Vascular Complications in Individuals with Type 2 Diabetes Mellitus Additionally Increase the Risk of Femoral Neck Fractures Due to Deteriorated Trabecular Microarchitecture
AbstractIndividuals with diabetes mellitus type 2 (T2DM) have an increased risk of hip fracture, especially if vascular complications are present. However, microstructural origins of increased bone fragility in T2DM are still controversial. DXA measurement of the contralateral hip and three-dimensional microCT analyses of femoral neck trabecular microarchitecture were performed in 32 individuals (26 women and 6 men, 78  ± 7 years). The specimens were divided to two groups: T2DM individuals with hip fracture (DMFx,n = 18) and healthy controls (CTL,n = 14). DMFx group con...
Source: Calcified Tissue International - July 24, 2021 Category: Orthopaedics Source Type: research

Depression and Osteoporosis: A Mendelian Randomization Study
AbstractObservational studies suggest a link between depression and osteoporosis, but these may be subject to confounding and reverse causality. In this two-sample Mendelian randomization analysis, we included the large meta-analysis of genome-wide association studies for depression among 807,553 individuals (246,363 cases and 561,190 controls) of European descent, the large meta-analysis to identify genetic variants associated with femoral neck bone mineral density (FN-BMD), forearm BMD (FA-BMD) and lumbar spine BMD (LS-BMD) among 53,236 individuals of European ancestry, and the GWAS summary data of heel BMD (HE-BMD) and ...
Source: Calcified Tissue International - July 14, 2021 Category: Orthopaedics Source Type: research

Fibroblast Growth Factor 2 High Molecular Weight Isoforms in Dentoalveolar Mineralization
We examined if the alveolar bone and dentin mineralization defects in HMWTg mice resulted from increased FGF23 expression and whether an FGF23 neutralizing antibody could rescue the hypomineralization phenotype. HMWTg and VectorTg control mice were given subcutaneous injections of FGF23 neutralizing antibody twice/week starting at postnatal day 21 for 6  weeks. Since Calcitriol (1,25D) have direct effects in promoting bone mineralization, we also determined if 1,25D protects against the defective dentin and alveolar bone mineralization. Therefore, HMWTg mice were given subcutaneous injections of 1,25D daily or concomi...
Source: Calcified Tissue International - July 10, 2021 Category: Orthopaedics Source Type: research

Acute Phase Reactions After Intravenous Infusion of Zoledronic Acid in Japanese Patients with Osteoporosis: Sub-analyses of the Phase III ZONE Study
This study is registered with ClinicalTrials.gov (identifier: NCT01522521; January 31, 2012). (Source: Calcified Tissue International)
Source: Calcified Tissue International - July 10, 2021 Category: Orthopaedics Source Type: research

Degenerations in Global Morphometry of Cancellous Bone in Rheumatoid Arthritis, Osteoarthritis and Osteoporosis of Femoral Heads are Similar but More Severe than in Ageing Controls
This study compared these properties with those of ageing controls by matching bone volume fraction (BV/TV), the most important determinant for bones ’ mechanical properties, to investigate whether these bones have similar properties and degenerative potentials. RA, OA and OP femoral heads were harvested from patients undergoing total hip replacement surgery. The selected patients were matched by similar cancellous bone BV/TV, with seven patien ts in each group. Four samples were prepared from each femoral head and scanned with micro-CT to quantify microarchitectural properties and compression tested to determine mec...
Source: Calcified Tissue International - July 9, 2021 Category: Orthopaedics Source Type: research

Early-Onset Osteoporosis
AbstractOsteoporosis is a skeletal disorder with enhanced bone fragility, usually affecting the elderly. It is very rare in children and young adults and the definition is not only based on a low BMD (aZ-score  
Source: Calcified Tissue International - July 8, 2021 Category: Orthopaedics Source Type: research

Osteoporosis Caused by Systemic Mastocytosis: Prevalence in a Cohort of 8392 Patients with Osteoporosis
AbstractIndolent systemic mastocytosis (ISM) is a group of heterogenous diseases characterized by abnormal accumulation of mast cells in at least one organ. ISM can be a cause of osteoporosis. The aim of this study is to determine the prevalence, and the prognosis of ISM in a cohort of patients with osteoporosis. In this monocentric and retrospective study, patients with osteoporosis who did not receive a bone biopsy (cohort 1) and patients that subsequently received a diagnostic bone biopsy for differential diagnosis (cohort 2) are compared with patients who are diagnosed with ISM (cohort 3). A total of 8392 patients are ...
Source: Calcified Tissue International - July 5, 2021 Category: Orthopaedics Source Type: research

Proton Pump Inhibitors Inhibit PHOSPHO1 Activity and Matrix Mineralisation In Vitro
AbstractProton pump inhibitors (PPIs) have been associated with an increased risk of fragility fractures in pharmaco-epidemiological studies. The mechanism is unclear, but it has been speculated that by neutralising gastric acid, they may reduce intestinal calcium absorption, causing secondary hyperparathyroidism and bone loss. Here we investigated that hypothesis that the skeletal effects of PPI might be mediated by inhibitory effects on the bone-specific phosphatase PHOSPHO1. We found that the all PPIs tested inhibited the activity of PHOSPHO1 with IC50 ranging between 0.73  µM for esomeprazole to 19.27 &...
Source: Calcified Tissue International - July 2, 2021 Category: Orthopaedics Source Type: research

Application of Machine Learning to Identify Clinically Meaningful Risk Group for Osteoporosis in Individuals Under the Recommended Age for Dual-Energy X-Ray Absorptiometry
AbstractDual-energy X-ray absorptiometry (DXA) is the gold standard for diagnosing osteoporosis; it is generally recommended in men  ≥ 70 and women ≥ 65 years old. Therefore, assessment of clinical risk factors for osteoporosis is very important in individuals under the recommended age for DXA. Here, we examine the diagnostic performance of machine learning-based prediction models for osteoporosis in individuals und er the recommended age for DXA examination. Data of 2210 men aged 50–69 and 1099 women aged 50–64 obtained from the Korea National Health and Nutrition Examina...
Source: Calcified Tissue International - June 30, 2021 Category: Orthopaedics Source Type: research

Persistent Abnormal Immunocytes Induced Systemic Bone Loss in Locally Irradiated Rats
This study aimed to observe persistent and systemic changes in locally irradiated rats and to determine the systemic pathological changes that persistently affect bone metabolism. We examined the inflammatory and oxidative stress responses that occurred after local irradiation using enzyme immunoassays and biochemical analyses. Lymphocytes obtained from the blood, spleen, thymus, and bone marrow were evaluated using flow cytometry. The proliferation and apoptosis characteristics of co-cultured bone marrow-derived mesenchymal stem cells (BMSCs) were detected by MTT assay and PI/Annexin V-FITC staining, respectively, and the...
Source: Calcified Tissue International - June 30, 2021 Category: Orthopaedics Source Type: research

A Panel-Based Sequencing Analysis of Patients with Paget ’s Disease of Bone Suggests Enrichment of Rare Genetic Variation in regulators of NF-κB Signaling and Supports the Importance of the 7q33 Locus
In conclusion, our findings support the involvement of genetic variation in modulators of NF- κB signaling in PDB and confirm the association of previously associated genes with the pathogenesis of PDB. (Source: Calcified Tissue International)
Source: Calcified Tissue International - June 25, 2021 Category: Orthopaedics Source Type: research

Long-Term Follow-Up Outcomes of 19 Patients with Osteogenesis Imperfecta Type XI and Bruck Syndrome Type I Caused by FKBP10 Variants
This study is valuable in terms of showing the follow-up findings of patients withFKBP10 variants for the first time. (Source: Calcified Tissue International)
Source: Calcified Tissue International - June 25, 2021 Category: Orthopaedics Source Type: research

MOF/Hip Fracture Ratio in a Belgian Cohort of Post-menopausal Women (FRISBEE): Potential Impact on the FRAX ® Score
AbstractThe ratio between major osteoporotic fractures (MOFs) and hip fractures in the Belgian FRAX ® tool to predict fractures is currently based on Swedish data. We determined these ratios in a prospective cohort of Belgian postmenopausal women. 3560 women, aged 60–85 years (70.1 ± 6.4 years), were included in a prospective study from 2007 to 2013 and surveyed yearly (FRISBEE). We anal yzed the number of validated incident fractures until October 2020 by age and sites and compared the MOFs/hip ratios in this cohort with those from the Swedish databases. We registered 1336 fracture...
Source: Calcified Tissue International - June 23, 2021 Category: Orthopaedics Source Type: research

A Novel IFITM5 Variant Associated with Phenotype of Osteoporosis with Calvarial Doughnut Lesions: A Case Report
This study describes a Japanese family with the skeletal phenotype of OP-CDL. The affected individuals have moderately severe, childhood-onset skeletal fragility with multiple long-bone fractures, scoliosis and bone deformities. In addition, they exhibit multiple CDLs or calvarial bumps with central radiolucency and peripheral radiopacity. However,SGMS2 sequencing was normal. Instead, whole-exome sequencing identified a novelIFITM5 missense mutation c.143A>G (p.N48S) (classified as a VUS by ACMG).IFITM5 encodes an osteoblast-restricted protein BRIL and a recurrent c.-14C>T mutation in its 5' UTR region results in OI ...
Source: Calcified Tissue International - June 22, 2021 Category: Orthopaedics Source Type: research

Bone Histomorphometry and 18F-Sodium Fluoride Positron Emission Tomography Imaging: Comparison Between only Bone Turnover-based and Unified TMV-based Classification of Renal Osteodystrophy
AbstractBone biopsy is the gold standard for characterization of renal osteodystrophy (ROD). However, the classification of the subtypes of ROD based on histomorphometric parameters is not unambiguous and the range of normal values for turnover differ in different publications.18F-Sodium Fluoride positron emission tomography (18F-NaF PET) is a dynamic imaging technique that measures turnover.18F-NaF PET has previously been shown to correlate with histomorphometric parameters.  In this cross-sectional study, 26 patients on dialysis underwent a18F-NaF PET and a bone biopsy. Bone turnover-based classification was assesse...
Source: Calcified Tissue International - June 17, 2021 Category: Orthopaedics Source Type: research

Teriparatide Treatment in Patients with Pregnancy- and Lactation-Associated Osteoporosis
AbstractPregnancy- and lactation-associated osteoporosis (PLO) is a rare disease, presenting in most cases with severe back pain due to low energy vertebral fractures (VFs). Our purpose was to assess the effect of teriparatide (TPTD)vs. conventional management on areal bone mineral density (aBMD) and trabecular bone score (TBS) in patients with PLO. A multicenter retrospective cohort study concerning premenopausal women with PLO. Nineteen women were treated with TPTD (20  μg/day) (group A) plus calcium and vitamin D and eight women with calcium and vitamin D only (group B) for up to 24 months. The primary end-...
Source: Calcified Tissue International - June 16, 2021 Category: Orthopaedics Source Type: research

Prevalence of Sarcopenia and its Association with Antirheumatic Drugs in Middle-Aged and Older Adults with Rheumatoid Arthritis: A Systematic Review and Meta-analysis
AbstractTo examine the prevalence of sarcopenia and its association with antirheumatic drugs in adults with rheumatoid arthritis (RA). This review was registered on PROSPERO and followed PRISMA guidelines. Electronic databases were searched for studies reporting on the prevalence of sarcopenia in adults with RA using any muscle index (muscle mass, strength and/or physical performance) and cutpoints as recommended by established criteria (EWGSOP1/2, AWGS, FNIH, SDOC). The secondary objective was to investigate the relationship between RA, antirheumatic drugs, and sarcopenia. Among 2240 middle-aged and older adults with RA (...
Source: Calcified Tissue International - June 16, 2021 Category: Orthopaedics Source Type: research

Deletion of Coagulation Factor IX Compromises Bone Mass and Strength: Murine Model of Hemophilia B (Christmas Disease)
AbstractOsteopenia and osteoporosis have increasingly become a recognized morbidity in those persons with hemophilia (PwH) receiving inadequate prophylactic clotting factor replacement. Animal models can control or eliminate genetic and environmental factors and allow for invasive testing not clinically permissible. Here, we describe the skeletal phenotype of juvenile and adult male mice with a genetically engineered deficiency in coagulation factor IX (FIX KO). Although the somatic growth of FIX KO mice matched that of their wild-type (WT) littermates at 10 and 20  weeks of age, the FIX KO mice displayed reduced bone...
Source: Calcified Tissue International - June 12, 2021 Category: Orthopaedics Source Type: research

The Bone Cartilage Interface and Osteoarthritis
AbstractThis review describes results obtained with tissue from prior studies of equine and human osteoarthritis (OA). The main methods considered are scanning electron microscopy, novel methods in light microscopy and X-ray Micro-tomography. The same samples have been re-utilised in several ways. The tissues described are hyaline articular cartilage (HAC; or substitutes), with its deep layer, articular calcified cartilage (ACC), whose deep surface is resorbed in cutting cone events to allow the deposition of subchondral bone (SCB). Multiple tidemarks are normal. Turnover at the osteochondral (ACC-HAC-SCB) junction is down...
Source: Calcified Tissue International - June 4, 2021 Category: Orthopaedics Source Type: research

Fracture Incidence and the Relevance of Dietary and Lifestyle Factors Differ in the United Kingdom and Hong Kong: An International Comparison of Longitudinal Cohort Study Data
AbstractGeographic variation in fracture risk may be due to divergent profiles of  dietary, lifestyle, and other risk factors between populations. We investigated differences in fracture rates between two older-population cohorts: the European Prospective Investigation into Cancer and Nutrition (EPIC) Norfolk cohort (n = 7732) in the United Kingdom (UK), and the Mr and Ms Os cohort (n = 3956) in Hong Kong (HK). Data were collected by questionnaires, laboratory assessments, and hospital records. Incidence of hip, spine, and wrist fractures in the two cohorts was calculated and multivari...
Source: Calcified Tissue International - June 3, 2021 Category: Orthopaedics Source Type: research

Vertebral Fractures in Ireland: A Sub-analysis of the DXA HIP Project
In this study we examined the prevalence of VF and associated major risk factors, using a sample of subjects who underwent vertebral fracture assessment (VFA) performed on 2 dual-energy X-ray absorptiometry (DXA) machines. A total of 1296 subjects aged 40  years and older had a valid VFA report and DXA information available, including 254 men and 1042 women. Subjects had a mean age of 70 years, 805 (62%) had prior fractures, mean spine T-score was − 1.4 and mean total hip T-scores was − 1.2, while mean FRAX scores were 15.4% and 4.8% for majo r osteoporotic fracture and hip fracture, respect...
Source: Calcified Tissue International - June 3, 2021 Category: Orthopaedics Source Type: research

Bone Density After Teriparatide Discontinuation With or Without Antiresorptive Therapy in Pregnancy- and Lactation-Associated Osteoporosis
AbstractPregnancy- and lactation-associated osteoporosis (PLO) is a rare and severe disorder that causes low-trauma or spontaneous fractures, most commonly multiple vertebral fractures, in the late pregnancy or lactation period  [1]. In severe PLO, teriparatide (TPTD) might aid in bone mineral density (BMD) recovery and subsequent fracture risk reduction. However, it is unclear whether TPTD can be discontinued without sequential antiresorptive therapy (ART) in premenopausal women with PLO. In this retrospective cohort stu dy, we investigated the changes in BMD in premenopausal women with PLO treated with TPTD 20 mcg d...
Source: Calcified Tissue International - May 26, 2021 Category: Orthopaedics Source Type: research

Correction to: Utilization of Mechanical Stress to Treat Osteoporosis: The Effects of Electrical Stimulation, Radial Extracorporeal Shock Wave, and Ultrasound on Experimental Osteoporosis in Ovariectomized Rats
A correction to this paper has been published:https://doi.org/10.1007/s00223-021-00867-8 (Source: Calcified Tissue International)
Source: Calcified Tissue International - May 25, 2021 Category: Orthopaedics Source Type: research

Investigating the Microchannel Architectures Inside the Subchondral Bone in Relation to Estimated Hip Reaction Forces on the Human Femoral Head
AbstractThe interplay between articular cartilage (AC) and subchondral bone (SB) plays a pivotal role in cartilage homeostasis and functionality. As direct connective pathways between the two are poorly understood, we examined the location-dependent characteristics of the 3D microchannel network within the SB that connects the basal cartilage layer to the bone marrow (i.e. cartilage-bone marrow microchannel connectors; CMMC). 43 measuring points were defined on five human cadaveric femoral heads with no signs of osteoarthritis (OA) (age  ≤ 60), and cartilage-bone cylinders with diameters of 2.00 mm we...
Source: Calcified Tissue International - May 22, 2021 Category: Orthopaedics Source Type: research

The Predictability of Frailty Associated with Musculoskeletal Deficits: A Longitudinal Study
AbstractWe investigated and quantified the predictability of frailty associated with musculoskeletal parameters. This longitudinal study included 287 men aged  ≥ 50 yr at baseline (2001–2006) from the Geelong Osteoporosis Study. Baseline musculoskeletal measures included femoral neck bone mineral density (BMD), appendicular lean mass index (ALMI, kg/m2) and whole-body fat mass index (FMI, kg/m2) and lower-limb strength. Frailty at the 15 yr-follow-up (2016 –2019) was defined as ≥ 3 and non-frail as 
Source: Calcified Tissue International - May 20, 2021 Category: Orthopaedics Source Type: research

Quantitative Evaluation of Osteocyte Morphology and Bone Anisotropic Extracellular Matrix in Rat Femur
In this study, the association between ECM orientation and anisotropy in the osteocyte lacuno-canalicular system, which is thought to be optimized along with the mechanical stimuli, was investigated using male rat femur. The degree of ECM orientation along the femur longitudinal axis was significantly and positively correlated with the anisotropic features of the osteocyte lacunae and canaliculi. At the femur middiaphysis, there are the osteocytes with lacunae that highly aligned along the bone long axis (principal stress direction) and canaliculi that preferentially extended perpendicular to the bone long axis, and the hi...
Source: Calcified Tissue International - May 19, 2021 Category: Orthopaedics Source Type: research

Diurnal Salivary Cortisol in Sarcopenic Postmenopausal Women: The OsteoLaus Cohort
AbstractSarcopenia, similar to hypercortisolism, is characterized by loss of muscle mass and strength. Cortisol circadian rhythm changes with aging (blunted late-day nadir values) were suggested to contribute to this decline. We aimed to explore the relationship between diurnal salivary cortisol values and sarcopenia diagnosis and its components in postmenopausal women. This is a cross-sectional study within the OsteoLaus population-based cohort in Lausanne (Switzerland). Participants had a body composition assessment by dual X-ray absorptiometry (DXA), a grip strength (GS) measure, and salivary cortisol measures (at awake...
Source: Calcified Tissue International - May 18, 2021 Category: Orthopaedics Source Type: research

Diagnosis and Management of Osteoporosis During COVID-19: Systematic Review and Practical Guidance
AbstractIt is acknowledged that the COVID-19 pandemic has caused profound disruption to the delivery of healthcare services globally. This has affected the management of many long-term conditions including osteoporosis as resources are diverted to cover urgent care. Osteoporosis is a public health concern worldwide and treatment is required for the prevention of further bone loss, deterioration of skeletal micro-architecture, and fragility fractures. This review provides information on how the COVID-19 pandemic has impacted the diagnosis and management of osteoporosis. We also provide clinical recommendations on the adapta...
Source: Calcified Tissue International - May 18, 2021 Category: Orthopaedics Source Type: research

Clinical Phenotype and Bone Biopsy Characteristics in a Child with Proteus Syndrome
AbstractProteus syndrome is a rare genetic disorder, which is characterized by progressive, segmental, or patchy overgrowth of diverse tissues of all germ layers, including the skeleton. Here, we present a 9-year-old girl with a somatic-activating mutation (c.49G  >  A; p.Glu17Lys) inAKT1 gene in a mosaic status typical for Proteus syndrome. She presented with hemihypertrophy of the right lower limb and a “moccasin” lesion among others. A transiliac bone biopsy was analyzed for bone histology/histomorphometry as well as bone mineralization density distribution (BMDD) and osteocyte lacunae secti...
Source: Calcified Tissue International - May 18, 2021 Category: Orthopaedics Source Type: research

Vasoactive Intestinal Peptide Promotes Fracture Healing in Sympathectomized Mice
AbstractVasoactive intestinal peptide (VIP) as a neuromodulator and neurotransmitter played a significant role in modulating bone homeostasis. Our previous study reported an essential role of VIP in in vitro BMSCs osteogenesis and in vivo bone defect repair. VIP was also revealed to have a promoting effect on embryonic skeletal element development. However, the role of VIP in fracture healing is not known yet. We hypothesized that the disorder of sympathetic nervous system impairs bone structure and fracture healing, whereas VIP may rescue the sympathetic inhibition effects and promote fracture healing. We employed a 6-hyd...
Source: Calcified Tissue International - May 17, 2021 Category: Orthopaedics Source Type: research

Psychometric Properties of the Chinese Version of the Sarcopenia and Quality of Life, a Quality of Life Questionnaire Specific for Sarcopenia
AbstractA quality of life questionnaire specific to sarcopenia (SarQoL ®) was successfully developed. There is a huge demand for translation and validation in Chinese. The aim of this study was to translate the SarQoL® into Chinese and investigate its psychometric properties. The translation and cross-cultural adaptation process recommended by the developers of the i nitial questionnaire was followed. A total of 159 participants were investigated. The translation process consists of five steps: (1) two bilinguals independently translate initial English to Chinese; (2) synthesize the two translations into one; (3) b...
Source: Calcified Tissue International - May 15, 2021 Category: Orthopaedics Source Type: research

Maintained Bone Density in Young Hypoestrogenized Women with a High BMI: Case Series
AbstractEstrogen deficiency and obesity are factors that affect bone mass in a manner that is independent and in opposing directions. Obesity favours higher bone mass and increased bone formation whereas estrogen deficiency leads to significant bone loss in leaner individuals. To report the impact of the competing effects of a hypoestrogenized state and obesity on long-term bone health, we present two cases of young chronically hypoestrogenized females whose bone parameters were assessed with high-resolution peripheral quantitative computed tomography (HR-pQCT) and revealed a bone mineral density and microstructure that di...
Source: Calcified Tissue International - May 12, 2021 Category: Orthopaedics Source Type: research

Bone Mediated and Moderated the Associations Between Sarcopenic Obesity Indices and Cardiovascular Disease Risk Scores
AbstractTo evaluate mediation and moderation of bone on the association of sarcopenic obesity (SO) indices using the metabolic load-capacity model with the 10-year cardiovascular disease risk scores (CVDR). In 2905 men and 3622 women (age  ≥ 30 years), dual-energy X-ray absorptiometry was used to measure bone indicators [total bone mineral content percentage(TBM%), bone mineral density of femur neck (BMD_FN) and lumbar spines(BMD_LS)], total muscle (TMM) and fat mass (TFM), appendicular skeletal muscle mass (ASM), and truncal fat mass (TrFM). Two SO indices were TMM/TFM and ASM/TrFM. The Framingham mo...
Source: Calcified Tissue International - May 11, 2021 Category: Orthopaedics Source Type: research

Prevalence of Sarcopenia and Relationships Between Muscle and Bone in Indian Men and Women
Abstract Both ethnicity and age are important determinants of musculoskeletal health. We aimed to determine the prevalence of sarcopenia, assess the suitability of current diagnostic guidelines, and explore muscle-bone relationships in adults from India. A total of 1009 young (20 –35 years) and 1755 older (>  40 years) men and women from existing studies were collated and pooled for the analysis. Dual-energy x-ray absorptiometry measured areal bone mineral density (aBMD) at the hip and spine, and fat and lean mass; hand dynamometer measured hand grip strength (HGS). Indian-specific cut-points fo...
Source: Calcified Tissue International - May 9, 2021 Category: Orthopaedics Source Type: research

Specific MicroRNAs Found in Extracellular Matrix Vesicles Regulate Proliferation and Differentiation in Growth Plate Chondrocytes
This study demonstrates the strong regulatory capability possessed by unique MV enriched microRNAs on growth plate chondrocytes and their potential for use as therapeutic agents. (Source: Calcified Tissue International)
Source: Calcified Tissue International - May 5, 2021 Category: Orthopaedics Source Type: research

Musculoskeletal Benefits from a Physical Activity Program in Primary School are Retained 4 Years after the Program is Terminated
This study evaluates whether the benefits remain 4  years after the intervention. We followed 45 boys and 36 girls who had had 40 min PA/school day during the nine compulsory school years and 21 boys and 22 girls who had had 60 min PA/school week (reference), with measurements at baseline and 4 years after the program terminated. Bone mineral co ntent (BMC; g) and bone mineral density (BMD; g/cm2) were measured by dual-energy X-ray absorptiometry and knee flexion peak torque relative to total body weight (PTflexTBW) at a speed of 180 degrees/second with a computerized dynamometer. Group differences are ...
Source: Calcified Tissue International - April 29, 2021 Category: Orthopaedics Source Type: research

The Role of Bone Biopsy in the Management of CKD-MBD: CKD-Related Osteoporosis or CKD-MBD/Osteoporosis?
(Source: Calcified Tissue International)
Source: Calcified Tissue International - April 29, 2021 Category: Orthopaedics Source Type: research

The Role of Bone Biopsy in the Management of CKD-MBD and Osteoporosis
(Source: Calcified Tissue International)
Source: Calcified Tissue International - April 28, 2021 Category: Orthopaedics Source Type: research

Associations Between Surrogates of Skeletal Muscle Mass and History of Bone Fracture in Patients with Chronic Kidney Disease: The Fukuoka Kidney disease Registry (FKR) Study
AbstractPatients with chronic kidney disease (CKD) are at increased risks of both sarcopenia and fragility fractures. However, information on the association between skeletal muscle mass (SMM) and the risk of bone fractures in patients with CKD is lacking. We performed a cross-sectional analysis of 4146 patients with CKD using the baseline dataset of the Fukuoka Kidney disease Registry Study, as a multicenter, prospective cohort study of pre-dialysis CKD patients. The main measure was estimated SMM (eSMM) calculated using an equation validated by bioelectrical impedance analysis with two independent datasets of 100 and 81 ...
Source: Calcified Tissue International - April 27, 2021 Category: Orthopaedics Source Type: research

Vitamin D Supplementation for Patients with Chronic Kidney Disease: A Systematic Review and Meta-analyses of Trials Investigating the Response to Supplementation and an Overview of Guidelines
AbstractA large proportion of patients with chronic kidney disease (CKD) are vitamin D deficient (plasma 25-hydroxyvitamin D (25(OH)D)  
Source: Calcified Tissue International - April 25, 2021 Category: Orthopaedics Source Type: research

Molecular Cloning of Mouse Homologue of Enamel Protein C4orf26 and Its Phosphorylation by FAM20C
AbstractIt is widely accepted that cellular processes are controlled by protein phosphorylation and has become increasingly clear that protein degradation, localization and conformation as well as protein –protein interaction are the examples of subsequent cellular events modulated by protein phosphorylation. Enamel matrix proteins belong to members of the secretory calcium binding phosphoprotein (SCPP) family clustered on chromosome 4q21, and most of the SCPP phosphoproteins have at least one S-X- E motifs (S; serine, X; any amino acid, E; glutamic acid). It has been reported that mutations inC4orf26 gene, located o...
Source: Calcified Tissue International - April 22, 2021 Category: Orthopaedics Source Type: research

Long-Term Efficacy of Intensive Zoledronate Therapy and Predictors of Retreatment in Paget ’s Disease of Bone
AbstractDespite the current debate on the best therapeutic approach, i.e. symptomatic vs intensive strategy, one zoledronate (Zol) infusion is effective in most patients with Paget ’s disease of bone (PDB), whereas few need retreatment, whose predictors are not well established. We aimed to evaluate long-term efficacy of intensive Zol therapy and predictors of retreatment in PDB. Pagetic complications, clinical and biochemical response to Zol together with frequency of retre atment were retrospectively assessed in forty-seven PDB patients (age, mean ± SD: 72.5 ± 8.9 year...
Source: Calcified Tissue International - April 19, 2021 Category: Orthopaedics Source Type: research

Correction to: Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation
A correction to this paper has been published: https://doi.org/10.1007/s00223-021-00849-w (Source: Calcified Tissue International)
Source: Calcified Tissue International - April 19, 2021 Category: Orthopaedics Source Type: research

Correction to: Rare Inherited forms of Paget ’s Disease and Related Syndromes
The original version of this article unfortunately contained a mistake in Funding section. The correct Funding section is given below. (Source: Calcified Tissue International)
Source: Calcified Tissue International - April 19, 2021 Category: Orthopaedics Source Type: research

Correction to: A Multicenter Study to Evaluate Harmonization of Assays for C-Terminal Telopeptides of Type I Collagen ( ß-CTX): A Report from the IFCC-IOF Committee for Bone Metabolism (C-BM)
A correction to this paper has been published: https://doi.org/10.1007/s00223-021-00839-y (Source: Calcified Tissue International)
Source: Calcified Tissue International - April 17, 2021 Category: Orthopaedics Source Type: research

A Retrospective Analysis of Longitudinal Changes in Bone Mineral Density in Women with Systemic Lupus Erythematosus
AbstractMost prospective studies of bone mineral density (BMD) in systemic lupus erythematosus (SLE) patients have been of relatively short duration, with a maximum of 6  years. To describe long-term changes in BMD in women with SLE and identify risk factors associated with BMD loss. We retrospectively evaluated 132 adult Mexican-Mestizo women with SLE who underwent dual X-ray absorptiometry (DXA). Demographic and clinical data were collected and BMD at the lumbar spine (L1–L4) and total hip were collected at baseline and during the follow up. At baseline, the mean age of participants was 43.4 ±&th...
Source: Calcified Tissue International - April 17, 2021 Category: Orthopaedics Source Type: research

Quantitative Backscattered Electron Imaging of Bone Using a Thermionic or a Field Emission Electron Source
AbstractQuantitative backscattered electron imaging is an established method to map mineral content distributions in bone and to determine the bone mineralization density distribution (BMDD). The method we applied was initially validated for a scanning electron microscope (SEM) equipped with a tungsten hairpin cathode (thermionic electron emission) under strongly defined settings of SEM parameters. For several reasons, it would be interesting to migrate the technique to a SEM with a field emission electron source (FE-SEM), which, however, would require to work with different SEM parameter settings as have been validated fo...
Source: Calcified Tissue International - April 10, 2021 Category: Orthopaedics Source Type: research

Characterization of Oral Health Status in Chilean Patients with X-Linked Hypophosphatemia
AbstractX-Linked Hypophosphatemia (XLH) is the most common cause of inherited hypophosphatemic rickets. Dental involvement, including spontaneous abscesses and/or fistulae, is an important part of the disease and has not been completely defined, especially in cohorts from developing countries. To describe oral health status in a cohort of Chilean patients with XLH and explore its correlation with biochemical presentation and treatment, we conducted a cross-sectional observational study of patients withPHEX mutation-confirmed XLH. All patients had an oral clinical exam, radiographic evaluation; clinical and biochemical data...
Source: Calcified Tissue International - April 10, 2021 Category: Orthopaedics Source Type: research

Fall Patterns Predict Mortality After Hip Fracture in Older Adults, Independent of Age, Sex, and Comorbidities
AbstractFalls are the most frequent cause of hip fracture. We aimed to investigate whether specific fall patterns have predictive value for mortality after hip fracture. In this cohort study, data of individuals presented to the Severance Hospital, Seoul, Korea, between 2005 and 2019 due to fragility hip fracture (n = 1986) were analyzed. Fall patterns were defined as causes, activities leading to falls, and a combination of both, based on electronic medical records using pre-specified classification from a prior study on video-captured falls. Mean age of study subjects were 77 years (71% women) and 211 patients (10.6%) di...
Source: Calcified Tissue International - April 8, 2021 Category: Orthopaedics Source Type: research

Risk of Fractures and Other Injuries in Children Treated with Antiseizure Medications for Epilepsy
This study aimed to investigate the prevalence of fractures and non-fracture injuries, including associated risk factors, in children with epilepsy prescribed antiseizure medications (ASM). A controlled, cross-sectional study was conducted in a hospital outpatient setting, comparing children with epilepsy prescribed ASMs with their non-epileptic siblings. Information was collected by questionnaire included history of fractures, non-fracture injuries and epilepsy, comorbidities and ASM use. 261 participants completed the questionnaire, 133 children with epilepsy (aged 10.7  ± 3.5 years, mean&thinsp...
Source: Calcified Tissue International - April 7, 2021 Category: Orthopaedics Source Type: research