Bacillus Calmette & #8211;Gu & #233;rin-induced perinuclear antineutrophil cytoplasmic antibodies associated vasculitis in bladder cancer
Sibel Yucel Kocak, Aysegul Kudu, Suheyla ApaydınJournal of Cancer Research and Therapeutics 2021 17(2):609-612 Intravesical instillation of Bacillus Calmette–Guérin (BCG) immunotherapy remains the most effective adjuvant treatment for noninvasive bladder cancer. Systemic BCG-related complications are rare and usually related to infective agent or an immune-mediated reaction. We discussed a case with perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) vasculitis, developing after instillation of BCG for non-invasive bladder cancer. A 68-year-old man presented with nephritic syndrome a few months afte...
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Sibel Yucel Kocak Aysegul Kudu Suheyla Apayd & #305;n Source Type: research

Kaposi sarcoma of the adrenal gland: A report of two cases with a review of the literature
We describe two cases of primary adrenal KS to report on this exceptional presentation of KS: the first case is a 67-year-old female with anaplastic KS wit fatal outcome. The second case is a 56-year-old male who presented a classic KS of the adrenal gland. Until now, no standard efficient treatment regimens have been clearly identified. There is a need for a further understanding of anaplastic KS's biology, and collecting a sizable patient cohort remains essential to review treatment outcome. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Sabrine Derqaoui Kaoutar Znati Zakia Bernoussi Source Type: research

A rare case of giant chromophobe renal cell carcinoma with sarcomatoid differentiation: Treatment and prognosis
Ketan Mehra, Ramanitharan Manikandan, Lalgudi Narayanan Dorairajan, Jinkala SreerekhaJournal of Cancer Research and Therapeutics 2021 17(2):602-605 Chromophobe renal cell carcinoma (RCC) with sarcomatoid differentiation is an infrequent entity. In the current era of advanced imaging techniques, RCCs are usually detected in early stages, and a localized giant tumor is rarely encountered. Recently, we encountered a patient with a localized giant RCC, which was 36 cm in the largest dimension and weighing 5.1 kg, which was resected entirely but presented relapse and succumbed within 3 months of surgery. (Source: Journal of Ca...
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Ketan Mehra Ramanitharan Manikandan Lalgudi Narayanan Dorairajan Jinkala Sreerekha Source Type: research

First case of acrometastases to the wrist reported from penile cancer
We report the first case of a patient with acrometastases to the left wrist reported from penile cancer. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Paulina Cegla Ewelina Konstanty Magdalena Fundowicz Katarzyna Pietrasz Krzysztof Matuszewski Aleksandra Heydrych Tomasz Piotrowski Source Type: research

The prostatic adenocarcinoma with mucinous features: A review of the literature with three case reports
In this study, the treatment and surveillance processes of our three patients with prostatic adenocarcinoma with mucinous features were presented along with a literature review. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Nejdet Karsiyakali Emre Karabay Ugur Yucetas Sevim Baykal Koca Ali Ferruh Akay Mustafa Kadihasanoglu Source Type: research

A rare case of bilateral synchronous renal tumors with different histology successfully treated with bilateral partial nephrectomy
We report one such case in a 45-year-old male patient, who was successfully managed by performing bilateral partial nephrectomy in two sittings. The histopathological examination revealed different histology on each side. Both preservations of renal parenchyma and tumor eradication should be considered in bilateral synchronous sporadic RCC before formulating a therapeutic regime. Management by nephron-sparing surgery approach performed in a staged manner offers adequate cancer-specific survival while ensuring good renal function. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Shashanka Dhanuka Ankit Kayal Tapan Kumar Mandal Jyoti Dhanuka Source Type: research

Primary intratesticular rhabdomyosarcoma, a rare entity: A case report with review of literature
Pavan Kumar Lachi, N Armugham, B Triveni, B Sheela, M Rama KrishnaJournal of Cancer Research and Therapeutics 2021 17(2):590-592 Paratesticular rhabdomyosarcoma is a very rare mesenchymal tumor. It is an intrascrotal tumor that is localized in paratesticular structures such as the epididymis or spermatic cord. Rhabdomyosarcoma is most often observed in children and adolescents, presenting as a painless scrotal mass. An 18-year-old man presented with a painless left scrotal mass and lump abdomen that had evolved over four months. A histological examination of the lesion revealed rhabdomyosarcoma. Chemotherapy with alternat...
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Pavan Kumar Lachi N Armugham B Triveni B Sheela M Rama Krishna Source Type: research

A rare case report of transitional urothelial carcinoma metastasizing to isolated upper cervical lymph node diagnosed on cytology
We report here a case of a 53-year-old male who presented with Level II cervical node enlargement after 5 years of being diagnosed and treated for urothelial carcinoma. The diagnosis of cervical metastasis from urothelial carcinoma was suggested by fine-needle aspiration cytology and confirmed by immunocytochemistry. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Sumaira Qayoom Mala Sagar Divya Goel Madhu Mati Goel Source Type: research

Recurrence of renal cell carcinoma after three decades in an octogenarian: Small molecules adding life to years
We present here a case of RCC with solitary metastasis to the pleura which occurred 32 years after nephrectomy. Our patient is an 86-year-old male who presented to us with a cough of 2 months and a history of having undergone a right nephrectomy 32 years back. Imaging of the chest showed left pleural effusion with a left pleural nodule. Computed tomography-guided fine-needle aspiration cytology from the pleural nodule was suggestive of malignancy with a clear cell morphology, suggestive of clear cell RCC. The patient was started on sunitinib 25 mg once daily. After the 1st month, the patient's performance status improv...
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Arun Philip Annie Jojo Pavithran Keechilat Source Type: research

Radiation cystitis: A late effect of radiotherapy in a patient with cervical rhabdomyosarcoma
In this report, we discuss a review of management strategies for cervical rhabdomyosarcoma and also throw some light on incidence and management of radiation cystitis after pelvic radiotherapy. We discuss the dose independence of radiation cystitis, which can be seen after as low as 4500 cGy of pelvic radiation. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Rituraj Upadhyay SM Carthikeyan Sushmita Pathy Source Type: research

Neuroendocrine carcinoma of prostate presenting with ascites
Nishant Sagar, Pritika Kushwaha, Varuna Mallya, Shyama Jain, Nita Khurana, NS HadkeJournal of Cancer Research and Therapeutics 2021 17(2):577-579 Prostate cancer is a very common cause of morbidity and mortality in India. The commonest type of prostate carcinoma is adenocarcinoma, most of them are confined to prostate at the time of presentation. Bone is the preferred site for metastasis. The following is a case of neuroendocrine carcinoma of prostate arising in a 36 years old male who presented with ascitis and jaundice to the emergency department. The ascitic tap was positive for malignant cells. CECT done to detect pri...
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Nishant Sagar Pritika Kushwaha Varuna Mallya Shyama Jain Nita Khurana NS Hadke Source Type: research

Effect of COVID-19 outbreak on community screening program for cancer prevention: A note from endemic area of cholangiocarcinoma
Sora Yasri, Viroj WiwanitkitJournal of Cancer Research and Therapeutics 2021 17(2):576-576 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Sora Yasri Viroj Wiwanitkit Source Type: research

Positron emission tomography-computed tomography use during the COVID-19 pandemic outbreak
Sibel Goksel, Sema Yilmaz RakiciJournal of Cancer Research and Therapeutics 2021 17(2):574-575 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Sibel Goksel Sema Yilmaz Rakici Source Type: research

Role of glutathione S-transferase P1 polymorphism in early transplant complications in patients undergoing allogeneic stem cell transplantation
Conclusions: TSI was higher in the GSTP1 polymorphism group. GSTP1 polymorphism had no effect on early transplantation complications. Although the OS and TRM ratios were higher in the GSTP1 polymorphism group, no statistically significant difference was found between the groups. Further studies with larger sample size are needed. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Hazen Saritas Elif Suyani Sezen G & #252;ntekin Aki & #350;ahika Zeynep Mehmet Ali Erg & #252;n B & #252;lent & #199;elik G & #252;lsan T & #252;rk & #246;z Sucak Source Type: research

Clinical presentation and course of the novel coronavirus disease 2019 in patients with various types of cancer: A retrospective case & #8211;control analysis of an experienced cancer center in Turkey
Conclusion: Our practices supported that cancer patients were more affected by COVID-19 disease than the normal population. However, our findings can not be generalized due to being retrospective and single centered study, Also, we did not compare the findings with noncancer patients with COVID19 disease. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Ramazan Acar Gulden Yilmaz Umit Savasci Musa Baris Aykan Halil Kiziloz Ferhat Cuce Ekin Kadioglu Mine Filiz Gonca Fidan Sami Eksert Gurhan Taskin Deniz Dogan Yakup Arslan Cant & #252;rk Tasci Neslihan Kayahan Tolga Dogan Bilgin Bahadir Basgoz Erdim Sertog Source Type: research

Strategies to ensure efficient laboratory functioning while navigating through the COVID-19 crisis in developing countries: An early experience from a tertiary care centre in India
Conclusion: We hope this will address the concerns of small to medium sized laboratories and help them build an effective strategy required for protecting the laboratory personnel from risk of exposure and also ensure smooth and optimum functioning of the laboratory services. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Puneet Kaur Somal Sankalp Sancheti Akash Pramod Sali Saloni Bansal Supreet Kaur Kalra Anantika Thakur Neha Gupta Rakesh Kapoor Source Type: research

Impact of the COVID-19 pandemic on health care activities at a Uruguayan mastology unit
Conclusions: The evidence suggests that, although medical appointments decreased by approximately 17%, we could maintain healthcare activities, continued most of the treatments while the most modified was CT with G-CSF to avoid myelosuppression. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Cecilia Castillo Natalia Camejo Dahiana Amarillo Florencia Rodriguez Florencia Vitureira Gabriel Krygier Luc & #237;a Delgado Source Type: research

Duramycin radiosensitization of MCA-RH 7777 hepatoma cells through the elevation of reactive oxygen species
Conclusion: Duramycin increased the intracellular ROS generation and also increased the radiosensitivity of MCA-RH 7777 cells. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Bowen Yang Xiaoke Huang Weiguo Li Samdeep Mouli Robert J Lewandowski Andrew Christian Larson Source Type: research

In vivo study of interferon- & #947;, transforming growth factor- & #946;, and interleukin-4 gene expression induced by radioadaptive response
Conclusion: These results indicate that the immune system plays an important role for radioadaptive response induction by LD radiation to adjust the harmful effects of HD irradiation. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Mohammad-Taghi Bahreyni-Toossi Mojtaba Sankian Hosein Azimian Maryam Najafi-Amiri Sara Khademi Sepideh Abdollahi-Dehkordi Nima Hamzian Source Type: research

A prospective observational study of chemotherapy-induced adverse drug reaction and the quality of life in cancer patients in a tertiary care hospital
Conclusion: Cancer is known to cause a significant impact on the health and socioeconomics of a nation. To boost the QoL in patients, it is essential to identify and manage the ADRs by taking appropriate measures to promote judicious use of drugs. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: D Krishnarajan K Sivasakthi R Ariyamol D Naveen Kumar Soniya Varghese Source Type: research

Daily waiting and treatment times at an advanced radiation oncology setup: A 4-year audit of consecutive patients from single institution
Conclusion: We have presented our results of patient-related times during RT. Our study covers the daily waiting times before RT as well as the actual treatment times during modern-day RT. This consecutive patient data from a large series shall be an important resource tool for future planners and policymakers. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Anusheel Munshi Saneg Krishnakutty Biplab Sarkar Tharmar Ganesh Bidhu K Mohanti Source Type: research

Complementary and alternative medicine in sarcoma patients treated in an Italian sarcoma center
Conclusions: This study shows that CAM use is frequent among adults and pediatric patients with bone and soft tissue sarcoma as in other cancer patients. Moreover, the profile of these Italian CAM consumers in sarcoma patients is similar to other studies. Patients disclosure to their oncologist or physician about the use of CAM was similar to other Italian studies, but higher compared to other international studies. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Alessandra Longhi Elisabetta Setola Cristina Ferrari Elisa Carretta Source Type: research

The relation between inflammation-based parameters and survival in metastatic pancreatic cancer
Conclusion: We determined, age, CA19-9, and basal high NLR as independent adverse prognostic factors for OS in APC. Fluorouracil, leucovorin, irinotecan, and oxaliplatin CT resulted in a significant increase in OS. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Sema Turker Ebru Cilbir Deniz Can Guven Cengiz Karacin Suayib Yalcin Source Type: research

Inhibitory effect of Bowman & #8211;Birk protease inhibitor on autophagy in MDAMB231 breast cancer cell line
Conclusion: According to our results, BBI could inhibit autophagy and induce apoptosis in MDA-MB-231 cell line. Thus, BBI may be used as a therapeutic drug in the treatment of breast cancer whether alone or with chemotherapeutic drugs. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Sudabeh Kyani Hassan Akrami Ali Mostafaei Samaneh Akbari Zohreh Salehi Source Type: research

Anticancer, antioxidant, and hepatoprotective activity of Saussurea lappa, C.B. clarke (qust) on human hepatoma cell line
Conclusion: The observed effect substantiated the anti-cancerous, antioxidant, and hepatoprotective activity of SLEs in HepG2 Cells. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Shabnam Ansari Kazim Hasan Sajad Bhat Source Type: research

Antitumor activity of Albizia lebbeck L. against Ehrlich ascites carcinoma in vivo and HeLa and A549 cell lines in vitro
Conclusion: The results showed that the ethanolic extract of A. lebbeck L. has a powerful antitumor activity because it was effective in significantly inhibiting the tumor growth in both in vivo and in vitro cancer cell lines. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Chilaka Naga Kavitha K Dilip Raja S Krishna Rao Source Type: research

Evaluation of antiangiogenic and antiproliferative potential of ethanolic extracts of Andrographis echioides using in vitro and in ovo assays
Conclusion: EEAE possessed significant antiangiogenic and antiproliferative activity, making them a promising substrate in the development of a novel anticancer drug and can be successfully used in the therapy of various cancers after establishment of the anticancer effects in animal models and subsequently in clinical trials. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Karthiga Muralidharan Punnagai Kumaravelu Darling Chellathai David Source Type: research

Racial/ancestral diversity in 174 toxicity-related radiogenomic studies: A systematic review
Conclusion: Most toxicity-related radiogenomic studies involved a single race/ancestry. Individual Participant Data meta-analyses or multinational studies need to be encouraged. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Siti Hajar Zuber Noorazrul Yahya Source Type: research

Antiproliferative capacity of combined extracts from Paramignya trimera and Phyllanthus amarus against cancer cell lines
Van Tang NguyenJournal of Cancer Research and Therapeutics 2021 17(2):471-476 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Van Tang Nguyen Source Type: research

Dosimetric impact of dwell time deviation constraint on inverse brachytherapy treatment planning and comparison with conventional optimization method for interstitial brachytherapy implants
Conclusions: One of the benefits of applying DTDC in IPSA-optimized plan is that it reduces high-dose volumes. Another advantage is the reduction in rectum and bladder dose. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Saurabh Roy V Subramani Kishore Singh Arun Kumar Rathi Source Type: research

Radiotherapy plan evaluation indices: A dosimetrical suitability check
Conclusion: CI, which has assimilated the presence of OAR in their formulation, shows more reliability in plan evaluation. Sigma index was found to be more efficient formula while evaluating homogeneity of a treatment plan. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Ganeshkumar Patel Abhijit Mandal Ravindra Shende Avinav Bharati Source Type: research

Evaluating the effects of metal artifacts on dose distribution of the pelvic region
Conclusion: For the precise implementation of the treatment and in order to minimize the systematic errors related to the calculated MUs, necessary corrections on the electron density of metal artifacts should be considered before the treatment planning. The issue will be more critical in advanced treatment modalities where dose escalation is needed. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Nooshin Banaee Mehdi Salehi Barough Sepideh Asgari Elham Hosseinzadeh Ehsan Salimi Source Type: research

Frequency and risk factors of bleomycin-induced pulmonary toxicity in South Indian patients with germ-cell tumors
Conclusions: The frequency of BPT in the study population is 27%, and cumulative bleomycin dose ≥240 mg has been found to be associated with increased risk of developing BPT. BPT does not negatively impact survival outcome in GCT patients receiving BEP regimen. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Dimpal N Thakkar Kesavan Ramasamy Subathra Adithan Sandhiya Selvarajan Biswajit Dubashi Source Type: research

Prognostic and clinicopathologic value of ki-67 and profilin 1 immunohistochemical expression in primary pT1 urothelial bladder cancer
Conclusions: Ki-67 is a highly predictive biomarker for recurrence-free, progression-free, and cancer-specific survival in pT1 bladder cancer patients, in whom prediction of recurrence and progression are difficult. Ki-67 expression can be safely combined with other prognostic factors. However, in pT1 bladder cancer patients, no significant relationship was found between profilin 1 expression and tumor characteristics or prognostic parameters. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Meftun Culpan Turgay Turan Sidika Seyma Ozkanli Tulay Zenginkinet Ozgur Kazan Taha Ucar Gokhan Atis Turhan Caskurlu Asif Yildirim Source Type: research

Diagnostic accuracy of Raman spectroscopy for the diagnosis of bladder cancer: A systematic review and meta-analysis
Conclusions: RS showed the potential to be an efficient tool with high accuracy for detecting malignant bladder lesions. More studies with in vivo real-time settings are warranted to validate our results. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Do Kyung Kim Yon Hee Kim Hyun Young Lee Soomin Lee Seung Whan Doo Won Jae Yang Yun Seob Song Ki Hyun Kim Jae Heon Kim Source Type: research

Differential effect of body mass index by gender on oncological outcomes in patients with renal cell carcinoma
Conclusions: Increasing BMI was associated with RCC prognosis. However, the clinical association between BMI and oncologic outcomes may be different between men and women. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Melih Balci Zachary A Glaser Sam S Chang S Duke Herrell Daniel A Barocas Kirk A Keegan Kelvin A Moses Matthew J Resnick Joseph A Smith Jr. David F Penson Kristen Scarpato Peter E Clark Source Type: research

Active surveillance in renal tumors: Clinical and oncological outcomes
Conclusions: AS is a reasonable and safe option for the management of small renal masses. No difference was observed in the growth rate between solid and complex cystic lesions during AS. Centers offering AS should present a standardized protocol and give exhaustive information to patients regarding benefits and risks. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Alfredo Aguilera Bazan Diego M Carrion Juan Gomez Rivas Jose Quesada-Olarte Luis M Quintana Mario Alvarez-Maestro Luis Mart & #237;nez-Pi & #241;eiro Source Type: research

Ezrin is a prognostic biomarker in patients with clear cell metastatic renal cell carcinoma receiving sunitinib
Conclusion: This is the first study in the literature showing that ezrin status is related with prognosis in patients with metastatic ccRCC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Bulent Cetin Ipek Isik Gonul Ozge Gumusay Baris Afsar Irem Bilgetekin Ahmet Ozet Aytug Uner Source Type: research

FCX, an arylidene derivative, induces apoptosis in androgen receptor-selective prostate cancer cells
Conclusions: Together with the results, it is evident that FCX has a wide therapeutic window in the in vitro inhibition of the prostate cancer cells mediated by hormone-dependent effects. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Rajagopalan Prasanna Ashraf A Elbessoumy Harish C Chandramoorthy Ayed Dera Majed Al Fayi Source Type: research

Zinc oxide nanofluids: The influence of modality combinations on prostate cancer DU145 cells
Conclusion: The results indicate that ZnO nanofluids in the presence of UVA irradiation could increase DOX efficiency in DU145 cells, suggesting such modality combinations as a promising approach in cancer treatment. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Afsaneh Azhdari Razieh Jalal Source Type: research

Addition of docetaxel or abiraterone to androgen deprivation therapy in metastatic hormone-sensitive prostate cancer in Indian population
Alok Gupta, Shaik Maheboob Hussain, Neha Sonthwal, Harit ChaturvediJournal of Cancer Research and Therapeutics 2021 17(2):389-392 Background: The addition of docetaxel or abiraterone to androgen deprivation therapy (ADT) achieves superior survival outcomes in metastatic hormone-sensitive prostate cancer (mHSPC) in predominantly Western population. We sought to evaluate the treatment outcomes of adding docetaxel or abiraterone to ADT in Indian population. Methods: We reviewed the medical records of ninety patients with newly diagnosed mHSPC who received treatment between January 2015 and June 2018. Patients received ADT a...
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Alok Gupta Shaik Maheboob Hussain Neha Sonthwal Harit Chaturvedi Source Type: research

Rectal wall sparing effect of a rectal retractor in prostate intensity-modulated radiotherapy
Conclusion: The application of a RR showed a remarkable rectal sparing effect during prostate IMRT. This may lead to reduced acute and late rectal toxicities in prostate IMRT. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Hamed Ghaffari Aram Rostami Mahdieh Afkhami Ardekani Bahram Mofid Seied Rabi Mahdavi Source Type: research

To evaluate volume changes on computerized tomography scan and magnetic resonance imaging-based delineation during radiotherapy treatment planning in prostate cancer
Conclusions: It can be concluded that MRI is found to be a better modality for GTV delineation, as it gives superior soft-tissue contrast. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Anil Sarolkar Shashank N Singh Priyusha Bagdare Virendra Bhandari Ashar Iqbal Lodi Sarthak Moharir Source Type: research

Can combined multiparametric magnetic resonance imaging of the prostate and prostate-specific antigen density improve the detection of clinically significant prostate cancer: A prospective single-center cross-sectional study
Conclusion: Both PIRADS v2 score and PSA density are eminently sensitive and specific in the detection of clinically significant prostate cancers individually. However the combination of PIRADS v2 and PSA density significantly improved the accuracy of clinically significant prostate cancer detection. Patients with combination of PIRADS v2 score 33 and PSA density 30.15 ng/ml/cc should undergo prostate biopsy. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Kuldeep Yadav Binit Sureka Poonam Elhence Gautam Ram Choudhary Himanshu Pandey Pawan Kumar Garg Taruna Yadav Pushpinder Singh Khera Source Type: research

Helical tomotherapy for prostate cancer radiation therapy: An audit of early toxicity and quality of life
Conclusion: Our initial clinical experience with helical tomotherapy in CaP confirms lower rate of toxicities and no significant worsening of QOL with RT. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Beena Kunheri JS Lakshmi Greeshma C Ravindran Haridas Vishal Marwaha Source Type: research

11C-choline positron emission tomography/computed tomography for detection of disease relapse in patients with history of biochemically recurrent prostate cancer and prostate-specific antigen & #8804;0.1 ng/ml
Conclusions: Surveillance11 C-choline PET/CT can detect early disease relapse at serum PSA ≤0.1 ng/ml in patients with a history of BCR PCa. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Ishan Garg Mark A Nathan Ann T Packard Eugene D Kwon Nicholas B Larson Val Lowe Brian J Davis Rimki Haloi Mindie L Mahon Ajit H Goenka Source Type: research

Ultrasound-guided transrectal implantation of fiducial markers for image-guided radiotherapy of prostate cancer without local anesthesia: Patient-reported gastrointestinal & #8211;genitourinary system complications and pain
Conclusion: IGRT accompanied by an ultrasound-guided implantation of fiducial markers without local anesthesia can be considered a safe method, given the associated acceptable levels of pain, low side effect profiles, and high prostate-specific antigen control rates. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Cenk Ahmet Sen Source Type: research

Calculation of radium-223 and actinium-225 & #945;-emitter radiopharmaceuticals dose rates in treatment of metastatic castration-resistant prostate cancer
Conclusion: The absorbed dose in the body organs due to 223Ra and 225Ac α-emitter radiopharmaceuticals which are used in metastasized castration-resistant prostate cancer (mCRPC), calculated in this study. The results of this study will assist in evaluating and analyzing human body organ doses from application of 223Ra and 225Ac that used in mCRPC patients. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Akbar Abbasi Mehdi Dadashpour Iraj Alipourfard Source Type: research

Prostate permanent implant brachytherapy with BARC I-125 Ocu-Prosta seeds
Conclusions: Low dose rate permanent implant brachytherapy has the advantage of being a one-time procedure and the existing long term follow-up supports its excellent outcome and low morbidity. BARC-BRIT is supplying the loose 125I seeds. These seeds can be easily implanted into the patient using Mick applicator. However, the pre-implant seed preparation and implant procedure may result some radiation exposure to staff involved. The radiation dose can be minimized with good practice. This report is one patient pilot study and intended to test the implant systems and standard operative procedure henceforth for permanent imp...
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: Siddanna R Palled Sathiyan Saminathan Tanvir Pasha T Naveen KM Ganesh V Lokesh Source Type: research

Magnitude and pattern of various cancers from tertiary health care center registry: A study in three southern states of India
H Magesh Rajan, S Mageswari, K Gayathri, S Satish, M Baluswamy, T Vijayapushpam, R VijayaprabhaJournal of Cancer Research and Therapeutics 2021 17(2):336-339 Many research studies have looked into the epidemiological aspects including various potential risk factors associated with cancers, namely environmental, dietary, genetic, and hormonal. The present article studies the magnitude and pattern of various cancers registered at tertiary health-care centers in three South Indian states. Data from hospital-based cancer registries compiled by the ICMR-National Centre for Disease Informatics and Research for the time periods ...
Source: Journal of Cancer Research and Therapeutics - June 11, 2021 Category: Cancer & Oncology Authors: H Magesh Rajan S Mageswari K Gayathri S Satish M Baluswamy T Vijayapushpam R Vijayaprabha Source Type: research