Effects of crosstalk between steroid hormones mediated thyroid hormone in zebrafish exposed to 4-tert-octylphenol: Estrogenic and anti-androgenic effects
Ecotoxicol Environ Saf. 2024 Apr 25;277:116348. doi: 10.1016/j.ecoenv.2024.116348. Online ahead of print.ABSTRACTAlkylphenols, such as nonylphenol and 4-tert-octylphenol (OP), are byproducts of the biodegradation of alkylphenol ethoxylates and present substantial ecological and health risks in aquatic environments and higher life forms. In this context, our study aimed to explore the effect of OP on reproductive endocrine function in both female and male zebrafish. Over a period of 21 days, the zebrafish were subjected to varying concentrations of OP (0, 0.02, 0.1, and 0.5 μg/L), based on the lowest effective concentratio...
Source: Ecotoxicology and Environmental Safety - April 26, 2024 Category: Environmental Health Authors: Jangjae Lee Seonggeun Zee Hugh I Kim Sung-Hee Cho Chang-Beom Park Source Type: research
Comprehensive Insights into Pediatric Craniopharyngioma: Endocrine and Metabolic Profiles, Treatment Challenges, and Long-term Outcomes with a Multicenter Approach
CONCLUSION: Recurrence was predominantly due to incomplete resection and the low rate of postoperative radiotherapy. It also emphasized challenges in multidisciplinary regular follow ups and suggested early interventions such as dietary restrictions and increased exercise to prevent obesity.PMID:38664994 | DOI:10.4274/jcrpe.galenos.2024.2024-1-3 (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - April 26, 2024 Category: Endocrinology Authors: Zeynep Şıklar Elif Özsu Sirmen K ızılcan Çetin Samim Özen Filiz Çizmecioğlu-Jones Hanife G ül Balkı Zehra Aycan Damla Goksen Fatih Kilci Sema Nilay Abseyi Ummahan Tercan G özde Gürpınar Şükran Poyrazoğlu Feyza Darendeliler Korcan Demir Ö Source Type: research
Availability of genome-matched therapy based on clinical practice
CONCLUSION: This study demonstrated the usefulness of CGP for patients with sarcoma and HNC in addition to lung cancer in clinical practice. Performing CGP at the front line has the potential to improve the availability of genome-matched therapy.PMID:38668785 | DOI:10.1007/s10147-024-02533-z (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Naomi Hayashi Seiichi Mori Akihiro Ohmoto Ippei Fukada Masumi Yamazaki Mari Hosonaga Xiaofei Wang Arisa Ueki Kazuma Kiyotani Akiko Tonooka Kengo Takeuchi Shunji Takahashi Source Type: research
Survival Outcomes in Thyroid Cancer Patients with Co-Occurring Breast Cancer: Evidence of Mortality Risk Attenuation
CONCLUSION: These findings suggest that hormone pathways may play a role in the co-occurrence of thyroid and breast cancers. Patients with TC coexisting with luminal A BC have higher survival rates. However, further studies on the mechanisms underlying the association between BC and TC are warranted.PMID:38670860 | DOI:10.1016/j.clbc.2024.04.002 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Matheus Wohlfahrt Baumgarten Iuri Martin Goemann Rafael Selbach Scheffel Ana Luiza Maia Source Type: research
Survival Outcomes in Thyroid Cancer Patients with Co-Occurring Breast Cancer: Evidence of Mortality Risk Attenuation
CONCLUSION: These findings suggest that hormone pathways may play a role in the co-occurrence of thyroid and breast cancers. Patients with TC coexisting with luminal A BC have higher survival rates. However, further studies on the mechanisms underlying the association between BC and TC are warranted.PMID:38670860 | DOI:10.1016/j.clbc.2024.04.002 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Matheus Wohlfahrt Baumgarten Iuri Martin Goemann Rafael Selbach Scheffel Ana Luiza Maia Source Type: research
Availability of genome-matched therapy based on clinical practice
CONCLUSION: This study demonstrated the usefulness of CGP for patients with sarcoma and HNC in addition to lung cancer in clinical practice. Performing CGP at the front line has the potential to improve the availability of genome-matched therapy.PMID:38668785 | DOI:10.1007/s10147-024-02533-z (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Naomi Hayashi Seiichi Mori Akihiro Ohmoto Ippei Fukada Masumi Yamazaki Mari Hosonaga Xiaofei Wang Arisa Ueki Kazuma Kiyotani Akiko Tonooka Kengo Takeuchi Shunji Takahashi Source Type: research
Availability of genome-matched therapy based on clinical practice
CONCLUSION: This study demonstrated the usefulness of CGP for patients with sarcoma and HNC in addition to lung cancer in clinical practice. Performing CGP at the front line has the potential to improve the availability of genome-matched therapy.PMID:38668785 | DOI:10.1007/s10147-024-02533-z (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Naomi Hayashi Seiichi Mori Akihiro Ohmoto Ippei Fukada Masumi Yamazaki Mari Hosonaga Xiaofei Wang Arisa Ueki Kazuma Kiyotani Akiko Tonooka Kengo Takeuchi Shunji Takahashi Source Type: research
Levothyroxine treatment in pregnant women with thyroid stimulating hormone levels ranging between 2.5 and 10 mIU/L: A propensity score matched analysis
CONCLUSION: LT-4 treatment was significantly associated with a lower risk of pregnancy loss and a higher risk of small-for-gestational-age infants in pregnant women with TSH levels of 2.5-10 mIU/L. An increased risk of preterm birth was observed in the LT-4-treated group among TPOAb-positive participants with TSH levels of 2.5-4.0 mIU/L.PMID:38666684 | DOI:10.1089/thy.2023.0662 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 26, 2024 Category: Endocrinology Authors: Shen Gao Xueran Wang Rong Zhao Yuchen Cui Shaofei Su Enjie Zhang Jianhui Liu Shuanghua Xie Yue Zhang Yuxi Yang Kaikun Huang Minhui Hu Wentao Yue Ruixia Liu Chenghong Yin Source Type: research
Macrophage-induced carboxypeptidase A4 promotes the progression of anaplastic thyroid cancer
CONCLUSIONS: Our data suggest that CPA4 stimulates the progression of thyroid cancer by mediating between M2 macrophages and ATC cells. CPA4 can be a new therapeutic target for the treatment of patients with ATC.PMID:38666696 | DOI:10.1089/thy.2023.0427 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 26, 2024 Category: Endocrinology Authors: Yeon-Sook Choi Min Ji Jeon Woo Kyung Lee Doolittle Dong Eun Song Kyunggon Kim Won Bae Kim Won Gu Kim Source Type: research
Puerarin Alleviates Experimental Autoimmune Thyroiditis by Regulating Macrophages
This study aimed to verify the therapeutic effect of puerarin on HT and explored its regulatory effect on macrophage polarization imbalance in HT. Through bioinformatics analysis and molecular biology methods, it was found that macrophages increased significantly in HT patients and model mice. Immunological staining showed that puerarin intervention could reduce tissue inflammatory cell infiltration. Molecular biological examination displayed that puerarin could inhibit local and systemic inflammation levels, and the expression of marker thyroglobulin and thyroid peroxidase Abs. In vivo experimental results indicated that ...
Source: Journal of Immunology - April 26, 2024 Category: Allergy & Immunology Authors: Qing Tao Yu Chen Qiao Liang Jianfeng Shi Zhiguo Wang Haiyan Min Qian Gao Xiaoming Yao Lei Wang Source Type: research
Extra-nuclear tert counteracts oxidative stress and promotes progression in papillary thyroid carcinoma
In conclusion, our data indicate that extra-nuclear TERT is involved in reducing the effect of excessive OS, thus promoting cancer cell survival. Extra-nuclear TERT may thus represent a marker of cancer progression and a possible therapeutic target in PTC.PMID:38670453 | DOI:10.1016/j.trsl.2024.04.004 (Source: Cell Research)
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Marina Muzza Gabriele Pogliaghi Carla Colombo Elisa Stellaria Grassi Erika Carbone Sonia Palazzo Francesco Frattini Giacomo Gazzano Luca Persani Laura Fugazzola Source Type: research
Extra-nuclear tert counteracts oxidative stress and promotes progression in papillary thyroid carcinoma
In conclusion, our data indicate that extra-nuclear TERT is involved in reducing the effect of excessive OS, thus promoting cancer cell survival. Extra-nuclear TERT may thus represent a marker of cancer progression and a possible therapeutic target in PTC.PMID:38670453 | DOI:10.1016/j.trsl.2024.04.004 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - April 26, 2024 Category: Laboratory Medicine Authors: Marina Muzza Gabriele Pogliaghi Carla Colombo Elisa Stellaria Grassi Erika Carbone Sonia Palazzo Francesco Frattini Giacomo Gazzano Luca Persani Laura Fugazzola Source Type: research
Are the elements zinc, copper, magnesium, and rubidium related to nutrition and iodine deficiency in pregnant Bulgarian women from iodine deficient region?
CONCLUSION: The high Cu levels were associated with subclinical hypothyroidism (SCH) and less pulse consumption during pregnancy in an iodine deficiency endemic area. SCH was found in 24% of the pregnant women in such an area while in 13% of them SCH had progressed to overt hypothyroidism.PMID:38669155 | DOI:10.21101/cejph.a7796 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Mariana Georgieva Bacelova Penka Dimitrova Gatseva Tanya Ivanova Deneva Delyana Miteva Davcheva Anelia Veselinova Bivolarska Source Type: research
A Horizontal and Longitudinal Study on the Changes of Aging Thyroid Function in Elderly Male Population
CONCLUSIONS: The thyroid function index of elderly men changes with age. In transverse analysis, the value of TSH is the highest, and FT3 is the lowest in the group ≥80 years old. There are differences between the changes in the longitudinal analysis and the results of the horizontal analysis. Therefore, the law of thyroid function changing with age in different individuals is not the same as that of the same individual with age, which should be paid more attention in medical research and clinical diagnosis and treatment.PMID:38665030 | DOI:10.24976/Discov.Med.202436183.77 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Renfei Zhang Juan Dong Yuepeng Li Shirou Xiao Lei Qiu Source Type: research
Exploring the diagnostic value of endothelial cell and angiogenesis-related genes in Hashimoto's thyroiditis Based on transcriptomics and single cell RNA sequencing
CONCLUSION: In this study, 5 biomarkers (CD52, CD74, CD79A, HLA-B and RGS1) were screened and their expressions in endothelial cells was compared to offer a new reference for the recognition and management of HT.PMID:38670301 | DOI:10.1016/j.abb.2024.110013 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - April 26, 2024 Category: Biochemistry Authors: Yihang Li Xiaokai Lu Weihan Cao Nianqiu Liu Xin Jin Yuting Li Shiying Tang Ling Tao Qian Zhu Hongmin Liang Source Type: research
