Hexane fraction of Annona muricata (Sour sop) seed ameliorates testosterone-induced benign prostatic hyperplasia in rats
ConclusionHFAM may serve as novel therapeutic agent against BPh.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 27, 2018 Category: Drugs & Pharmacology Source Type: research
Hexane fraction of Annona muricata (Sour sop) seed ameliorates testosterone-induced benign prostatic hyperplasia in rats.
CONCLUSION: HFAM may serve as novel therapeutic agent against BPh.
PMID: 30594779 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 27, 2018 Category: Drugs & Pharmacology Authors: Adaramoye OA, Oladipo TD, Akanni OO, Abiola OJ Tags: Biomed Pharmacother Source Type: research
Effect of Morinda citrifolia and Annona muricata on Erhlich Tumor Cells in Swiss Albino Mice and In Vitro Fibroblast Cells
Journal of Medicinal Food, Ahead of Print. (Source: Journal of Medicinal Food)
Source: Journal of Medicinal Food - November 9, 2018 Category: Nutrition Authors: Cleber da Silveira Torres Francisnaira da Silva Santos Elen Landgraf Guiguer Adriano Cressoni de Ara újo Sandra Maria Barbalho Patr ícia Cincotto dos Santos Bueno Maricelma Silva Soares de Souza Danilo Antonini Alves Marcelo Lancellott Haydee Maria More Source Type: research
Physicochemical and Microbiological Quality of Dietetic Functional Mixed Cerrado Fruit Jam during Storage.
The objective of the research was to evaluate changes of dietetic functional mixed cerrado fruit jam (marolo, sweet passion fruit, and soursop) processed in a vacuum pot and stored for 180 days in BODs at 25°C and 35°C. The parameters evaluated were pH, soluble solids (SS), titratable acidity (TA), total sugars (TS), total carotenoids (TC), total phenolics (TP), vitamin C, antioxidant activity (DPPH), and microbiological analysis. There was a significant effect of storage time on pH, SS, TA, TC, TS, and TP. Vitamin C and DPPH showed an effect for the temperature x storage time interaction. Statistical models are not adju...
Source: The Scientific World Journal - September 20, 2018 Category: Science Tags: ScientificWorldJournal Source Type: research
Effect of spray drying on bioactive and volatile compounds in soursop (Annona muricata) fruit pulp
Publication date: Available online 17 September 2018Source: Food Research InternationalAuthor(s): Maria Terezinha Santos Leite Neta, Mônica Silva de Jesus, John Lennon Alves da Silva, Hannah Caroline Santos Araujo, Rafael Donizete Dutra Sandes, Saravanan Shanmugam, Narendra NarainAbstractSoursop is seasonal and highly perishable fruit, which limits its commercialization. Thus it is necessary to conserve its pulp so that it is available throughout the year. One of the most common forms of fruit preservation is by dehydration. This work had an objective to dehydrate soursop pulp by spray drying at optimum conditions and to ...
Source: Food Research International - September 18, 2018 Category: Food Science Source Type: research
[Self medication with Annona muricata L. (corossol) as an anti-cancer agent in Reunion].
CONCLUSIONS: A quarter of patients treated by chemotherapy for a lung cancer in Reunion consume graviola regularly as self medication. The consequences of this intake, drug interactions and side effects are unknown and would be interesting to identify.
PMID: 30195454 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 11, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Bioaccessibility of phenolic compounds in native and exotic frozen pulps explored in Brazil using a digestion model coupled with a simulated intestinal barrier
Publication date: 15 February 2019Source: Food Chemistry, Volume 274Author(s): Aline Macedo Dantas, Isis Meireles Mafaldo, Priscila Mayara de Lima Oliveira, Marcos dos Santos Lima, Marciane Magnani, Graciele da Silva Campelo BorgesAbstractThe bioaccessibility of phenolics and antioxidant activity were determined in açaí, cupuaçu, blackberry, blueberry, jabuticaba, raspberry, cajá and soursop frozen pulps (FPs) using a digestion model coupled with a simulated intestinal barrier. Cyanidin 3-glucoside (6.56%) and pelargonidin 3-glucoside (28.33%) were bioaccessible in blueberry and raspberry. Catechin had the highest bioa...
Source: Food Chemistry - September 4, 2018 Category: Food Science Source Type: research
Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells.
This study aimed to investigate the effects of crude graviola extract in vitro on breast cancer cells; in particular, we aimed to identify an agent against triple negative breast cancer (TNBC). We used the TNBC MDA-MB-231 cell line as the experimental model and the ER(+) non-TNBC MCF-7 breast cancer cell line as the control. We identified annonaceous acetogenins, including annonacin isomers, characteristic to this plant by using liquid chromatography tandem mass spectrometry (LC/MS/MS). We observed a significant decrease in the cell viability in both cell lines within 48 h, whereas impaired cell motility and invasiveness w...
Source: Evidence-based Complementary and Alternative Medicine - August 16, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Phytochemical analysis and central effects of Annona muricata Linnaeus: possible involvement of ...
This study correlates the neurochemical profile with the behavioral effects of the hydroalcoholic extract from the leaves of Annona muricata (HLEAM) in mice, proposing to elucidate their mechanism of action on the central nervous system. Flavonoids and phenolic compounds were identified and quantified by High Performance Liquid Chromatography (HPLC) method. The acute toxicity (median lethal dose - LD50) was determined by probitos method using the percentage of mortality based on the Hippocratic screen. HLEAM (25, 50 and 100 mg/kg) was tested, intraperitoneally (i.p.), in models of sedation, anxiety, motor coordination and ...
Source: Iranian Journal of Pharmaceutical Research - July 31, 2018 Category: Drugs & Pharmacology Source Type: research
Adsorption of methylene blue on agroindustrial wastes: Experimental investigation and phenomenological modelling
Publication date: Available online 25 July 2018Source: Progress in Biophysics and Molecular BiologyAuthor(s): L. Meili, P.V.S. Lins, M.T. Costa, R.L. Almeida, A.K.S. Abud, J.I. Soletti, G.L. Dotto, E.H. Tanabe, L. Sellaoui, S.H.V. Carvalho, A. ErtoAbstractIn this work, agro-wastes coming from soursop (peel, seeds and pulp fiber) and sugarcane (bagasse) are used as low-cost biosorbents to remove methylene blue (MB) from aqueous media. Batch experiments are performed under different experimental conditions investigating the effects of biosorbent amount, dye concentration and stirring rate. The best results were found using s...
Source: Progress in Biophysics and Molecular Biology - July 26, 2018 Category: Molecular Biology Source Type: research
Phytochemical analysis and central effects of Annona muricata Linnaeus: possible involvement of ...
This study correlates the neurochemical profile with the behavioral effects of the hydroalcoholic extract from the leaves of Annona muricata (HLEAM) in mice, proposing to elucidate their mechanism of action on the central nervous system. Flavonoids and phenolic compounds were identified and quantified by High Performance Liquid Chromatography (HPLC) method. The acute toxicity (median lethal dose - LD50) was determined by probitos method using the percentage of mortality based on the Hippocratic screen. HLEAM (25, 50 and 100 mg/kg) was tested, intraperitoneally (i.p.), in models of sedation, anxiety, motor coordination and ...
Source: Iranian Journal of Pharmaceutical Research - July 21, 2018 Category: Drugs & Pharmacology Source Type: research
Effects of Soursop flowers (Annona muricata L.) extract on chemical changes of refined palm olein stored at frying temperature
In this study, the antioxidant activity of soursop flowers extract in delaying palm olein oxidation at frying temperature was assessed. The oil was supplemented with the extract at concentrations 200–1800 ppm, and stored in the oven at 180 °C for 6 days (4 h heating per day). Palm olein containing butylated hydroxytoluene (BHT) served as positive control while the same oil without antioxidant (Control) served as negative one, in order to monitor changes in oils. After each two heating days, oil samples were collected, and their chemical indexes were determined. Peroxide, para-anisidine, TOTOX, thioba...
Source: Food Science and Human Wellness - July 11, 2018 Category: Food Science Source Type: research
Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice
Publication date: May 2018Source: Saudi Journal of Biological Sciences, Volume 25, Issue 4Author(s): Elizângela Beneval Bento, Francisco Elizaudo de Brito Júnior, Dayanne Rakelly de Oliveira, Cícera Norma Fernandes, Gyllyandeson de Araújo Delmondes, Francisco Rafael Alves Santana Cesário, Cristina Kelly de Sousa Rodrigues, Valterlúcio dos Santos Sales, Francisco Rodolpho Sobreira Dantas Nóbrega de Figueiredo, Izabel Cristina Santiago Lemos, Álefe Brito Monteiro, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Marta Regina KerntopfAbstractAnnona muricata Linnaeus, popularly known as “graviola” an...
Source: Saudi Journal of Biological Sciences - July 11, 2018 Category: Biology Source Type: research
Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity
Publication date: July 2018Source: Arabian Journal of Chemistry, Volume 11, Issue 5Author(s): Ana V. Coria-Téllez, Efigenia Montalvo-Gónzalez, Elhadi M. Yahia, Eva N. Obledo-VázquezAbstractAnnona muricata L. (Magnoliales: Annonaceae) is a tropical plant species known for its edible fruit which has some medicinal merits, but also some toxicological effects. This review focuses on the phytochemicals contents, bioactivity, biological actions and toxicological aspects of extracts and isolated compounds, as well as medicinal uses of A. muricata, with the objective of stimulating further studies on extracts and fruit pulp use...
Source: Arabian Journal of Chemistry - July 11, 2018 Category: Chemistry Source Type: research
Diets supplemented with Annona muricata improve the symptoms of fibromyalgia
In this study, the effect of the consumption of Annona muricata L. (Annonaceae) leaves (AM) was investigated on a model for intermittent cold stress (ICS)-induced fibromyalgia in mice. An aqueous extract of AM was investigated in experiments involving 60 five-week-old female mice C57BL/6J.The animals were allocated into six groups (n = 10). Groups (I) Healthy control, (II) ICS control, and (III) ICS + acetaminophen (0.5%), were all fed a standard diet, while groups (IV) and (V) received standard diets supplemented with 15% (AM15) and 30% (AM30) aqueous extract of AM leaves, respectively. Group (VI) received a stand...
Source: PharmaNutrition - July 10, 2018 Category: Nutrition Source Type: research
