Structural Lung Disease and Clinical Phenotype in Bronchiectasis Patients: The EMBARC CT Study
CONCLUSION: Patients with bronchiectasis have highly heterogeneous type and extent of structural lung abnormalities. Strong relationships between radiological disease and clinical features suggest CT analysis may be a useful tool for clinical phenotyping.PMID:38635862 | DOI:10.1164/rccm.202311-2109OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 18, 2024 Category: Intensive Care Authors: Angelina L P Pieters Tjeerd van der Veer Jennifer J Meerburg Eleni-Rosalina Andrinopoulou Menno M Vd Eerden Pierluigi Ciet Stefano Aliberti Pierre-Regis Burgel Megan L Crichton Amelia Shoemark Pieter C Goeminne Michal Shteinberg Michael R Loebinger Charle Source Type: research

An assessment of the association between patient characteristics and timely lung cancer treatment
ConclusionsWithin a Medicare Advantage population, patient demographics were found to be significantly associated with the decision to pursue surgery, but factors other than stage were not significantly associated with time to non-systemic treatment. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - April 18, 2024 Category: Cancer & Oncology Source Type: research

Uptake and 4-week quit rates from an opt-out co-located smoking cessation service delivered alongside community-based low-dose computed tomography screening within the Yorkshire Lung Screening Trial
Extract Low-dose computed tomography (LDCT) screening for lung cancer has been shown to reduce lung cancer-specific mortality in two large, randomised trials [1, 2], and implementation of screening is currently underway in many high- and middle-income countries [3]. Of those people responding to an invitation for lung cancer screening and subsequently eligible, between 30% and 50% are currently smoking [4, 5]. Evidence of the impact of screening alone on smoking cessation rates in randomised trials is mixed. Three studies have compared quit rates in participants randomised to LDCT screening versus a non-screened control gr...
Source: European Respiratory Journal - April 18, 2024 Category: Respiratory Medicine Authors: Murray, R. L., Alexandris, P., Baldwin, D., Brain, K., Britton, J., Crosbie, P. A. J., Gabe, R., Lewis, S., Parrott, S., Quaife, S. L., Tam, H. Z., Wu, Q., Beeken, R., Copeland, H., Eckert, C., Hancock, N., Lindop, J., McCutchan, G., Marshall, C., Neal, R Tags: COPD and smoking Original Articles: Smoking cessation Source Type: research

Influenza vaccination coverage and determinants of vaccination in peripheral arterial disease patients
Conclusions: This study highlights the low adherence to influenza vaccination in the PAD population of 2 university hospital centers. Vaccination is often related to age, and there is a need for adapted information regarding influenza consequences on cardiovascular disease overall, particularly on PAD. Addressing common information and advice about vaccination will be a challenge.PMID:38629325 | DOI:10.1024/0301-1526/a001120 (Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases)
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - April 17, 2024 Category: Surgery Authors: Lucie Chastaingt Marie Laure Toba Carine Boulon Loubna Dari Joel Constans Hela Daoud Romain Chauvet Caroline Adou Julien Magne Philippe Lacroix Source Type: research

Sex differences and determinants of anxiety symptoms in patients with COPD initiating pulmonary rehabilitation
CONCLUSION: Over a third of COPD patients had clinically relevant anxiety symptoms with a higher prevalence in women than men. Anxiety was associated with younger age, female gender, and impaired QoL. Early recognition and treatment of anxiety in patients with COPD is worthy of consideration for those attending PR, especially women.PMID:38631527 | DOI:10.1016/j.rmed.2024.107633 (Source: Respiratory Care)
Source: Respiratory Care - April 17, 2024 Category: Respiratory Medicine Authors: A M Yohannes R Casaburi S Dryden N A Hanania Source Type: research

Piece of Cake: Slicing through the Complex Layers of COPD with Lung Tissue Network Analysis
Am J Respir Crit Care Med. 2024 Apr 17. doi: 10.1164/rccm.202403-0560ED. Online ahead of print.NO ABSTRACTPMID:38631039 | DOI:10.1164/rccm.202403-0560ED (Source: Respiratory Care)
Source: Respiratory Care - April 17, 2024 Category: Respiratory Medicine Authors: Matthew Moll John McDonough Source Type: research

Piece of Cake: Slicing through the Complex Layers of COPD with Lung Tissue Network Analysis
Am J Respir Crit Care Med. 2024 Apr 17. doi: 10.1164/rccm.202403-0560ED. Online ahead of print.NO ABSTRACTPMID:38631039 | DOI:10.1164/rccm.202403-0560ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 17, 2024 Category: Intensive Care Authors: Matthew Moll John McDonough Source Type: research

Piece of Cake: Slicing through the Complex Layers of COPD with Lung Tissue Network Analysis
Am J Respir Crit Care Med. 2024 Apr 17. doi: 10.1164/rccm.202403-0560ED. Online ahead of print.NO ABSTRACTPMID:38631039 | DOI:10.1164/rccm.202403-0560ED (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 17, 2024 Category: Respiratory Medicine Authors: Matthew Moll John McDonough Source Type: research

GSE240656 Multi-center Korean cohort study based on RNA-sequencing data targeting COPD patients
This study confirmed gene expression differences in non-coding RNA in COPD patients according to the degree of airflow limitation through RNA-Seq transcriptome analysis. These results may provide valuable predictive resources for future COPD research. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Abnormal heart rate responses to exercise in non-severe COPD: relationship with pulmonary vascular volume and ventilatory efficiency
Despite being a prognostic predictor, cardiac autonomic dysfunction (AD) has not been well investigated in chronic obstructive pulmonary disease (COPD). We aimed to characterise computed tomography (CT), spiro... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - April 17, 2024 Category: Respiratory Medicine Authors: Minghui Shi, Shiwei Qumu, Siyuan Wang, Yaodie Peng, Lulu Yang, Ke Huang, Ruoxi He, Feng Dong, Hongtao Niu, Ting Yang and Chen Wang Tags: Research Source Type: research

New | phs001472.v3.p2 | NHLBI TOPMed: Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE)
​ NHLBI TOPMed: Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE)  (study page |release notes) (Source: dbGaP, the database of Genotypes and Phenotypes)
Source: dbGaP, the database of Genotypes and Phenotypes - April 16, 2024 Category: Genetics & Stem Cells Tags: StudyRelease Source Type: research

Intercostal Muscle Function During Noninvasive Ventilation and Acute Hypercapnic Respiratory Failure
CONCLUSIONS: There is a positive relation between intercostal muscle TF measured by ultrasound and NIV failure, even after adjusting for APACHE II and SOFA scores.PMID:38626952 | DOI:10.4187/respcare.11676 (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Mira ç Öz Serhat Erol Fatma Arslan Ayd ın Çiledağ Ak ın Kaya Source Type: research

Optimizing Pharmacotherapy Management of COPD: Don't Miss the Forest for the Trees
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202402-0338VP. Online ahead of print.NO ABSTRACTPMID:38626371 | DOI:10.1164/rccm.202402-0338VP (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Jean Bourbeau Mohit Bhutani Paul Hernandez Erika Penz Darcy D Marciniuk Source Type: research

Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
CONCLUSIONS: A novel multi-layer network analysis is able to identify clinically relevant COPD patient communities. Patients with similarly low FEV1 and emphysema can have molecularly distinct small airways and immune response patterns, indicating that different endotypes can lead to similar clinical presentation.PMID:38626356 | DOI:10.1164/rccm.202303-0500OC (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Nuria Olvera Jon S ánchez-Valle Iker N úñez-Carpintero Joselyn Rojas-Quintero Guillaume Noell Sandra Casas-Recasens Alen Faiz Philip Hansbro Angela Guirao Rosalba Lepore Davide Cirillo Alvar Agust í Francesca Polverino Alfonso Valencia Rosa Faner Source Type: research

Identifying COPD patients with poor health status and low exercise tolerance through the five-repetition sit-to-stand test and modified Medical Research Council Dyspnea Score
CONCLUSIONS: COPD patients with concurrent conditions have worse clinical status. The diagnostic model developed to discriminate these patients shows good internal validation.PMID:38627182 | DOI:10.1016/j.ejim.2024.03.032 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - April 16, 2024 Category: Internal Medicine Authors: Roberto Bernab éu-Mora Silvana Loana Oliveira-Sousa Francesc Medina-Mirapeix Mariano Gacto-S ánchez Group of Investigation SAQ_COPD Source Type: research