Diets supplemented with Annona muricata improve the symptoms of fibromyalgia

In this study, the effect of the consumption of Annona muricata L. (Annonaceae) leaves (AM) was investigated on a model for intermittent cold stress (ICS)-induced fibromyalgia in mice. An aqueous extract of AM was investigated in experiments involving 60 five-week-old female mice C57BL/6J. The animals were allocated into six groups (n = 10). Groups (I) Healthy control, (II) ICS control, and (III) ICS + acetaminophen (0.5%), were all fed a standard diet, while groups (IV) and (V) received standard diets supplemented with 15% (AM15) and 30% (AM30) aqueous extract of AM leaves, respectively. Group (VI) received a standard diet supplemented with 30% of aqueous extract of AM leaves and 0.5% of acetaminophen over a period of 4 weeks. After having been subjected to the ICS model, the mice of the (II–VI) groups were tested for their nociception and behaviour. The results indicate that daily consumption of the leaves of AM confers protection not only against chronic pain of fibromyalgia, but also against other associated symptoms, such as anxiety and depression. Graphical abstract
Source: PharmaNutrition - Category: Nutrition Source Type: research