Traditional Medicine and Its Role in the Management of Diabetes Mellitus: "Patients' and Herbalists' Perspectives".
Conclusion: Patients and herbalists provided a range of perspectives regarding the use of traditional medicines to treat diabetes. Further research is needed to identify bioactive compounds present in commonly used traditional medicines and their efficacy.
PMID: 31354852 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 30, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Alkaloids from the root of Indonesian Annona muricata L.
Abstract
Annona muricata L. has been used traditionally in Indonesia to treat disease. Phytochemical studies on the alkaloid fractions from the root of Annona muricata L. from Malang-Indonesia resulted in the isolation of an unreported benzylisoquinoline alkaloid (+)-xylopine 5 as well as four known alkaloids (1-4). The crude methanol extract and alkaloid fractions were tested against Plasmodium falciparum K1 and against bacteria (Escherichia coli, Klebsiella pneumonia, Acinetobacter buamanii, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus) with insignificant activities (MIC > 3...
Source: Natural Product Research - July 7, 2019 Category: Biochemistry Authors: Nugraha AS, Haritakun R, Lambert JM, Dillon CT, Keller PA Tags: Nat Prod Res Source Type: research
Administration of a Nutraceutical Mixture Composed by Aloe arborescens, Annona muricata, Morinda citrifolia, Beta rubra, Scutellaria baicalensis, and Vaccinium myrtillus Reduces Doxorubicin-Induced Side Effects
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - June 30, 2019 Category: Cancer & Oncology Authors: Natasha Irrera Giovanni Pallio Federica Mannino Rosario Gugliotta Daniela Metro Domenica Altavilla Francesco Squadrito Source Type: research
Administration of a Nutraceutical Mixture Composed by Aloe arborescens, Annona muricata, Morinda citrifolia, Beta rubra, Scutellaria baicalensis, and Vaccinium myrtillus Reduces Doxorubicin-Induced Side Effects.
Abstract
The antibiotic doxorubicin is often used as an anti-neoplastic drug; however, many patients showed very unpleasant side-effects. Previous studies have demonstrated that dietary substances such as Aloe arborescens, Annona muricata, Morinda citrifolia, Beta rubra, Scutellaria baicalensis, and Vaccinium myrtillus may have anti-oxidant, anti-proliferative, and anti-inflammatory effects. The purpose of this study was to investigate the protective effects of a mixture of these components in an experimental model of doxorubicin toxicity. Rats (n = 30) received doxorubicin (5 mg/kg/day) for 4 week...
Source: Nutrition and Cancer - June 30, 2019 Category: Cancer & Oncology Authors: Irrera N, Pallio G, Mannino F, Gugliotta R, Metro D, Altavilla D, Squadrito F Tags: Nutr Cancer Source Type: research
Administration of a Nutraceutical Mixture Composed by Aloe arborescens, Annona muricata, Morinda citrifolia, Beta rubra, Scutellaria baicalensis, and Vaccinium myrtillus Reduces Doxorubicin-Induced Side Effects
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - June 30, 2019 Category: Cancer & Oncology Authors: Natasha Irrera Giovanni Pallio Federica Mannino Rosario Gugliotta Daniela Metro Domenica Altavilla Francesco Squadrito Source Type: research
NMR-Based Metabolomic Screening for Metabolites Associated with Resistance to Meloidogyne javanica in Annona muricata Roots
The resistance of Annona muricata roots to the nematode Meloidogyne javanica was investigated by nuclear magnetic resonance (NMR)-based metabolomics in combination with principal component analysis (PCA). Metabolic changes in roots exposed and not exposed to the nematode were evaluated and compared. In addition, the presence of nematicidal compounds in the root extracts was investigated through in vitro assay against Meloidogyne javanica second-stage juveniles. Plants exposed to nematodes showed significant changes in their metabolism after 24 h. Several resistance-related metabolites, including dopamine, xanthine and arom...
Source: Journal of the Brazilian Chemical Society - May 24, 2019 Category: Chemistry Source Type: research
Antibacterial effect of traditional food ingredients for healthcare on Helicobacter pylori.
CONCLUSIONS: The study results on antibacterial effect of traditional food ingredients of vegetables and herbs on H. pylori showed that Scutellaria baicalensis, Annona muricata and Agrimonia pilosa can be considered as healthcare functional materials through the inhibition of H. Pylori.
PMID: 31156188 [PubMed - as supplied by publisher] (Source: Technology and Health Care)
Source: Technology and Health Care - May 23, 2019 Category: Medical Devices Authors: Lee JH, Park JS Tags: Technol Health Care Source Type: research
Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways
AbstractCurrent therapeutic interventions for memory loss are inadequate and are associated with numerous adverse effects. There is an urgent need for new alternative agents for the treatment of memory loss and related disorders. Here, we investigated the potential neuroprotective role of soursop fruit extract (SSFE) in scopolamine (SCO)-induced amnesia and oxidative damage in the hippocampus of rats. Thirty-five rats were randomly allocated into 5 groups: control, SCO, SSFE, SCO, SSFE+SCO and N-acetylcysteine (NAC) + SCO. SCO-treatment increased acetylcholine esterase activity and decreased hippocampal levels of acet...
Source: Metabolic Brain Disease - May 15, 2019 Category: Neurology Source Type: research
Graviola attenuates DMBA-induced breast cancer possibly through augmenting apoptosis and antioxidant pathway and downregulating estrogen receptors.
This study aimed to investigate the protective effects of graviola on 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat breast cancer. Fifty female Wistar rats were allocated into four groups: control group (gastro-gavaged by sesame oil), DMBA-treated group (gastro-gavaged a single dose of DMBA [50 mg/kg body mass, diluted in 1 ml sesame oil]) at the age 57 days, DMBA+G37-treated group (gastro-gavaged a single dose of DMBA [50 mg/kg body mass, diluted in 1 ml sesame oil]) at the age of 57 days plus graviola (200 mg/kg body mass) two times weekly (p.o.) at the age of 37 days till the end of the experiment, and DMBA+G57-trea...
Source: Environmental Science and Pollution Research International - March 28, 2019 Category: Environmental Health Authors: Zeweil MM, Sadek KM, Taha NM, El-Sayed Y, Menshawy S Tags: Environ Sci Pollut Res Int Source Type: research
The protective efficacy of soursop fruit extract against hepatic injury associated with acetaminophen exposure is mediated through antioxidant, anti-inflammatory, and anti-apoptotic activities.
Abstract
In the current report, we examined the potential beneficial role of soursop fruit extract (SSFE) on liver injury induced by a single paracetamol (APAP) overdose (2000 mg/kg). Thirty-five Wistar albino rats were randomly divided into five groups as follows: control, SSFE, APAP, SSFE+APAP, and silymarin (SIL)+APAP. APAP intoxication was found to elevate alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total bilirubin levels. Moreover, it increased the levels of malondialdehyde, nitrites, and nitrates and depleted glutathione, superoxide dismutase, catalase, glutathion...
Source: Environmental Science and Pollution Research International - March 25, 2019 Category: Environmental Health Authors: Al-Brakati AY, Fouda MS, Tharwat AM, Elmahallawy EK, Kassab RB, Abdel Moneim AE Tags: Environ Sci Pollut Res Int Source Type: research
Antiproliferative activity of ionic liquid-graviola fruit extract against human breast cancer (MCF-7) cell lines using flow cytometry techniques
Conclusionsionic liquid Graviola fruit extract affect the cytokinetics behaviour of MCF-7 cells by reducing cell viability, induce apoptosis and cell cycle arrest at the G0/G1 phase.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - March 9, 2019 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 24, Pages 904: Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from Annona muricata By-Products and Pulp
González
Ultrasound-assisted extraction (UAE) is widely used; however, the efficiency of extraction depends on the raw materials. Therefore, optimization of UAE must be investigated for each type of plant material. By-products from soursop fruit have not been studied as a source of bioactive compounds. In this work, the optimization of UAE conditions (extraction time (5, 10, and 15 min), pulse cycle (0.4, 0.7, and 1 s), and sonication amplitude (40%, 70%, and 100%)) for the extraction of phenolic compounds (soluble, hydrolyzable, condensed tannins, and total polyphenols) from soursop by-products (seed, peel, and colum...
Source: Molecules - March 4, 2019 Category: Chemistry Authors: Gabriela Aguilar-Hern ández Mar ía de Lourdes García-Magaña Mar ía de los Ángeles Vivar-Vera Sonia Guadalupe S áyago-Ayerdi Jorge Alberto S ánchez-Burgos Juliana Morales-Castro Luis Miguel Anaya-Esparza Efigenia Montalvo Gonz ález Tags: Article Source Type: research
Antiplasmodial potential and GC-MS fingerprint of endophytic fungal extracts derived from Cameroonian Annona muricata
ConclusionThese results have opened new avenues for discovery of novel antimalarial lead compounds from endophytic fungi associated with Annona muricata - a medicinally important plant.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 7, 2019 Category: Drugs & Pharmacology Source Type: research
Solid lipid nanoparticles of Annona muricata fruit extract: Formulation, optimization and in vitro Cytotoxicity studies.
Authors: Sabapati M, Palei NN, C K AK, M RB
Abstract
The present study was aimed to develop Annona muricata fruit extract loaded solid lipid nanoparticles (SLNs) and explore its cytotoxic potential in vitro model of breast cancers. Extract loaded SLNs was successfully prepared by high-pressure homogenization followed by ultrasonication method and optimized using 23 full factorial design. The extract loaded SLNs were characterized using different parameters such as particle size (PS), % entrapment efficiency (EE), zeta potential (ZP) and % cumulative drug release (CDR). The SLNs formulation was optimized on...
Source: Drug Development and Industrial Pharmacy - January 23, 2019 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Evaluation of MCM-41 and MCM-48 mesoporous materials as sorbents in matrix solid phase dispersion method for the determination of pesticides in soursop fruit (Annona muricata)
Publication date: Available online 11 January 2019Source: Inorganic Chemistry CommunicationsAuthor(s): Luís Fabrício Santana Santos, Roberta Anjos de Jesus, José Arnaldo Santana Costa, Lucas Gabriel Teixeira Gouveia, Maria Eliane de Mesquita, Sandro NavickieneAbstractThe MCM-41 and MCM-48 mesoporous materials were tested for extraction of thiamethoxam, thiacloprid, thiophanate-methyl, teflubenzuron, and bifenthrin from the fruit of soursop (Annona muricata), using liquid chromatography with ultraviolet diode array detection as the analysis technique. Extractions performed at one fortification level (0.5 mg kg−1, n...
Source: Inorganic Chemistry Communications - January 12, 2019 Category: Chemistry Source Type: research
