Diets supplemented with Annona muricata improve the symptoms of fibromyalgia
In this study, the effect of the consumption of Annona muricata L. (Annonaceae) leaves (AM) was investigated on a model for intermittent cold stress (ICS)-induced fibromyalgia in mice. An aqueous extract of AM was investigated in experiments involving 60 five-week-old female mice C57BL/6J.The animals were allocated into six groups (n = 10). Groups (I) Healthy control, (II) ICS control, and (III) ICS + acetaminophen (0.5%), were all fed a standard diet, while groups (IV) and (V) received standard diets supplemented with 15% (AM15) and 30% (AM30) aqueous extract of AM leaves, respectively. Group (VI) received a stand...
Source: PharmaNutrition - July 10, 2018 Category: Nutrition Source Type: research
Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors
ConclusionThe suggested strategy provides a reliable means of prospecting in-silico screening of natural products databases in the search for new dug leads as aromatase inhibitors. The hits so obtained can then be subjected to further phytochemical studies, to isolate and identify suitable compounds for further in-vitro testing.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Cytotoxicity, antitumor-promoting and antioxidant activities of Annona muricata in vitro
This study aimed to determine the cytotoxicity, antitumor-promoting and antioxidant activities of Annona muricata various extracts and its isolated acetogenin, annonacin in vitro. All samples were subjected to the inhibition of Epstein-Barr virus early antigen (EBV-EA) activation assay induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA) on Raji cells. Prior to EBV-EA assay, [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] (MTT) assay was performed to determine the samples’ cytotoxicity against Raji cells. Antioxidant activity was performed via 2, 2’-azino-bis(3-ethylbenzothiazoline...
Source: Journal of Herbal Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research
Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice
Publication date: May 2018Source: Saudi Journal of Biological Sciences, Volume 25, Issue 4Author(s): Elizângela Beneval Bento, Francisco Elizaudo de Brito Júnior, Dayanne Rakelly de Oliveira, Cícera Norma Fernandes, Gyllyandeson de Araújo Delmondes, Francisco Rafael Alves Santana Cesário, Cristina Kelly de Sousa Rodrigues, Valterlúcio dos Santos Sales, Francisco Rodolpho Sobreira Dantas Nóbrega de Figueiredo, Izabel Cristina Santiago Lemos, Álefe Brito Monteiro, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Marta Regina KerntopfAbstractAnnona muricata Linnaeus, popularly known as “graviola” an...
Source: Saudi Journal of Biological Sciences - July 6, 2018 Category: Biology Source Type: research
Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors
ConclusionThe suggested strategy provides a reliable means of prospecting in-silico screening of natural products databases in the search for new dug leads as aromatase inhibitors. The hits so obtained can then be subjected to further phytochemical studies, to isolate and identify suitable compounds for further in-vitro testing.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity
Publication date: July 2018Source: Arabian Journal of Chemistry, Volume 11, Issue 5Author(s): Ana V. Coria-Téllez, Efigenia Montalvo-Gónzalez, Elhadi M. Yahia, Eva N. Obledo-VázquezAbstractAnnona muricata L. (Magnoliales: Annonaceae) is a tropical plant species known for its edible fruit which has some medicinal merits, but also some toxicological effects. This review focuses on the phytochemicals contents, bioactivity, biological actions and toxicological aspects of extracts and isolated compounds, as well as medicinal uses of A. muricata, with the objective of stimulating further studies on extracts and fruit pulp use...
Source: Arabian Journal of Chemistry - July 5, 2018 Category: Chemistry Source Type: research
Diets supplemented with Annona muricata improve the symptoms of fibromyalgia
In this study, the effect of the consumption of Annona muricata L. (Annonaceae) leaves (AM) was investigated on a model for intermittent cold stress (ICS)-induced fibromyalgia in mice. An aqueous extract of AM was investigated in experiments involving 60 five-week-old female mice C57BL/6J.The animals were allocated into six groups (n = 10). Groups (I) Healthy control, (II) ICS control, and (III) ICS + acetaminophen (0.5%), were all fed a standard diet, while groups (IV) and (V) received standard diets supplemented with 15% (AM15) and 30% (AM30) aqueous extract of AM leaves, respectively. Group (VI) received a stand...
Source: PharmaNutrition - July 5, 2018 Category: Nutrition Source Type: research
Cytotoxicity, antitumor-promoting and antioxidant activities of Annona muricata in vitro
This study aimed to determine the cytotoxicity, antitumor-promoting and antioxidant activities of Annona muricata various extracts and its isolated acetogenin, annonacin in vitro. All samples were subjected to the inhibition of Epstein-Barr virus early antigen (EBV-EA) activation assay induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA) on Raji cells. Prior to EBV-EA assay, [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] (MTT) assay was performed to determine the samples’ cytotoxicity against Raji cells. Antioxidant activity was performed via 2, 2’-azino-bis(3-ethylbenzothiazoline...
Source: Journal of Herbal Medicine - July 5, 2018 Category: Complementary Medicine Source Type: research
Effects of Soursop flowers (Annona muricata L.) extract on chemical changes of refined palm olein stored at frying temperature
In this study, the antioxidant activity of soursop flowers extract in delaying palm olein oxidation at frying temperature was assessed. The oil was supplemented with the extract at concentrations 200–1800 ppm, and stored in the oven at 180 °C for 6 days (4 h heating per day). Palm olein containing butylated hydroxytoluene (BHT) served as positive control while the same oil without antioxidant (Control) served as negative one, in order to monitor changes in oils. After each two heating days, oil samples were collected, and their chemical indexes were determined. Peroxide, para-anisidine, TOTOX, thioba...
Source: Food Science and Human Wellness - July 5, 2018 Category: Food Science Source Type: research
Exploring the Leaves of Annona muricata L. as a Source of Potential Anti-inflammatory and Anticancer Agents
Siti Mariam Abdul Wahab, Ibrahim Jantan, Md. Areeful Haque, Laiba Arshad (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 20, 2018 Category: Drugs & Pharmacology Source Type: research
Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors
Conclusion The suggested strategy provides a reliable means of prospecting in-silico screening of natural products databases in the search for new dug leads as aromatase inhibitors. The hits so obtained can then be subjected to further phytochemical studies, to isolate and identify suitable compounds for further in-vitro testing. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - June 20, 2018 Category: Drugs & Pharmacology Source Type: research
Diets supplemented with Annona muricata improve the symptoms of fibromyalgia
In this study, the effect of the consumption of Annona muricata L. (Annonaceae) leaves (AM) was investigated on a model for intermittent cold stress (ICS)-induced fibromyalgia in mice. An aqueous extract of AM was investigated in experiments involving 60 five-week-old female mice C57BL/6J. The animals were allocated into six groups (n = 10). Groups (I) Healthy control, (II) ICS control, and (III) ICS + acetaminophen (0.5%), were all fed a standard diet, while groups (IV) and (V) received standard diets supplemented with 15% (AM15) and 30% (AM30) aqueous extract of AM leaves, respectively. Group (VI) received a stan...
Source: PharmaNutrition - May 17, 2018 Category: Nutrition Source Type: research
Cytotoxicity, antitumor-promoting and antioxidant activities of Annona muricata in vitro
This study aimed to determine the cytotoxicity, antitumor-promoting and antioxidant activities of Annona muricata various extracts and its isolated acetogenin, annonacin in vitro. All samples were subjected to the inhibition of Epstein-Barr virus early antigen (EBV-EA) activation assay induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA) on Raji cells. Prior to EBV-EA assay, [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] (MTT) assay was performed to determine the samples’ cytotoxicity against Raji cells. Antioxidant activity was performed via 2, 2’-azino-bis(3-ethylbenzothiazoline...
Source: Journal of Herbal Medicine - May 1, 2018 Category: Complementary Medicine Source Type: research
Characterization of enzyme-liquefied soursop (Annona muricata L.) puree
Publication date: August 2018 Source:LWT, Volume 94 Author(s): Lee Sin Chang, Roselina Karim, Abdulkarim Sabo Mohammed, Hasanah Mohd Ghazali Soursop (Annona muricata L.) is a tropical fruit that undergoes rapid postharvest deterioration. Conversion into puree is a way to value add the fruit. Pectinex® Ultra SP-L, Celluclast® 1.5 L, and Fungamyl® 800 L (0–5% v/w) were used to treat fruit pulp and pectinase at 1.5% (v/w) concentration was chosen as the primary enzyme in combined enzymes study because it produced the best result in liquefaction. A liquefied puree with reduced viscosity of up to 50% (15.20 ±...
Source: LWT Food Science and Technology - April 20, 2018 Category: Food Science Source Type: research
Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: potential nanoshuttles for brain-delivery of phenolic compounds
Conclusions : Overall, phytosome formulations registered the best performance in terms of binding efficiency, enzyme inhibition and scavenging activity, thus representing a promising multipotent phenolic-rich nanoshuttle for future in vivo depression treatment. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - March 20, 2018 Category: Drugs & Pharmacology Source Type: research
