Identifying Risk Indicators of Cardiovascular Disease in Fasa Cohort Study (FACS): An Application of Generalized Linear Mixed-Model Tree
CONCLUSION: Given the superior performance of the GLMM tree compared with the standard tree and the lack of significant difference with the GLMM, using this model is suggested due to its simpler interpretation and fewer assumptions. Using updated statistical models for more accurate CVD prediction can result in more precise frameworks to aid in proactive patient detection planning.PMID:38690790 | DOI:10.34172/aim.2024.35 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - May 1, 2024 Category: Middle East Health Authors: Fariba Asadi Reza Homayounfar Mojtaba Farjam Yaser Mehrali Fatemeh Masaebi Farid Zayeri Source Type: research
Thyroid abnormalities identified on CT screening for lung cancer
CONCLUSION: ITNs are detected at LDCT however, no malignancy was found. Certain predictors for ITNs in females have been identified including breast density, which may point towards a common causal pathway.PMID:38691910 | DOI:10.1016/j.clinimag.2024.110162 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Maaike van Gerwen Teng Ma Rowena Yip Chris Choi Natela Paksashvili David Yankelevitz Claudia Henschke Source Type: research
Thyroid abnormalities identified on CT screening for lung cancer
CONCLUSION: ITNs are detected at LDCT however, no malignancy was found. Certain predictors for ITNs in females have been identified including breast density, which may point towards a common causal pathway.PMID:38691910 | DOI:10.1016/j.clinimag.2024.110162 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Maaike van Gerwen Teng Ma Rowena Yip Chris Choi Natela Paksashvili David Yankelevitz Claudia Henschke Source Type: research
Genome-wide analysis of two different regions of brain reveals the molecular changes of fertility related genes in rln3a < sup > -/- < /sup > mutants in male Nile tilapia (Oreochromis niloticus)
Gen Comp Endocrinol. 2024 Apr 29:114543. doi: 10.1016/j.ygcen.2024.114543. Online ahead of print.ABSTRACTRelaxin3 (rln3) has been associated with various emotional and cognitive processes, including stress, anxiety, learning, memory, motivational behavior, and circadian rhythm. Notably, previous report revealed that Rln3a played an indispensable role in testicular development and male fertility in Nile tilapia (Oreochromis niloticus). However, the underlying molecular mechanisms remain largely unknown. We found that Rln3a is expressed exclusively in the diencephalon* (Di*) of the brain. Deficiency of Rln3a resulted in a si...
Source: General and Comparative Endocrinology - May 1, 2024 Category: Endocrinology Authors: Tengfei Wu You Wu Yanlong Li Yiyun Du Saining Feng Deshou Wang Linyan Zhou Source Type: research
Characteristics of Human Leukocyte Antigen Class II Genes in Japanese Patients with Type 1 Diabetes and Autoimmune Thyroid Disease
Tohoku J Exp Med. 2024 May 2. doi: 10.1620/tjem.2024.J027. Online ahead of print.NO ABSTRACTPMID:38692862 | DOI:10.1620/tjem.2024.J027 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 1, 2024 Category: Research Authors: Risa Kajita Haruna Takahashi Satoshi Yoshino Shunichi Matsumoto Kazuhiko Horiguchi Shuichi Okada Masanobu Yamada Eijiro Yamada Source Type: research
Identifying Risk Indicators of Cardiovascular Disease in Fasa Cohort Study (FACS): An Application of Generalized Linear Mixed-Model Tree
CONCLUSION: Given the superior performance of the GLMM tree compared with the standard tree and the lack of significant difference with the GLMM, using this model is suggested due to its simpler interpretation and fewer assumptions. Using updated statistical models for more accurate CVD prediction can result in more precise frameworks to aid in proactive patient detection planning.PMID:38690790 | DOI:10.34172/aim.2024.35 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - May 1, 2024 Category: Middle East Health Authors: Fariba Asadi Reza Homayounfar Mojtaba Farjam Yaser Mehrali Fatemeh Masaebi Farid Zayeri Source Type: research
Genome-wide analysis of two different regions of brain reveals the molecular changes of fertility related genes in rln3a < sup > -/- < /sup > mutants in male Nile tilapia (Oreochromis niloticus)
Gen Comp Endocrinol. 2024 Apr 29:114543. doi: 10.1016/j.ygcen.2024.114543. Online ahead of print.ABSTRACTRelaxin3 (rln3) has been associated with various emotional and cognitive processes, including stress, anxiety, learning, memory, motivational behavior, and circadian rhythm. Notably, previous report revealed that Rln3a played an indispensable role in testicular development and male fertility in Nile tilapia (Oreochromis niloticus). However, the underlying molecular mechanisms remain largely unknown. We found that Rln3a is expressed exclusively in the diencephalon* (Di*) of the brain. Deficiency of Rln3a resulted in a si...
Source: General and Comparative Endocrinology - May 1, 2024 Category: Endocrinology Authors: Tengfei Wu You Wu Yanlong Li Yiyun Du Saining Feng Deshou Wang Linyan Zhou Source Type: research
Characteristics of Human Leukocyte Antigen Class II Genes in Japanese Patients with Type 1 Diabetes and Autoimmune Thyroid Disease
Tohoku J Exp Med. 2024 May 2. doi: 10.1620/tjem.2024.J027. Online ahead of print.NO ABSTRACTPMID:38692862 | DOI:10.1620/tjem.2024.J027 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 1, 2024 Category: Research Authors: Risa Kajita Haruna Takahashi Satoshi Yoshino Shunichi Matsumoto Kazuhiko Horiguchi Shuichi Okada Masanobu Yamada Eijiro Yamada Source Type: research
Fibrinogen exacerbates GCase ubiquitination via ATF5-induced TRIP12 activation in Parkinson's Disease
Background: Blood-brain-barrier disruption occurs in Parkinson's disease (PD), which may be accompanied with the deposition of Fibrinogen (FG) in brain parenchyma. However, the relationship between FG and glucocerebrosidase (GCase) reduction, which may contribute to α-synuclein aggregation in PD, is under investigation. Recently, there is evidence that PD patients without GBA mutation also exhibits GCase reduction in brain, and Thyroid-Hormone-Receptor-Interactor-12 (TRIP12) was found to be a key ubiquitin enzyme of GCase degradation. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: H. Zhong, Q. Wang, Z. Huang Source Type: research
Impact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies
Cell Death & Disease, Published online: 01 May 2024; doi:10.1038/s41419-024-06690-xImpact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies (Source: Cell death and disease)
Source: Cell death and disease - May 1, 2024 Category: Internal Medicine Authors: Maria Virginia Giolito Serguei Bodoirat Theo La Rosa Mathieu Reslinger Gabriela D. A. Guardia Jana Mourtada Leo Claret Alain Joung Pedro A. F. Galante Luiz O. F. Penalva Michelina Plateroti Source Type: research
Artificial intelligence in endocrinology: a comprehensive review
ConclusionsBy embracing AI in endocrinology, a future can be envisioned where medical professionals and AI systems synergistically collaborate, ultimately enhancing the lives of individuals affected by endocrine disorders. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Experimental rat models for Hashimoto ’s thyroiditis
ConclusionTwo rat models of autoimmune thyroiditis were obtained. EAT caused in Wistar rats by immunization with rat Tg is similar to Hashimoto ’s thyroiditis. EAT induced with porcine Tg was accompanied by oxyphil cell metaplasia in the parathyroids and hypocalcemia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Risks of suboptimal and excessive thyroid hormone replacement across ages
ConclusionSuboptimal and excessive LT4 replacement of the preventable non-communicable disease hypothyroidism requires more focus from the healthcare system and from the global political systems to prevent the personally devastating and socioeconomically challenging consequences. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Thyroid function and iodine intake: global recommendations and relevant dietary trends
Nature Reviews Endocrinology, Published online: 01 May 2024; doi:10.1038/s41574-024-00983-zThis Review discusses the importance of adequate iodine intake for thyroid function, outlining the varying global intake recommendations. Iodine is also considered in the context of the increasing prevalence of overweight and obesity, as well as dietary trends such as cardioprotective salt restriction and plant-based diets. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - May 1, 2024 Category: Endocrinology Authors: Sarah C. Bath Source Type: research
Application and subgroup analysis of competing risks model based on different lymph node staging systems in differentiated thyroid cancer
This study evaluates the prognostic value of various lymph node staging systems in DTC using a competing risks model. We used SEER database records (1998 –2016) of 16,527 DTC patients, analyzing N stage, positive lymph node numbers (PLNNs), metastatic lymph node ratio (MLNR), log odds of positive lymph nodes (LODDS), and log odds of the negative lymph node (NLN)/T stage ratio (LONT). Univariate and multivariate analyses in a competing risks model w ere performed, along with subgroup analyses based on demographic and clinical characteristics. In this study of 16,527 patients with DTC, different lymph node staging systems ...
Source: Updates in Surgery - May 1, 2024 Category: Surgery Source Type: research
