Annona muricata Linn. leaf as a source of antioxidant compounds with in vitro antidiabetic and inhibitory potential against α-amylase, α-glucosidase, lipase, non-enzymatic glycation and lipid peroxidation
This study presents new biological activities not yet described for A. muricata, which contributes to the understanding of the potential effectiveness in the use of the A. muricata leaf, especially its polyphenols-enriched fractions, for the management of diabetes mellitus and its complications. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 7, 2018 Category: Drugs & Pharmacology Source Type: research
Annona muricata Linn. leaf as a source of antioxidant compounds with in vitro antidiabetic and inhibitory potential against α-amylase, α-glucosidase, lipase, non-enzymatic glycation and lipid peroxidation.
This study presents new biological activities not yet described for A. muricata, which contributes to the understanding of the potential effectiveness in the use of the A. muricata leaf, especially its polyphenols-enriched fractions, for the management of diabetes mellitus and its complications.
PMID: 29425747 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 6, 2018 Category: Drugs & Pharmacology Authors: Justino AB, Miranda NC, Franco RR, Martins MM, Silva NMD, Espindola FS Tags: Biomed Pharmacother Source Type: research
Identification and characterization of a new Bacillus atrophaeus strain B5 as biocontrol agent of postharvest anthracnose disease in soursop (Annona muricata) and avocado (Persea americana)
In this study, we evaluated the activity of metabolites contained in the cell free supernatant, obtained from Bacillus strain B5 culture, against micelial growth and spore germination of two virulent strains of C. gloeosporioides isolated from soursop and avocado. On the basis of 16S rDNA gene sequence analysis, this strain was identified as Bacillus atrophaeus. A preventive treatment using cell free supernatant, reduced severity and incidence of anthracnose disease on harvested soursop and avocado fruit. B. atrophaeus strain B5 harbors genes involved in the production of antibiotics such as surfactin, bacillomycin and itu...
Source: Microbiological Research - February 2, 2018 Category: Infectious Diseases Source Type: research
Molecular docking studies of bioactive compounds from Annona muricata Linn as potential inhibitors for Bcl-2, Bcl-w and Mcl-1 antiapoptotic proteins
AbstractAnnona muricata Linn or usually identified as soursop is a potential anticancer plant that has been widely reported to contain valuable chemopreventive agents known as annonaceous acetogenins. The antiproliferative and anticancer activities of this tropical and subtropical plant have been demonstrated in cell culture and animal studies.A. muricata L. exerts inhibition against numerous types of cancer cells, involving multiple mechanism of actions such as apoptosis, a programmed cell death that are mainly regulated by Bcl-2 family of proteins. Nonetheless, the binding mode and the molecular interactions of the plant...
Source: Apoptosis - December 4, 2017 Category: Molecular Biology Source Type: research
Anonna muricata L. (soursop) seed oil improves type 1 diabetes parameters in vivo and in vitro
In this study, we identified the immunomodulatory potential of A. muricata seed oil (AmSO) in streptozotocin (STZ)-induced in vivo and in vitro experimental model of T1D and whole blood cell culture from diabetic patients. AmSO cytotoxicity was evaluated by MTT-tetrazolium and resazurin. AmSO was orally administered to BALB/c mice for 48days and were divided into groups: control, STZ (diabetic), STZ–AmSO (diabetic, treated with 1.0mg/kg AmSO), and AmSO groups (nondiabetic, treated with 1.0mg/kg AmSO). T1D was induced with intraperitoneal administration of STZ (3×100mg/Kg). Biochemistry and histopathological analysis and...
Source: PharmaNutrition - November 10, 2017 Category: Nutrition Source Type: research
Effects of Soursop flowers (Annona muricata L.) extract on chemical changes of refined palm olein stored at frying temperature
In this study, the antioxidant activity of soursop flowers extract in delaying palm olein oxidation at frying temperature was assessed. The oil was supplemented with the extract at concentrations 200–1800ppm, and stored in the oven at 180°C for 6days (4hours heating per day). Palm olein containing butylated hydroxytoluene (BHT) served as positive control while the same oil without antioxidant (Control) served as negative one, in order to monitor changes in oils. After each two heating days, oil samples were collected, and their chemical indexes were determined. Peroxide, para-anisidine, TOTOX, thiobarbituric acid and io...
Source: Food Science and Human Wellness - September 23, 2017 Category: Food Science Source Type: research
Estimates of repeatability coefficients and the number of the optimum measure to select superior genotypes in Annona muricata L.
Abstract
The aim of this study was to evaluate repeated measures over the years to estimate repeatability coefficient and the number of the optimum measure to select superior genotypes in Annona muricata L. The fruit production was evaluated over 16 years in 71 genotypes without an experimental design. The estimation of variance components and the prediction of the permanent phenotypic value were performed using REML/BLUP proceedings. The coefficient of determination, accuracy, and selective efficiency increased when measures increased. The coefficient of determination of 80% was reached beyond 8 crop seas...
Source: Genetics and Molecular Research - September 21, 2017 Category: Genetics & Stem Cells Authors: Sanchéz CFB, Alves RS, Garcia ADP, Teodoro PE, Peixoto LA, Silva LA, Bhering LL, Resende MDV Tags: Genet Mol Res Source Type: research
Annona muricata: is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects
Publication date: Available online 13 September 2017 Source:Asian Pacific Journal of Tropical Medicine Author(s): Yahaya Gavamukulya, Fred Wamunyokoli, Hany A. El-Shemy Annona muricata (A. muricata) is a tropical plant species belonging to family Annonaceae and known for its many medicinal uses. This review focuses on the research history of its traditional uses, phytochemicals, pharmacological activities, toxicological aspects of the extracts and isolated compounds, as well as the in vitro propagation studies with the objective of stimulating further studies on this plant for human consumption and treatment. A. muric...
Source: Asian Pacific Journal of Tropical Medicine - September 13, 2017 Category: Tropical Medicine Source Type: research
Cameroonian medicinal plants belonging to Annonaceae family: radical scavenging and antifungal activities.
Abstract
The free-radical scavenging activity of ethanolic and methanolic extracts of leaves, stems and roots of Annona muricata, Monodora tenuifolia, Uvaria comperei, Uvaria muricata and Xylopia africana was evaluated using DPPH and ORAC assays. Further, phytochemical analysis, total phenolic and total flavonoid contents were also determined. Moreover, the antifungal activity of extracts was studied. The findings indicated that A. muricata and U. comperei extracts own antiradical activities and moderate antifungal properties.
PMID: 28814106 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - August 17, 2017 Category: Biochemistry Authors: Simo MK, Nguepi MD, Sameza ML, Toghueo RK, Fekam FB, Froldi G Tags: Nat Prod Res Source Type: research
Annona muricata leaves extracts prevent DMBA/TPA-induced skin tumorigenesis via modulating antioxidants enzymes system in ICR mice.
Abstract
Annona muricata, locally known as soursop has been reported to exhibit antiproliferative activities against various cancer cell lines. In this current study, we have investigated the antitumor promotion of various fractions of Annona muricata leaves (AML); hexane (AMLH), dichloromethane (AMLD) and methanol (AMLM) fraction respectively on 7, 12-dimethylbenz[α]anthracene (DMBA) induced and 12-0-tetradecaboylphorbol-13-acetate (TPA) promoted skin tumorigenesis in mice via morphological assessment, biochemical analysis and histopathological evaluation. The results of the study revealed significant in...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 2, 2017 Category: Drugs & Pharmacology Authors: Md Roduan MR, Hamid RA, Sulaiman H, Mohtarrudin N Tags: Biomed Pharmacother Source Type: research
Reliance on medicinal plant therapy among cancer patients in Jamaica
ConclusionA large proportion of Jamaican cancer patients use medicinal plants in self-medicating practices and their perceptions and habits need to be considered by physicians, in the design of safe and effective care regimes. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - July 15, 2017 Category: Cancer & Oncology Source Type: research
Anticancer activity test of ethyl acetate extract of endophytic fungi isolated from soursop leaf (Annona muricata L.)
Conclusions The endophytic fungi isolated from soursop leaf has the potential to be used as a source of anticancer agents. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 21, 2017 Category: Tropical Medicine Source Type: research
Structural Characterisation of Acetogenins from Annona muricata by Supercritical Fluid Chromatography Coupled to High ‐Resolution Tandem Mass Spectrometry
ConclusionThe use of SFC‐MS/MS allows the reduction of the time of analysis, of environmental impact and an increase in the chromatographic resolution, compared to liquid chromatography. This new methodology enlightened a new group of acetogenins, isomers of montanacin‐D. Copyright © 2017 John Wiley & Sons, Ltd. (Source: Phytochemical Analysis)
Source: Phytochemical Analysis - June 19, 2017 Category: Biochemistry Authors: Laurent Laboureur, Natacha Bonneau, Pierre Champy, Alain Brunelle, David Touboul Tags: Research Article Source Type: research
Nutritional characteristics and bioactive compound content of guava purees and their effect on biochemical markers of hyperglycemic and hypercholesterolemic rats
Publication date: August 2017 Source:Journal of Functional Foods, Volume 35 Author(s): Yolanda E. Pérez-Beltrán, Eduardo Mendeleev Becerra-Verdín, Sonia G. Sáyago-Ayerdi, Nuria E. Rocha-Guzmán, Emma G. García-López, Alfonso Castañeda-Martínez, Rubén Montalvo-González, Cristian Rodríguez-Aguayo, Efigenia Montalvo-González The nutritional characteristics and bioactive compound content in purees elaborated with guava-strawberry, guava-blackberry, guava-soursop or guava-passion fruit were evaluated as well as their effect on biochemical markers of hyperglycemic and hypercholesterolemic rats. Over a 4-we...
Source: Journal of Functional Foods - June 13, 2017 Category: Nutrition Source Type: research
The effect of an Annona muricata leaf extract on nutritional status and cytotoxicity in colorectal cancer: a randomized controlled trial.
The objective of this study was to elucidate the effects of A. muricata leaf extract in humans and human cell lines.
METHODS AND STUDY DESIGN: Thirty outpatients with colorectal cancer who had undergone primary tumor resection were enrolled in a randomized double-blind placebo- controlled pre-post-trial. They were divided into two groups: those who ingested A. muricata leaf extract (n=14) and those who ingested a placebo (n=14) daily for 8 weeks. Twenty-eight subjects completed the trial; they were equally distributed between the two groups. Serum from patients of both groups was compared for cytotoxicity against c...
Source: Asia Pacific Journal of Clinical Nutrition - June 7, 2017 Category: Nutrition Authors: Indrawati L, Ascobat P, Bela B, Abdullah M, Surono IS Tags: Asia Pac J Clin Nutr Source Type: research
