An Integrated Experimental Design for the Assessment of Multiple Toxicological End Points in Rat Bioassays
Conclusion: This integrated study design is efficient in that the same generational cohort of rats used for evaluating long-term outcomes can be monitored in satellite parallel experiments to measure biomarkers and other parameters related to system-specific responses including metabolic alterations and endocrine disturbances.
Citation: Manservisi F, Babot Marquillas C, Buscaroli A, Huff J, Lauriola M, Mandrioli D, Manservigi M, Panzacchi S, Silbergeld EK, Belpoggi F. 2017. An integrated experimental design for the assessment of multiple toxicological end points in rat bioassays. Environ Health Perspect 125:289–295; http://dx.doi.org/10.1289/EHP419
Address correspondence to F. Belpoggi, Cesare Maltoni Cancer Research Center, Ramazzini Institute, Via Saliceto, 3, 40010 Bentivoglio, Bologna, Italy. Telephone: 39 051 6640460. E-mail: belpoggif@ramazzini.it
*C. Babot Marquillas is a visiting researcher from the University of Barcelona, Barcelona, Spain.
We thank L. De Angelis and L. Falcioni of the Cesare Maltoni Cancer Research Center, Ramazzini Institute, for their suggestions and assistance in the development of this integrated model.
There were no funds received to support the writing or production of this paper.
The authors declare they have no actual or potential competing financial interests.
Received: 12 October 2015
Revised: 27 April 2016
Accepted: 20 June 2016
Published: 22 July 2016
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Source: EHP Research - Category: Environmental Health Authors: Web Admin Tags: Commentaries March 2017 Source Type: research
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