Thrombocytopenia Secondary to COVID-19: Outcomes Analysis in Terms of Thrombotic Microangiopathy, Acute Kidney Injury, and Mortality
Conclusion: We outlined TMA in COVID-19 patients, which could be responsible for kidney injury and mortality in critically COVID-19 patients.PMID:38680710 | PMC:PMC11055419 | DOI:10.18502/ijhoscr.v18i1.14740 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Bahareh Gheiasi Fakhredin Taghinezhad Darshik Kumar Patel Ebrahim Salimi Mashallah Babashahi Aliashraf Mozafari Source Type: research
Results of Autologous Hematopoietic Stem Cell Transplantation in Patients with Multiple Myeloma(MM) and Renal Impairment: A Retrospective Single-Center Study
Conclusion: Auto-HSCT is a safe and effective treatment for patients with MM complicated by acute kidney injury. Fourteen of 23 (61%) patients became dialysis-independent.PMID:38680711 | PMC:PMC11055427 | DOI:10.18502/ijhoscr.v18i1.14745 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Maiia Soloveva Maxim Solovev Daria Mironova Larisa Mendeleeva Source Type: research
Clinical Characteristics and Outcomes in Hospitalized Patients with COVID-19 and Cancer History: A Multicenter Cross-Sectional Study in Southwestern Iran
Conclusion: This study showed that older age, loss of consciousness, low oxygen saturation, and suffering from autoimmune disorders were the predictors of death in cancer patients with COVID-19. These results can have important implications for the management and care of cancer patients with COVID-19.PMID:38680712 | PMC:PMC11055421 | DOI:10.18502/ijhoscr.v18i1.14744 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Javad Zarei Abbas Sheikhtaheri Mehrnaz Ahmadi Maria Cheraghi Abdolhassan Talaiezadeh Adeleh Khazami Source Type: research
The Effect of Tumor Resection and Radiotherapy on the Expression of Stem Cell Markers (CD44 and CD133) in Patients with Squamous Cell Carcinoma
Conclusion: The results also indicated that the expression of CD44 significantly decreased after tumor resection and radiotherapy. The upregulation of mRNA level of Bcl-2 and ALDH, and the downregulation of Bax and Bak gene expression were noted in these cases when compared to the healthy control group.PMID:38680713 | PMC:PMC11055418 | DOI:10.18502/ijhoscr.v18i1.14748 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Ladan Paya Ali Rafat Mehdi Talebi Amirala Aghbali Nikzad Shahidi Babak Nejati Parya Emamverdizadeh Hojjatollah Nozad Charoudeh Source Type: research
The Expression Analysis of < em > MEST1 < /em > and < em > GJA1 < /em > Genes in Gastric Cancer in Association with Clinicopathological Characteristics
Conclusion: The obtained data showed the important role of EMT-related genes, Gja1 and Mest1 in the clinical progression of the tumor. Further studies with larger sample sizes are required to confirm these genes as biomarker candidates for detecting gastric cancer.PMID:38680714 | PMC:PMC11055422 | DOI:10.18502/ijhoscr.v18i1.14747 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Nooshin Pourjamal Reza Shirkoohi Elham Rohani Mehrdad Hashemi Source Type: research
Cost-Effectiveness of Lovotibeglogene Autotemcel (Lovo-Cel) Gene Therapy for Patients with Sickle Cell Disease and Recurrent Vaso-Occlusive Events in the United States
ConclusionsOur analysis of lovo-cel gene therapy compared with common care for patients in the US with SCD with recurrent VOEs estimated meaningful improvements in survival, quality of life, and other clinical outcomes accompanied by increased overall costs for the health care system and for broader society. The predicted economic value of lovo-cel gene therapy was influenced by uncertainty in long-term clinical effects and by positive spillover effects on patient productivity and caregiver burden. (Source: PharmacoEconomics)
Source: PharmacoEconomics - April 29, 2024 Category: Health Management Source Type: research
Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia
Molecular Psychiatry, Published online: 29 April 2024; doi:10.1038/s41380-024-02568-8Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - April 29, 2024 Category: Psychiatry Authors: Angeliki Spathopoulou Gabriella A. Sauerwein Valentin Marteau Martina Podlesnic Theresa Lindlbauer Tobias Kipura Madlen Hotze Elisa Gabassi Katharina Kruszewski Marja Koskuvi J ános M. Réthelyi Ágota Apáti Luciano Conti Manching Ku Therese Koal Udo M Source Type: research
Clonal hematopoiesis–derived therapy-related myeloid neoplasms after autologous hematopoietic stem cell transplant for lymphoid and non-lymphoid disorders
Leukemia, Published online: 29 April 2024; doi:10.1038/s41375-024-02258-yClonal hematopoiesis–derived therapy-related myeloid neoplasms after autologous hematopoietic stem cell transplant for lymphoid and non-lymphoid disorders (Source: Leukemia)
Source: Leukemia - April 29, 2024 Category: Hematology Authors: Hussein Awada Carmelo Gurnari Valeria Visconte Arda Durmaz Teodora Kuzmanovic Hassan Awada Zheng Jin Tu James R. Cook Brian J. Bolwell Ronald Sobecks Matt Kalaycio David Bosler Jaroslaw P. Maciejewski Source Type: research
Temporomandibular Joint and Dental Complications in Long-Term Survivors of Children with Leukemia after Chemoradiotherapy and Stem Cell Transplantation
AbstractThe purpose of this study was to investigate the long-term effects of chemoradiotherapy and transplantation on the temporomandibular joint (TMJ) and dental status in leukemia and stem cell transplantation (SCT) patients. The study included 44 patients and 22 controls. Participants were categorized into three groups: patients with leukemia in Group-1 (n = 22), patients with SCT in Group-2 (n = 22), and controls in Group-3 (n = 22). All patients were evaluated using the Diagnostic Criteria for TMJ Disorders (TMD), as well as clinical and radiographic assessments. TMD was found in 19 (86%) of the 22 patien...
Source: Indian Journal of Hematology and Blood Transfusion - April 29, 2024 Category: Hematology Source Type: research
Identification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells
Cell Death & Disease, Published online: 29 April 2024; doi:10.1038/s41419-024-06667-wIdentification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells (Source: Cell death and disease)
Source: Cell death and disease - April 29, 2024 Category: Internal Medicine Authors: Francesca Ascenzi Antonella Esposito Sara Bruschini Valentina Salvati Claudia De Vitis Valeria De Arcangelis Giulia Ricci Angiolina Catizione Simona di Martino Simonetta Buglioni Massimiliano Bassi Federico Venuta Francesca De Nicola Alice Massacci Isabel Source Type: research
The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions
by Irene Fasciani, Francesco Petragnano, Ziming Wang, Ruairidh Edwards, Narasimha Telugu, Ilaria Pietrantoni, Ulrike Zabel, Henrik Zauber, Marlies Grieben, Maria E. Terzenidou, Jacopo Di Gregorio, Cristina Pellegrini, Silvano Santini Jr, Anna R. Taddei, B ärbel Pohl, Stefano Aringhieri, Marco Carli, Gabriella Aloisi, Francesco Marampon, Eve Charlesworth, Alexandra Roman, Sebastian Diecke, Vincenzo Flati, Franco Giorgi, Fernanda Amicarelli, Andrew B. Tobin, Marco Scarselli, Kostas Tokatlidis, Mario Rossi, Martin J. Lohse, Paolo Annibale, Roberto Magg io
Muscarinic acetylcholine receptors are prototypical G protein-coupled...
Source: PLoS Biology: Archived Table of Contents - April 29, 2024 Category: Biology Authors: Irene Fasciani Source Type: research
Cancers, Vol. 16, Pages 1743: Quantitative Assessment of Tumor Contact with Neurogenic Zones and Its Effects on Survival: Insights beyond Traditional Predictors
In this study, we assessed the impact of GBM&rsquo;s relationship with the cortex, SVZ and SGZ on clinical variables using fully automated segmentation methods. In 177 glioblastoma patients, we calculated optimal cutpoints of minimal distances to the SVZ and SGZ to distinguish poor from favorable survival. The impact of tumor contact with neurogenic zones on clinical parameters, such as overall survival, multifocality, MGMT promotor methylation, Ki-67 and KPS score was also examined by multivariable regression analysis, chi-square test and Mann&ndash;Whitney-U. The analysis confirmed shorter survival in tum...
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: Jung Kempter Prokop Herrmann Griessmair Kim Delbridge Meyer Bernhardt Combs Zimmer Wiestler Schmidt-Graf Metz Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1739: Reappraisal of the Roles of the Sonic Hedgehog Signaling Pathway in Hepatocellular Carcinoma
Juei Jeng
HCC remains one of the leading causes of cancer-related death globally. The main challenges in treatments of hepatocellular carcinoma (HCC) primarily arise from high rates of postoperative recurrence and the limited efficacy in treating advanced-stage patients. Various signaling pathways involved in HCC have been reported. Among them, the Sonic hedgehog (SHH) signaling pathway is crucial. The presence of SHH ligands is identified in approximately 60% of HCC tumor tissues, including tumor nests. PTCH-1 and GLI-1 are detected in more than half of HCC tissues, while GLI-2 is found in over 84% of HCC tissues. The...
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: Kuo-Shyang Jeng Chiung-Fang Chang Yuk-Ming Tsang I-Shyan Sheen Chi-Juei Jeng Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1727: The Tumor Stroma of Squamous Cell Carcinoma: A Complex Environment That Fuels Cancer Progression
Crișan
The tumor microenvironment (TME), a complex assembly of cellular and extracellular matrix (ECM) components, plays a crucial role in driving tumor progression, shaping treatment responses, and influencing metastasis. This narrative review focuses on the cutaneous squamous cell carcinoma (cSCC) tumor stroma, highlighting its key constituents and their dynamic contributions. We examine how significant changes within the cSCC ECM&mdash;specifically, alterations in fibronectin, hyaluronic acid, laminins, proteoglycans, and collagens&mdash;promote cancer progression, metastasis, and drug resistance. T...
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: Alexandra Buruian ă Bogdan-Alexandru Gheban Ioana-Andreea Gheban-Ro șca Carmen Georgiu Doin ța Crișan Maria Cri șan Tags: Review Source Type: research
Comparing the effect of using 2-Mercaptoethanol in the cell culture medium of different cell passages of human mesenchymal stem cells
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):35-39. doi: 10.14715/cmb/2024.70.4.6.ABSTRACTPreparing a suitable cell culture medium that supports the biological needs of the growing cells is crucial to enhancing the success rate of any in vitro and in vivo experiments and minimizing undesirable interferences. Mesenchymal stem cells ( MSCs) which are powerful regenerative stem cells require being grown in proper culture media to preserve their stemness and therapeutic properties. MSCs are usually grown in Dulbecco's Modified Eagle low glucose Medium (DMEM low glucose) which contains 5.6 mmol/L of glucose and is suppleme...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Ramada R Khasawneh Ejlal Abu-El-Rub Source Type: research
