Neuroanatomical Changes Underlying Vertical HIV Infection in Adolescents

Conclusion: This study found that HIV-infected pubertal children showed a delayed cortical maturation with atrophy. This abnormal pattern of cortical development may be the structural basis for cognitive impairment in HIV-infected children. Introduction Acquired immune deficiency syndrome (AIDS)-related encephalopathy is one of the most serious complications of AIDS and is more common in children than in adults (1). At present, there are nearly 2 million children living with human immunodeficiency virus (HIV) in the world, almost all newly infected children are infected through mother-to-child transmission (2). Effective antiretroviral therapy (ART) can significantly reduce mortality and the incidence of HIV encephalopathy (3). Although the children's HIV/AIDS has been transformed into chronic, controllable disease patterns, due to the HIV virus, antiretroviral drugs and a variety of environmental factors, a series of neuropsychological defects can still appear on HIV-infected (HIV+) children, sometimes even after the treatment has fully been accepted (4). Currently, some studies have reported and summarized the neurocognitive impairment and behavioral abnormality in children infected with HIV. For example, language barriers, delayed motor development, poor school performance, etc., and some may even have psychological problems such as anxiety and depression (5, 6). Although highly active antiretroviral therapy can improve the cognitive function of HIV+ childre...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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This study aimed to assess the relative safety and short-term efficacy of drug-eluting bead transarterial chemoembolization (DEB-TACE) and conventional transarterial chemoembolization (c-TACE) for treating peculiar anatomical sites of gastric cancer liver metastasis. MATERIAL AND METHODS Of the 68 patients with gastric cancer liver metastases confirmed by imaging and pathology, 35 were treated with DEB-TACE and 33 with c-TACE. The DEB-TACE group comprised 26 males and 9 females aged 28-75 years (56.8±6.3), and the c-TACE group included 19 males and 14 females aged 33-77 (60.2±9.4) years. Liver functions of th...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS The network pharmacology analysis reveals the molecular biological mechanism of Artemisia annua anti-NSCLC via multiple active components, multi-channels, and multi-targets. This suggests that Artemisia annua might be developed as a promising anti-NSCLC drug. PMID: 32474568 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Optical scanning holography (OSH) is an attractive technique since 3D information can be obtained with a single pixel detector. However, ...
Source: Optics Letters - Category: Physics Authors: Source Type: research
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Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Infectious diseases Science Microbiology Medical research UK news US news Australia news Source Type: news
Publication date: Available online 31 May 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Badmus O. Olufunto, Njan Anoka, Ologe M. Olufunmilayo, Olatunji A. Lawrence
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
His group will study how abnormal calcium signals may contribute to human diseases such as allergies and asthma. (read more)
Source: Environmental Factor - NIEHS Newsletter - Category: Environmental Health Source Type: news
BACKGROUND: Research suggests that acute alcohol consumption impairs processing of emotional faces. As emotion processing plays a key role in effective social interaction, these impairments may be one mechanism by which alcohol changes social behaviour. Th...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
BACKGROUND: The United States (US) and Canada are in the midst of an opioid overdose epidemic. Many people who use illicit drugs (PWUD) do not call an emergency number 911 at the scene of an overdose due to fear of arrest. In the US and Canada, when an ind...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
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