Effect of acetogenin fraction of Annona muricata leaves on antioxidant status and some indices of benign prostatic hyperplasia in rats.
Conclusion: Oral administration of acetogenin-rich fraction of Annona muricata leaves ameliorated TP-induced BPH in rats and significantly enhanced the antioxidant capacity of the rats.
PMID: 32878595 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - September 4, 2020 Category: Biochemistry Authors: Ogbu PN, Ugota EO, Onwuka RU, Ogbu IM, Aloke C Tags: Redox Rep Source Type: research
Foliar application of green nanoparticles in Annona muricata L. plants and their effects in physiological and biochemical parameters
Publication date: Available online 15 August 2020Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Fermin Jonapá-Hernández, Federico Gutiérrez-Miceli, Ana Santos-Espinosa, Nancy Ruíz-Lau, Victor Ruíz-Valdiviezo, Benjamín Valdez-Salas, Daniel González-Mendoza (Source: Biocatalysis and Agricultural Biotechnology)
Source: Biocatalysis and Agricultural Biotechnology - August 15, 2020 Category: Biotechnology Source Type: research
RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata.
Abstract
Up-regulation of MMP-2 and MMP-9 plays a significant role in promoting cancer progression by degrading the components of the extracellular matrix, thereby enhancing the migration of tumor cells. Although the antiproliferative and apoptotic effect of Annona muricata is well established, its effect on MMP-2 and MMP-9, a major target in several types of cancers, has not been studied. Powdered samples of various parts of A. muricata like fruit, stem, seed, and twig extracted using aqueous methanol showed significant dose-dependent inhibition of MMP-2 and MMP-9 in a highly metastatic fibrosarcoma cell ...
Source: Journal of Biosciences - July 15, 2020 Category: Biomedical Science Authors: Drishya G, Nambiar J, Shaji SK, Vanuopadath M, Achuthan A, Kumar A, Alias A, Sherif A, Joseph C, Divya P, Kumar DS, Bose C, Nair SV, Sudarslal S, Kumar GB, Lakshmi S, Nair BG Tags: J Biosci Source Type: research
Reduced cutaneous inflammation associated with antioxidant action after topical application of the aqueous extract of Annona muricata leaves
This study investigated the effect of the aqueous extract ofA. muricata leaves (AEAM) on TPA-induced ear inflammation and antioxidant capacity, both in vitro and in vivo. The in vitro antioxidant capacity of AEAM was measured by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing/antioxidant power (FRAP) and lipoperoxidation assays. Cytotoxicity and reactive oxygen species (ROS) release were evaluated in the L929 fibroblasts. Swiss mice were submitted to TPA application and were topically treated with AEAM (0.3, 1 or 3 mg/ear). After 6 h, inflammatory and oxidative parameters were evaluated. Quercetin 3-glucoside,...
Source: Inflammopharmacology - July 8, 2020 Category: Drugs & Pharmacology Source Type: research
Graviola leaves extract enhances the anticancer effect of cisplatin on various cancer cell lines
ConclusionThese results demonstrate that Graviola leaves extract optimizes the antitumor potential of cisplatin and could be utilized as a natural adjuvant to decrease cisplatin side effects. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 28, 2020 Category: Cytology Source Type: research
Molecules, Vol. 25, Pages 2612: Chemical Profile and Biological Activity of Cherimoya (Annona cherimola Mill.) and Atemoya (Annona atemoya) Leaves
rita Bertea
Annona cherimola (Cherimoya) and Annona atemoya (Atemoya) are tropical plants known for their edible fruit. Scientific data suggest that their leaves, used in traditional medicine in the form of teas or infusions without evidence of toxicity, contain several bioactive compounds. However, only Annona muricata among all the Annona species is currently used in the nutraceutical field, and its dried leaves are marketed for tea preparation. In this work, we explored the nutraceutical potential of Atemoya and Cherimoya leaves, by evaluating their chemical profile and functional properties. Phytochemical analyses ...
Source: Molecules - June 3, 2020 Category: Chemistry Authors: Giuseppe Mannino Carla Gentile Alessandra Porcu Chiara Agliassa Fabio Caradonna Cinzia Margherita Bertea Tags: Article Source Type: research
Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies.
Authors: Omara T, Kiprop AK, Ramkat RC, Cherutoi J, Kagoya S, Moraa Nyangena D, Azeze Tebo T, Nteziyaremye P, Nyambura Karanja L, Jepchirchir A, Maiyo A, Jematia Kiptui B, Mbabazi I, Kiwanuka Nakiguli C, Nakabuye BV, Chepkemoi Koske M
Abstract
The burden of neoplastic diseases is a significant global health challenge accounting for thousands of deaths. In Uganda, about 32,617 cancer cases were reported in 2018, accompanied by 21,829 deaths. In a view to identify some potential anticancer plant candidates for possible drug development, the current study was designed to compile the inventory of plants with r...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
[ASAP] Cyclic Peptides in Seed of < italic toggle="yes" > Annona muricata < /italic > Are Ribosomally Synthesized
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b01209 (Source: Journal of Natural Products)
Source: Journal of Natural Products - April 2, 2020 Category: Biochemistry Authors: Mark F. Fisher †, Jingjing Zhang†, Oliver Berkowitz‡, James Whelan‡, and Joshua S. Mylne*† Source Type: research
Evaluation of the toxic effects of the bottled medicine (garrafada) containing the Echinacea purpurea, Annona muricata, Tabebuia avellanedae, Pterodon emarginatus and Uncaria tomentosa in rats
This study evaluated if the oral administration of a bottled medicine containing Echinacea, Graviola, Purple Ipe, Sucupira and Cats claw could cause changes in biochemical, coagulation, hematological and histopathological parameters in rats. This study arised after a report to Ceatox of a patient who used a bottled medicine and developed hematological, renal and histopathological changes. Th... (Source: Journal of Medicinal Plants Research)
Source: Journal of Medicinal Plants Research - March 25, 2020 Category: Complementary Medicine Source Type: research
Annona Genus: Traditional Uses, Phytochemistry and Biological Activities.
Abstract
Species from the Annona (Anonaceae) genus are used in traditional medicine for the treatment of various diseases. Ethnobotanical studies provide information regarding the plant part and the preparation method being used, while scientific studies such as in vitro, in vivo, and clinical tests can provide evidence supporting ethnopharmacological reports, directing studies towards the isolation of compounds which may be active for specific pathologies. Annona muricata and Annona squamosa were the most commonly reported species from those studied, with Annona cherimola and Annona classiflora also stand...
Source: Current Pharmaceutical Design - March 23, 2020 Category: Drugs & Pharmacology Authors: da Costa JGM, Leite DOD, de Fátima Alves Nonato C, Janaíne C, de Carvalho NKG, da Nóbrega MGLA, Pereira RC Tags: Curr Pharm Des Source Type: research
Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies
ConclusionThis study suggests the possible anti-obesity mechanism ofA. muricata is via down-regulation of FTO with concomitant up-regulation of STAT-3 genes. This study confirmed the use of this plant in the management of obesity and the probable compounds responsible for its antiobesity effect are annonaine and annonioside. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - March 11, 2020 Category: Endocrinology Source Type: research
Molecules, Vol. 25, Pages 1139: Ultrasound-Assisted Extraction of Total Acetogenins from the Soursop Fruit by Response Surface Methodology
nzález
The soursop fruit or Annona muricata (A. muricata) fruit is recognized by its bioactive compounds and acetogenins (ACG) are among the most important. The effect of ACGs, with greater importance in health, is that they present anti-tumor activity; however, the methods of extraction of ACGs are very slow and with a high expenditure of solvents. To our knowledge, there is no report of an optimal method for the extraction of acetogenins from the Annonaceae family by ultrasound-assisted extraction (UAE); therefore, the aim was to find the best UEA conditions of acetogenins from A. muricata fruit (peel, pulp, seed, a...
Source: Molecules - March 2, 2020 Category: Chemistry Authors: Aguilar-Hern ández Vivar-Vera Garc ía-Magaña Gonz ález-Silva P érez-Larios Montalvo-Gonz ález Tags: Article Source Type: research
Neuroprotective effect of Annona muricata-derived polysaccharides in neuronal HT22 cell damage induced by hydrogen peroxide.
Abstract
Crude extracts and phytochemical compounds derived from Annona muricata leaves have been demonstrated to exert neuroprotective effects. However, the neuroprotective effects of Annona muricata leaves-derived polysaccharide extracts (ALPs) have not been investigated. ALP treatment was shown to induce concentration-dependent antioxidant activity in HT22 cells, and to increase cell viability in H2O2-treated HT22 cells. These effects were correlated with a decrease in major components of oxidation, including: Ca2+, ROS, and malondialdehyde (MDA). Mediators of the intracellular response to oxidation, in...
Source: Bioscience, Biotechnology, and Biochemistry - January 20, 2020 Category: Biochemistry Authors: Kim WS, Kim YE, Cho EJ, Byun EB, Park WY, Song HY, Kim K, Park SH, Byun EH Tags: Biosci Biotechnol Biochem Source Type: research
Polysaccharides from Annona muricata leaves protect normal human epidermal keratinocytes and mice skin from radiation-induced injuries
This study was conducted to investigate the protective effects of Annona muricata leaf polysaccharide (ALP) on radiation-induced skin injuries by using in vitro and in vivo models. In normal human epidermal keratinocytes (NHEKs), ALP treatments reduced irradiation-induced apoptosis by increasing antioxidant enzymes activities, including superoxide dismutase (SOD) and catalase. Furthermore, ALP treatments decreased levels of interleukin-1β, nucleotide-binding domain and leucine-rich-repeat-containing family pyrin 3 (NLRP3), and cleavage of caspase-1 and caspase-3. Most importantly, the topical application of the ALP cream ...
Source: Radiation Physics and Chemistry - January 9, 2020 Category: Physics Source Type: research
Phenolic Compounds and Metals in Some Edible Annonaceae Fruits.
Abstract
The concentrations of 3,4-dihydroxybenzoic acid, caffeic acid, catechin, chlorogenic acid, epicatechin, gallic acid, p-coumaric acid, quercetin, rutin, ferulic acid, and the major metals in graviola (Annona muricata), atemoya (A. squamosa x A. cherimola), fruta do conde (A. squamosa), biribá (Rollinia mucosa), and the North American pawpaw (Asimina triloba) were determined by UPLC-ESI (-)-MS/MS. It enabled the identification and quantification of phenolic compounds. Catechin was only found in atemoya, at a concentration of 38.6 μg/g-dw. Only 3,4-dihydroxybenzoic acid was found in the fruit pulp...
Source: Biological Trace Element Research - January 6, 2020 Category: Biology Authors: de Moraes MR, Ryan SM, Godoy HT, Thomas AL, Maia JGS, Richards KM, Tran K, Smith RE Tags: Biol Trace Elem Res Source Type: research
