C-Reactive Protein and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis
C-Reactive Protein and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis Xiaohui Qiu†, Yousheng Xiao†, Jingjing Wu, Lu Gan, Yanning Huang and Jin Wang* Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China Background: C-reactive protein (CRP) has been identified as a common inflammation-related cytokine. Although publications indicate that CRP is associated with the pathogenesis of neurological disorders and deemed to be a “risk factor” for Parkinson's disease (PD), the evidence exists still indefinitely. Here, we performed a systematic review with meta-analysis synthesizing all the eligible studies on serum, plasma, and cerebrospinal fluid (CSF) CRP levels and PD risk to investigate the potential relevance. Methods: A systematical search up to October 2018 was performed via PubMed, Embase, Science Direct, ISI Web of Science as well as three Chinese medical databases: China National Knowledge Infrastructure database (CNKI), VIP database and WanFang database. Risk was assessed by standardized mean difference (SMD) with 95% confidence interval (CI) to investigate the involvement of CRP levels in PD patients. Results: Twenty-three eligible case-control studies involving 4,598 individuals (2,646 PD patients and 1,932 healthy controls) were incorporated into this meta-analysis. Results have indicated significant increase of CRP levels in PD subjects when compared wi...
Conclusions: The intake of calcium, folic acid and magnesium was negatively associated with blood glucose levels in individuals in different quantiles of FPG. Appropriate prevention and treatment strategies should be developed for people with different blood glucose levels. PMID: 31983911 [PubMed]
Thank you, for providing me with the opportunity to respond to Dr Grant’s Letter to the Editor regarding: Preserving Pulmonary Function: A Palliative Approach published in the September 2019 issue of The Journal for Nurse Practitioner. Dr. Grant is on-target and not only following recommendations for earlier palliative interventions for cancer patients by the American Society of Oncologists (ASCO) and the National Comprehensive Cancer Network (NCCN). Equally important to recognize is the National Quality Forum (NQF) who serve as the gold standard for patient outcome measurements in the U.S.
Several new studies are investigating the use of NOACs in other medical conditions beyond stroke prevention in AF and the prevention or treatment of VTE.European Heart Journal
What are the signs and symptoms of youth-onset type 2 diabetes, and how is this disease best managed?Pediatric Nursing
A chartered flight with about 210 Americans aboard arrived in Alaska to refuel on its first US stop since leaving the epicenter of the coronavirus outbreak in China.
An airliner from Wuhan, China, is expected to land in Ontario, California, on Wednesday, filled with US citizens who could possibly be infected with the deadly Wuhan coronavirus.
The flight left Wuhan Wednesday, then headed to Alaska for refueling and land in California.
The outbreak of the Wuhan coronavirus in central China has infected thousands and spread overseas, raising the specter of a potential global epidemic as authorities desperately try to contain it.
Chinese officials confirmed nearly 6,000 cases of the mysterious illness as foreign governments airlifted their citizens out of Wuhan, the outbreak ’s epicenter.
The coronavirus outbreak that started in central China has left at least 132 people dead and infected thousands around the world.
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