Minimal Residual Disease Status in Multiple Myeloma 1 Year After Autologous Hematopoietic Cell Transplantation and Lenalidomide Maintenance Are Associated With Long-Term Overall Survival
CONCLUSION: To our knowledge, this first, prospective US cooperative group, multicenter study demonstrates that MRDneg at Y1 after AutoHCT with lenalidomide maintenance is prognostic for improved 6-year PFS and OS. Serial MRD measurements may direct trials to test how further therapy may improve long-term PFS and OS.PMID:38701390 | DOI:10.1200/JCO.23.00934 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Marcelo C Pasquini Paul K Wallace Brent Logan Manmeet Kaur Joseph D Tario Alan Howard Yali Zhang Claudio Brunstein Yvonne Efebera Nancy Geller Sergio Giralt Parameswaran Hari Mary M Horowitz John Koreth Amrita Krishnan Heather Landau George Somlo Nina Sha Source Type: research
Minimal Residual Disease Status in Multiple Myeloma 1 Year After Autologous Hematopoietic Cell Transplantation and Lenalidomide Maintenance Are Associated With Long-Term Overall Survival
CONCLUSION: To our knowledge, this first, prospective US cooperative group, multicenter study demonstrates that MRDneg at Y1 after AutoHCT with lenalidomide maintenance is prognostic for improved 6-year PFS and OS. Serial MRD measurements may direct trials to test how further therapy may improve long-term PFS and OS.PMID:38701390 | DOI:10.1200/JCO.23.00934 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Marcelo C Pasquini Paul K Wallace Brent Logan Manmeet Kaur Joseph D Tario Alan Howard Yali Zhang Claudio Brunstein Yvonne Efebera Nancy Geller Sergio Giralt Parameswaran Hari Mary M Horowitz John Koreth Amrita Krishnan Heather Landau George Somlo Nina Sha Source Type: research
Mesenchymal stem cell-derived exosomes for management of prostate cancer: An updated view
Int Immunopharmacol. 2024 May 2;134:112171. doi: 10.1016/j.intimp.2024.112171. Online ahead of print.ABSTRACTProstate cancer represents the second most prevalent form of cancer found in males, and stands as the fifth primary contributor to cancer-induced mortality on a global scale. Research has shown that transplanted mesenchymal stem cells (MSCs) can migrate by homing to tumor sites in the body. In prostate cancer, researchers have explored the fact that MSC-based therapies (including genetically modified delivery vehicles or vectors) and MSC-derived exosomes are emerging as attractive options to improve the efficacy and...
Source: International Immunopharmacology - May 3, 2024 Category: Allergy & Immunology Authors: Fahimeh Lavi Arab Akram Hoseinzadeh Fatemeh Hafizi Fatemeh Sadat Mohammadi Farid Zeynali Melika Hadad Tehran Amirreza Rostami Source Type: research
Addressing challenges for repairing adult spinal cord with insights from neonates
Cell Stem Cell. 2024 May 2;31(5):585-586. doi: 10.1016/j.stem.2024.04.008.ABSTRACTStem cell therapy has emerged as a promising area of scientific investigation, sparking considerable interest, especially in spinal cord injury (SCI). Sun et al.1 discover that the extracellular matrix (ECM) from the neonatal spinal cord transmits biochemical signals to endogenous axons, thus promoting axonal regeneration.PMID:38701752 | DOI:10.1016/j.stem.2024.04.008 (Source: Cell Stem Cell)
Source: Cell Stem Cell - May 3, 2024 Category: Stem Cells Authors: Mickey E Abraham Joel Martin Joseph D Ciacci Source Type: research
Actin pushes open a leaky lumen
Cell Stem Cell. 2024 May 2;31(5):587-588. doi: 10.1016/j.stem.2024.04.003.ABSTRACTUsing a human stem cell-based model to understand how the human epiblast forms at the very beginning of implantation, Indana et al.1 establish a role for pushing forces that are generated by apical actin polymerization and reveal a two-stage, biomechanics-driven lumen growth process underlying epiblast cavity morphogenesis.PMID:38701753 | DOI:10.1016/j.stem.2024.04.003 (Source: Cell Stem Cell)
Source: Cell Stem Cell - May 3, 2024 Category: Stem Cells Authors: Jia Guo Yue Shao Source Type: research
Sox9-coordinated cellular neighborhoods generate fibrosis
Cell Stem Cell. 2024 May 2;31(5):589-590. doi: 10.1016/j.stem.2024.04.009.ABSTRACTPoorly regenerative organs deposit scar tissue to mend damage. Aggarwal et al. establish that transient Sox9 activity is necessary for early proximal tubule epithelial regeneration, while Trogisch et al. and Aggarwal et al. show that persistent Sox9 activity in epithelial and endothelial cells activates fibroblasts creating fibrotic microdomains in multiple organs.PMID:38701754 | DOI:10.1016/j.stem.2024.04.009 (Source: Cell Stem Cell)
Source: Cell Stem Cell - May 3, 2024 Category: Stem Cells Authors: Darrian Bugg Jennifer Davis Source Type: research
Connie Eaves (May 22, 1944-March 7, 2024)
Cell Stem Cell. 2024 May 2;31(5):593-596. doi: 10.1016/j.stem.2024.04.007.NO ABSTRACTPMID:38701756 | DOI:10.1016/j.stem.2024.04.007 (Source: Cell Stem Cell)
Source: Cell Stem Cell - May 3, 2024 Category: Stem Cells Authors: Ali Turhan Franck Nicolini Fran çois Lemoine Laure Coulombel Saghi Ghaffari Source Type: research
Hallmarks of cancer stemness
Cell Stem Cell. 2024 May 2;31(5):617-639. doi: 10.1016/j.stem.2024.04.004.ABSTRACTCancer stemness is recognized as a key component of tumor development. Previously coined "cancer stem cells" (CSCs) and believed to be a rare population with rigid hierarchical organization, there is good evidence to suggest that these cells exhibit a plastic cellular state influenced by dynamic CSC-niche interplay. This revelation underscores the need to reevaluate the hallmarks of cancer stemness. Herein, we summarize the techniques used to identify and characterize the state of these cells and discuss their defining and emerging hallmarks,...
Source: Cell Stem Cell - May 3, 2024 Category: Stem Cells Authors: Jia-Jian Loh Stephanie Ma Source Type: research
Lumen expansion is initially driven by apical actin polymerization followed by osmotic pressure in a human epiblast model
Cell Stem Cell. 2024 May 2;31(5):640-656.e8. doi: 10.1016/j.stem.2024.03.016.ABSTRACTPost-implantation, the pluripotent epiblast in a human embryo forms a central lumen, paving the way for gastrulation. Osmotic pressure gradients are considered the drivers of lumen expansion across development, but their role in human epiblasts is unknown. Here, we study lumenogenesis in a pluripotent-stem-cell-based epiblast model using engineered hydrogels. We find that leaky junctions prevent osmotic pressure gradients in early epiblasts and, instead, forces from apical actin polymerization drive lumen expansion. Once the lumen reaches ...
Source: Cell Stem Cell - May 3, 2024 Category: Stem Cells Authors: Dhiraj Indana Andrei Zakharov Youngbin Lim Alexander R Dunn Nidhi Bhutani Vivek B Shenoy Ovijit Chaudhuri Source Type: research
The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
Cell Stem Cell. 2024 Apr 27:S1934-5909(24)00140-1. doi: 10.1016/j.stem.2024.04.013. Online ahead of print.ABSTRACTIn mammals, the circadian clock network drives daily rhythms of tissue-specific homeostasis. To dissect daily inter-tissue communication, we constructed a mouse minimal clock network comprising only two nodes: the peripheral epidermal clock and the central brain clock. By transcriptomic and functional characterization of this isolated connection, we identified a gatekeeping function of the peripheral tissue clock with respect to systemic inputs. The epidermal clock concurrently integrates and subverts brain sig...
Source: Cell Stem Cell - May 3, 2024 Category: Stem Cells Authors: Thomas Mortimer Valentina M Zinna Muge Atalay Carmelo Laudanna Oleg Deryagin Guillem Posas Jacob G Smith Elisa Garc ía-Lara Mireia Vaca-Dempere Leonardo Vin ícius Monteiro de Assis Isabel Heyde Kevin B Koronowski Paul Petrus Carolina M Greco Stephen For Source Type: research
Microbial metabolite steers intestinal stem cell fate under stress
Cell Stem Cell. 2024 May 2;31(5):591-592. doi: 10.1016/j.stem.2024.04.006.ABSTRACTRecently in Cell Metabolism, Wei et al.1 unveiled a brain-to-gut pathway that conveys psychological stress to intestinal epithelial cells, leading to their dysfunction. This gut-brain axis involves a microbial metabolite, indole-3-acetate (IAA), as a niche signal that hampers mitochondrial respiration to skew intestinal stem cell (ISC) fate.PMID:38701755 | DOI:10.1016/j.stem.2024.04.006 (Source: Cell Stem Cell)
Source: Cell Stem Cell - May 3, 2024 Category: Stem Cells Authors: Shu Zhu Wen Pan Source Type: research
Unveiling the mystery of nuclear RNA homeostasis
Cell Stem Cell. 2024 May 2;31(5):583-585. doi: 10.1016/j.stem.2024.03.014.ABSTRACTHow nuclear RNA homeostasis impacts cellular functions remains elusive. In this issue of Cell Stem Cell, Han et al.1 utilized a controllable protein degradation system targeting EXOSC2 to perturb RNA homeostasis in mouse pluripotent embryonic stem cells, revealing its vital role in orchestrating crucial nuclear events for cellular fitness.PMID:38701751 | DOI:10.1016/j.stem.2024.03.014 (Source: Cell Stem Cell)
Source: Cell Stem Cell - May 3, 2024 Category: Stem Cells Authors: Lin Shan Ling-Ling Chen Source Type: research
Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation
Cell Stem Cell. 2024 May 2;31(5):754-771.e6. doi: 10.1016/j.stem.2024.04.001.ABSTRACTDevelopment of embryonic stem cells (ESCs) into neurons requires intricate regulation of transcription, splicing, and translation, but how these processes interconnect is not understood. We found that polypyrimidine tract binding protein 1 (PTBP1) controls splicing of DPF2, a subunit of BRG1/BRM-associated factor (BAF) chromatin remodeling complexes. Dpf2 exon 7 splicing is inhibited by PTBP1 to produce the DPF2-S isoform early in development. During neuronal differentiation, loss of PTBP1 allows exon 7 inclusion and DPF2-L expression. Dif...
Source: Cell Stem Cell - May 3, 2024 Category: Stem Cells Authors: Mohammad Nazim Chia-Ho Lin An-Chieh Feng Wen Xiao Kyu-Hyeon Yeom Mulin Li Allison E Daly Xianglong Tan Ha Vu Jason Ernst Michael F Carey Stephen T Smale Douglas L Black Source Type: research
Comparison of Whole Blood and Plasma for Monitoring Cytomegalovirus and Epstein-Barr Virus
New Microbiol. 2024 May;47(1):52-59.ABSTRACTMonitoring Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection after transplantation is recommended to enable preemptive therapy. However, the most suitable sample type remains unclear. Patients who underwent hematopoietic stem cell or liver transplantation were included in this study. Viral loads in sequential whole-blood and plasma samples were retrospectively analyzed. EBV DNA was detected more frequently in whole blood (55%) than in plasma (18%). The detection rate of CMV DNA was similar between the two sample types. The correlation of viral loads between the two sam...
Source: New Microbiologica - May 3, 2024 Category: Microbiology Authors: Yuto Fukuda Yuka Torii Ken-Ichi Iwata Kazunori Haruta Makoto Yamaguchi Takako Suzuki Atsushi Narita Hideki Muramatsu Yasuhiro Ogura Yoshiyuki Takahashi Yoshinori Ito Jun-Ichi Kawada Source Type: research
Umbilical Cord Blood and UC-MSCs Combined with Low-Dose Immunosuppressant in the Treatment of Elderly Patients with Pure Red Cell Aplastic: A Case Series
CONCLUSION: This report provides an effective regimen of using UCB and UC-MSCs combined with low-dose CsA (1-3 mg/kg/d) to treat PRCA, especially for elderly patients with multiple complications who cannot use the conventional dosage.PMID:38698745 | DOI:10.2174/011574888X290378240424075002 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - May 3, 2024 Category: Stem Cells Authors: Wei-Wei Zhu Sujing Zhuang Zhe Yu Xin Li Tian-Jie Han Yue Ma Li-Jun Li Zhi-Rui Zhao Source Type: research
