Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients
Developing novel therapeutic agents to treat amyotrophic lateral sclerosis (ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal drug administration shows promise due t... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 21, 2020 Category: Neurology Authors: Lucas R. Sass, Mohammadreza Khani, Jacob Romm, Marianne Schmid Daners, Kyle McCain, Tavara Freeman, Gregory T. Carter, Douglas L. Weeks, Brian Petersen, Jason Aldred, Dena Wingett and Bryn A. Martin Tags: Research Source Type: research

Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study
Both aging and changes in blood flow velocity between the extracranial (intraspinal) and intracranial regions of cerebral vessels have an impact on brain hydro-hemodynamics. Arterial and venous cerebral blood ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 14, 2020 Category: Neurology Authors: Armelle Lokossou, Serge Metanbou, Catherine Gondry-Jouet and Olivier Bal édent Tags: Research Source Type: research

Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium
Genetic disruption of slc4a10, which encodes the sodium-dependent chloride/bicarbonate exchanger Ncbe, leads to a major decrease in Na+-dependent HCO3 − import into choroid plexus epithelial cells in mice and to a... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 7, 2020 Category: Neurology Authors: Inga Baasch Christensen, Qi Wu, Anders Solitander Bohlbro, Marianne Gerberg Skals, Helle Hasager Damkier, Christian Andreas H übner, Robert Andrew Fenton and Jeppe Praetorius Tags: Research Source Type: research

Can pulsatile CSF flow across the cerebral aqueduct cause ventriculomegaly? A prospective study of patients with communicating hydrocephalus
Communicating hydrocephalus is a disease where the cerebral ventricles are enlarged. It is characterized by the absence of detectable cerebrospinal fluid (CSF) outflow obstructions and often with increased CSF... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 23, 2019 Category: Neurology Authors: P. Holmlund, S. Qvarlander, J. Malm and A. Eklund Tags: Research Source Type: research

The legacy of Malcolm Beverley Segal (1937 –2019) on the science and fields concerned with choroid plexus and cerebrospinal fluid physiology
This article highlights the scientific achievements, professional career, and personal interactions of Malcolm B. Segal who passed away in July this year. Born in 1937 in Goodmayes, Essex, UK, Segal rose to th... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 19, 2019 Category: Neurology Authors: Adam Chodobski, Jean-Fran çois Ghersi-Egea, Jane Preston-Kennedy, Zoran Redzic, Nathalie Strazielle, Joanna Szmydynger-Chodobska and Robert G. Thorne Tags: Letter to the Editor Source Type: research

Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients
A growing body of evidence suggests that the accumulation of amyloid- β and tau (HPτ) in the brain of patients with the dementia subtype idiopathic normal pressure hydrocephalus (iNPH) is associated with delaye... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 18, 2019 Category: Neurology Authors: Md Mahdi Hasan-Olive, Rune Enger, Hans-Arne Hansson, Erlend A. Nagelhus and Per Kristian Eide Tags: Research Source Type: research

Region-specific blood –brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer’s disease
Research into amisulpride use in Alzheimer ’s disease (AD) implicates blood–brain barrier (BBB) dysfunction in antipsychotic sensitivity. Research into BBB transporters has been mainly directed towards the ABC ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 17, 2019 Category: Neurology Authors: Gayathri Nair Sekhar, Alice L. Fleckney, Sevda Tomova Boyanova, Huzefa Rupawala, Rachel Lo, Hao Wang, Doaa B. Farag, Khondaker Miraz Rahman, Martin Broadstock, Suzanne Reeves and Sarah Ann Thomas Tags: Research Source Type: research

Repeated lumbar punctures within 3 days may affect CSF biomarker levels
Lumbar puncture (LP) is a common way of collecting cerebrospinal fluid (CSF) both in the clinic and in research. In this extension of a study on the relationship between sleep deprivation and CSF biomarkers fo... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 13, 2019 Category: Neurology Authors: Martin Olsson, Johan Ärlig, Jan Hedner, Kaj Blennow and Henrik Zetterberg Tags: Short paper Source Type: research

Abstracts from Hydrocephalus 2019: The Eleventh Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders
(Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 5, 2019 Category: Neurology Tags: Meeting abstracts Source Type: research

Preclinical update on regulation of intracranial pressure in relation to idiopathic intracranial hypertension
Elevated intracranial pressure (ICP) is observed in association with a range of brain disorders. One of these challenging disorders is idiopathic intracranial hypertension (IIH), characterized by raised ICP of... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 26, 2019 Category: Neurology Authors: Sajedeh Eftekhari, Connar Stanley James Westgate, Maria Schmidt Uldall and Rigmor Hoejland Jensen Tags: Review Source Type: research

Effect of blood contamination of cerebrospinal fluid on amino acids, biogenic amines, pterins and vitamins
Cerebrospinal fluid (CSF) metabolomic investigations are a powerful tool for studying neurometabolic diseases. We aimed to assess the effect of CSF contamination with blood on the concentrations of selected bi... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 14, 2019 Category: Neurology Authors: Marta Batllori, Mercedes Casado, Cristina Sierra, Maria del Carmen Salgado, Laura Marti-Sanchez, Joan Maynou, Guerau Fernandez, Angels Garcia-Cazorla, Aida Ormazabal, Marta Molero-Luis and Rafael Artuch Tags: Research Source Type: research

B waves: a systematic review of terminology, characteristics, and analysis methods
Although B waves were introduced as a concept in the analysis of intracranial pressure (ICP) recordings nearly 60 years ago, there is still a lack consensus on precise definitions, terminology, amplitude, freq... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 15, 2019 Category: Neurology Authors: Isabel Martinez-Tejada, Alexander Arum, Jens E. Wilhjelm, Marianne Juhler and Morten Andresen Tags: Review Source Type: research

Uncertainty quantification of parenchymal tracer distribution using random diffusion and convective velocity fields
Influx and clearance of substances in the brain parenchyma occur by a combination of diffusion and convection, but the relative importance of these mechanisms is unclear. Accurate modeling of tracer distributi... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 30, 2019 Category: Neurology Authors: Matteo Croci, Vegard Vinje and Marie E. Rognes Tags: Research Source Type: research

Claudin-12 is not required for blood –brain barrier tight junction function
The blood –brain barrier (BBB) ensures central nervous system (CNS) homeostasis by strictly controlling the passage of molecules and solutes from the bloodstream into the CNS. Complex and continuous tight junct... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 12, 2019 Category: Neurology Authors: Mariana Castro Dias, Caroline Coisne, Pascale Baden, Gaby Enzmann, Lillian Garrett, Lore Becker, Sabine M. H ölter, Martin Hrabě de Angelis, Urban Deutsch and Britta Engelhardt Tags: Research Source Type: research

Abstracts from the 22nd International Symposium on Signal Transduction at the Blood –Brain Barriers
(Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 11, 2019 Category: Neurology Tags: Meeting abstracts Source Type: research

Correction to: An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons
Following publication of the original article [1], the author has reported that in Figure 1 (b and c) the y-axis TEER ( © x cm2) should be replaced with TEER (Ω x cm2). (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 10, 2019 Category: Neurology Authors: Scott G. Canfield, Matthew J. Stebbins, Madeline G. Faubion, Benjamin D. Gastfriend, Sean P. Palecek and Eric V. Shusta Tags: Correction Source Type: research

Tau-protein concentrations are not elevated in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML), caused by infection with John Cunningham polyoma virus (JCPyV) in immune-compromised patients, is a serious demyelinating disease of the central nervous system... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 5, 2019 Category: Neurology Authors: Nora M öhn, Yi Luo, Thomas Skripuletz, Philipp Schwenkenbecher, Inga Zerr, Peter Lange and Martin Stangel Tags: Short paper Source Type: research

Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood –brain barrier model
Human induced pluripotent stem cells (hiPSC) hold great promise for use in cell therapy applications and for improved in vitro models of human disease. So far, most hiPSC differentiation protocols to astroglia... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 29, 2019 Category: Neurology Authors: Louise Delsing, Ther ése Kallur, Henrik Zetterberg, Ryan Hicks and Jane Synnergren Tags: Research Source Type: research

Streptococcus agalactiae disrupts P-glycoprotein function in brain endothelial cells
Bacterial meningitis is a serious life threatening infection of the CNS. To cause meningitis, blood –borne bacteria need to interact with and penetrate brain endothelial cells (BECs) that comprise the blood–bra... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 22, 2019 Category: Neurology Authors: Brandon J. Kim, Maura A. McDonagh, Liwen Deng, Benjamin D. Gastfriend, Alexandra Schubert-Unkmeir, Kelly S. Doran and Eric V. Shusta Tags: Short paper Source Type: research

An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons
Brain microvascular endothelial cells (BMECs) astrocytes, neurons, and pericytes form the neurovascular unit (NVU). Interactions with NVU cells endow BMECs with extremely tight barriers via the expression of t... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 7, 2019 Category: Neurology Authors: Scott G. Canfield, Matthew J. Stebbins, Madeline G. Faubion, Benjamin D. Gastfriend, Sean P. Palecek and Eric V. Shusta Tags: Research Source Type: research

The Kuopio idiopathic normal pressure hydrocephalus protocol: initial outcome of 175 patients
The Kuopio University Hospital (KUH) idiopathic normal pressure hydrocephalus (iNPH) cerebrospinal fluid (CSF) shunting protocol is described together with the initial outcomes of 175 patients with probable iN... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 25, 2019 Category: Neurology Authors: A. Junkkari, A. J. Luikku, N. Danner, H. K. Jyrkk änen, T. Rauramaa, V. E. Korhonen, A. M. Koivisto, O. Nerg, M. Kojoukhova, T. J. Huttunen, J. E. Jääskeläinen and V. Leinonen Tags: Research Source Type: research

The role of mutations associated with familial neurodegenerative disorders on blood –brain barrier function in an iPSC model
Blood –brain barrier dysfunction is associated with many late-stage neurodegenerative diseases. An emerging question is whether the mutations associated with neurodegenerative diseases can independently lead to... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 15, 2019 Category: Neurology Authors: Moriah E. Katt, Lakyn N. Mayo, Shannon E. Ellis, Vasiliki Mahairaki, Jeffrey D. Rothstein, Linzhao Cheng and Peter C. Searson Tags: Research Source Type: research

In response to “Is solute movement within the extracellular spaces of brain gray matter brought about primarily by diffusion or flow?”
In our work, “Analysis of Convective and Diffusive Transport in the Brain Interstitium”, published in this journal (2019, 16:6), we estimate the interstitial superficial velocity by comparison of transport model ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 12, 2019 Category: Neurology Authors: Lori Ray, Jeffrey J. Iliff and Jeffrey J. Heys Tags: Letter to the Editor Response Source Type: research

Is solute movement within the extracellular spaces of brain gray matter brought about primarily by diffusion or flow? A commentary on “Analysis of convective and diffusive transport in the brain interstitium” Fluids and Barriers of the CNS (2019) 16:6 by L. Ray, J.J. Iliff and J.J. Heys
Solutes can enter and leave gray matter in the brain by perivascular routes. The glymphatic hypothesis supposes that these movements are a consequence of inward flow along periarterial spaces and an equal outw... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 12, 2019 Category: Neurology Authors: Stephen B. Hladky and Margery A. Barrand Tags: Letter to the Editor Source Type: research

Correction to: A26 Cerebrospinal fluid outflow resistance is increased following small-moderate ischaemic stroke
After publication of this supplement [1], it was brought to our attention that in the results the line “(0.3 ± 0.04 mmHg/μl/min, and 0.54 ± 0.04 mmHg/μl/min, respectively)” should actually read “(0.54 ± 0.04 m... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 11, 2019 Category: Neurology Authors: Adjanie Patabendige, Nick MacKovski, Debbie Pepperall, Rebecca Hood and Neil Spratt Tags: Correction Source Type: research

Human ES-derived MSCs correct TNF- α-mediated alterations in a blood–brain barrier model
Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood –brain barrier (BBB) is a hallmark of these pathologies and a potential ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 1, 2019 Category: Neurology Authors: Shujun Ge, Xi Jiang, Debayon Paul, Li Song, Xiaofang Wang and Joel S. Pachter Tags: Research Source Type: research

Abstracts from the 13th International Conference on Cerebral Vascular Biology (CVB 2019)
(Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 20, 2019 Category: Neurology Tags: Meeting abstracts Source Type: research

Hydraulic resistance of periarterial spaces in the brain
Periarterial spaces (PASs) are annular channels that surround arteries in the brain and contain cerebrospinal fluid (CSF): a flow of CSF in these channels is thought to be an important part of the brain ’s syst... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 20, 2019 Category: Neurology Authors: Jeffrey Tithof, Douglas H. Kelley, Humberto Mestre, Maiken Nedergaard and John H. Thomas Tags: Research Source Type: research

A perfusion bioreactor-based 3D model of the subarachnoid space based on a meningeal tissue construct
Altered flow of cerebrospinal fluid (CSF) within the subarachnoid space (SAS) is connected to brain, but also optic nerve degenerative diseases. To overcome the lack of suitable in vitro models that faithfully... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 13, 2019 Category: Neurology Authors: Albert Neutzner, Laura Power, Markus D ürrenberger, Hendrik P. N. Scholl, Peter Meyer, Hanspeter E. Killer, David Wendt and Corina Kohler Tags: Research Source Type: research

Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D
Pericytes of the blood –brain barrier (BBB) are embedded within basement membrane between brain microvascular endothelial cells (BMECs) and astrocyte end-feet. Despite the direct cell–cell contact observed in v... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 6, 2019 Category: Neurology Authors: John J. Jamieson, Raleigh M. Linville, Yuan Yuan Ding, Sharon Gerecht and Peter C. Searson Tags: Research Source Type: research

Proteome analysis of xylose metabolism in Rhodotorula toruloides during lipid production
Rhodotorula toruloides is a promising platform organism for production of lipids from lignocellulosic substrates. Little is known about the metabolic aspects of lipid production from the lignocellolosic sugar xyl... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 4, 2019 Category: Neurology Authors: Ievgeniia A. Tiukova, Jule Brandenburg, Johanna Blomqvist, Sabine Sampels, Nils Mikkelsen, Morten Skaugen, Magnus Ø. Arntzen, Jens Nielsen, Mats Sandgren and Eduard J. Kerkhoven Tags: Research Source Type: research

Genetic variation of biomass recalcitrance in a natural Salix viminalis (L.) population
Salix spp. are high-productivity crops potentially used for lignocellulosic biofuels such as bioethanol. In general, pretreatment is needed to facilitate the enzymatic depolymerization process. Biomass resistance... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 3, 2019 Category: Neurology Authors: Jonas A. Ohlsson, Henrik R. Hallingb äck, Mohamed Jebrane, Anne E. Harman-Ware, Todd Shollenberger, Stephen R. Decker, Mats Sandgren and Ann-Christin Rönnberg-Wästljung Tags: Research Source Type: research

A novel thermostable chitinolytic machinery of Streptomyces sp. F-3 consisting of chitinases with different action modes
The biodegradation of chitin is an important part of the carbon and nitrogen cycles in nature. Speeding up the biotransformation of chitin substrates can not only reduce pollution, but also produce high value-... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 3, 2019 Category: Neurology Authors: Xiaomeng Sun, Yingjie Li, Zhennan Tian, Yuanchao Qian, Huaiqiang Zhang and Lushan Wang Tags: Research Source Type: research

High-efficiency nuclear transformation of the microalgae Nannochloropsis oceanica using Tn5 Transposome for the generation of altered lipid accumulation phenotypes
One of the major problems in the production of lipids for biotechnological purposes using microalgae is maintaining a high productivity of these molecules without reducing cellular biomass. High production rat... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 1, 2019 Category: Neurology Authors: Hector Osorio, Carol Jara, Karen Fuenzalida, Emma Rey-Jurado and M ónica Vásquez Tags: Research Source Type: research

Magnet anode enhances extracellular electron transfer and enrichment of exoelectrogenic bacteria in bioelectrochemical systems
In this study, we construct magnetic microbial fuel cells (MFCs) with magnets with dif... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 31, 2019 Category: Neurology Authors: Huihui Zhou, Xiaoxue Mei, Bingfeng Liu, Guojun Xie and Defeng Xing Tags: Research Source Type: research

The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells
Brain endothelial cell-based in vitro models are among the most versatile tools in blood –brain barrier research for testing drug penetration to the central nervous system. Transcytosis of large pharmaceuticals... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 30, 2019 Category: Neurology Authors: Andrea E. Toth, Simone S. E. Nielsen, Weronika Tomaka, N. Joan Abbott and Morten S. Nielsen Tags: Research Source Type: research

The need for mathematical modelling of spatial drug distribution within the brain
The blood brain barrier (BBB) is the main barrier that separates the blood from the brain. Because of the BBB, the drug concentration-time profile in the brain may be substantially different from that in the b... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 16, 2019 Category: Neurology Authors: Esm ée Vendel, Vivi Rottschäfer and Elizabeth C. M. de Lange Tags: Review Source Type: research

Dispersion in porous media in oscillatory flow between flat plates: applications to intrathecal, periarterial and paraarterial solute transport in the central nervous system
As an alternative to advection, solute transport by shear-augmented dispersion within oscillatory cerebrospinal fluid flow was investigated in small channels representing the basement membranes located between... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 6, 2019 Category: Neurology Authors: M. Keith Sharp, Roxana O. Carare and Bryn A. Martin Tags: Research Source Type: research

Enhanced in vitro model of the CSF dynamics
Fluid dynamics of the craniospinal system are complex and still not completely understood. In vivo flow and pressure measurements of the cerebrospinal fluid (CSF) are limited. Whereas in silico modeling can be... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 29, 2019 Category: Neurology Authors: Anne Benninghaus, Olivier Bal édent, Armelle Lokossou, Carlos Castelar, Steffen Leonhardt and Klaus Radermacher Tags: Research Source Type: research

Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases
The fine balance between the secretion, composition, volume and turnover of cerebrospinal fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance can be disrupted. A sign... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 10, 2019 Category: Neurology Authors: Steven William Bothwell, Damir Janigro and Adjanie Patabendige Tags: Review Source Type: research

Spinal CSF flow in response to forced thoracic and abdominal respiration
Respiration-induced pressure changes represent a powerful driving force of CSF dynamics as previously demonstrated using flow-sensitive real-time magnetic resonance imaging (MRI). The purpose of the present st... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 4, 2019 Category: Neurology Authors: G ökmen Aktas, Jost M. Kollmeier, Arun A. Joseph, Klaus-Dietmar Merboldt, Hans-Christoph Ludwig, Jutta Gärtner, Jens Frahm and Steffi Dreha-Kulaczewski Tags: Research Source Type: research

The human central nervous system discharges carbon dioxide and lactic acid into the cerebrospinal fluid
The central nervous system was previously thought to draw oxygen and nutrition from the arteries and discharge carbon dioxide and other metabolic wastes into the venous system. At present, the functional role ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 29, 2019 Category: Neurology Authors: Tetsuya Akaishi, Eiko Onishi, Michiaki Abe, Hiroaki Toyama, Kota Ishizawa, Michio Kumagai, Ryosuke Kubo, Ichiro Nakashima, Masashi Aoki, Masanori Yamauchi and Tadashi Ishii Tags: Research Source Type: research

Effect of extradural constriction on CSF flow in rat spinal cord
Fluid homeostasis in the central nervous system (CNS) is essential for normal neurological function. Cerebrospinal fluid (CSF) in the subarachnoid space and interstitial fluid circulation in the CNS parenchyma... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 26, 2019 Category: Neurology Authors: Joel A. Berliner, Thomas Woodcock, Elmira Najafi, Sarah J. Hemley, Magdalena Lam, Shaokoon Cheng, Lynne E. Bilston and Marcus A. Stoodley Tags: Research Source Type: research

Analysis of convective and diffusive transport in the brain interstitium
Despite advances in in vivo imaging and experimental techniques, the nature of transport mechanisms in the brain remain elusive. Mathematical modelling verified using available experimental data offers a power... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 6, 2019 Category: Neurology Authors: Lori Ray, Jeffrey J. Iliff and Jeffrey J. Heys Tags: Research Source Type: research

Comorbidity of diabetes mellitus in idiopathic normal pressure hydrocephalus: a systematic literature review
Idiopathic normal pressure hydrocephalus (iNPH) is a subtype of hydrocephalus that occurs more often in the elderly population. It is usually characterized by gait disturbance, dementia and urinary incontinenc... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 12, 2019 Category: Neurology Authors: Miles Hudson, Caden Nowak, Richard J. Garling and Carolyn Harris Tags: Review Source Type: research

The year in review: progress in brain barriers and brain fluid research in 2018
This editorial focuses on the progress made in brain barrier and brain fluid research in 2018. It highlights some recent advances in knowledge and techniques, as well as prevalent themes and controversies. Are... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 5, 2019 Category: Neurology Authors: Richard F. Keep, Hazel C. Jones and Lester R. Drewes Tags: Editorial Source Type: research

Claudin-5: gatekeeper of neurological function
Tight junction proteins of the blood –brain barrier are vital for maintaining integrity of endothelial cells lining brain blood vessels. The presence of these protein complexes in the space between endothelial ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 29, 2019 Category: Neurology Authors: Chris Greene, Nicole Hanley and Matthew Campbell Tags: Review Source Type: research

Opposing CSF hydrodynamic trends found in the cerebral aqueduct and prepontine cistern following shunt treatment in patients with normal pressure hydrocephalus
This study investigated cerebrospinal fluid (CSF) hydrodynamics using cine phase-contrast MRI in the cerebral aqueduct and the prepontine cistern between three distinct groups: pre-shunt normal pressure hydroc... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 22, 2019 Category: Neurology Authors: Robert B. Hamilton, Fabien Scalzo, Kevin Baldwin, Amber Dorn, Paul Vespa, Xiao Hu and Marvin Bergsneider Tags: Research Source Type: research

Disruption of the hippocampal and hypothalamic blood –brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate
Type II diabetes is a vascular risk factor for cognitive impairment and increased risk of dementia. Disruption of the blood –retinal barrier (BRB) and blood–brain barrier (BBB) are hallmarks of subsequent retin... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 8, 2019 Category: Neurology Authors: Therese S. Salameh, William G. Mortell, Aric F. Logsdon, D. Allan Butterfield and William A. Banks Tags: Research Source Type: research

Abstracts from hydrocephalus 2018: the tenth meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders
(Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 24, 2018 Category: Neurology Tags: Meeting abstracts Source Type: research