixed ratio between 0.6 and 0.8. In this perspective, we discuss the uncertainties and consequences...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 1, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Minimal Important and Detectable Differences of Respiratory Measures in Outpatients with AECOPD †.
This study established MDD and MID for respiratory measures in outpatients with AECOPD following pharmacological treatment. COPD assessment test (CAT), modified Borg scale (MBS), modified British Medical Research Council (mMRC) questionnaire, peripheral oxygen saturation (SpO2), computerised respiratory sounds and forced expiratory volume in one second (FEV1) were collected within 24-48 hour of an AECOPD and after 45 days of pharmacological treatment. MID and MDD were calculated using anchor- (receiver operating characteristic and linear regression analysis) and distribution-based methods (effect size, SEM, 0.5*SD a...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 6, 2018 Category: Respiratory Medicine Tags: COPD Source Type: research

Obesity in COPD: Comorbidities with Practical Consequences?
Authors: Zewari S, Hadi L, van den Elshout F, Dekhuijzen R, Heijdra Y, Vos P Abstract COPD and obesity often coexist and there is a complex interaction between them. Our aim was to evaluate the prevalence of obesity in a secondary care COPD population. Furthermore, the presence of comorbidities in obese (COPDOB) and non-obese COPD (COPDNO) individuals was studied. In 1654 COPD patients (aged ≥18 years) who visited a pulmonologist between January 2015 and December 2015, patient characteristics, pulmonary function tests and comorbidities were obtained from the medical records. Subjects were categorized according t...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 6, 2018 Category: Respiratory Medicine Tags: COPD Source Type: research

Monitoring Antioxidant Enzyme Activity during Exacerbations of Chronic Obstructive Pulmonary Disease.
In this study, we investigated whether activities of these enzymes are altered in the airways of patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). SOD and CAT activities were measured in the sputum, exhaled breath condensate, and serum of 36 COPD patients experiencing a severe exacerbation. Measurements were performed using colorimetric assays in samples collected at the time of hospital admission and at the time of hospital discharge following treatment of AECOPD. For comparison, antioxidants were also assessed in 24 stable COPD patients and 23 healthy control subjects. SOD a...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 28, 2018 Category: Respiratory Medicine Tags: COPD Source Type: research

Pattern of Cardiovascular Comorbidity in COPD in a Country with Low-smoking Prevalence: Results from Two-population-based Cohorts from Sweden.
Authors: Eriksson B, Backman H, Ekerljung L, Axelsson M, Lindberg A, Rönmark E, Lundbäck B Abstract Cardiovascular diseases are the most common comorbidities in COPD, due to common risk factors such as smoking. The prevalence of current smokers in Sweden has decreased over four decades to around 10%. The aim of the present study was to investigate the prevalence, distribution and associations of cardiovascular comorbidities in COPD by disease severity in two large areas of Sweden, both with low-smoking prevalence. Data from clinical examinations in 2009-2012, including spirometry and structured interview,...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 28, 2018 Category: Respiratory Medicine Tags: COPD Source Type: research

Role of Stem Cells in the Pathogenesis of Chronic Obstructive Pulmonary Disease and Pulmonary Emphysema.
Authors: Coppolino I, Ruggeri P, Nucera F, Cannavò MF, Adcock I, Girbino G, Caramori G Abstract There are only few human translational studies performed in the area of stem cell research in patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary emphysema. Before progress to clinical trials with stem cells we strongly believe that more human translational studies are essential, otherwise, the clinical rationale would be solely based on limited in vitro and animal studies. In the future, stem cell therapy could be a treatment for this incurable disease. As of now, stem cell therapy is stil...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 25, 2018 Category: Respiratory Medicine Tags: COPD Source Type: research

COPD Assessment Test (CAT) is a Valid and Simple Tool to Measure the Impact of Bronchiectasis on Affected Patients.
Authors: Lanza FC, Castro RAS, de Camargo AA, Zanatta DJM, Rached S, Athanazio R, Cukier A, Stelmach R, Dal Corso S Abstract The COPD assessment test (CAT) is a short questionnaire developed to help patients and clinicians to assess the impact of symptoms in routine clinical practice. We aimed to validate and to test the reproducibility of CAT in patients with bronchiectasis and correlate with the severity of dyspnea, aerobic and functional capacity, and physical activity in daily life. This is a cross-sectional study, patients with bronchiectasis underwent spirometry, cardiopulmonary exercise test (CPET), incremen...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 25, 2018 Category: Respiratory Medicine Tags: COPD Source Type: research

The Impact of Loneliness on Outcomes of Pulmonary Rehabilitation in Patients with COPD.
Authors: Reijnders T, Schuler M, Jelusic D, Troosters T, Janssens W, Schultz K, von Leupoldt A Abstract Psychological factors such as negative affect have been demonstrated to impact course and treatment of chronic obstructive pulmonary disease (COPD). However, little is known about the respective impact of social factors. In several other chronic diseases, loneliness has been shown to predict morbidity, but little is known about its impact on COPD. Therefore, this study examined the associations between loneliness and outcome measures of a pulmonary rehabilitation program (PR). Before and after a 3-week inpatient ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 9, 2018 Category: Respiratory Medicine Tags: COPD Source Type: research