The roles of epigenetic regulation in graft-versus-host disease
Biomed Pharmacother. 2024 Apr 30;175:116652. doi: 10.1016/j.biopha.2024.116652. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (aHSCT) is utilized as a potential curative treatment for various hematologic malignancies. However, graft-versus-host disease (GVHD) post-aHSCT is a severe complication that significantly impacts patients' quality of life and overall survival, becoming a major cause of non-relapse mortality. In recent years, the association between epigenetics and GVHD has garnered increasing attention. Epigenetics focuses on studying mechanisms that affect gene expression without...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Yimin Wang Qi Liu Lei Deng Xiting Ma Yuling Gong Yifei Wang Fang Zhou Source Type: research
The Effect of Glycyrrhizin on the Viability and Proliferation of Dental Pulp Stem Cells Compared to Intracanal Medicaments
CONCLUSION: Based upon the potential of GA on DPSCs proliferation compared with Ca(OH)2 and TAP, It is conceivable to acknowledge that GA could be used as an intracanal medicaments for revascularization process of necrotic immature teeth.CLINICAL SIGNIFICANCE: This study emphasizes the significance of assessing alternative root canal medicaments and their impact on the proliferation and viability of DPSCs. The results regarding GA, specifically its impact on the viability and growth of DPSCs, provide essential understanding for its potential application as an intracanal medicine. This study adds to the continuous endeavors...
Source: J Contemp Dent Pract - May 1, 2024 Category: Dentistry Authors: Mohammad A Alrashidi Manal F Badawi Mohamed G Elbeltagy Amany E Badr Source Type: research
NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2
CONCLUSIONS: This study provides new molecular insights into the role of NANOG as a key determinant of pluripotency in TGCTs through the regulation of MIR9-2-5p, a novel epigenetic modulator of cancer stemness. Our data also highlight the potential negative feedback mediated by MIR9-2-5p on NANOG expression, which could be exploited as a therapeutic strategy for the treatment of TGCTs.PMID:38693576 | DOI:10.1186/s13287-024-03724-1 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Ryan P Cardenas Ahmad Zyoud Alan McIntyre Ramiro Alberio Nigel P Mongan Cinzia Allegrucci Source Type: research
Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation
CONCLUSION: EVs delivered to tissues by hBMDSCs contain specific miRNAs that prevent terminal differentiation and drive repair and regeneration. Delivery of microRNAs is a novel treatment paradigm with the potential to replace BMDSCs in cell-free regenerative therapies.PMID:38693588 | DOI:10.1186/s13287-024-03716-1 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Giulia Bonavina Ramanaiah Mamillapalli Graciela Krikun Yuping Zhou Nimisha Gawde Hugh S Taylor Source Type: research
MSCs promote the efferocytosis of large peritoneal macrophages to eliminate ferroptotic monocytes/macrophages in the injured endometria
CONCLUSION: The data collectively demonstrated first the roles of LPMs via removal of ferroptotic monocytes/macrophages and provided a novel mechanism of MSCs in repairing the endometrial injury.PMID:38693589 | DOI:10.1186/s13287-024-03742-z (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Jiali Wang Jingman Li Lijie Yin Xiuzhu Wang Yue Dong Guangfeng Zhao Sunan Shen Yayi Hou Source Type: research
Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease
Cell Stem Cell. 2024 Apr 22:S1934-5909(24)00129-2. doi: 10.1016/j.stem.2024.04.002. Online ahead of print.ABSTRACTNephron progenitor cells (NPCs) self-renew and differentiate into nephrons, the functional units of the kidney. Here, manipulation of p38 and YAP activity allowed for long-term clonal expansion of primary mouse and human NPCs and induced NPCs (iNPCs) from human pluripotent stem cells (hPSCs). Molecular analyses demonstrated that cultured iNPCs closely resemble primary human NPCs. iNPCs generated nephron organoids with minimal off-target cell types and enhanced maturation of podocytes relative to published human...
Source: Cell Stem Cell - May 1, 2024 Category: Stem Cells Authors: Biao Huang Zipeng Zeng Sunghyun Kim Connor C Fausto Kari Koppitch Hui Li Zexu Li Xi Chen Jinjin Guo Chennan C Zhang Tianyi Ma Pedro Medina Megan E Schreiber Mateo W Xia Ariel C Vonk Tianyuan Xiang Tadrushi Patel Yidan Li Riana K Parvez Balint Der Jyun Hao Source Type: research
Editor's Note: Tumor Resection Recruits Effector T Cells and Boosts Therapeutic Efficacy of Encapsulated Stem Cells Expressing IFN β in Glioblastomas
Clin Cancer Res. 2024 May 1;30(9):1993. doi: 10.1158/1078-0432.CCR-24-0858.NO ABSTRACTPMID:38690598 | DOI:10.1158/1078-0432.CCR-24-0858 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - May 1, 2024 Category: Cancer & Oncology Authors: Sung Hugh Choi Daniel W Stuckey Sara Pignatta Clemens Reinshagen Jasneet Kaur Khalsa Nicolaas Roozendaal Jordi Martinez-Quintanilla Kaoru Tamura Erhan Keles Khalid Shah Source Type: research
Tracheobronchomalacia following allogeneic haematopoietic stem cell transplantation
We present two patients who developed tracheobronchomalacia (TBM) following allogeneic haematopoietic stem cell transplantation (HSCT) and were initially treated for post-transplant bronchiolitis obliterans syndrome (BOS) but did not experience symptom improvement. However, after treatment with continuous positive airway pressure, their symptom subsided. AbstractTracheobronchomalacia (TBM) occurs due to the weakening of cartilaginous part of the trachea, resulting in compromised airway function and leading to symptoms such as dyspnea, cough, and inability to clear secretions. Bronchiolitis obliterans syndrome (BOS) is the ...
Source: Respirology Case Reports - May 1, 2024 Category: Respiratory Medicine Authors: Pitirat Panpruang,
Dararat Eksombatchai,
Viboon Boonsarngsuk Tags: CASE REPORT Source Type: research
A self-amplifying loop of TP53INP1 and P53 drives oxidative stress-induced apoptosis of bone marrow mesenchymal stem cells
AbstractBone marrow mesenchymal stem cell (BMSC) transplantation is a promising regenerative therapy; however, the survival rate of BMSCs after transplantation is low. Oxidative stress is one of the main reasons for the high apoptosis rate of BMSCs after transplantation, so there is an urgent need to explore the mechanism of oxidative stress-induced apoptosis of BMSCs. Our previous transcriptome sequencing results suggested that the expression of P53-induced nuclear protein 1 (TP53INP1) and the tumor suppressor P53 (P53) was significantly upregulated during the process of oxidative stress-induced apoptosis of BMSCs. The pr...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
Advances in the application of extracellular vesicles derived from three-dimensional culture of stem cells
Stem cells (SCs) have been used therapeutically for decades, yet their applications are limited by factors such as the risk of immune rejection and potential tumorigenicity. Extracellular vesicles (EVs), a key... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - May 1, 2024 Category: Nanotechnology Authors: Wenya Chen, Peipei Wu, Can Jin, Yinjie Chen, Chong Li and Hui Qian Tags: Review Source Type: research
Roles of Plasminogen Activator Inhibitor-1 in Heterotopic Ossification Induced by Achilles Tenotomy in Thermal Injured Mice
In conclusion, the present study showed that PAI-1 deficiency promoted HO in Achilles tendons after trauma/burn treatment partly by enhancing osteoblast differentiation and ALP activity in mice. Endogenous PAI-1 may play protective roles against HO after injury and inflammation. (Source: Calcified Tissue International)
Source: Calcified Tissue International - May 1, 2024 Category: Orthopaedics Source Type: research
The Comparative Effect of Plasma Exosomes of Young and Old People on the Expression of BCL-2 and BAX Genes in Hematopoietic Stem Cells
AbstractApoptosis may disrupt differentiation of hematopoietic stem cells (HSCs), which can affect aging. Thus, the main goal of this study was to compare the effect of plasma exosomes from young and old people on the expression of Bcl-2-associated X (BAX) and B-cell lymphoma 2 (BCL-2) genes in the HSCs. Plasma samples were acquired from four elderly adults and four younger adults, referring to Blood Transfusion Organization of Tehran-Iran during August 2022 – September 2022.Then, the exosomes of the samples were extracted and analyzed using DLS, TEM, and CD63 surface marker. HSCs were isolated from umbilical cord blood ...
Source: Indian Journal of Hematology and Blood Transfusion - May 1, 2024 Category: Hematology Source Type: research
A human pluripotent stem cell-derived in vitro model of the blood –brain barrier in cerebral malaria
Blood –brain barrier (BBB) disruption is a central feature of cerebral malaria (CM), a severe complication of Plasmodium falciparum (Pf) infections. In CM, sequestration of Pf-infected red blood cells (Pf-iRBCs) t... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 1, 2024 Category: Neurology Authors: Adnan Gopinadhan, Jason M. Hughes, Andrea L. Conroy, Chandy C. John, Scott G. Canfield and Dibyadyuti Datta Tags: Research Source Type: research
A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria
ConclusionThese findings demonstrate the validity of our hiPSC-BMECs based model of the BBB, that displays enhanced barrier integrity and appropriate TJ protein localization. In the hiPSC-BMEC co-culture withPf-iRBCs, reduced TEER, increased paracellular permeability, changes in TJ protein localization, increase in expression of adhesion molecules, and markers of angiogenesis and cellular stress all point towards a novel model with enhanced barrier properties, suitable for investigating pathogenic mechanisms underlying BBB disruption in CM. (Source: Fluids and Barriers of the CNS)
Source: Fluids and Barriers of the CNS - May 1, 2024 Category: Neuroscience Source Type: research
Airway hillocks are injury-resistant reservoirs of unique plastic stem cells
Nature, Published online: 01 May 2024; doi:10.1038/s41586-024-07377-1In the lungs, recently identified epithelial structures known as hillocks can act as injury-resistant reservoirs of stem cells. (Source: Nature AOP)
Source: Nature AOP - May 1, 2024 Category: Research Authors: Brian Lin Viral S. Shah Chaim Chernoff Jiawei Sun Gergana G. Shipkovenska Vladimir Vinarsky Avinash Waghray Jiajie Xu Andrew D. Leduc Constantin A. Hintschich Manalee Vishnu Surve Yanxin Xu Diane E. Capen Jorge Villoria Zhixun Dou Lida P. Hariri Jayaraj R Source Type: research
