Inhibition of the hypoxia-induced factor-1 & #945; and vascular endothelial growth factor expression through ginsenoside Rg3 in human gastric cancer cells
Conclusion: Rg3 can inhibit expression of HIF-1α and VEGF in human gastric cancer cells and may influence abdominal implantation metastasis of gastric cancer through inhibiting its expression. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Bingqiang Li Guofeng Qu Source Type: research

Antitumor activity of interleukin-18 on A549 human lung cancer cell line
Conclusion: Using a lentiviral expression vector, IL-18 was expressed stably and efficiently in A549 cells, which showed attenuated proliferation and tumor cell growth, and enhanced tumor cell apoptosis. IL-18 expression also induced the secretion of IFN-γ, while decreasing the production of IL-4, therefore restoring the balance between Th1/Th2 cell subsets. These findings further demonstrated the antitumor activity of IL-18 and might open new therapeutic avenues for the prevention and treatment of lung cancer. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Donglan Xiong Rui Feng Sheng Yang Tingyan Lin Xiangqi Chen Source Type: research

Camrelizumab combined with microwave ablation improves the objective response rate in advanced non-small cell lung cancer
Conclusions: Camrelizumab administration combined with MWA was safe in the treatment of advanced NSCLC, and the combination improved the ORR of camrelizumab alone compared to previous reports. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Zhigang Wei Xia Yang Xin Ye Guanghui Huang Wenhong Li Xiaoying Han Jiao Wang Min Meng Yang Ni Zhigeng Zou Qiang Wen Source Type: research

Salvage therapy of reactive capillary hemangiomas: Apatinib alleviates the unique adverse events induced by camrelizumab in non-small cell lung cancer
Conclusion: The combination of camrelizumab and apatinib in the treatment of NSCLC reduced the incidence of RCHs. Apatinib appeared to be a salvage therapy of RCHs, which leads to rapid regression of RCHs with no impairment on the quality of life. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Wenhong Li Zhigang Wei Xia Yang Guanghui Huang Xiaoying Han Yang Ni Jiao Wang Min Meng Zhigeng Zou Qiang Wen Xin Ye Source Type: research

A comparison between radiofrequency ablation combined with transarterial chemoembolization and surgical resection in hepatic carcinoma: A meta-analysis
Conclusion: SR should remain as the first-line therapy for early HCC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Hongye Wang Yihai Liu Kangjie Shen Yuxiang Dong Jinyu Sun Yimei Shu Xiaojie Wan Xiaohan Ren Xiyi Wei Bo Zhai Source Type: research

Application of the transosseous approach for computed tomography-guided radioactive 125-iodine seed implantation for the treatment of thoracic and abdominal lymph node metastases
Conclusions: The transosseous approach for CT-guided radioactive 125I seed implantation was safe, effective, and minimally invasive for the treatment of thoracic and abdominal lymph node metastases. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Jian Chen Jin Chen Xiu-Hua Lin Rui-Xiang Lin Yuan Yan Qing-Feng Lin Zheng-Yu Lin Source Type: research

Metformin enhances radiosensitivity in hepatocellular carcinoma by inhibition of specificity protein 1 and epithelial-to-mesenchymal transition
Conclusion: Metformin demonstrated enhanced radiosensitivity and inhibition of EMT in HCC cells. Sp1 might be a target of metformin in radiosensitization. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Ke-Fen Zhang Jun Wang Jiao Guo Yue-Ying Huang Tian-Ren Huang Source Type: research

MALAT1 and BACH1 are prognostic biomarkers for triple-negative breast cancer
Conclusions: These findings provide further insight into the expression pattern of MALAT1 and BACH1 in TNBC and suggest them as prognostic biomarkers for TNBC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Xueqi Ou Guanfeng Gao Meiheban Bazhabayi Kaiming Zhang Feng Liu Xiangsheng Xiao Source Type: research

Individualized and inverse optimized needle configuration for combined intracavitary-interstitial brachytherapy in locally advanced cervical cancer
Conclusions: Using the proposed methods of customizing and optimizing the IS needle configuration, the limitation in the standardized design of combined IC/IS applicators can be addressed, and sufficient target coverage is obtained in cervical cancer patients with unfavorable tumor topography and/or extra lateral expansion. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Daguang Zhang Zhiyong Yang Shan Jiang Lin Zhou Zeyang Zhou Wei Wang Source Type: research

Correlations between maximum standardized uptake value measured via 18F-fluorodeoxyglucose positron emission tomography/computed tomography and clinical variables and biochemical indicators in adult lymphoma
Conclusions: 18F-FDG PET/CT may yield reliable measurements of tumor proliferation, and an SUVmax >8.5 may distinguish between aggressive and indolent NHLs. In adults with newly diagnosed lymphoma, SUVmax correlates with Ki-67 index and IPI score. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Hongling Li Xiaohuan Wang Lingfang Zhang Xuemei Yi Yujie Qiao Qianqian Jin Source Type: research

Tumor shrinkage rate as a potential marker for the prediction of long-term outcome in advanced non-small cell lung cancer treated with first-line tyrosine kinase inhibitors
Conclusions: These cumulative data support that TSR may be an early predictor of the treatment efficacy in NSCLC with EGFR mutations treated with first-line TKIs. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Shanshan Yu Xingchen Wang Xiaoyan Wang Xueyuan Wu Rongrong Xu Xiaoqi Wang Xue Zhang Chunhong Zhang Kun Chen Dezhi Cheng Li Wenfeng Source Type: research

Preliminary clinical efficacy of iodine-125 seed implantation for the treatment of advanced malignant lung tumors
Conclusions: CT-guided percutaneous interstitial brachytherapy with iodine-125 seeds can be used for the treatment of lung malignant tumors. Its clinical curative effect is remarkable and it results in limited trauma, reducing the incidence of adverse reactions and improving patient quality of life. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Fuxin Kou Song Gao Shaoxing Liu Xiaodong Wang Hui Chen Xu Zhu Jianhai Guo Xin Zhang Aiwei Feng Baojiang Liu Source Type: research

Efficacy and safety of nanoparticle albumin-bound paclitaxel as neoadjuvant chemotherapy in HER2-negative breast cancer
Conclusions: As neoadjuvant therapy, the Nab-PTX regimen has advantages over conventional taxane regimen in patients with HER2-negative breast cancer. With this regimen, a high pCR rate was achieved with a good safety profile. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Miaomiao Yang Huajun Qu Aina Liu Jiannan Liu Ping Sun Hua Li Source Type: research

Computed tomography-guided iodine-125 brachytherapy for unresectable hepatocellular carcinoma
Conclusion: CT-guided iodine-125 brachytherapy may be an effective and safe alternative with promising survival and increased local control rate in unresectable HCC treatment. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Zhaomin Song Jiacheng Ye Yongzheng Wang Yuliang Li Wujie Wang Source Type: research

Specific inhibition of Notch1 signaling suppresses properties of lung cancer stem cells
Conclusion: Our discovery demonstrated a depression of growth in CD44+/CD24– and A549 cells caused by blockade of Notch signaling pathway. Further studies are needed to demonstrate the detailed effects of Notch1 blocking on the LCSCs. Nevertheless, targeting the Notch pathway has exhibited great potential to be an improved lung cancer treatment. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Haibo Cai Wei Lu Yueying Zhang Hengyao Liu Zhaopeng Wang Yi Shen Source Type: research

Comparison between direct factor Xa inhibitors and low-molecular-weight heparin for efficacy and safety in the treatment of cancer-associated venous thromboembolism: A meta-analysis
Conclusions: Direct factor Xa inhibitors are superior to LMWH in efficacy in the treatment of VTE in cancer patients, and the safety between the two regimens is comparable except for a slightly higher rate of minor bleeding when the former is used. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Min Yang Jiang Li Rui Sun Yanfeng Wang Haiyan Xu Boyan Yang Xiaoming Wu Lei Yu Source Type: research

Comparison between ultrasound-guided percutaneous radiofrequency and microwave ablation in benign thyroid nodules
Conclusions: RFA and MWA are both effective and safe techniques for treating BTNs. Higher VRRs were observed at the 6- and 12-month follow-ups in the RFA group. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Ke Hu Jingjing Wu Yi Dong Zhiping Yan Zhiqiang Lu Lingxiao Liu Source Type: research

Risk factors for 30-day unplanned reoperation after pancreatoduodenectomy: A single-center experience
Conclusions: Our results suggest that diabetes, intraoperative blood loss ≥400 mL, PPH, and PEA leak were independent risk factors for unplanned reoperation after primary PD. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Hua Qiu Ren-Feng Shan Jun-Hua Ai Shan-Ping Ye Jun Shi Source Type: research

Safety and efficacy of ultrasound-guided percutaneous thermal ablation in treating low-risk papillary thyroid microcarcinoma: A pilot and feasibility study
Conclusion: Thermal ablation is a short-term safe and effective method in treating low-risk small PTMCs, which can be considered a potential alternative therapy for patients with PTMC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Liping Wang Dong Xu Yan Yang Mingkui Li Chuanming Zheng Xinguang Qiu Bin Huang Source Type: research

Cost & #8211;utility analysis of screening for colorectal precancerous lesions and cancer in Beijing: A case & #8211;control study
Conclusion: The colorectal cancer screening program could improve health-related quality of life and reduce medical expenditure. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Hanyue Ding Ayan Mao Lian Wen Pei Dong Yujie Yang Xuan Cheng Wuqi Qiu Source Type: research

Value of intravoxel incoherent motion magnetic resonance imaging for differentiating metastatic from nonmetastatic mesorectal lymph nodes with different short-axis diameters in rectal cancer
Conclusion: IVIM parameters can differentiate metastatic from nonmetastatic LNs with smaller short-axis diameters (× ≤7 mm) in rectal cancer, and the short-axis diameter is a significant factor in identifying metastatic and nonmetastatic LNs in larger short-axis diameter groups (× >7 mm). (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Ling Long Haiping Zhang Xiaojing He Jun Zhou Dajing Guo Xinjie Liu Source Type: research

Melanoma liver metastases with special imaging features on magnetic resonance imaging after microwave ablations: How to evaluate technical efficacy ?
Conclusion: MWA is a technically feasible option for melanoma liver metastases with special imaging features on MRI. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Fei Cao Lin Xie Han Qi Song Ze Shuanggang Chen Lujun Shen Xiaoshi Zhang Weijun Fan Source Type: research

125I implantation under computed tomography guidance to treat patients with recurrent pelvic tumors: Retrospective analysis of clinical results
Conclusions: When using CT-guided 125I implantation, patients with malignant abdominal tumors undergo a convenient operation, sustain little trauma, and have an improved quality of life. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Li Chuang Wang Ruoyu Wang Zhe Zhao Guangsheng Zhou Jun Source Type: research

Endobronchial ultrasound-guided transbronchial needle aspiration can improve the diagnostic accuracy of positron emission tomography/computed tomography in hilar and/or mediastinal lymphadenopathy
Conclusions: EBUS-TBNA combined with PET/CT could effectively reduce false-positive and false-negative rates in the diagnosis of hilar and mediastinal lymphadenopathy, which might provide accurate staging, determine optimum therapeutic strategy and improve survival in patients with lung cancer. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Chuan-Cai Xu Wei Lei Jun-Hong Jiang Zi-Rui Wang Chong-Jun Ni Jian-An Huang Source Type: research

Synchronous core-needle biopsy and microwave ablation for highly suspicious malignant pulmonary nodule via a coaxial cannula
Conclusions: Synchronous core-needle biopsy and MWA via a coaxial cannula is technically safe and feasible in the management of highly suspicious malignant pulmonary nodules, and this procedure has lesser complications and similar effects (both 100% effective treatment) compared with sequential procedures. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Dongdong Wang Bin Li Zhixin Bie Yuanming Li Xiaoguang Li Source Type: research

Ultrasound-guided percutaneous microwave ablation assisted by a three-dimensional visualization preoperative treatment planning system for larger adrenal metastasis (D & #8805; 4 cm): Preliminary results
Conclusions: US-PMWA assisted by 3D visualization preoperative treatment planning system maybe a safe and efficient therapy for LAM, which could promote ablation precision, improve the clinical outcomes. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Songsong Wu Xin Li Jie Yu Xiaoling Yu Zhigang Cheng Fangyi Liu Zhiyu Han Shaobo Duan Ping Liang Source Type: research

Decitabine: An effective and safe treatment for myelodysplastic syndrome and acute myeloid leukemia
Conclusions: Our data demonstrated that decitabine was effective and relatively safe in treating MDS and AML. Patients with agranulocytosis and severe anemia were prone to have poor survival, which should be monitored in clinical practice. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Xianqi Feng Xiangyun Chen Shumin Nie Yanyan Chang Fanjun Meng Jingjing Zhou Chunxia Mao Tianlan Li Xueshen Yan Junxia Huang Shanshan Liu Yan Gao Shuxin Xiao Source Type: research

Nonspecific benign pathological results on computed tomography-guided lung biopsy: A predictive model of true negatives
Conclusions: Our predictive model showed good predictive ability for identifying true negatives among nonspecific benign lung biopsy results. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Yu-Fei Fu Li-Hua Jiang Tao Wang Guang-Chao Li Wei Cao Yi-Bing Shi Source Type: research

Effectiveness and safety of robotic versus traditional laparoscopic gastrectomy for gastric cancer: An updated systematic review and meta-analysis
Hua Qiu, Jun-Hua Ai, Jun Shi, Ren-Feng Shan, Dong-Jun YuJournal of Cancer Research and Therapeutics 2019 15(7):1450-1463 Gastrectomy is considered the gold standard treatment for gastric cancer patients. Currently, there are two minimally invasive surgical methods to choose from, robotic gastrectomy (RG) and laparoscopic gastrectomy (LG). Nevertheless, it is still unclear which is superior between the two. This meta-analysis aimed to investigate the effectiveness and safety of RG and LG for gastric cancer. A systematic literature search was performed using PubMed, Embase, and the Cochrane Library databases until September...
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Hua Qiu Jun-Hua Ai Jun Shi Ren-Feng Shan Dong-Jun Yu Source Type: research

Risk of serious adverse event and fatal adverse event with molecular target anticancer drugs in cancer patients: A meta-analysis
Zhiwei Wang, Xiao Yang, Jitao Wang, Shuai Wang, Xiaorong Mao, Mingxing Li, Yongzhao Zhao, Weidong Wang, Xiaolong Qi, Tongwei WuJournal of Cancer Research and Therapeutics 2019 15(7):1435-1449 Molecular target anticancer drugs are commonly used in various forms of cancers. It is a concern that the risk of serious adverse events (SAEs) and fatal adverse events (FAEs) of molecular target drugs are increasing. An up-to-date meta-analysis of all Phase II/III/IV randomized trials of molecular target anticancer drugs was conducted to calculate the increased risk of SAEs and FAEs. A systematic search of PubMed, Web of Science, an...
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Zhiwei Wang Xiao Yang Jitao Wang Shuai Wang Xiaorong Mao Mingxing Li Yongzhao Zhao Weidong Wang Xiaolong Qi Tongwei Wu Source Type: research

Expert consensus on computed tomography-assisted three-dimensional-printed coplanar template guidance for interstitial permanent radioactive 125I seed implantation therapy
Junjie Wang, Shude Chai, Ruoyu Wang, Guangjun Zheng, Kaixian Zhang, Bin Huo, Xiaodong Huo, Yuliang Jiang, Zhe Ji, Ping Jiang, Ran PengJournal of Cancer Research and Therapeutics 2019 15(7):1430-1434 Interstitial permanent radioactive seed implantation delivers a high local dose to tumors and sharply drops off at surrounding normal tissues. Radioactive seeds implanted via ultrasound or computed tomography (CT) guidance are minimally invasive and facilitate quick recovery. Transrectal ultrasound-guided 125I seed implantation assisted by a transperineal plane template is standard for early-stage prostate carcinoma, with a hi...
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Junjie Wang Shude Chai Ruoyu Wang Guangjun Zheng Kaixian Zhang Bin Huo Xiaodong Huo Yuliang Jiang Zhe Ji Ping Jiang Ran Peng Source Type: research

Computed tomography-guided percutaneous core-needle biopsy after thermal ablation for lung ground-glass opacities: Is the method sound ?
Xiaoguang Li, Xin YeJournal of Cancer Research and Therapeutics 2019 15(7):1427-1429 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - January 13, 2020 Category: Cancer & Oncology Authors: Xiaoguang Li Xin Ye Source Type: research

Erratum: Primary large cell neuroendocrine carcinoma of the prostate in a hormone naive patient: A case report from Taiwan
Journal of Cancer Research and Therapeutics 2019 15(6):1425-1425 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Source Type: research

Erratum: Anticancer activity of britannin through the downregulation of cyclin D1 and CDK4 in human breast cancer cells
Journal of Cancer Research and Therapeutics 2019 15(6):1424-1424 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Source Type: research

Erratum: Primary large cell neuroendocrine carcinoma of the prostate in a hormone naive patient: A case report from Taiwan
Journal of Cancer Research and Therapeutics 2019 15(6):1425-1425 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Source Type: research

Erratum: Anticancer activity of britannin through the downregulation of cyclin D1 and CDK4 in human breast cancer cells
Journal of Cancer Research and Therapeutics 2019 15(6):1424-1424 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Source Type: research

Mesenchymal stem cells in cancer therapy
Mohammad Reza AtashzarJournal of Cancer Research and Therapeutics 2019 15(6):1422-1423 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Mohammad Reza Atashzar Source Type: research

Cost & #8211;risk analysis of available cervix cancer vaccine: Situation analysis from Thailand
Somsri Wiwanitkit, Viroj WiwanitkitJournal of Cancer Research and Therapeutics 2019 15(6):1421-1421 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Somsri Wiwanitkit Viroj Wiwanitkit Source Type: research

Synchronous benign Brenner & #39;s tumor of ovary with leiomyoma and endometrial adenocarcinoma in a postmenopausal female
We present a case of 50-year-old postmenopausal women who presented with coexisting incidental Brenner tumor with leiomyoma and Endometrial adenocarcinoma. Only few authors have reported similar tumor occurrence in the past. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Jyotsana Harit Gaur Mohammad Jaseem Hassan Arifa Anwar Elahi Shaan Khetrapal Sabina Khan Sujata Jetley Source Type: research

Peritoneal metastasis in Stage IB1 adenocarcinoma cervix: A rare entity
Seema Singhal, Sunesh Kumar, Dayanand N Sharma, Sandeep MathurJournal of Cancer Research and Therapeutics 2019 15(6):1415-1417 The presence of ovarian or peritoneal metastasis in early-stage cervical malignancy is a rare entity. It often poses a diagnostic challenge whether it is a synchronous primary tumor or a metastatic lesion. A 63-year-old postmenopausal woman presented with Stage 1B1 carcinoma cervix with ascites, and a 5.8 cm × 4.2 cm × 3.5 cm left solid adnexal mass. She underwent Type III radical hysterectomy, excision of peritoneal mass, with bilateral pelvic and paraaortic lymphadenectomy and infracol...
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Seema Singhal Sunesh Kumar Dayanand N Sharma Sandeep Mathur Source Type: research

Lobular carcinoma of the breast with metastasis to the uterine cervix
The objective of the current study was to report a clinical case considered rare in the literature, as well as discuss its implications and peculiarities. This case report describes a 57-year-old patient with lobular carcinoma metastatic to the uterine cervix, >3 years after the termination of the left breast cancer treatment. A literature analysis confirmed that most cases presented with vaginal bleeding or abdominal discomfort, but many were asymptomatic. Common characteristics between the cases were the patient's age, the time period between primary tumor diagnosis and the emergence of metastatic lesions, treatm...
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Danilo Rafael Silva Fontinele Sabas Carlos Vieira Raimundo Ger & #244;nimo da Silva J & #250;nior Tatyanne Silva Rodrigues Source Type: research

Sister Mary Joseph & #39;s nodule in endometrial cancer: A case report and review of the literature
We reported a case of SMJN detected within the primary diagnosis of endometrial cancer, in which a 1-year vaginal relapse occurs. A robotic single-site total hysterectomy and a bilateral salpingo-oophorectomy were performed to treat the primary tumor, followed by an adjuvant radiotherapy. The SMJN was resected during the surgical procedure. The relapse was treated by a partial colpectomy. No evidence of disease has been observed to date, and an overall survival of 31 months has been achieved. Due to the rare occurrence of an umbilical metastasis from an endometrial carcinoma, SMJN is difficult to recognize in this contest;...
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Martina De Angeli Mariantonia Carosi Enrico Vizza Giacomo Corrado Source Type: research

Carcinoma cervix de novo with widespread cutaneous/subcutaneous metastasis: A rare case report
Shraddha Raj, Neha Kakkar, Prachi Agrawal, Satya Dutta, KT BhowmikJournal of Cancer Research and Therapeutics 2019 15(6):1405-1407 Cancer of the uterine cervix is one of the leading gynecological malignancies of developing nations including India. A 45-year-old female presented with menstrual irregularities and other nonspecific symptoms. After initial workup, she was diagnosed with carcinoma cervix, Stage IV A, while she was being planned to take up radical concomitant chemoradiotherapy, she developed widespread nodules over various sites over the body, which were histopathologically proven as metastatic lesions. She was...
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Shraddha Raj Neha Kakkar Prachi Agrawal Satya Dutta KT Bhowmik Source Type: research

Isolated acrometastasis: A rare presenting feature of endometrial carcinoma
We report a case of a postmenopausal female presented with pain and swelling involving right foot. Biopsy revealed metastatic adenocarcinoma. The patient denied any history of vaginal bleeding or other gynecological symptoms. Bone scan suggested increased uptake in multiple tarsal bones. Uterine curettage confirmed the diagnosis of endometrial adenocarcinoma. The patient was successfully treated with debulking surgery, palliative radiotherapy to the right foot, bisphosphonates, and systemic chemotherapy with marked improvement in local symptoms and is under follow-up for the last 6 months after completion of the treatment....
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Irappa V Madabhavi Apurva Patel Malay S Sarkar Mitul G Modi Suhas Aagre Source Type: research

Primary extraneural ependymoma of the broad ligament: A rare entity
Anita Kumari, Preeti Diwaker, Priyanka Gogoi, Vinod K Arora, Pankaj Kumar Garg, Rambha PandeyJournal of Cancer Research and Therapeutics 2019 15(6):1398-1401 Extraneural broad ligament ependymoma is a rare entity. Herein, we present a case of unusually large broad ligament ependymoma in a 32-year-old female with pain and lump in the lower abdomen. Contrast-enhanced computed tomography abdomen revealed multiple heterogeneously enhancing pelvic masses with lobulated surface in bilateral adnexa along with multiple peritoneal nodules. Her relevant serum tumor markers were unremarkable. Core biopsy revealed tumor composed of e...
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Anita Kumari Preeti Diwaker Priyanka Gogoi Vinod K Arora Pankaj Kumar Garg Rambha Pandey Source Type: research

A diagnostic dilemma: A rare case of an ovarian carcinoma with signet ring cells hidden behind a substantial dermatomyositis
Asim Armagan Aydin, Hulya Ayik, Arif Hakan Onder, Banu Ozturk, Mustafa YildizJournal of Cancer Research and Therapeutics 2019 15(6):1395-1397 Dermatomyositis (DM) is a malignancy-associated inflammatory connective tissue disease which involves muscles and skin. It accompanies many cancer types. Herein, we aimed to present a 42-year-old patient with primary signet ring cell ovarian carcinoma which has not been seen hitherto. Presentation with DM induces rapid and aggressive progression and emphasizes the importance of more comprehensive malignancy screening in these patients. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Asim Armagan Aydin Hulya Ayik Arif Hakan Onder Banu Ozturk Mustafa Yildiz Source Type: research

Primary vaginal malignant melanoma: A rare entity with review of literature
Shailja Puri, Sarita AsotraJournal of Cancer Research and Therapeutics 2019 15(6):1392-1394 Primary vaginal malignant melanoma (PVMM) is an extremely rare tumor of the female genital tract, accounting for only 3% of melanomas of the female genital tract and 0.3%–0.8% of all melanomas in females. Vaginal melanoma is a very aggressive tumor with a 5-year survival rate of 5%–25%. High incidence of recurrence, spread to regional lymph nodes, and distant metastasis are responsible for poor prognosis of PVMM. Grossly, amelanotic melanoma of the vagina may be mistaken for other primary vaginal mal...
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Shailja Puri Sarita Asotra Source Type: research

A phase 2 randomized controlled trial of oral resistant starch supplements in the prevention of acute radiation proctitis in patients treated for cervical cancer
Conclusion: The study did not demonstrate a significant benefit in administering resistant starch over and above normal diet to patients receiving pelvic radiotherapy. The reasons may be attributed to concurrent use of chemotherapy and decrease in intestinal probiotics. The use of digestible starch in the control arm may have contributed to lower incidence of the toxicity endpoints as well. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Balu Krishna Sasidharan Balamurugan Ramadass PN Viswanathan Prasanna Samuel Mahasampath Gowri Srinivasan Pugazhendhi Balakrishnan S Ramakrishna Source Type: research

Adjuvant radiotherapy for uterine carcinosarcoma: A retrospective assessment of treatment outcomes
Conclusions: Surgery and adjuvant RT seem beneficial for excellent LRC rate. However, survival rates are low due to distant metastases. Thus, there is a great need for better systemic therapies. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Ugur Yilmaz Senem Alanyali Arif Bulent Aras Zeynep Ozsaran Source Type: research

Study of the effects of dwell time deviation constraints on inverse planning simulated annealing optimized plans of intracavitary brachytherapy of cancer cervix
Conclusions: One of the benefits of applying DTDC constrained in IPSA plan is that, it removes local hot spots. It's another advantage is the reduction in rectum and bladder dose. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 24, 2019 Category: Cancer & Oncology Authors: Saurabh Roy V Subramani Kishore Singh Arun Kumar Rathi Arora Savita Aggarwal Aditi Source Type: research