Prediction of Metabolic Syndrome for the Survival of Patients With Digestive Tract Cancer: A Meta-Analysis

Conclusions: Our findings indicate that metabolic syndrome is associated with an increased risk of postsurgical digestive tract cancer-specific mortality. Continued investigations are needed to uncover the precise molecule mechanism linking metabolic syndrome and digestive tract cancer. Introduction The burden of metabolic syndrome is increasing globally, and the clusters of metabolic risk factors differ regionally (1). Emerging evidence from epidemiologic, clinical and experimental studies indicates that metabolic syndrome confers a differential risk for the development and progression of many types of cancer, especially in the digestive tract system (2–4). For example, metabolic syndrome affects over one in four persons with cancer history, yet less than one in five persons without (5). As demonstrated by the Chinese FIESTA cohort, the presence of metabolic syndrome respectively contributed to a 1.45-, 2.30-, and 2.98-fold increase in postsurgical mortality risk of esophageal squamous cell carcinoma (6), gastric cancer (7), and colorectal cancer (8). Additionally, as tumor is highly energy-demanding tissue, metabolic intermediates are required to foster cancer cell proliferation, survival, and metastasis (9, 10). Based on the above lines of evidence, we here developed a hypothesis that metabolic syndrome may be an important prognostic factor for common digestive tract cancer. However, a literature search has failed to reveal any comprehensive evaluation on thi...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research