Analysis of ischemic stroke-mediated effects on blood –brain barrier properties along the arteriovenous axis assessed by intravital two-photon imaging
Early breach of the blood –brain barrier (BBB) and consequently extravasation of blood-borne substances into the brain parenchyma is a common hallmark of ischemic stroke. Although BBB breakdown is associated wi... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 15, 2024 Category: Neurology Authors: Jil Protzmann, Felix Jung, Lars Jakobsson and Linda Fredriksson Tags: Research Source Type: research
C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity
The blood-brain barrier (BBB) serves as a highly intricate and dynamic interface connecting the brain and the bloodstream, playing a vital role in maintaining brain homeostasis. BBB dysfunction has been associ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 11, 2024 Category: Neurology Authors: Ana Arag ón-González, Allan C Shaw, Jannigje R Kok, Florence S Roussel, Cleide dos Santos Souza, Sarah M Granger, Tatyana Vetter, Yolanda de Diego, Kathrin C Meyer, Selina N Beal, Pamela J Shaw and Laura Ferraiuolo Tags: Research Source Type: research
Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR δ activation
The blood-brain barrier (BBB) is pivotal for the maintenance of brain homeostasis and it strictly regulates the cerebral transport of a wide range of endogenous compounds and drugs. While fasting is increasing... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 8, 2024 Category: Neurology Authors: St éphanie Chasseigneaux, Véronique Cochois-Guégan, Lucas Lecorgne, Murielle Lochus, Sophie Nicolic, Corinne Blugeon, Laurent Jourdren, David Gomez-Zepeda, Stefan Tenzer, Sylvia Sanquer, Valérie Nivet-Antoine, Marie-Claude Menet, Jean-Louis Laplanche, Tags: Research Source Type: research
SARS-CoV-2 causes dysfunction in human iPSC-derived brain microvascular endothelial cells potentially by modulating the Wnt signaling pathway
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which is associated with various neurological symptoms, including nausea, dizziness, headache, encephali... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 8, 2024 Category: Neurology Authors: Shigeru Yamada, Tadahiro Hashita, Shota Yanagida, Hiroyuki Sato, Yukuto Yasuhiko, Kaori Okabe, Takamasa Noda, Motohiro Nishida, Tamihide Matsunaga and Yasunari Kanda Tags: Research Source Type: research
Single-cell analysis of mesenchymal cells in permeable neural vasculature reveals novel diverse subpopulations of fibroblasts
In the choroid plexus and pituitary gland, vasculature is known to have a permeable, fenestrated phenotype which allows for the free passage of molecules in contrast to the blood brain barrier observed in the ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 5, 2024 Category: Neurology Authors: William E. Bastedo, R. Wilder Scott, Martin Arostegui and T. Michael Underhill Tags: Research Source Type: research
[1-11C]-Butanol Positron Emission Tomography reveals an impaired brain to nasal turbinates pathway in aging amyloid positive subjects
Reduced clearance of cerebrospinal fluid (CSF) has been suggested as a pathological feature of Alzheimer ’s disease (AD). With extensive documentation in non-human mammals and contradictory human neuroimaging d... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 2, 2024 Category: Neurology Authors: Neel H. Mehta, Xiuyuan Wang, Samantha A. Keil, Ke Xi, Liangdong Zhou, Kevin Lee, Wanbin Tan, Edward Spector, Amirhossein Goldan, James Kelly, Nicolas A. Karakatsanis, P. David Mozley, Sadek Nehmeh, J. Levi Chazen, Simon Morin, John Babich & hellip; Tags: Research Source Type: research
Cognitive decline, A β pathology, and blood–brain barrier function in aged 5xFAD mice
Patients with Alzheimer's disease (AD) develop blood –brain barrier dysfunction to varying degrees. How aging impacts Aβ pathology, blood–brain barrier function, and cognitive decline in AD remains largely unkn... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 27, 2024 Category: Neurology Authors: Geetika Nehra, Sasivimon Promsan, Ruedeemars Yubolphan, Wijitra Chumboatong, Pornpun Vivithanaporn, Bryan J. Maloney, Anusorn Lungkaphin, Bjoern Bauer and Anika M. S. Hartz Tags: Research Source Type: research
Role of aquaporin-4 polarization in extracellular solute clearance
Waste from the brain has been shown to be cleared via the perivascular spaces through the so-called glymphatic system. According to this model the cerebrospinal fluid (CSF) enters the brain in perivascular spa... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 26, 2024 Category: Neurology Authors: Laura Bojarskaite, Sahar Nafari, Anne Katrine Ravnanger, Mina Martine Frey, Nadia Skauli, Knut Sindre Åbjørsbråten, Lena Catherine Roth, Mahmood Amiry-Moghaddam, Erlend A. Nagelhus, Ole Petter Ottersen, Inger Lise Bogen, Anna E. Thoren and Rune Enger Tags: Brief Report Source Type: research
Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood –brain barrier
A principal protective component of the mammalian blood –brain barrier (BBB) is the high expression of the multidrug efflux transporters P-glycoprotein (P-gp, encoded by ABCB1) and ABCG2 (encoded by ABCG2) on the ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 15, 2024 Category: Neurology Authors: Joanna R. Thomas, William J. E. Frye, Robert W. Robey, Andrew C. Warner, Donna Butcher, Jennifer L. Matta, Tamara C. Morgan, Elijah F. Edmondson, Paula B. Salazar, Suresh V. Ambudkar and Michael M. Gottesman Tags: Research Source Type: research
Transient but not chronic hyperglycemia accelerates ocular glymphatic transport
Glymphatic transport is vital for the physiological homeostasis of the retina and optic nerve. Pathological alterations of ocular glymphatic fluid transport and enlarged perivascular spaces have been described... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 12, 2024 Category: Neurology Authors: Christine Delle, Xiaowei Wang, Michael Giannetto, Evan Newbold, Weiguo Peng, Ryszard Stefan Gomolka, Antonio Ladr ón-de-Guevara, Neža Cankar, Elise Schiøler Nielsen, Celia Kjaerby, Pia Weikop, Yuki Mori and Maiken Nedergaard Tags: Research Source Type: research
Freezing of gait in idiopathic normal pressure hydrocephalus
This study ’s objective was to evaluate the frequency of FoG in a large cohort of iNPH pati... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 8, 2024 Category: Neurology Authors: Carl-Johan Kihlstedt, Jan Malm, Alfonso Fasano and David B äckström Tags: Research Source Type: research
Validating the accuracy of real-time phase-contrast MRI and quantifying the effects of free breathing on cerebrospinal fluid dynamics
Understanding of the cerebrospinal fluid (CSF) circulation is essential for physiological studies and clinical diagnosis. Real-time phase contrast sequences (RT-PC) can quantify beat-to-beat CSF flow signals. ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 7, 2024 Category: Neurology Authors: Pan Liu, Kimi Owashi, Heimiri Monnier, Serge Metanbou, Cyrille Capel and Olivier Bal édent Tags: Research Source Type: research
The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact
Hydrocephalus (HC) is a heterogenous disease characterized by alterations in cerebrospinal fluid (CSF) dynamics that may cause increased intracranial pressure. HC is a component of a wide array of genetic synd... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 4, 2024 Category: Neurology Authors: Andrew T. Hale, Hunter Boudreau, Rishi Devulapalli, Phan Q. Duy, Travis J. Atchley, Michael C. Dewan, Mubeen Goolam, Graham Fieggen, Heather L. Spader, Anastasia A. Smith, Jeffrey P. Blount, James M. Johnston, Brandon G. Rocque, Curtis J. Rozzelle, Zechen Tags: Review Source Type: research
The proteome of the blood –brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture
The active transport of molecules into the brain from blood is regulated by receptors, transporters, and other cell surface proteins that are present on the luminal surface of endothelial cells at the blood –br... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 4, 2024 Category: Neurology Authors: Tammy-Lynn Tremblay, Wael Alata, Jacqueline Slinn, Ewa Baumann, Christie E. Delaney, Maria Moreno, Arsalan S. Haqqani, Danica B. Stanimirovic and Jennifer J. Hill Tags: Research Source Type: research
Deep learning segmentation of the choroid plexus from structural magnetic resonance imaging (MRI): validation and normative ranges across the adult lifespan
The choroid plexus functions as the blood-cerebrospinal fluid (CSF) barrier, plays an important role in CSF production and circulation, and has gained increased attention in light of the recent elucidation of ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 29, 2024 Category: Neurology Authors: Jarrod J. Eisma, Colin D. McKnight, Kilian Hett, Jason Elenberger, Caleb J. Han, Alexander K. Song, Ciaran Considine, Daniel O. Claassen and Manus J. Donahue Tags: Research Source Type: research
