Safety, Tolerability, and Clinical Assessment of Bemdaneprocel for Parkinson ’s Disease: 18-Month Results From a Phase 1 Study
Background: Bemdaneprocel is an investigational cellular therapy comprising pluripotent stem cell –derived dopaminergic neuron precursor cells under development for the treatment of Parkinson’s Disease. This first-in-human phase 1 study assesses the safety, tolerability, and clinical outcomes of bemdaneprocel in participants with Parkinson’s disease. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Fasano, C. Henchcliffe, H. Sarva, A. Lozano, S. Kalia, K.K.H. Yu, C. Brennan, W. Stemple, N. Abid, M. Yountz, A. Enayetallah, A. Lampron, V. Tabar Source Type: research
The history of haploidentical stem cell transplantation: a trip from the bench to the bedside
Hematology. 2024 Dec;29(1):2346401. doi: 10.1080/16078454.2024.2346401. Epub 2024 Apr 30.ABSTRACTAllogeneic bone marrow transplantation is a curative intervention for both neoplastic and non-malignant conditions. However, not all patients have an HLA-matched donor. Therefore, the development of an approach that expand the donor pool was of paramount relevance. The development of post-transplantation cyclophosphamide as graft versus host disease prophylaxis allows the safe use of haploidentical donors, solving the donor availability problem to the vast majority of patients in need. The present paper reviews the history of t...
Source: Hematology - April 30, 2024 Category: Hematology Authors: Mariana G Meade Javier Bola ños-Meade Source Type: research
Resveratrol promotes the differentiation of human umbilical cord mesenchymal stem cells into esophageal fibroblasts via AKT signaling pathway
Conclusion: Our data suggest that resveratrol promotes the differentiation of human umbilical cord mesenchymal stem cells into fibroblasts. The underlying mechanism is associated with the downregulation of IL-6 and TGF-β via the AKT pathway and by inhibiting the NF-ĸB pathway. Resveratrol may be useful for esophageal tissue engineering.PMID:38688472 | PMC:PMC11062234 | DOI:10.1177/03946320241249397 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Xiujing Chen Zihao Sun Qian Wu Lijuan Shao Jiaxin Bei Yiguang Lin Hongjie Chen Size Chen Source Type: research
Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier
CONCLUSION: This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM management. Elucidation of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.PMID:38686045 | PMC:PMC11056000 | DOI:10.32604/or.2024.047278 (Source: Oncology Research)
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Karan Wadhwa Payal Chauhan Shobhit Kumar Rakesh Pahwa Ravinder Verma Rajat Goyal Govind Singh Archana Sharma Neha Rao Deepak Kaushik Source Type: research
PL-hMSC and CH-hMSC derived soluble factors inhibit proliferation but improve hGBM cell migration by activating TGF- β and inhibiting Wnt signaling
Biosci Rep. 2024 Apr 30:BSR20231964. doi: 10.1042/BSR20231964. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. GBM resists most chemotherapeutic agents, resulting in a high mortality rate in patients. Human mesenchymal stem cells (hMSCs), which are parts of the cancer stroma, have been shown to be involved in the development and progression of GBM. However, different sources of hMSCs might affect GBM cells differently. In the present study, we established hMSCs from placenta(PL-hMSC) and chorion (CH-hMSC) to study the effects of their released soluble facto...
Source: Bioscience Reports - April 30, 2024 Category: Biomedical Science Authors: Tanawat Uthanaphun Sirikul Manochantr Chairat Tantrawatpan Duangrat Tantikanlayaporn Pakpoom Kheolamai Source Type: research
The history of haploidentical stem cell transplantation: a trip from the bench to the bedside
Hematology. 2024 Dec;29(1):2346401. doi: 10.1080/16078454.2024.2346401. Epub 2024 Apr 30.ABSTRACTAllogeneic bone marrow transplantation is a curative intervention for both neoplastic and non-malignant conditions. However, not all patients have an HLA-matched donor. Therefore, the development of an approach that expand the donor pool was of paramount relevance. The development of post-transplantation cyclophosphamide as graft versus host disease prophylaxis allows the safe use of haploidentical donors, solving the donor availability problem to the vast majority of patients in need. The present paper reviews the history of t...
Source: Hematology - April 30, 2024 Category: Hematology Authors: Mariana G Meade Javier Bola ños-Meade Source Type: research
Resveratrol promotes the differentiation of human umbilical cord mesenchymal stem cells into esophageal fibroblasts via AKT signaling pathway
Conclusion: Our data suggest that resveratrol promotes the differentiation of human umbilical cord mesenchymal stem cells into fibroblasts. The underlying mechanism is associated with the downregulation of IL-6 and TGF-β via the AKT pathway and by inhibiting the NF-ĸB pathway. Resveratrol may be useful for esophageal tissue engineering.PMID:38688472 | PMC:PMC11062234 | DOI:10.1177/03946320241249397 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Xiujing Chen Zihao Sun Qian Wu Lijuan Shao Jiaxin Bei Yiguang Lin Hongjie Chen Size Chen Source Type: research
Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier
CONCLUSION: This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM management. Elucidation of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.PMID:38686045 | PMC:PMC11056000 | DOI:10.32604/or.2024.047278 (Source: Oncology Research)
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Karan Wadhwa Payal Chauhan Shobhit Kumar Rakesh Pahwa Ravinder Verma Rajat Goyal Govind Singh Archana Sharma Neha Rao Deepak Kaushik Source Type: research
Albiflorin Inhibits Advanced Glycation End Products-Induced ROS and MMP-1 Expression in Gingival Fibroblasts
CONCLUSION: Albiflorin exhibited protective effects against AGEs-induced oxidative stress and inflammation in gingival fibroblasts, highlighting its potential as a therapeutic agent for periodontitis in diabetic patients. The modulation of the NF-κB and Nrf2 pathways by albiflorin provides insight into its mechanism of action.PMID:38685787 | DOI:10.2174/011574888X302174240420165019 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - April 30, 2024 Category: Stem Cells Authors: Linlin Gao Wenqi Fu Yanyan Liu Lili Fan Shiwei Liu Nan Zhang Source Type: research
The history of haploidentical stem cell transplantation: a trip from the bench to the bedside
Hematology. 2024 Dec;29(1):2346401. doi: 10.1080/16078454.2024.2346401. Epub 2024 Apr 30.ABSTRACTAllogeneic bone marrow transplantation is a curative intervention for both neoplastic and non-malignant conditions. However, not all patients have an HLA-matched donor. Therefore, the development of an approach that expand the donor pool was of paramount relevance. The development of post-transplantation cyclophosphamide as graft versus host disease prophylaxis allows the safe use of haploidentical donors, solving the donor availability problem to the vast majority of patients in need. The present paper reviews the history of t...
Source: Hematology - April 30, 2024 Category: Hematology Authors: Mariana G Meade Javier Bola ños-Meade Source Type: research
PL-hMSC and CH-hMSC derived soluble factors inhibit proliferation but improve hGBM cell migration by activating TGF- β and inhibiting Wnt signaling
Biosci Rep. 2024 Apr 30:BSR20231964. doi: 10.1042/BSR20231964. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. GBM resists most chemotherapeutic agents, resulting in a high mortality rate in patients. Human mesenchymal stem cells (hMSCs), which are parts of the cancer stroma, have been shown to be involved in the development and progression of GBM. However, different sources of hMSCs might affect GBM cells differently. In the present study, we established hMSCs from placenta(PL-hMSC) and chorion (CH-hMSC) to study the effects of their released soluble facto...
Source: Bioscience Reports - April 30, 2024 Category: Biomedical Science Authors: Tanawat Uthanaphun Sirikul Manochantr Chairat Tantrawatpan Duangrat Tantikanlayaporn Pakpoom Kheolamai Source Type: research
The link between autophagy and psoriasis
Acta Histochem. 2024 Apr 29;126(4):152166. doi: 10.1016/j.acthis.2024.152166. Online ahead of print.ABSTRACTAutophagy is a lysosome-dependent, self-renewal mechanism that degrades and recycles cellular components in eukaryotic cells to maintain the homeostasis of the intracellular environment. Psoriasis is featured by increased inflammatory response, epidermal hyperproliferation and abnormal differentiation, infiltration of immune cells and increased expression levels of both endothelial adhesion molecules and angiogenic mediators. Evidence indicates that autophagy has important roles in many different types of cells, such...
Source: Acta Histochemica - April 30, 2024 Category: Biochemistry Authors: Nannan Liang Kaiming Zhang Source Type: research
Malvidin attenuates trauma-induced heterotopic ossification of tendon in rats by targeting Rheb for degradation via the ubiquitin-proteasome pathway
This study aimed to investigate the effect of MA in treating trauma-induced HO and unravel its underlying mechanisms. Herein, the effectiveness of MA in preventing HO formation was assessed through local injection in a rat model. The potential mechanism underlying MA's treatment was investigated in the tendon-resident progenitor cells of tendon-derived stem cells (TDSCs), exploring its pathway in HO formation. The findings demonstrated that MA effectively hindered the osteogenic differentiation of TDSCs by inhibiting the mTORC1 signalling pathway, consequently impeding the progression of trauma-induced HO of Achilles tendo...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Huaji Jiang Yan Ding Xuemei Lin Qinyu Tian Yakui Liu Hebei He Yongfu Wu Xinggui Tian Stefan Zwingenberger Source Type: research
Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis
This study aimed to explore the molecular mechanism of long non-coding RNA H19 in osteoporosis after SCI and provide new research directions for existing prevention strategies. We used small interfering RNA to knockdown H19 expression and regulated miR-29b-2p expression using miR-29b-3p mimetics and inhibitors. Western blotting, real-time fluorescence quantitative PCR, Alizarin red staining, alkaline phosphatase staining and double-luciferase reporter gene assays were used to assess gene expression, osteogenic ability and binding sites. lncRNA H19 was upregulated in BMSCs from the osteoporosis group, whereas miR-29b-3p was...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Sen Qin Da Liu Source Type: research
Comparative evaluation of bone marrow and dental pulp mesenchymal stem cells for motor functional recovery in rat sciatic nerve injury
This study delves into the impact of mesenchymal stem cells derived from bone marrow (BM-MSCs) and those sourced from dental pulp (DP-MSCs) on the recovery of motor function and morphological aspects of the rat's sciatic nerve after crush injuries. The findings highlight that the groups treated with BM-MSCs, DP-MSCs or a combination of both (BM + DP-MSCs) displayed enhanced sciatic functional index values when juxtaposed with the sham group. This points to bettered motor functionalities. A deeper morphological analysis showed that all the groups had retained perineurium structure and fascicular arrangement. Notably, the sh...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Elgin Or çum Uzunlu Zeki O ğurtan Source Type: research
