A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report
We describe a case of a young man who presented with progressive cough, increased abdominal girth and ankle swelling for a few months. On examination, he had jaundice, bilateral exophthalmos, diffuse goiter, ascites, and significant lower limb edema. Laboratory investigations showed increased Thyroxin level with a suppressed thyroid stimulating hormone and positive anti-thyrotropin receptor antibodies. Also, the patient had pancytopenia, coagulopathy and cholestatic pattern of elevated liver enzymes. Echocardiography demonstrated mildly reduced left ventricular function with diastolic dysfunction, but electrocardiogram did...
Source: Clinical Case Reports - April 25, 2024 Category: General Medicine Authors: Mohamed Kamal Sabra,
Anwar Joudeh,
Mahmoud Al Niserat,
Riyadh Hammamy Tags: CASE REPORT Source Type: research
Impact of methimazole ‐induced hypothyroidism on postnatal swine
The objective of this study was to evaluate the impact of hypothyroidism induced with the antithyroid medication methimazole (MMI). 10 mg/kg MMI significantly decreased circulating triiodothyronine (T3) for the duration of treatment but had only a transient effect on circulating thyroxine (T4). Thyroid tissue weight was significantly increased by more than 3.5-fold in response to MMI treatment. Histologically, the eosinophilic c olloid was largely absent from the thyroid follicle which displayed a disorganized columnar epithelium consistent with goiter. MMI induced hypothyroidism has no effect on growth rate over 28 d...
Source: Physiological Reports - April 25, 2024 Category: Physiology Authors: James C. Fazioli,
Margaret K. Mulligan,
Erin K. Ison,
J. Alex Pasternak Tags: ORIGINAL ARTICLE Source Type: research
Cancers, Vol. 16, Pages 1646: Protective Effects of Melatonin against Carcinogen-Induced Oxidative Damage in the Thyroid
a
Melatonin, primarily synthesized in the pineal gland, plays a crucial role in regulating circadian rhythms and possesses significant antioxidative properties. By neutralizing free radicals and reducing oxidative stress, melatonin emerges as a promising agent for the prevention and therapy of many different disorders, including cancer. This paper reviews the relationship between the thyroid gland and melatonin, presenting experimental evidence on the protective effects of this indoleamine against oxidative damage to macromolecules in thyroid tissue caused by documented carcinogens (as classified by the International A...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Jan St ępniak Ma łgorzata Karbownik-Lewińska Tags: Review Source Type: research
Calcium oxalate crystals as a cause of multiple punctate echogenic foci in benign thyroid lesions
ConclusionAppearance of MPEF in GDs and FNDs is not because of psammoma bodies; it is attributable to CaOx crystals larger than 100 μm. Therefore, MPEF is not an indicator of malignancy. (Source: Journal of Medical Ultrasonics)
Source: Journal of Medical Ultrasonics - April 25, 2024 Category: Radiology Source Type: research
Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model
To characterize aspects of triiodothyronine (T3) induced chondrocyte terminal maturation within the molecular osteoarthritis pathophysiology using the previously established T3 human ex vivo osteochondral explant... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 25, 2024 Category: Rheumatology Authors: N. M. Korthagen, E. Houtman, I. Boone, R. Coutinho de Almeida, K. Sivasubramaniyan, R. Mahdad, R. G. H. H Nelissen, Y. F. M. Ramos, M. A Tessari and I. Meulenbelt Tags: Research Source Type: research
The European Association of Nuclear Medicine (EANM) ’s Response to the 2023 European Thyroid Association (ETA) clinical practice guidelines for thyroid nodule management and nuclear medicine: a deliberate oversight?
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
< em > TAF1 < /em > is needed for the proliferation and maturation of thyroid follicle cells < em > via < /em > Notch signaling
This study showed that TAF1 promoted Notch signaling and that this association played a pivotal role in thyroid development.PMID:38656129 | DOI:10.1152/ajpendo.00403.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Caoxu Zhang Liu Yang Haiyang Zhang Fengyao Wu Yue Zhang Kaiwen Zhang Chenyang Wu Rui Li Mei Dong Shuangxia Zhao Huaidong Song Source Type: research
Patterns in the Reporting of Aggressive Histologic Subtypes in Papillary Thyroid Cancer
CONCLUSIONS: Aggressive subtypes of PTC are associated with worse outcomes. Academic and other facilities in the Middle Atlantic were more likely to report aPTC. This suggests the need for further evaluation of environmental or geographic factors versus a need for increased awareness and more accurate diagnosis of these subtypes.PMID:38657351 | DOI:10.1016/j.jss.2024.03.023 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Yeon J Lee Caitlin E Egan Jacques A Greenberg Teagan Marshall Abhinay Tumati Brendan M Finnerty Toni Beninato Rasa Zarnegar Thomas J Fahey Minerva A Romero Arenas Source Type: research
Efficacy and safety of fibrin sealant application in patients undergoing thyroidectomy: a systematic review and meta-analysis
BMC Surg. 2024 Apr 24;24(1):122. doi: 10.1186/s12893-024-02414-2.ABSTRACTVarious studies have focused on the application of fibrin sealants (FS) in thyroid surgery. Utilizing a meta-analysis, this systematic review analyzed the findings of recent randomized controlled trials on the safety and efficacy of FS in patients who underwent thyroidectomy. The Cochrane Library, Web of Science, Embase, PubMed, and Medline databases were searched for relevant studies, without any language restrictions. Seven randomized controlled trials were included in the originally identified 69 studies. Overall, 652 patients received FS during th...
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: XiaoGang Zheng Fan Wang Yong Cheng Su Chao Yang Xu Ming Zheng Wang Source Type: research
Thyroid Cancer and Endocrine Disruptive Chemicals: A Case-Control Study on Per-fluoroalkyl Substances (PFAS) and Other Persistent Organic Pollutants (POPs)
CONCLUSIONS: Our study suggests, for the first time in a case-control population, that exposure to some PFAS and PCBs associates with TC and some clinical and molecular features. On the contrary, an inverse correlation was found with both PFHxS and pollutants' mixture, likely due to a potential reverse causality.PMID:38657654 | DOI:10.1530/ETJ-23-0192 (Source: Cancer Control)
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Valentina Cirello Marina Lugaresi Claudia Moneta Patrice Dufour Alessandro Manzo Erika Carbone Carla Colombo Laura Fugazzola Corinne Charlier Catherine Pirard Source Type: research
< em > TAF1 < /em > is needed for the proliferation and maturation of thyroid follicle cells < em > via < /em > Notch signaling
This study showed that TAF1 promoted Notch signaling and that this association played a pivotal role in thyroid development.PMID:38656129 | DOI:10.1152/ajpendo.00403.2023 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 24, 2024 Category: Endocrinology Authors: Caoxu Zhang Liu Yang Haiyang Zhang Fengyao Wu Yue Zhang Kaiwen Zhang Chenyang Wu Rui Li Mei Dong Shuangxia Zhao Huaidong Song Source Type: research
Identification of Eukaryotic Translation Initiation Factor 4B as a Novel Candidate Gene for Congenital Hypothyroidism
CONCLUSION: These experimental data supported a role for EIF4B function in the pathogenesis of the hypothyroid phenotype seen in CH patients. Our work indicated that EIF4B was identified as a novel candidate gene in CH. EIF4B is essential for animal survival, but further studies are needed to validate its role in the pathogenesis of CH.PMID:38654471 | DOI:10.1210/clinem/dgae270 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 24, 2024 Category: Endocrinology Authors: Feng Sun Rui-Jia Zhang Ya Fang Cheng-Yan Yan Chang-Run Zhang Feng-Yao Wu Rui-Meng Yang Bing Han Huai-Dong Song Shuang-Xia Zhao Source Type: research
Inappropriate laboratory test utilization in outpatient tertiary care: Implications for value-based healthcare
CONCLUSION: The study identified significantly high rates of inadequate repetitions of frequently requested laboratory tests. Urgent action is therefore crucial to overcoming such an issue.PMID:38657991 | DOI:10.15537/smj.2024.45.4.20230512 (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - April 24, 2024 Category: Middle East Health Authors: Nouf F Almasoud Mohammed A Aldosari Ahmed S Mahmoud Yaser A Alendijani Abdullah H Alkhenizan Source Type: research
Diagnostic interobserver agreement for thyroid fine-needle aspirates: Effects of reviewer experience and molecular diagnostics
CONCLUSIONS: Atypia of undetermined significance of thyroid FNAs harboring BRAF V600E is uncommon yet relatively reproducible, particularly among pathologists with experience. It is advisable to sequence BRAF across V600 in such cases.PMID:38656386 | DOI:10.1093/ajcp/aqae043 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 24, 2024 Category: Pathology Authors: Hamza N Gokozan Maria Mostyka Theresa Scognamiglio James P Solomon Shaham Beg Evan Stern Abha Goyal Momin T Siddiqui Jonas J Heymann Source Type: research
Associations of per- and polyfluoroalkyl substances with maternal early second trimester sex-steroid hormones
CONCLUSION: PFAS mixture modeled using QGComp was not associated with maternal sex-steroid hormones due to potential opposing effects of certain PFAS. Additional prospective studies could corroborate these findings.PMID:38657330 | DOI:10.1016/j.ijheh.2024.114380 (Source: International Journal of Hygiene and Environmental health)
Source: International Journal of Hygiene and Environmental health - April 24, 2024 Category: Environmental Health Authors: Diana C Pacyga George D Papandonatos Libeth Rosas Jason Whalen Sabrina Smith June-Soo Park Joseph C Gardiner Joseph M Braun Susan L Schantz Rita S Strakovsky Source Type: research
