Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
Biological functions of LncRNA SNHG14 in the development of thyroid cancer cells via targeting miR-206
This study aimed to determine lncRNA SNHG14 and miR-206 in Thyroid Cancer ( TC) and to explore the related mechanisms. Sixty-four samples of thyroid tissue were collected from patients with TC. TC cell lines and a normal human thyroid cell line (HTori-3) were bought. lncRNA SNHG14-siRNA (si-lncRNA SNHG14), lncRNA SNHG14-shRNA (sh-lncRNA SNHG14), blank plasmid (siRNA-NC), miR-206-inhibitor, miR-206-mimics were transfected into BHT101 and Ocut-2C cells. qRT-PCR quantified the expression of lncRNA SNHG14 and miR-206, and the expression of vimentin, Snail, N-cadherin, Slug, E-cadherin and ZO-1 proteins were identified via WB. ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Yiming Sang Rui Min Tao Huang Jizong Zhang Source Type: research
Naive and regulatory B-cell transcription patterns guide the increased risk of papillary thyroid carcinoma in obesity
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):118-126. doi: 10.14715/cmb/2024.70.4.19.ABSTRACTA growing number of studies suggest a positive association between obesity and the high incidence of papillary thyroid cancer (PTC), suggesting that the abnormal levels of adipokines associated with obesity may be a risk factor for these aggressive thyroid cancers, but the underlying regulatory mechanisms are not yet clear. We downloaded bulk RNA sequence data for subcutaneous adipose tissue (SAT) in obesity and healthy population and tumor tissues of PTC from GEO database. Through analysis of Differential Expression Genes (DE...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Zihui Yu Ziying Xu Shang Li Ziyan Tian Jing Yuan Source Type: research
From Bench-to-Bedside: How Artificial Intelligence Is Changing Thyroid Nodule Diagnostics
CONCLUSIONS: Models predominantly used ultrasound images to predict malignancy. Of four FDA-approved products, only S-Detect was extensively validated. Implementing an AI model locally requires data sanitization and re-validation to ensure appropriate clinical performance.PMID:38679750 | DOI:10.1210/clinem/dgae277 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 28, 2024 Category: Endocrinology Authors: Vivek R Sant Ashwath Radhachandran Vedrana Ivezic Denise T Lee Masha J Livhits James X Wu Rinat Masamed Corey W Arnold Michael W Yeh William Speier Source Type: research
Presacral Neuroendocrine Neoplasms: A Multi-site Review of Surgical Outcomes
CONCLUSION: The study underscores the complex management of PNENs and emphasizes the need for multicenter research to better understand and manage these tumors. It provides valuable insights into surgical outcomes, recurrence rates, and overall survival, guiding future treatment strategies for PNEN patients.PMID:38679679 | DOI:10.1245/s10434-024-15328-3 (Source: Ann Oncol)
Source: Ann Oncol - April 28, 2024 Category: Cancer & Oncology Authors: Tommaso Violante Brenda Murphy Davide Ferrari Rondell P Graham Patrick Navin Amit Merchea David W Larson Eric J Dozois Thorvardur R Halfdanarson William R Perry Source Type: research
Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research
Naive and regulatory B-cell transcription patterns guide the increased risk of papillary thyroid carcinoma in obesity
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):118-126. doi: 10.14715/cmb/2024.70.4.19.ABSTRACTA growing number of studies suggest a positive association between obesity and the high incidence of papillary thyroid cancer (PTC), suggesting that the abnormal levels of adipokines associated with obesity may be a risk factor for these aggressive thyroid cancers, but the underlying regulatory mechanisms are not yet clear. We downloaded bulk RNA sequence data for subcutaneous adipose tissue (SAT) in obesity and healthy population and tumor tissues of PTC from GEO database. Through analysis of Differential Expression Genes (DE...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Zihui Yu Ziying Xu Shang Li Ziyan Tian Jing Yuan Source Type: research
Biological functions of LncRNA SNHG14 in the development of thyroid cancer cells via targeting miR-206
This study aimed to determine lncRNA SNHG14 and miR-206 in Thyroid Cancer ( TC) and to explore the related mechanisms. Sixty-four samples of thyroid tissue were collected from patients with TC. TC cell lines and a normal human thyroid cell line (HTori-3) were bought. lncRNA SNHG14-siRNA (si-lncRNA SNHG14), lncRNA SNHG14-shRNA (sh-lncRNA SNHG14), blank plasmid (siRNA-NC), miR-206-inhibitor, miR-206-mimics were transfected into BHT101 and Ocut-2C cells. qRT-PCR quantified the expression of lncRNA SNHG14 and miR-206, and the expression of vimentin, Snail, N-cadherin, Slug, E-cadherin and ZO-1 proteins were identified via WB. ...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Yiming Sang Rui Min Tao Huang Jizong Zhang Source Type: research
Comparison of lifetime mortality risk, incidence risk, and DALYs of baseline cancer rates among countries as a benchmark for radiation-related cancer risk
Statistical benchmark data are necessary when considering the basis for radiation protection criteria based on calculated risks. We herein focused on baseline mortality and incidence cancer rates as benchmark data collected from 33 countries. Furthermore, we calculated the lifetime mortality and incidence risks and disability-adjusted life years (DALYs) for all solid cancers, colon cancer, lung cancer, breast cancer, thyroid cancer, and leukemia using the baseline cancer rates and compared them among the countries. The results showed that the lifetime mortality and incidence risks and DALYs for all solid cancers differed a...
Source: Journal of Radiological Protection - April 28, 2024 Category: Physics Authors: Jun Hirouchi, Ikuo Kujiraoka, Shogo Takahara, Momo Takada, Thierry Schneider and Michiaki Kai Source Type: research
SYVN1 modulates papillary thyroid carcinoma progression by destabilizing HMGB1
This study aimed to investigate SYVN1 ’s roles and molecular pathways in papillary thyroid cancer (PTC). The functi... (Source: Cell Division)
Source: Cell Division - April 28, 2024 Category: Cytology Authors: Fei Duan, Fanli Kong, Taifeng Jiang and Hongbing Liu Tags: Research Source Type: research
A Case of Thyroid Gland Abscess Caused by Brucella melitensis
Mikrobiyol Bul. 2024 Apr;58(2):217-223. doi: 10.5578/mb.20249810.ABSTRACTBrucellosis is a zoonotic disease endemic in many developing countries, including Türkiye. Among the species that are pathogenic for humans; Brucella melitensis is isolated from livestock animals like sheep and goats, Brucella abortus from cattle and Brucella suis from pigs. Laboratory diagnosis of infection caused by Brucella species with gram-negative coccobacillus morphology; can be made through characteristic culture features, serological tests and molecular methods. Brucellosis, which has a wide distribution of clinical signs and symptoms; can c...
Source: Mikrobiyoloji Bulteni - April 27, 2024 Category: Microbiology Authors: Ilgaz Kazaz Ertu ğrul Yazici İsmail Selçuk Aygar Tu ğrul Hoşbul Source Type: research
Exploring salivary iodine concentration as a biomarker for iodine status and thyroid nodules in females from different water iodine areas: a cross-sectional study
CONCLUSIONS: Using SIC as a biomarker, females in CIDA exhibited mild iodine deficiency, those in IIDA and IAA demonstrated moderate iodine deficiency, and those in IEA and IEHA exhibited an excess of iodine, consistent with SUIC to assess iodine status. SIC can be used as a good biomarker to evaluate the iodine status in population.PMID:38677523 | DOI:10.1016/j.ajcnut.2024.04.023 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 27, 2024 Category: Nutrition Authors: Ying Zhang Xiuwei Li Jianqiang Wang Wei Ma Haiyan Wang Jinpeng Wang Jing Xu Source Type: research
