Experimental rat models for Hashimoto ’s thyroiditis
ConclusionTwo rat models of autoimmune thyroiditis were obtained. EAT caused in Wistar rats by immunization with rat Tg is similar to Hashimoto ’s thyroiditis. EAT induced with porcine Tg was accompanied by oxyphil cell metaplasia in the parathyroids and hypocalcemia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Risks of suboptimal and excessive thyroid hormone replacement across ages
ConclusionSuboptimal and excessive LT4 replacement of the preventable non-communicable disease hypothyroidism requires more focus from the healthcare system and from the global political systems to prevent the personally devastating and socioeconomically challenging consequences. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Thyroid function and iodine intake: global recommendations and relevant dietary trends
Nature Reviews Endocrinology, Published online: 01 May 2024; doi:10.1038/s41574-024-00983-zThis Review discusses the importance of adequate iodine intake for thyroid function, outlining the varying global intake recommendations. Iodine is also considered in the context of the increasing prevalence of overweight and obesity, as well as dietary trends such as cardioprotective salt restriction and plant-based diets. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - May 1, 2024 Category: Endocrinology Authors: Sarah C. Bath Source Type: research
Application and subgroup analysis of competing risks model based on different lymph node staging systems in differentiated thyroid cancer
This study evaluates the prognostic value of various lymph node staging systems in DTC using a competing risks model. We used SEER database records (1998 –2016) of 16,527 DTC patients, analyzing N stage, positive lymph node numbers (PLNNs), metastatic lymph node ratio (MLNR), log odds of positive lymph nodes (LODDS), and log odds of the negative lymph node (NLN)/T stage ratio (LONT). Univariate and multivariate analyses in a competing risks model w ere performed, along with subgroup analyses based on demographic and clinical characteristics. In this study of 16,527 patients with DTC, different lymph node staging systems ...
Source: Updates in Surgery - May 1, 2024 Category: Surgery Source Type: research
Antitumor activity of extracellular signal-regulated kinases 1/2 inhibitor BVD-523 (ulixertinib) on thyroid cancer cells
CONCLUSION: This study reveals the potent antitumor activity of BVD-523 against thyroid cancer cells bearing MAPK-activating mutations, offering promise for treating aggressive forms of thyroid cancer.PMID:38687926 | DOI:10.4103/jcrt.jcrt_1504_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yulu Chen Xi Xiao Guanghui Hu Rengyun Liu Junyu Xue Source Type: research
Accuracy of Large Language Models in Thyroid Nodule-Related Questions Based on the Korean Thyroid Imaging Reporting and Data System (K-TIRADS)
Korean J Radiol. 2024 May;25(5):499-500. doi: 10.3348/kjr.2024.0229.NO ABSTRACTPMID:38685738 | DOI:10.3348/kjr.2024.0229 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 30, 2024 Category: Radiology Authors: Esat Kaba Nur H ürsoy Merve Solak Fatma Beyazal Çeliker Source Type: research
Free TcO4- in 99mTc-PSMA Scan: A Case Report and Review of an Old Pitfall in the New Era of Modern Imaging
Clin Nucl Med. 2024 Apr 30. doi: 10.1097/RLU.0000000000005240. Online ahead of print.ABSTRACTIn a recent 99mTc-HYNIC-PSMA study conducted at our department, we examined 2 patients with prostate cancer referred for initial staging on the same day. The whole-body scans revealed radiotracer uptake in the gastric mucosa and thyroid glands, alluding to high levels of free TcO4- in the injected vial. The scans were repeated after confirming acceptable radiopharmaceutical purity of 97% (normal range, 95%-100%). Interestingly, 1 patient had liver metastases at presentation, which remained non-PSMA-avid after repeating the scan. We...
Source: Clinical Prostate Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Pegah Sahafi Kamran Aryana Soroush Zarehparvar Moghadam Kayvan Sadri Emran Askari Source Type: research
The clinical value of iodine-125 seed implantation in the treatment of iodine-refractory differentiated thyroid carcinoma
CONCLUSION: Most lesions treated with 125I seed implantation in RAIR-DTC patients showed shrinkage and improved pain symptoms.CLINICAL TRIAL REGISTRATION: https://www.clinicaltrials.gov, identifier NCT06362772.PMID:38686207 | PMC:PMC11056783 | DOI:10.3389/fendo.2024.1327766 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Qin Wan Liling Tan Xinlan Tang Wenjun Wang Yu Su Zhen Wu Mengmeng Ke Zhijun Chen Source Type: research
Protective effect of higher free thyroxine levels within the reference range on biliary tract cancer risk: a multivariable mendelian randomization and mediation analysis
CONCLUSION: The findings suggest that higher FT4-RR may have a protective effect against BTC, which is partially mediated by decreased risk of MetS and a reduction in WC. This study highlights the potential role of FT4 in the pathogenesis of BTC and underscores that MetS and WC may play mediation effects as two mediators in this process.PMID:38686204 | PMC:PMC11056546 | DOI:10.3389/fendo.2024.1379607 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Yuxian Chen Hao Dong Baozhen Qu Xuezhen Ma LinLin Lu Source Type: research
Influence of Thyroglobulin (Tg) Autoantibodies on Tg levels Measured by Different Methodologies: (IMA, LC-MS/MS and RIA)
CONCLUSIONS: 1) Between-method Tg variability necessitates method continuity when monitoring the Tg trends of TgAb- DTC patients. 2) The presence and concentration of TgAb appeared to have a lowering effect on serum Tg measured by all methodologies (IMA, MS and RIA). 3) Since the reliability of Tg measured in the presence of TgAb is often uncertain, the TgAb trend (measured by the same method) may be a useful surrogate DTC tumor marker.PMID:38686504 | DOI:10.1210/clinem/dgae286 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Ivana Petrovic Jonathan LoPresti Shireen Fatemi Andrew Gianoukakis Kenneth Burman Cristiane J Gomez-Lima Caroline T Nguyen Carole Ann Spencer Source Type: research
Accuracy of Large Language Models in Thyroid Nodule-Related Questions Based on the Korean Thyroid Imaging Reporting and Data System (K-TIRADS)
Korean J Radiol. 2024 May;25(5):499-500. doi: 10.3348/kjr.2024.0229.NO ABSTRACTPMID:38685738 | DOI:10.3348/kjr.2024.0229 (Source: Korean J Radiol)
Source: Korean J Radiol - April 30, 2024 Category: Radiology Authors: Esat Kaba Nur H ürsoy Merve Solak Fatma Beyazal Çeliker Source Type: research
One-stage thyroid cartilage laryngotracheal reconstruction for children & lt;1 year of age with congenital subglottic stenosis
J Laryngol Otol. 2024 Apr 30:1-14. doi: 10.1017/S0022215124000653. Online ahead of print.NO ABSTRACTPMID:38685689 | DOI:10.1017/S0022215124000653 (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - April 30, 2024 Category: ENT & OMF Authors: Chao Chen Yihua Ni Letian Tan Yue Huang Zheng-Min Xu Source Type: research
Two thyroperoxidase-inhibiting chemicals induce shared transcriptional changes in hippocampus of developing rats
Toxicology. 2024 Apr 27:153822. doi: 10.1016/j.tox.2024.153822. Online ahead of print.ABSTRACTThyroid hormone (TH) system disrupting compounds can impair brain development by perturbing TH action during critical life stages. Human exposure to TH system disrupting chemicals is therefore of great concern. To better protect humans against such chemicals, sensitive test methods that can detect effects on the developing brain are critical. Worryingly, however, current test methods are not sensitive and specific towards TH-mediated effects. To address this shortcoming, we performed RNA-sequencing of rat brains developmentally ex...
Source: Toxicology - April 30, 2024 Category: Toxicology Authors: Louise Ramh øj Terje Svingen Bertrand Evrard Fr édéric Chalmel Marta Axelstad Source Type: research
Associations between short-term exposure to air pollution and thyroid function in a representative sample of the Korean population
CONCLUSIONS: As the subtle changes in thyroid function can affect various organ systems, the present results may have substantial public health implications despite the relatively modest effect sizes. Because this was a cross-sectional study, it is necessary to conduct further experimental or repeated-measures studies to consolidate the current results.PMID:38685294 | DOI:10.1016/j.envres.2024.119018 (Source: Environmental Research)
Source: Environmental Research - April 30, 2024 Category: Environmental Health Authors: Kyoung-Nam Kim SoHyun Park Junseo Choi Il-Ung Hwang Source Type: research
In Vitro Effects of Boric Acid on Cell Cycle, Apoptosis, and miRNAs in Medullary Thyroid Cancer Cells
Biol Trace Elem Res. 2024 Apr 30. doi: 10.1007/s12011-024-04188-3. Online ahead of print.ABSTRACTMedullary thyroid cancer (MTC) is a highly aggressive and chemotherapy-resistant cancer originating from the thyroid's parafollicular C cells. Due to its resistance to conventional treatments, alternative therapies such as boric acid have been explored. Boric acid, a boron-based compound, has shown anticarcinogenic effects, positioning it as a potential treatment option for MTC. TT medullary thyroid carcinoma cell line (TT cells) and human thyroid fibroblast (HThF cells) were utilized for the cell culture experiments. Cell viab...
Source: Biological Trace Element Research - April 30, 2024 Category: Biology Authors: Onurcan Y ıldırım M ücahit Seçme Yavuz Dodurga G ülçin Abban Mete Semin Melahat Fenkci Source Type: research
