Protective effect of higher free thyroxine levels within the reference range on biliary tract cancer risk: a multivariable mendelian randomization and mediation analysis

CONCLUSION: The findings suggest that higher FT4-RR may have a protective effect against BTC, which is partially mediated by decreased risk of MetS and a reduction in WC. This study highlights the potential role of FT4 in the pathogenesis of BTC and underscores that MetS and WC may play mediation effects as two mediators in this process.PMID:38686204 | PMC:PMC11056546 | DOI:10.3389/fendo.2024.1379607
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research