Graviola mitigates acetic acid-induced ulcerative colitis in rats: insight on apoptosis and Wnt/Hh signaling crosstalk.
In this study, we elucidated the potential protective effects of graviola leaves, compared with sulfasalazine, against acetic acid (AA)-induced ulcerative colitis (UC) in rats. Twenty-eight mature male rats were divided into four groups, Sham, Colitis, Colitis/Sulfa, and Colitis/Graviola, and were treated orally with either saline, saline, sulfasalazine (100 mg/kg/day), or graviola (100 mg/kg/day), respectively, for 7 days. On the 4th day, UC was induced by transrectal administration of 4% AA. Colon tissues were excised for macroscopic and histopathological evaluation and immunohistochemical analysis of caspase-3, B-cell l...
Source: Environmental Science and Pollution Research International - February 9, 2021 Category: Environmental Health Authors: Helal MG, Abd Elhameed AG Tags: Environ Sci Pollut Res Int Source Type: research
Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products.
Conclusion: The aqueous leaf extracts of Annona muricata, Persea americana, and their combination products possess antihypertensive properties, with combination products showing synergism and safety with use.
PMID: 33488751 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 26, 2021 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Postharvest disease management of Alternaria spots on tomato fruit by Annona muricata fruit extracts
Publication date: Available online 23 January 2021Source: Saudi Journal of Biological SciencesAuthor(s): Humaira Rizwana, Najat A. Bokahri, Sarah A. Alsahli, Amal S. Al Showiman, Rawan M. Alzahrani, Horiah A. Aldehish (Source: Saudi Journal of Biological Sciences)
Source: Saudi Journal of Biological Sciences - January 24, 2021 Category: Biology Source Type: research
Evaluation of Metabolomics Behavior of Human Colon Cancer HT29 Cell Lines Treated with Ionic Liquid Graviola Fruit Pulp Extract
Publication date: Available online 12 January 2021Source: Journal of EthnopharmacologyAuthor(s): Djabir Daddiouaissa, Azura Amid, Muhamad Shirwan Abdullah Sani, Ahmed A.M. Elnour (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 12, 2021 Category: Drugs & Pharmacology Source Type: research
Antitumour activity of Annona muricata L. leaf methanol extracts against Ehrlich Ascites Carcinoma and Dalton's Lymphoma Ascites mediated tumours in Swiss albino mice.
This study thus indicates that LEAM possesses potent cytotoxic and antineoplastic activity and calls for more methodical safety assessments and other end-points of anti-tumourigenesis. Abbreviations: LEAM: Leaf methanol extract of Annona muricata; DLA: Dalton's Lymphoma Ascites; EAC: Ehrlich Ascites Carcinoma; IC50 : Half maximal inhibitory concentration; CPCSEA: Committee for the Purpose of Control Supervision of Experiments on Animal; IAEC: Institutional Animal Ethics Committee; ARRIVE: Animal Research: Reporting In-vivo Experiments; DMSO: Dimethyl sulphoxide; LD50 : Lethal Dose, 50%; SD: Standard Deviation; Hb: Haemoglo...
Source: Libyan Journal of Medicine - January 2, 2021 Category: General Medicine Tags: Libyan J Med Source Type: research
Natural Products as Anticancer Agents.
Abstract
Medicinal plants and mushrooms have alwaysfascinated the world as an attractive source of natural compounds for cancer therapy. From ancient times, they have been valued as gourmet food and folk medicine in Oriental practice. For over 40 years, world has witnessed the overwhelming interest of western scientific fraternity in pharmaceutical potential of natural products in combating cancer. The plants and mushrooms credited with success against angiogenesis and cancer metastasis belong to certain Plants including Catharanthus roseus, Aloe Vera,Annona muricata,Curcuma longa, Withania somnifera, and ...
Source: Current Drug Targets - December 30, 2020 Category: Drugs & Pharmacology Authors: Varghese R, Dalvi YB Tags: Curr Drug Targets Source Type: research
Synthesis of biodiesel from Annona muricata – Calophyllum inophyllum oil blends using calcined waste wood ash as a heterogeneous base catalyst
Publication date: Available online 23 December 2020Source: MethodsXAuthor(s): T.F. Adepoju (Source: MethodsX)
Source: MethodsX - December 23, 2020 Category: Science Source Type: research
Phytochemical fractions from Annona muricata seeds and fruit pulp inhibited the growth of breast cancer cells through cell cycle arrest at G0/G1 phase
In this study, we have extracted phytochemicals that exhibited anti-cancer property from the (a) fruit pulp using methanol (AMPM) and water (AMPW); and (b) seeds using methanol (AMSM). Qualitative phytochemical analysis showed the presence of phenolics, tannins, alkaloids, flavonoids, sterols, terpenoids, carbohydrates and proteins in AMPM and AMPW. All three extracts were first checked for in vitro antioxidant and anti-inflammatory properties and then tested for efficacy against MCF-7 and MDA-MB-231.
Results: Among these three extracts, AMSM showed the highest antioxidant power as well as ~80% inhibition at 32...
Source: Journal of Cancer Research and Therapeutics - December 18, 2020 Category: Cancer & Oncology Authors: Shashanka K Prasad Prashanth M Veeresh Pushkal S Ramesh Suma M Natraj SubbaRao V Madhunapantula Devananda Devegowda Source Type: research
Prevalence of Complementary/Alternative Medicine use in Cancer Patients in a Tertiary Hospital in Puerto Rico.
CONCLUSION: Our data show that CAM use is significantly more common in those with higher education, younger age, and those living in non-metropolitan areas. Vitamin C and soursop (Graviola or guanábana) proved to be the two most common CAM treatments, respectively.
PMID: 33320457 [PubMed - in process] (Source: Puerto Rico Health Sciences Journal)
Source: Puerto Rico Health Sciences Journal - December 17, 2020 Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
Selective cytotoxic and anti-metastatic activity in DU-145 prostate cancer cells induced by Annona muricata L. bark extract and phytochemical, annonacin
Annona muricata L. was identified as a popular medicinal plant in treatment regimens among cancer patients in Jamaica by a previously conducted structured questionnaire. Ethnomedically used plant parts, were exam... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - December 10, 2020 Category: Complementary Medicine Authors: Kimberley Foster, Omolola Oyenihi, Sunelle Rademan, Joseph Erhabor, Motlalepula Matsabisa, James Barker, Moses K. Langat, Amy Kendal-Smith, Helen Asemota and Rupika Delgoda Tags: Research article Source Type: research
Influence of Storage Conditions on the Quality, Metabolites, and Biological Activity of Soursop (Annona muricata. L.) Kombucha
This study aimed to optimize the production of soursop kombucha and determine the effects of different storage conditions on the quality, metabolites, and biological activity. The response surface method (RSM) results demonstrated that the optimum production parameters were 300 ml soursop juice, 700 ml black tea, and 150 g sugar and 14 days fermentation at 28°C. The storage conditions showed significant (P < 0.05) effects on the antioxidant activity including the highest antioxidant activity for the sample stored for 14 days at 25°C in light and the highest total phenolic content (TPC) for the sample stored for 7 days...
Source: Frontiers in Microbiology - December 4, 2020 Category: Microbiology Source Type: research
Effects of Annona muricata Extract on Triple-Negative Breast Cancer Cells Mediated Through EGFR Signaling
(Source: Cancer Management and Research)
Source: Cancer Management and Research - December 3, 2020 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Functional beverage production using acetous fermentation of soursop: Physicochemical, toxicity and organoleptic properties
Publication date: Available online 30 November 2020Source: Food BioscienceAuthor(s): Chin Wai Ho, Lee Sin Chang, Syarifah Kauthar Syed Muzni, Shazrul Fazry, Azwan Lazim, Umi Kalsum Hj Hussain Zaki, Seng Joe Lim (Source: Food Bioscience)
Source: Food Bioscience - December 2, 2020 Category: Food Science Source Type: research
In vitro evaluation of Annona muricata L. (Soursop) leaf methanol extracts on inhibition of tumorigenicity and metastasis of breast cancer cells.
Conclusion: LMAM proved as a potent ethno-chemopreventive agent and a potential lead in cancer treatment attributable to the synergistic interactive properties of phytoconstituents.
PMID: 33048613 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - October 15, 2020 Category: Research Tags: Biomarkers Source Type: research
Purification, characterization of mosquito larvicidal lectin from Annona muricata and its eco-toxic effect on non-target organism
Publication date: Available online 26 September 2020Source: Process BiochemistryAuthor(s): Ezhumalai Parthiban, Charles Arokiyaraj, Sundaram Janarthanan, Ravichandran Ramanibai (Source: Process Biochemistry)
Source: Process Biochemistry - September 27, 2020 Category: Biochemistry Source Type: research
