In Vitro Effects of Boric Acid on Cell Cycle, Apoptosis, and miRNAs in Medullary Thyroid Cancer Cells
Biol Trace Elem Res. 2024 Apr 30. doi: 10.1007/s12011-024-04188-3. Online ahead of print.ABSTRACTMedullary thyroid cancer (MTC) is a highly aggressive and chemotherapy-resistant cancer originating from the thyroid's parafollicular C cells. Due to its resistance to conventional treatments, alternative therapies such as boric acid have been explored. Boric acid, a boron-based compound, has shown anticarcinogenic effects, positioning it as a potential treatment option for MTC. TT medullary thyroid carcinoma cell line (TT cells) and human thyroid fibroblast (HThF cells) were utilized for the cell culture experiments. Cell viab...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Onurcan Y ıldırım M ücahit Seçme Yavuz Dodurga G ülçin Abban Mete Semin Melahat Fenkci Source Type: research
Antitumor activity of extracellular signal-regulated kinases 1/2 inhibitor BVD-523 (ulixertinib) on thyroid cancer cells
CONCLUSION: This study reveals the potent antitumor activity of BVD-523 against thyroid cancer cells bearing MAPK-activating mutations, offering promise for treating aggressive forms of thyroid cancer.PMID:38687926 | DOI:10.4103/jcrt.jcrt_1504_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yulu Chen Xi Xiao Guanghui Hu Rengyun Liu Junyu Xue Source Type: research
Accuracy of Large Language Models in Thyroid Nodule-Related Questions Based on the Korean Thyroid Imaging Reporting and Data System (K-TIRADS)
Korean J Radiol. 2024 May;25(5):499-500. doi: 10.3348/kjr.2024.0229.NO ABSTRACTPMID:38685738 | PMC:PMC11058430 | DOI:10.3348/kjr.2024.0229 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 30, 2024 Category: Radiology Authors: Esat Kaba Nur H ürsoy Merve Solak Fatma Beyazal Çeliker Source Type: research
Free TcO4- in 99mTc-PSMA Scan: A Case Report and Review of an Old Pitfall in the New Era of Modern Imaging
Clin Nucl Med. 2024 Apr 30. doi: 10.1097/RLU.0000000000005240. Online ahead of print.ABSTRACTIn a recent 99mTc-HYNIC-PSMA study conducted at our department, we examined 2 patients with prostate cancer referred for initial staging on the same day. The whole-body scans revealed radiotracer uptake in the gastric mucosa and thyroid glands, alluding to high levels of free TcO4- in the injected vial. The scans were repeated after confirming acceptable radiopharmaceutical purity of 97% (normal range, 95%-100%). Interestingly, 1 patient had liver metastases at presentation, which remained non-PSMA-avid after repeating the scan. We...
Source: Clinical Prostate Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Pegah Sahafi Kamran Aryana Soroush Zarehparvar Moghadam Kayvan Sadri Emran Askari Source Type: research
Influence of Thyroglobulin (Tg) Autoantibodies on Tg levels Measured by Different Methodologies: (IMA, LC-MS/MS and RIA)
CONCLUSIONS: 1) Between-method Tg variability necessitates method continuity when monitoring the Tg trends of TgAb- DTC patients. 2) The presence and concentration of TgAb appeared to have a lowering effect on serum Tg measured by all methodologies (IMA, MS and RIA). 3) Since the reliability of Tg measured in the presence of TgAb is often uncertain, the TgAb trend (measured by the same method) may be a useful surrogate DTC tumor marker.PMID:38686504 | DOI:10.1210/clinem/dgae286 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Ivana Petrovic Jonathan LoPresti Shireen Fatemi Andrew Gianoukakis Kenneth Burman Cristiane J Gomez-Lima Caroline T Nguyen Carole Ann Spencer Source Type: research
Accuracy of Large Language Models in Thyroid Nodule-Related Questions Based on the Korean Thyroid Imaging Reporting and Data System (K-TIRADS)
Korean J Radiol. 2024 May;25(5):499-500. doi: 10.3348/kjr.2024.0229.NO ABSTRACTPMID:38685738 | PMC:PMC11058430 | DOI:10.3348/kjr.2024.0229 (Source: Korean J Radiol)
Source: Korean J Radiol - April 30, 2024 Category: Radiology Authors: Esat Kaba Nur H ürsoy Merve Solak Fatma Beyazal Çeliker Source Type: research
Two thyroperoxidase-inhibiting chemicals induce shared transcriptional changes in hippocampus of developing rats
Toxicology. 2024 Apr 27:153822. doi: 10.1016/j.tox.2024.153822. Online ahead of print.ABSTRACTThyroid hormone (TH) system disrupting compounds can impair brain development by perturbing TH action during critical life stages. Human exposure to TH system disrupting chemicals is therefore of great concern. To better protect humans against such chemicals, sensitive test methods that can detect effects on the developing brain are critical. Worryingly, however, current test methods are not sensitive and specific towards TH-mediated effects. To address this shortcoming, we performed RNA-sequencing of rat brains developmentally ex...
Source: Toxicology - April 30, 2024 Category: Toxicology Authors: Louise Ramh øj Terje Svingen Bertrand Evrard Fr édéric Chalmel Marta Axelstad Source Type: research
Associations between short-term exposure to air pollution and thyroid function in a representative sample of the Korean population
CONCLUSIONS: As the subtle changes in thyroid function can affect various organ systems, the present results may have substantial public health implications despite the relatively modest effect sizes. Because this was a cross-sectional study, it is necessary to conduct further experimental or repeated-measures studies to consolidate the current results.PMID:38685294 | DOI:10.1016/j.envres.2024.119018 (Source: Environmental Research)
Source: Environmental Research - April 30, 2024 Category: Environmental Health Authors: Kyoung-Nam Kim SoHyun Park Junseo Choi Il-Ung Hwang Source Type: research
Accuracy of Large Language Models in Thyroid Nodule-Related Questions Based on the Korean Thyroid Imaging Reporting and Data System (K-TIRADS)
Korean J Radiol. 2024 May;25(5):499-500. doi: 10.3348/kjr.2024.0229.NO ABSTRACTPMID:38685738 | PMC:PMC11058430 | DOI:10.3348/kjr.2024.0229 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 30, 2024 Category: Radiology Authors: Esat Kaba Nur H ürsoy Merve Solak Fatma Beyazal Çeliker Source Type: research
Accuracy of Large Language Models in Thyroid Nodule-Related Questions Based on the Korean Thyroid Imaging Reporting and Data System (K-TIRADS)
Korean J Radiol. 2024 May;25(5):499-500. doi: 10.3348/kjr.2024.0229.NO ABSTRACTPMID:38685738 | PMC:PMC11058430 | DOI:10.3348/kjr.2024.0229 (Source: Korean J Radiol)
Source: Korean J Radiol - April 30, 2024 Category: Radiology Authors: Esat Kaba Nur H ürsoy Merve Solak Fatma Beyazal Çeliker Source Type: research
Two thyroperoxidase-inhibiting chemicals induce shared transcriptional changes in hippocampus of developing rats
Toxicology. 2024 Apr 27:153822. doi: 10.1016/j.tox.2024.153822. Online ahead of print.ABSTRACTThyroid hormone (TH) system disrupting compounds can impair brain development by perturbing TH action during critical life stages. Human exposure to TH system disrupting chemicals is therefore of great concern. To better protect humans against such chemicals, sensitive test methods that can detect effects on the developing brain are critical. Worryingly, however, current test methods are not sensitive and specific towards TH-mediated effects. To address this shortcoming, we performed RNA-sequencing of rat brains developmentally ex...
Source: Toxicology - April 30, 2024 Category: Toxicology Authors: Louise Ramh øj Terje Svingen Bertrand Evrard Fr édéric Chalmel Marta Axelstad Source Type: research
Accuracy of Large Language Models in Thyroid Nodule-Related Questions Based on the Korean Thyroid Imaging Reporting and Data System (K-TIRADS)
Korean J Radiol. 2024 May;25(5):499-500. doi: 10.3348/kjr.2024.0229.NO ABSTRACTPMID:38685738 | PMC:PMC11058430 | DOI:10.3348/kjr.2024.0229 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 30, 2024 Category: Radiology Authors: Esat Kaba Nur H ürsoy Merve Solak Fatma Beyazal Çeliker Source Type: research
Accuracy of Large Language Models in Thyroid Nodule-Related Questions Based on the Korean Thyroid Imaging Reporting and Data System (K-TIRADS)
Korean J Radiol. 2024 May;25(5):499-500. doi: 10.3348/kjr.2024.0229.NO ABSTRACTPMID:38685738 | PMC:PMC11058430 | DOI:10.3348/kjr.2024.0229 (Source: Korean J Radiol)
Source: Korean J Radiol - April 30, 2024 Category: Radiology Authors: Esat Kaba Nur H ürsoy Merve Solak Fatma Beyazal Çeliker Source Type: research
Two thyroperoxidase-inhibiting chemicals induce shared transcriptional changes in hippocampus of developing rats
Toxicology. 2024 Apr 27;505:153822. doi: 10.1016/j.tox.2024.153822. Online ahead of print.ABSTRACTThyroid hormone (TH) system disrupting compounds can impair brain development by perturbing TH action during critical life stages. Human exposure to TH system disrupting chemicals is therefore of great concern. To better protect humans against such chemicals, sensitive test methods that can detect effects on the developing brain are critical. Worryingly, however, current test methods are not sensitive and specific towards TH-mediated effects. To address this shortcoming, we performed RNA-sequencing of rat brains developmentall...
Source: Toxicology - April 30, 2024 Category: Toxicology Authors: Louise Ramh øj Terje Svingen Bertrand Evrard Fr édéric Chalmel Marta Axelstad Source Type: research
The Underestimated Impact of Hashimoto Thyroiditis on Thyroid Papillary Carcinoma
In this study, our aim is to investigate the effect of the presence of HT on clinicopathological data in patients with PTC. All 356 patients whose pathology was reported as PTC who were operated between 2015 and 2023 were included in the study. PTC patients were divided into 2 groups as those with and without HT. The effect of HT association on clinicopathological features was investigated. In 356 PTC patients, the rate of HT was 31.2%. PTC patients with HT had less multifocality (p < 0.05), more lymph node metastases (LNM) (p < 0.01) compared to PTC patients without HT. The presence of HT did not affect th...
Source: Updates in Surgery - April 30, 2024 Category: Surgery Source Type: research
