Helicobacter pylori infection and pancreatic cancer
Amin Talebi Bezmin AbadiJournal of Cancer Research and Therapeutics 2020 16(8):253-253 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Amin Talebi Bezmin Abadi Source Type: research

Dermatomyositis: Look beyond skin
Karthik K Prasad, Manish S Bhatia, Nagesh T SirsathJournal of Cancer Research and Therapeutics 2020 16(8):251-252 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Karthik K Prasad Manish S Bhatia Nagesh T Sirsath Source Type: research

Paraoxonase and arylesterase are the same enzyme in humans
Mike MacknessJournal of Cancer Research and Therapeutics 2020 16(8):250-250 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Mike Mackness Source Type: research

Isolated dural metastasis of follicular carcinoma of the thyroid presenting as scalp swelling
Vikram Singh, Apinderpreet Singh, Sanjay Kumar Bhadada, Ritambhra NadaJournal of Cancer Research and Therapeutics 2020 16(8):248-249 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Vikram Singh Apinderpreet Singh Sanjay Kumar Bhadada Ritambhra Nada Source Type: research

Risk of cancer due to flower garland for offering in religious practice
Sora Yasri, Viroj WiwanitkitJournal of Cancer Research and Therapeutics 2020 16(8):246-247 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Sora Yasri Viroj Wiwanitkit Source Type: research

Brain atypical teratoid rhabdoid tumor in an adult with long-term survival: Case report and review of literature
We report the case of a 24-year-old male who was diagnosed with left parietal AT/RT after total resection and who is still in good health and recurrence free 4 years after surgery and adjuvant chemotherapy and radiotherapy. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Rim Moujahed Khalil Ghedira Alia Zehani Slim Charfi Sonia Nagi Source Type: research

F-18 fluorodeoxyglucose positron emission tomography/computed tomography in conjunctival melanoma with recurrence
Anurag Jain, Arun Ravi John, Braj Kishore, MG Vishnoi, Aniruddha G Pandit, Amit Sharma, Abhinav Jaimini, Mayuri Jain, Anirudh SinghJournal of Cancer Research and Therapeutics 2020 16(8):240-242 Ocular melanoma is classified under the category of noncutaneous melanomas. Noncutaneous melanomas are relatively rare. Ocular melanoma commonly arises from choroid. Conjunctival melanoma is a rare but potentially lethal form of ocular melanoma. It can invade locally. Systemic spread is seen in up to 25% of cases, often associated with lymph node involvement. Metastatic sites include the lungs, liver, gastrointestinal tract, an...
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Anurag Jain Arun Ravi John Braj Kishore MG Vishnoi Aniruddha G Pandit Amit Sharma Abhinav Jaimini Mayuri Jain Anirudh Singh Source Type: research

Gastric signet ring cell carcinoma presenting with widespread osteoblastic metastases
Ayşegül İdil Soylu, Eylem Odabaşı, Seda Gün, Mustafa Bekir SelçukJournal of Cancer Research and Therapeutics 2020 16(8):237-239 Gastric cancer infrequently metastasizes to the bone. These metastases are generally osteolytic. On the other hand, osteoblastic metastases are very rare. In this case report, a patient with signet ring cell gastric carcinoma presenting with diffuse osteoblastic bone metastases who had no laboratory abnormalities at the time of diagnosis is described. To our knowledge, our patient represents the longest surviving case compared with the similar cases in literatur...
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Ay & #351;eg & #252;l & #304;dil Soylu Eylem Odaba & #351; & #305; Seda G & #252;n Mustafa Bekir Sel & #231;uk Source Type: research

Epithelial & #8211;myoepithelial carcinoma at the base of the tongue presented with metastatic disease in the absence of myoepithelial anaplasia
Mahima Yadav, Neha Gupta, Richa Katiyar, Shashikant C U. PatneJournal of Cancer Research and Therapeutics 2020 16(8):233-236 Epithelial–myoepithelial carcinoma (EMC) is a biphasic low-grade malignant tumor that shows ductal structures lined by the ductal cells with surrounding myoepithelial cells. EMC is most commonly reported in the parotid gland followed by other major and minor salivary glands. EMC of the tongue is an extremely uncommon tumor, with only five previously published case reports. We herein report the sixth case of EMC of the tongue. A 40-year-old female who had throat pain, dysphagia, and right earac...
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Mahima Yadav Neha Gupta Richa Katiyar Shashikant C U. Patne Source Type: research

Radiation-induced leiomyosarcoma of oral cavity: Two cases with a review of literature
We report two such cases who presented with swelling in the oral cavity with a history of moderately differentiated squamous cell carcinoma. Both cases prior to the diagnosis of LMS had been managed with surgery and radiation therapy and later developed swelling in the oral cavity. The management of LMS is uncertain; hence, this article aims to spread awareness about this rare diagnosis and to know the importance of differentiation from other more common lesions including recurrence. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Nishant Sagar Meeta Singh Neelakshi Goyal Nita Khurana Kishore Singh Ravi Meher Source Type: research

Ten years and counting: Survival in stage IV metastatic squamous cell carcinoma of anal canal following radical treatment
Shaurav Maulik, Vinod Hande, Reena Engineer, Umesh MahantshettyJournal of Cancer Research and Therapeutics 2020 16(8):227-229 A 60-year-old male ptient presented with a 2-month history of altered bowel habits and occasional bleeding per rectum. On evaluation, he was diagnosed with squamous cell carcinoma of the anal canal (SCCAC) with an isolated hepatic lesion in segment II estimated as 4.3 cm × 3.5 cm on ultrasound. Subsequent needle biopsy confirmed metastatic squamous cell carcinoma deposits. The final diagnosis was SCCAC, cT4N1M1 (Stage IV). The patient was offered radical intent treatment. As per institutional ...
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Shaurav Maulik Vinod Hande Reena Engineer Umesh Mahantshetty Source Type: research

Preoperative diagnosis of pancreatic schwannoma & #8211; Myth or reality
Vaibhav Kumar Varshney, Taruna Yadav, Poonam Elhence, Binit SurekaJournal of Cancer Research and Therapeutics 2020 16(8):222-226 Pancreatic schwannoma is a rare, well-encapsulated tumor of the pancreas. Preoperative diagnosis of this tumor is uncommon due to marked degenerative change, its rarity, and overlapping clinical and imaging features with other pancreatic neoplasms. Here, we report two cases of pancreatic schwannoma, suspected preoperatively based on their multimodal imaging features, so that enucleation was possible. Extensive pancreatic surgeries can be avoided if imaging can provide clues about the benign natu...
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Vaibhav Kumar Varshney Taruna Yadav Poonam Elhence Binit Sureka Source Type: research

Diffuse peritoneal leiomyomatosis: An exceptional entity in a male patient
Hajar Khibri, Amal Bousseaden, Badreddine Alami, Saïd Boujraf, Samira RabhiJournal of Cancer Research and Therapeutics 2020 16(8):217-222 Diffuse peritoneal leiomyomatosis is a benign peritoneal tumor which develops from smoother muscular fibers. It is a rare entity in females undergoing hormonal effects. This pathological entity is exceptional in male patients. Hence, we report a unique case of diffuse peritoneal leiomyomatosis that occurred in a male patient without hormonal stimulations. The etiopathology and genesis are not completely elucidated. Besides, the clinical symptoms are not specific. The positive diagn...
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Hajar Khibri Amal Bousseaden Badreddine Alami Sa & #239;d Boujraf Samira Rabhi Source Type: research

Radiation-induced neovascular glaucoma: A devastating disease
This report is aimed to discuss a case of NVG caused secondary to radiotherapy (RT) given for a nasal malignancy. A 50-year-old male presented with enophthalmos, dry eye, and NVG 3 years after receiving RT for chondrosarcoma of nasal and paranasal cavities. He was given topical antiglaucoma medications, retinal laser, and intravitreal bevacizumab injection and thus prevented the eye from becoming a painful blind eye. The radiation oncologist and ear, nose, and throat specialists have to liaise closely with ophthalmologist when patients receive radiation involving the eye in the treatment field to prevent, diagnose, and tre...
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Megha Gopalakrishna Kavitha Srinivasan Venkatesh Rengaraj Source Type: research

Fungal profile and antifungal susceptibility pattern of candidiasis in esophageal cancer patients
Conclusion: The present study revealed the emergence of multidrug-resistant, nonalbicans Candida isolates in cancer esophagus patients with candidiasis in northeast India. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Abhijit Talukdar Rashmisnata Barman Anupam Sarma Manigreeva Krishnatreya Jagannath Dev Sharma Amal Chandra Kataki Source Type: research

Lutetium therapy-induced carcinoid crisis: A case report and review of literature
Sanjay Kumar Yadav, Chandan Kumar Jha, Shrinivas Patil, Deepanksha Datta, Anjali Mishra, PK PradhanJournal of Cancer Research and Therapeutics 2020 16(8):206-208 Peptide receptor radionuclide therapy with 177lutetium (Lu)-labeled somatostatin analogs is a promising new tool in the management of patients with inoperable or metastatic neuroendocrine tumors. Some of these patients may present with carcinoid syndrome and it is known that rarely carcinoid crisis can be precipitated by surgical or other interventions in these patients. However, there are anecdotal reports of carcinoid crisis after Lu-labeled peptide therapy. We...
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Sanjay Kumar Yadav Chandan Kumar Jha Shrinivas Patil Deepanksha Datta Anjali Mishra PK Pradhan Source Type: research

Single-nucleotide polymorphisms in dendritic cell (dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin) gene of hepatocellular carcinoma patients from India
Conclusion: Mutation in the promoter region of the DC-SIGN gene may be a possible risk factor for the development of HCC in India. The findings of the study reveal the possible role of these mutants with HCC, and future large-scale prospective studies will further validate the findings of the current study. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Manash Pratim Sarma Dipu Bharali Akan Das Minakshi Bhattacharjee Premashis Kar Source Type: research

Long-term oncologic and complication outcomes in anal cancer patients treated with radiation therapy
Conclusion: Despite moderately high radiation doses, local recurrence, and late complications were problems in treating anal cancer. In the intensity-modulated radiotherapy era, consensus on accurate target volume based on the pattern of failure analysis is required. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Ji Hyeon Joo Jin-hong Park Sang Min Yoon Jin Cheon Kim Chang Sik Yu Tae Won Kim Jong Hoon Kim Source Type: research

Preoperative neutrophil-to-lymphocyte ratio as a predictive factor for survival in nonmetastatic colorectal cancer
Conclusion: A preoperative NLR of more than 2.8 might be an independent predictor for OS in patients with CRC. This simple and routinely available laboratory parameter may be used as a useful marker for identifying patients with a worse prognosis. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Kaptan G & #252;lben U & #287;ur Berbero & #287;lu Bahad & #305;r & #214;nde & #351; Osman Uyar Onur Can G & #252;ler Sevim Turanl & #305; Source Type: research

A study on the frequency and clinicopathological correlates of mismatch repair-deficient colorectal cancer
Conclusions: dMMR tumors in our study were more common in males, presented earlier, were bulky, were less likely to show lymphovascular or perineural invasion, had lower preoperative carcinoembryonic antigen levels, and yielded high number of lymph nodes. Expected differences in age, stage, and grade were not observed. Compared to other studies, a higher proportion of cases in our study had MSH2 and PMS2 loss. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Paraashar R Rai Nishitha Shetty Pareekshith R Rai Dinesh Shet Arpitha Shetty Source Type: research

The effect of body mass index on location of recurrence and survival in early-stage colorectal cancer
Conclusion: In this study, we observed that the high BMI increased the risk of recurrence, especially in Stage III CRC patients, and that the recurrence frequently occurred locally. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Abdullah Sakin Nilay Sengul Samanci Saban Secmeler Serdar Arici Orcun Can Nurgul Yasar Caglayan Geredeli Cumhur Demir Sener Cihan Source Type: research

Increased incidence of young age presentation of colorectal carcinoma: A tertiary cancer hospital study
Conclusions: Study shows that there is a rise in younger age presentation in our institution with rectal site predominance, advanced stage, and poor histopathological variants. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Pandu Ranga Kumari Motepalli Rajya Lakshmi Nukala Source Type: research

Downregulation of human leukocyte antigen Class I expression: An independent prognostic factor in colorectal cancer
Conclusions:HLA Class I expression is an independent and sensitive clinical prognostic marker that might be used in CRC patients. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Ehsan Nazemalhosseini-Mojarad Hamid Asadzadeh-Aghdaei Somayeh Mohammadpour Amir Torshizi Esfahani Mohammad Amin Porhoseingholi Mahsa Molaei Amir Jalali Peter J K. Kuppen Mohammad Reza Zali Source Type: research

Sentinel lymph node mapping in colorectal cancers with radioactive tracer; is it an efficient method ?
Conclusions: We used the same traditional method in both the groups, and our sensitivity, accuracy and upstaging rate were fewer than similar studies. Our recommendation for further studies is to use intensive SLN biopsy method in both groups of SLNs and non-SLNs. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Seyed Hassan Babaee Mehdi Jabbari Nooghabi Ramin Sadeghi Abbas Abdollahi Amer Falsafi Mehrdad Fakhlaei Zahra Gholami Source Type: research

LRFN2 gene variant rs2494938 provides susceptibility to esophageal cancer in the population of Jammu and Kashmir
Conclusion: The study highlights LRFN2 as a candidate gene for esophageal cancer susceptibility in the population of J&K and calls for a detailed study with a large sample size and involving more ethnic groups of India. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Ruchi Shah Varun Sharma Hemender Singh Indu Sharma Gulzar Ahmed Bhat Idrees Ayoub Shah Beenish Iqbal Rumisa Rafiq Najma Nissa Mansha Muzaffar Malik Tariq Rasool Ghulam Nabi Lone Sandeep Kaul Mohd Maqbool Lone Ekta Rai Nazir Ahmed Dar Swarkar Sharma Source Type: research

Human papillomavirus infection and p53 mutation in esophageal squamous cell carcinoma and its impact on treatment outcome
Conclusion: Clinical findings of our result can be used to sum up that both HPV infection and p53 mutation status are reliable biomarkers and can help clinicians to predict treatment outcome and prognosticate patients better. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Tanmay Singh Nadia Shirazi Saurabh Bansal Meenu Gupta Sunil Saini Mushtaq Ahmad Source Type: research

The hematologic inflammatory index is a new prognostic marker in patients resected for gastric cancer
Conclusions: In this retrospective study, HII is independently associated with both DFS and OS in gastric cancer. HII is an inexpensive, powerful, and easily accessible prognostic marker. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Hayriye Sahinli Sema T & #252;rker Source Type: research

A retrospective evaluation of geriatric patients with gastric cancer receiving systemic chemotherapy
Conclusion: Advanced age chemotherapy receiving rates in patients with metastatic gastric cancer is decreasing. Survival is not associated with age, but pretreatment ECOG PS is important. Therefore, ECOG PS and comorbidities should be evaluated in detail, and combination therapies could contribute to patient survival. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Ali Murat Tatli Zuhat Urakci Didem Tastekin Dogan Koca Sema Sezgin Goksu Ummugul Uyeturk Mehmet Ali Kaplan Hasan Senol Coskun Source Type: research

Dosimetric comparison of modern radiotherapy techniques for gastric cancer after total gastrectomy
Conclusion: In comparison of the four techniques, 3D seems to be the most unsuitable method regarding sparing the normal tissues. According to availability, HT and VMAT should be primarily preferred. IMRT can also be used with carefully paying attention to the clinical condition of the patient. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Pelin Altinok Ertugrul Tek & #231;e Fatih Karak & #246;se Kemal Berk & #220;mm & #252;han Kalafat Huriye Senay Kiziltan Z & #252;leyha Akg & #252;n Alpaslan Mayadagli Source Type: research

Is there any relationship between Helicobacter pylori infection and human epidermal growth factor receptor 2 expression in gastric cancer ?
Conclusions: Our results suggest that there is no relationship between HP infection and HER2 status in patients with GC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Efnan Algin Meltem Baykara Guldal Yilmaz Bulent Cetin Ozgur Ekinci Aytug Uner Ahmet Ozet Source Type: research

Clinical impact of adjuvant chemotherapy and radiation for carcinoma stomach: Experience from a tertiary care center
Conclusion: Adjuvant chemotherapy and radiation using conformal technique are well-tolerated. These were reflected in the overall outcome and survival of the patients. Based on the surgical pathology findings, an individualized approach of adjuvant treatment protocol can improve the outcome. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Jomon Raphael Chalissery T Anilkumar Jose Sreekumar Pillai Harikumar Unni K Mathew Varghese G Paul Gopu K Venkatesan Source Type: research

The age-adjusted Charlson comorbidity index is an independent prognostic factor in pancreatic cancer patients who receive curative resection followed by adjuvant chemotherapy
Conclusions: The ACCI was a risk factor for the OS in patients who underwent curative surgery followed by adjuvant chemotherapy for pancreatic cancer. An effective plan is needed for determining the optimum surgical strategy according to the ACCI. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Toru Aoyama Naoto Yamamoto Mariko Kamiya Masaaki Murakawa Hiroshi Tamagawa Sho Sawazaki Masakatsu Numata Satoshi Kobayashi Makoto Ueno Manabu Morimoto Manabu Shiozawa Norio Yukawa Takashi Oshima Takaki Yoshikawa Yasushi Rino Munetaka Masuda Soichiro Morin Source Type: research

Circulating annexin A2 as a biomarker in patients with pancreatic cancer
Conclusions: AnxA2 is identified as a novel secretory biomarker for PC, but it has no role as a prognostic or predictive marker. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Mehmet Karabulut Cigdem Usul Afsar Murat Serilmez Senem Karabulut Source Type: research

Demographic and clinicopathological profile of patients of gastrointestinal stromal tumor from a tertiary care center of North India: An observational study
Conclusions: Patients who underwent upfront surgery followed by adjuvant imatinib has shown good response to the treatment. However, the limitation of the small sample size and short follow-up in this study may not be a true data representation of the entire population (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Mayank Aggarwal Archana Aggarwal Savita Arora Arun Kumar Rathi Kishore Singh Source Type: research

Prognostic and predictive factors in cancer patients with obstructive jaundice treated by percutaneous transhepatic biliary drainage: A single-center experience
Conclusion: Lower serum PLT level following PTBD is associated with the short-term survival. Survival of patients who are not able to receive chemotherapy after PTBD, having a low level of serum albumin, and patients with liver metastasis were shorter. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Hayriye Sahinli Ahmet & #214;zet Source Type: research

Therapeutic results of Denver percutaneous peritoneovenous shunt in cancer patients with malignant ascites
Conclusions: The Denver shunt for malignant ascites is useful for improving patients' quality of life if the indications are selected properly. Drainage of intraoperative ascites was a risk factor for postoperative complications after the Denver shunt technique in cancer patients with malignant ascites. Further experience and discussion are necessary to establish the patient selection criteria. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Hiroshi Tamagawa Toru Aoyama Hirohide Inoue Hirohito Fujikawa Sho Sawazaki Masakatsu Numata Tsutomu Sato Takashi Oshima Norio Yukawa Manabu Morimoto Makoto Ueno Yashushi Rino Munetaka Masuda Source Type: research

Bioinformatics analysis of regulated MicroRNAs by placental growth factor signaling in cancer stem cells
Conclusions: Bioinformatic analysis revealed that regulatory miRNAs and their target genes in PlGF pathway played important roles in the progression of CSCs-related signaling pathways. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Zohreh Salehi Hassan Akrami Homeyra Seydi Source Type: research

Antiangiogenic activity of zinc and zinc-sorafenib combination using the chick chorioallantoic membrane assay: A descriptive study
Conclusion: Zinc caused significant antiangiogenic activity in the CAM assay. The lack of addition/synergism in the zinc-sorafenib combination could have been due to the variability in the dose/ratio selection. Addition of zinc to sorafenib therapy could improve treatment tolerability, reduce cost of therapy, and reduce the emergence of drug resistance. Future mechanistic studies could identify the exact pharmacodynamics of zinc as an angiogenesis inhibitor. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Manu Kumar Girish Gulab Meshram Tripti Rastogi Sonal Sharma Rachna Gupta Seema Jain Anisha Prasad Vikas Galav SK Bhattacharya Source Type: research

Decreased risk of cholangiocarcinoma in diabetic patients treated with metformin
Conclusion: The results show a slight decreased risk of cholangiocarcinoma in that scenario. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Pathum Sookaromdee Viroj Wiwanitkit Source Type: research

Inhibition of Ehrlich ascites cancer, hypoxia-inducible factor-1 alpha, and the kinase insert domain-containing receptor/fms-like tyrosine kinase-binding domains of vascular endothelial growth factor by Thiazole Acetamide Derivatives
Conclusion: These results conclude the anticancer and anti-angiogenic property of the synthesized thiazole-acetamide derivatives. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: LN Madhu Sandeep Telkar Divyalaxmi Kamath Melita Evan D. Souza Shama Rao Prakash S Nayak BK Sarojini Source Type: research

Regulation of XPA could play a role in inhibition of radiation-induced bystander effects in QU-DB cells at high doses
Conclusion: Gene expression profile was distinctive in bystander cells compared to target cells. The observed linear increasing of the ratio of XPA/BAX could support the hypothesis that the DNA repair system is stimulated and causes a reduction in RIBE at high doses. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Mohammad Taghi Bahreyni Toossi Hosein Azimian Shokouhozaman Soleymanifard Habibeh Vosoughi Elham Dolat Abdul Rahim Rezaei Sara Khademi Source Type: research

Estimation of cancer risk due to radiation exposure for some daily consumption of foods
Conclusions: The ELCR due to five main daily diets was a little more than the acceptable ELCR limit of 10–3 for radiological risk in general. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Akbar Abbasi Vali Bashiry Source Type: research

The radioprotective effect of melatonin against radiation-induced DNA double-strand breaks in radiology
Conclusion: The present study showed that melatonin will prove effective in radioprotection against ionizing radiation (IR)-induced DNA damage in human lymphocytes. Our results suggest ingestion of 100-mg melatonin by patients before exposure to IR in radiology. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Farid Esmaely Aziz Mahmoudzadeh Mohsen Cheki Alireza Shirazi Source Type: research

Cytopathology-histopathology correlation and the effect of nodule diameter on diagnostic performance in patients undergoing thyroid fine-needle aspiration biopsy
Conclusion: Despite a higher rate of false negativity, FNAB has higher specificity and accuracy in large nodules than those in the small nodules. Nodule diameter should not be used alone as a criterion to recommend thyroidectomy to the patient. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Nusret Yilmaz Guven Baris Cansu Serap Toru Ramazan Sari Guzide Gokhan Ocak Cumhur Arici Hasan Ali Altunbas Mustafa Kemal Balci Source Type: research

Eyelid carcinoma: An experience from a tertiary cancer center
Conclusion: Eyelid tumors are less common cancer with good prognosis if treated appropriately. The morbidity associated with treatment can be reduced if treated early. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Shivakumar Thiagarajan Ameya Bahani Devendra Chaukar Anil K Dcruz Source Type: research

Good prognostic factor in patients with nonmetastatic nasopharyngeal carcinoma: Programmed death ligand-1 expression in tumor cells
Conclusion: PD-L1 expression is an important prognostic factor in NPC. PD-L1 expression positively correlates with survival. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Hayriye Sahinli Nalan Aky & #252;rek Mukaddes Y & #305;lmaz Olcay Kandemir Ay & #351;e Ocak Duran Sezer Kula & #231;o & #487;lu G & #246;khan U & #231;ar Elif Acar Ahmet & #214;zet O Berna & #199;. & #214;ks & #252;zo & #487;lu Nuriye Y & #214;zdemir Source Type: research

Butyrylcholinesterase: An economical marker of disease activity in oral squamous cell carcinoma before and after therapy
Conclusion: BChe can be used as an inexpensive, easy to use, noninvasive biomarker for the evaluation of disease-free survival in OSCC patients. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Shradha Gagan Jaiswal Gagan Rajesh Jaiswal Source Type: research

Predicting outcome of advanced head-and-neck cancer by measuring tumor blood perfusion in patients receiving neoadjuvant chemotherapy
Conclusions: Evaluation of tumor blood flow by perfusion CT is helpful in predicting chemotherapy outcome and deciding appropriate treatment modality, but further evaluation with more number of patients is required for validating the predictive role of each perfusion parameters. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Kishore Singh Rubu Sunku Arun K Rathi Gaurav S Pradhan Source Type: research

The relevance of long noncoding RNAs in colorectal cancer biology and clinical settings
Atefeh Talebi, Mazaher Azizpour, Shahram Agah, Mohsen Masoodi, Gholam Reza Mobini, Abolfazl AkbariJournal of Cancer Research and Therapeutics 2020 16(8):22-33 Colorectal cancer (CRC) is one of the most frequent causes of cancer-related death worldwide. The prognosis of the malignancy and patient survival is commonly poor. Therefore, the discovery of pertinent biomarkers is essential to provide an accurate diagnosis and effective therapy. Newly, a group of noncoding RNAs named long noncoding RNAs (lncRNAs) has been found to involve in CRC development and progression. In this review, we highlighted the biological function o...
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Atefeh Talebi Mazaher Azizpour Shahram Agah Mohsen Masoodi Gholam Reza Mobini Abolfazl Akbari Source Type: research

Thyroid paraganglioma: A case-based systematic review of literature
Pritinanda Mishra, Somanath Padhi, Gayatri BeheraJournal of Cancer Research and Therapeutics 2020 16(8):11-21 Thyroid paragangliomas are distinctly rare primary thyroid neoplasms with nearly 75 cases reported worldwide. Due to their similar embryological origin and cytohistomorphology with other thyroid neoplasms, they may pose great diagnostic challenges for pathologists, radiologists, endocrinologists, as well as surgeons leading to unnecessary aggressive therapy. With recent advances in molecular genetics, the prognostic significance of such seemingly innocuous thyroid neoplasms has been better understood. In this manu...
Source: Journal of Cancer Research and Therapeutics - December 28, 2020 Category: Cancer & Oncology Authors: Pritinanda Mishra Somanath Padhi Gayatri Behera Source Type: research