Prevention of post-operative adhesions: Model development and pilot outcomes of human placental stem cell-based interventions
This study presents a novel rat model for abdominal adhesions and reports pilot results of human placental stem cell (hPSC)-based therapies.METHODS: Forty-four (n = 44) male Sprague-Dawley rats (250-350 g) were used in the experiment. Of these, thirty-eight (n = 38) were included in a preliminary data set to determine a minimum treatment effect. Adhesions were created in a reproducible model to the abdominal wall and between organs. Experimental groups included the control group (Model No Treatment, MNT), Plasmalyte A (Media Alone, MA, 10 mL), hPSC (5 × 106 cells/10 mL Plasmalyte A), hPSC-CM (hPSC secretome, conditioned m...
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Samuel P Carmichael Prafulla K Chandra John W Vaughan David M Kline Edward H Ip John B Holcomb Anthony Atala Source Type: research
High CD34-positive cell dose in matched unrelated donor allogeneic hematopoietic stem cell transplant is not associated with graft-versus-host disease or mortality
DISCUSSION: We found no difference in survival, relapse, or GVHD incidence or severity in patients receiving CD34+ doses above prior cutoffs reported in the literature. These data do not support the routine use of graft CD34+ dose reduction.PMID:38693089 | DOI:10.1111/trf.17864 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Zachary M Avigan Ajoy L Dias Laura E Dodge Jon E Arnason Robin M Joyce Jessica Liegel Jacalyn Rosenblatt Matthew J Weinstock David E Avigan Richard L Haspel Source Type: research
Evolution of natural killer cell-targeted therapy for acute myeloid leukemia
Int J Hematol. 2024 May 1. doi: 10.1007/s12185-024-03778-0. Online ahead of print.ABSTRACTIn hematologic oncology, acute myeloid leukemia (AML) presents a significant challenge due to its complex genetic landscape and resistance to conventional therapies. Despite advances in treatment, including intensive chemotherapy and hematopoietic stem cell transplantation (HSCT), the prognosis for many patients with AML remains poor. Recently, immunotherapy has emerged as a promising approach to improve outcomes by augmenting existing treatments. Natural killer (NK) cells, a subset of innate lymphoid cells, have garnered attention fo...
Source: International Journal of Hematology - May 1, 2024 Category: Hematology Authors: Yuta Kaito Yoichi Imai Source Type: research
The roles of epigenetic regulation in graft-versus-host disease
Biomed Pharmacother. 2024 Apr 30;175:116652. doi: 10.1016/j.biopha.2024.116652. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (aHSCT) is utilized as a potential curative treatment for various hematologic malignancies. However, graft-versus-host disease (GVHD) post-aHSCT is a severe complication that significantly impacts patients' quality of life and overall survival, becoming a major cause of non-relapse mortality. In recent years, the association between epigenetics and GVHD has garnered increasing attention. Epigenetics focuses on studying mechanisms that affect gene expression without...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Yimin Wang Qi Liu Lei Deng Xiting Ma Yuling Gong Yifei Wang Fang Zhou Source Type: research
The Effect of Glycyrrhizin on the Viability and Proliferation of Dental Pulp Stem Cells Compared to Intracanal Medicaments
CONCLUSION: Based upon the potential of GA on DPSCs proliferation compared with Ca(OH)2 and TAP, It is conceivable to acknowledge that GA could be used as an intracanal medicaments for revascularization process of necrotic immature teeth.CLINICAL SIGNIFICANCE: This study emphasizes the significance of assessing alternative root canal medicaments and their impact on the proliferation and viability of DPSCs. The results regarding GA, specifically its impact on the viability and growth of DPSCs, provide essential understanding for its potential application as an intracanal medicine. This study adds to the continuous endeavors...
Source: J Contemp Dent Pract - May 1, 2024 Category: Dentistry Authors: Mohammad A Alrashidi Manal F Badawi Mohamed G Elbeltagy Amany E Badr Source Type: research
Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease
Cell Stem Cell. 2024 Apr 22:S1934-5909(24)00129-2. doi: 10.1016/j.stem.2024.04.002. Online ahead of print.ABSTRACTNephron progenitor cells (NPCs) self-renew and differentiate into nephrons, the functional units of the kidney. Here, manipulation of p38 and YAP activity allowed for long-term clonal expansion of primary mouse and human NPCs and induced NPCs (iNPCs) from human pluripotent stem cells (hPSCs). Molecular analyses demonstrated that cultured iNPCs closely resemble primary human NPCs. iNPCs generated nephron organoids with minimal off-target cell types and enhanced maturation of podocytes relative to published human...
Source: Cell Stem Cell - May 1, 2024 Category: Stem Cells Authors: Biao Huang Zipeng Zeng Sunghyun Kim Connor C Fausto Kari Koppitch Hui Li Zexu Li Xi Chen Jinjin Guo Chennan C Zhang Tianyi Ma Pedro Medina Megan E Schreiber Mateo W Xia Ariel C Vonk Tianyuan Xiang Tadrushi Patel Yidan Li Riana K Parvez Balint Der Jyun Hao Source Type: research
Editor's Note: Tumor Resection Recruits Effector T Cells and Boosts Therapeutic Efficacy of Encapsulated Stem Cells Expressing IFN β in Glioblastomas
Clin Cancer Res. 2024 May 1;30(9):1993. doi: 10.1158/1078-0432.CCR-24-0858.NO ABSTRACTPMID:38690598 | DOI:10.1158/1078-0432.CCR-24-0858 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - May 1, 2024 Category: Cancer & Oncology Authors: Sung Hugh Choi Daniel W Stuckey Sara Pignatta Clemens Reinshagen Jasneet Kaur Khalsa Nicolaas Roozendaal Jordi Martinez-Quintanilla Kaoru Tamura Erhan Keles Khalid Shah Source Type: research
Advances in natural and synthetic macromolecules with stem cells and extracellular vesicles for orthopedic disease treatment
Int J Biol Macromol. 2024 Apr 29:131874. doi: 10.1016/j.ijbiomac.2024.131874. Online ahead of print.ABSTRACTSerious orthopedic disorders resulting from myriad diseases and impairments continue to pose a considerable challenge to contemporary clinical care. Owing to its limited regenerative capacity, achieving complete bone tissue regeneration and complete functional restoration has proven challenging with existing treatments. By virtue of cellular regenerative and paracrine pathways, stem cells are extensively utilized in the restoration and regeneration of bone tissue; however, low survival and retention after transplanta...
Source: International Journal of Biological Macromolecules - May 1, 2024 Category: Biochemistry Authors: Supeng Wang Zhiqiang Jia Minghai Dai Xujun Feng Chengxuan Tang Liangle Liu Lingling Cao Source Type: research
Evolution of natural killer cell-targeted therapy for acute myeloid leukemia
Int J Hematol. 2024 May 1. doi: 10.1007/s12185-024-03778-0. Online ahead of print.ABSTRACTIn hematologic oncology, acute myeloid leukemia (AML) presents a significant challenge due to its complex genetic landscape and resistance to conventional therapies. Despite advances in treatment, including intensive chemotherapy and hematopoietic stem cell transplantation (HSCT), the prognosis for many patients with AML remains poor. Recently, immunotherapy has emerged as a promising approach to improve outcomes by augmenting existing treatments. Natural killer (NK) cells, a subset of innate lymphoid cells, have garnered attention fo...
Source: International Journal of Hematology - May 1, 2024 Category: Hematology Authors: Yuta Kaito Yoichi Imai Source Type: research
High CD34-positive cell dose in matched unrelated donor allogeneic hematopoietic stem cell transplant is not associated with graft-versus-host disease or mortality
DISCUSSION: We found no difference in survival, relapse, or GVHD incidence or severity in patients receiving CD34+ doses above prior cutoffs reported in the literature. These data do not support the routine use of graft CD34+ dose reduction.PMID:38693089 | DOI:10.1111/trf.17864 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Zachary M Avigan Ajoy L Dias Laura E Dodge Jon E Arnason Robin M Joyce Jessica Liegel Jacalyn Rosenblatt Matthew J Weinstock David E Avigan Richard L Haspel Source Type: research
Prevention of post-operative adhesions: Model development and pilot outcomes of human placental stem cell-based interventions
This study presents a novel rat model for abdominal adhesions and reports pilot results of human placental stem cell (hPSC)-based therapies.METHODS: Forty-four (n = 44) male Sprague-Dawley rats (250-350 g) were used in the experiment. Of these, thirty-eight (n = 38) were included in a preliminary data set to determine a minimum treatment effect. Adhesions were created in a reproducible model to the abdominal wall and between organs. Experimental groups included the control group (Model No Treatment, MNT), Plasmalyte A (Media Alone, MA, 10 mL), hPSC (5 × 106 cells/10 mL Plasmalyte A), hPSC-CM (hPSC secretome, conditioned m...
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Samuel P Carmichael Prafulla K Chandra John W Vaughan David M Kline Edward H Ip John B Holcomb Anthony Atala Source Type: research
WNT5B drives osteosarcoma stemness, chemoresistance and metastasis
CONCLUSIONS: Together, these data define WNT5B's role in driving osteosarcoma cancer stem cell expansion and methotrexate resistance and provide evidence that the WNT5B pathway is a promising candidate for treating osteosarcoma patients.KEY POINTS: WNT5B expression is high in osteosarcoma stem cells leading to increased stem cell proliferation and migration through SOX2. WNT5B expression in stem cells increases rates of osteosarcoma metastasis to the lungs and liver in vivo. The hyaluronic acid degradation enzyme HYAL1 is regulated by WNT5B in osteosarcoma contributing to metastasis. Inhibition of WNT5B with a ROR1 antibod...
Source: Clinical Lung Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Rachel S Perkins Glenn Murray Sarocha Suthon Lindsey Davis Nicholson B Perkins Lily Fletcher Amanda Bozzi Saylor L Schreiber Jianjian Lin Steven Laxton Rahul R Pillai Alec J Wright Gustavo A Miranda-Carboni Susan A Krum Source Type: research
Combined Effects of Clonal Hematopoiesis and Carotid Stenosis on Cardiovascular Mortality
CONCLUSIONS: CH status in combination with the extent of carotid atherosclerosis jointly predict long-term mortality. Determination of CH can provide additional prognostic information in patients with asymptomatic carotid atherosclerosis.PMID:38692825 | DOI:10.1016/j.jacc.2024.02.043 (Source: Atherosclerosis)
Source: Atherosclerosis - May 1, 2024 Category: Cardiology Authors: Roland J äger Matthias Hoke Florian J Mayer Stefanie Boden Cornelia Englisch Cihan Ay Robert Kralovics Christoph J Binder Source Type: research
NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2
CONCLUSIONS: This study provides new molecular insights into the role of NANOG as a key determinant of pluripotency in TGCTs through the regulation of MIR9-2-5p, a novel epigenetic modulator of cancer stemness. Our data also highlight the potential negative feedback mediated by MIR9-2-5p on NANOG expression, which could be exploited as a therapeutic strategy for the treatment of TGCTs.PMID:38693576 | DOI:10.1186/s13287-024-03724-1 (Source: Cancer Control)
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Ryan P Cardenas Ahmad Zyoud Alan McIntyre Ramiro Alberio Nigel P Mongan Cinzia Allegrucci Source Type: research
Impact of the thyroid hormone T3 and its nuclear receptor TRalpha1 on colon cancer stem cell phenotypes and response to chemotherapies
Cell Death Dis. 2024 May 1;15(5):306. doi: 10.1038/s41419-024-06690-x.ABSTRACTColorectal cancers (CRCs) are highly heterogeneous and show a hierarchical organization, with cancer stem cells (CSCs) responsible for tumor development, maintenance, and drug resistance. Our previous studies showed the importance of thyroid hormone-dependent signaling on intestinal tumor development and progression through action on stem cells. These results have a translational value, given that the thyroid hormone nuclear receptor TRα1 is upregulated in human CRCs, including in the molecular subtypes associated with CSC features. We used an e...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Maria Virginia Giolito Serguei Bodoirat Theo La Rosa Mathieu Reslinger Gabriela D A Guardia Jana Mourtada Leo Claret Alain Joung Pedro A F Galante Luiz O F Penalva Michelina Plateroti Source Type: research
