Cervical mass as the initial manifestation of occult papillary thyroid carcinoma: Report of three cases
We reported the clinical data of patients, including chief complaint, ultrasonography, computed tomography, and pathology results. We attempt to raise awareness regarding this particular disease and as a reference for clinical diagnosis and treatment. Examinations are needed to confirm the diagnosis for occult cancer of the thyroid. Surgical procedure is the major treatment method at present. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Zhao Yongfu Li Ziyu Liu Chen Xu Jingchao Source Type: research

Recurrent fibrosarcoma of maxillary sinus involving the cranial base: A rare case
Lei Jin, Hong-Yu Yang, Yu-Fan Wang, Hui-Jun YangJournal of Cancer Research and Therapeutics 2018 14(9):542-543Adult fibrosarcoma (FS) of the maxillary sinus and the cranial base is a rare soft tissue sarcoma which is clinically characterized by a high frequency of local repeated recurrence if not excised widely. At present, the standard treatment option for FS is surgical resection. Here, we report a case of a 46-year-old male with a 5 months history recurrent FS of the maxillary sinus. The patient possessed an enormous mass in the right maxillofacial region extending to the cranial base, as observed by computed tomography...
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Lei Jin Hong-Yu Yang Yu-Fan Wang Hui-Jun Yang Source Type: research

Surgical treatment of esophageal carcinoma after distal partial gastrectomy: Case report and literature review
The objective of the study was to highlight the significance of surgical treatment for esophageal carcinoma after distal gastrectomy and provide suitable surgical options. A patient with esophageal carcinoma and previous distal partial gastrectomy was treated by replacing the esophagus with remnant stomach and moving the spleen into the thoracic cavity. We then systematically reviewed the literature on the treatment of such conditions. Postoperative recovery went well. During the 2-year follow-up, the patient did not complain any discomfort and had no signs of metastasis or recurrence. For esophageal carcinoma patients who...
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Su Chen Naixiang Huang Source Type: research

Ventricular bigeminal rhythm associated with trastuzumab: A potential cardiac side effect
Mustafa Karaca, Hakan Kocoglu, Irem Bilgetekin, Ahmet Ozet, Hayriye Sahinli, Hacer Demir, Aykut Kankoc, Deniz Tural, Orhan Kemal YucelJournal of Cancer Research and Therapeutics 2018 14(9):536-537Cardiac side effects of targeted chemotherapy agents are getting more and more important topic nowadays. However, the studies on this topic are limited. Because multiple agent chemotherapy is not a common treatment option, it is hard to establish controlled study groups (as before chemotherapy and after chemotherapy); further, cancer, itself, may cause cardiac side effects and uncertainty of the symptoms may be associated with pre...
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Mustafa Karaca Hakan Kocoglu Irem Bilgetekin Ahmet Ozet Hayriye Sahinli Hacer Demir Aykut Kankoc Deniz Tural Orhan Kemal Yucel Source Type: research

Primary pulmonary epithelioid angiosarcoma: A case report and literature review
Ying Zhang, Xiaochun Huang, Chuangliang Peng, Yongbin Wang, Qian Wu, Zhen Wu, Hongyan Shao, Wei WangJournal of Cancer Research and Therapeutics 2018 14(9):533-535Primary pulmonary epithelioid angiosarcoma is an extremely rare malignancy. Herein, we report the case of an elderly Chinese patient with primary pulmonary epithelioid angiosarcoma. The 72-year-old man presented with a 1-month history of persistent hemoptysis and left chest pain and weight loss of 3 kg. A chest computed tomography (CT) scan revealed two masses (maximum size 3.0 cm × 2.0 cm and 0.8 cm × 0.5 cm) in right lower lobe. We performed a left tho...
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Ying Zhang Xiaochun Huang Chuangliang Peng Yongbin Wang Qian Wu Zhen Wu Hongyan Shao Wei Wang Source Type: research

Association of cytotoxic T-lymphocyte antigen 4 rs231775 gene polymorphism with colorectal cancer risk
Conclusion: The association between CTLA4 G allele/AA genotype and colorectal cancer risk was found in this meta-analysis. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Yanli Zhang Suiliang Zhang Wei Xia Zhiyong Dong Source Type: research

Baicalein and Ly294002 induces liver cancer cells apoptosis via regulating phosphatidyl inositol 3-kinase/Akt signaling pathway
Conclusion: Baicalein can inhibit liver cancer cell proliferation and promote cell apoptosis by affecting PI3K/Akt signaling pathway together with LY294002. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Kai He Xiaolan Yu Xiaoyan Wang Li Tang Yong Cao Jiyi Xia Jinnan Cheng Source Type: research

CCND1 rs9344 polymorphism is associated with the risk of hepatocellular carcinoma in Caucasian population
Conclusions: This meta-analysis suggested that CCND1 rs9344 polymorphism might be associated with the risk of HCC among Caucasians. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Da-dong Wang Wei-dong Duan Zi-man Zhu Yu-liang Tu Chun-qing Dou Ming-ming Han Bao Zhang Wei Zhao Kai Jiang Source Type: research

Clinical outcome of 30 patients with bone marrow metastases
Conclusion: To make primary origin clear and start systemic antitumor therapy is beneficial for patients with bone marrow metastases. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Min Hang Zhou Zhi Hong Wang Hong Wei Zhou Mo Liu Yong Jian Gu Jun Zhong Sun Source Type: research

Anti-tumor effects of phenolic alkaloids of menispermum dauricum on gastric cancer in vivo and in vitro
Conclusions: PAMD could suppress gastric tumor growth in vivo, possibly through increasing the expression of pro-apoptotic genes expression then leading to cell apoptosis and inhibiting oncogenic K-RAS expression. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Di Wu Jiankuo Du Yan Zhang Yunming Su Hongfeng Zhang Source Type: research

Association between Kr & #252;ppel like factor 6 intervening sequence 1-27 G & #62; A and cancer susceptibility: A meta-analysis
Conclusions: KLF6 IVS 1-27 G > A may not be associated with cancer susceptibility, especially the susceptibility of unselected prostate cancer. However, there was insufficient data to fully confirm the association between KLF6 IVS 1-27 G > A and familial prostate cancer, sporadic prostate cancer, gastric cancer, and cancers from different ethnicity, and the results should be interpreted with caution. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Jiaxuan Qin Fanping Meng Zhilin Chu Xinquan Gu Source Type: research

The expression of insulin receptor substrate 1 and estrogen receptor as prognostic factor on breast cancer patient
Conclusion: ER and IRS-1 subgroups appear to be critical factors for the prediction of breast cancer recurrence. In particular, we suggest that the patients who have ER-positive and IRS-1-negative breast cancer undergo more aggressive treatment because they have poorer prognoses. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Hyun Goo Kim Sang Uk Woo Hoon Yub Kim Gil Soo Son Jae Bok Lee Jeong Won Bae Ok Hee Woo Dae Sik Yang Jae Hong Seo Ae-Ree Kim Source Type: research

MiR-499 rs3746444 polymorphism and hepatocellular carcinoma risk: A meta-analysis
Conclusions: This meta-analysis suggested that mir-499 rs3746444 polymorphism was associated with an increased HCC risk. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Dapeng Qiu Feng Han Hao Zhuang Source Type: research

Clinical significance and association of GSTP1 hypermethylation with hepatocellular carcinoma: A meta-analysis
Conclusions: The results of this meta-analysis suggest that GSTP1 hypermethylation induces the inactivation of GSTP1 gene, plays an important role in hepatocarcinogenesis, and is associated with an increased risk of HCC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Yang Li Yihong Cai He Chen Leijin Mao Source Type: research

Imbalance of T-helper 1/T-helper 2 cytokines and impaired glucose tolerance among patient with acute coronary syndrome
Conclusion: Shifts in the balance of Th1/Th2 toward a predominance of Th1 may represent more severe inflammatory status in ACS patients with type T2D or IGT. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Shao-Li Zhao Zhao-Hui Mo Hong-Hui He Li-Ling Zhao Yan-Hong Xie Source Type: research

Modulation of the gamma-secretase activity as a therapy against human hepatocellular carcinoma
Conclusion: GSIs may be appealing candidates for the development of new therapies against HCC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Yuqing Shen Ying Yin Yaqin Peng Dan Lv Fengqin Miao Fei Dou Jianqiong Zhang Source Type: research

Does serum alkaline phosphatase level really indicate the prognosis in patients with osteosarcoma ? A meta-analysis
Conclusion: This meta-analysis suggests that high serum ALP level is obviously associated with lower OS rate in patients with osteosarcoma, and it is an effective biomarker of prognosis. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Rui Gu Yifu Sun Source Type: research

Association of CYP3A5 & #42;3 polymorphisms and prostate cancer risk: A meta-analysis
Conclusion: Our data support that the CYP3A5*3 polymorphism may be associated with increased risk of prostate cancer, particularly in African populations. Large and well-designed studies are needed to validate this association. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Ying Liang Wen Han Hongwei Yan Qiqi Mao Source Type: research

Clinical efficiency of repeated pulmonary metastasectomy in sarcoma patients with recurrent pulmonary metastasis: A meta-analysis
Conclusion: Selected sarcoma patients with recurrent pulmonary metastasis following the first pulmonary metastasectomy could still benefit from RPM, despite its unfavorable aspects. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Yongjiang Li Wenbiao Zhang Shuangjiang Li Chongqi Tu Source Type: research

Evaluation of the relationship of erythrocyte membrane Na & #43;/K & #43;-ATPase enzyme activity and tumor response to chemoradiotherapy in patients diagnosed with locally advanced nonsmall cell lung cancer and glioblastoma multiforme
Conclusion: Levels of Na +/K +-ATPase activity were initially high in patients with NSCLC and GBM, and decreased after the completion of CRT. This supports a linkage between the altered activity of Na +/K +-ATPase and the treatment effects of CRT. The observed change in Na +/K +-ATPase activity in cancer patients receiving CRT suggests that targeting this enzyme could represent a novel mean of combatting NSCLC and GBM. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Cigdem Damla Cetinkaya Mehmet Gurbilek Mehmet Koc Source Type: research

Study on early diagnosis of epithelial ovarian cancer by analysis of plasma septin-9 and clusterin level
Conclusion: The plasma levels of septin-9 and clusterin in ovarian cancer patients were abnormally elevated, which might be used as potential candidates of peripheral blood tumor biomarkers for early diagnosis of EOC and septin-9 might be related to distal metastases of EOC. The septin-9 might play the promotion role, which protein level relates to not only the distal metastases but also the prognosis of EOC. Due to the limit of sample volume, further enlargement of the sample size and set up of the follow-up system is in need to in-depth study the relationship between plasma protein concentration with the distal metastase...
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Nenan Lyu Yinuo Wang Jianhua Wang Zhenyu Zhang Weimin Kong Source Type: research

Low molecular weight heparin in treating patients with lung cancer received chemotherapy: A meta-analysis
Conclusion: LMWH improves the 1- and 2-year OS rates of the patients with lung cancer received chemotherapy and reduces the incidence of VTE, not increase the incidence of major bleeding events and thrombocytopenia. These show that there is a certain effect of LMWH, and the security is good. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Zi-Li Liu Qian Wang Ming Wang Bin Wang Li-Nian Huang Source Type: research

Serum B7 homologous body 4 for the diagnosis of ovarian cancer in Chinese Han women: A meta-analysis
Conclusion: Serum B7-H4 detection, either alone or in combination with carbohydrate antigen 125, has an acceptable value in the diagnosis of OC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Zhu Lan Dan Fu Mingrong Xi Source Type: research

Retrospective analysis on the efficacy of sunitinib/sorafenib in combination with dendritic cells-cytokine-induced killer in metastasis renal cell carcinoma after radical nephrectomy
Conclusions: SU/SO with DC-CIK could significantly prolong the median PFS, improve the 3-year OS rate, prolong the 3-year OS. It is likely to be a new approach for mRCC after radical nephrectomy. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Hai-Xing Mai Guo-Hui Mei Fei-Long Zhao Bo-Tao Li Yong-Yong Tang Bin Zhang Xiao-Jie Xu Li-Jun Chen Source Type: research

A modified method by differential adhesion and serum-free culture medium for enrichment of cancer stem cells
Conclusion: Trypsin-resistant cells showed specific CSCs characterizations. They were able to be isolated successfully with a modified method by a combination of differential adhesion method and SFM method. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Yong-Tong Zhu Chun-Yan Wang Shi-Yu Pang Cheng-Yong Lei Yang Luo Wan-Long Tan Source Type: research

Positron imaging for verification of irradiation field during radiotherapy
Conclusions: The factors influencing the half-life of radiation activity in various tissues were different from the first order kinetic reaction in physics. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Wen-Yong Tu Zhi-Yuan Zhang Zeng Jun Xuan-Li Xu Ji-Ping Ding Ji-Hui Su Zi-Mu Chen Source Type: research

Patterns of care of nonsmall cell lung cancer patients in China and implications for survival
Conclusions: Despite the benefits of anti-cancer treatments confirmed in this study, over a quarter patients did not receive any such treatment. Finding the reasons for the patients who did not receive cancer-specific treatment may improve the quality of patient care in this population. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Yutong He Xue Qin Yu Qingwei Luo Xiaoli Xu Yudong Wang Shumei Li Baoen Shan Source Type: research

Role of taurine upregulated gene 1 as a predictor of poor outcome in osteosarcoma
Conclusions: In conclusion, our data support TUG1 as a potential prognostic predictor and gene therapy target with its high expression in tumor tissues and its association with carcinogenesis and progression in osteosarcoma. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Qunli Wang Qi Chen Source Type: research

Diagnostic value of CYFRA 21-1 and carcinoembryonic antigen in diagnosis of operable lung cancer from benign lung disease
Conclusion: Our results indicate that the combination of these two tumor markers resulted in higher sensitivity compared to use CYFRA 21-1 or CEA along. Given its lower sensitivity and higher specificity, positive CYFRA 21-1 or positive CEA strongly supports lung cancer in patients with nodular shadow in imaging scan. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Feng Chen Jia Li Xin Qi Jun Qi Source Type: research

Gemstone spectral imaging dual-energy computed tomography for differentiation of renal cell carcinoma and minimal-fat renal angiomyolipoma
Conclusion: GSI-DECT has provided a new idea and method for differential diagnosis of ischemic RCC and MF-RAML, with high-clinical values. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Yamin Wan Hua Guo Lijuan Ji Zhizhen Li Jianbo Gao Source Type: research

Longan flower proanthocyanidins induce apoptosis in HT-29 colorectal carcinoma spheroids
Conclusion: The ability of LFP to induce apoptosis in CRC spheroids warrants further investigation of its composition and identification of tumor-active components. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Yuan-Chiang Chung Hua-Che Chiang Hsiang Chang Chih-Cheng Lin Li-Tsai Lo Ai-Yih Wang Kuo-Feng Chou Chih-Ping Hsu Source Type: research

Promoter methylation of WNT inhibitory factor-1 may be associated with the pathogenesis of multiple human tumors
Conclusion: WIF-1 gene methylation in tumor tissues was significantly more frequent as compared to that in adjacent normal tissues, indicating that WIF-1 gene methylation may be an important event in the pathogenesis of multiple human tumors. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Yong Zhou Zhaohua Li Yinlu Ding Peng Zhang Jinqing Wang Jianliang Zhang Hao Wang Source Type: research

Relationship between angiotensin-converting enzyme insertion/deletion gene polymorphism and prostate cancer susceptibility
Conclusions: There was an association between ACE I/D gene polymorphism and prostate cancer risk for the Asians and Latino population in this meta-analysis. However, more investigations should be performed to confirm this relationship. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Zhong-Yang Wang Hong-Yan Li Zong-Pei Jiang Tian-Biao Zhou Source Type: research

Breast cancer metastasis suppressor gene, breast cancer metastasis suppressor 1, may be associated with clinicopathological features of breast cancer
Conclusion: Our meta-analysis results showed that reduced BRMS1 expression level was significantly associated with clinicopathological features of breast cancer, suggesting that loss of expression or reduced levels of BRMS1 might be a strong indicator of the metastatic capacity of breast cancer, with poor prognosis. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Lizhong Lin Miaoguo Cai Yuechu Dai Zhibao Zheng Fangfang Jiang Lili Shi Yin Pan Han-Bing Song Source Type: research

Serum paraoxonase and arylesterase can be useful markers to predict neoadjuvant chemotherapy requirement in patients with breast cancer
Conclusion: BC patients have lower serum PON and ARE levels than healthy controls. Also, serum ARE levels (but not PON) were negatively correlated with body mass index in BC patients. Both serum PON and ARE levels were lower in patients who needed NAC than in patients who did not need such therapy. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Yildiz Okuturlar Meral Gunaldi Hakan Kocoglu Mehmet Hursitoglu Asuman Gedikbasi Didem Acarer Ozlem Harmankaya Abdulbaki Kumbasar Source Type: research

Extent of breast cancer type 1 promoter methylation correlates with clinicopathological features in breast cancers
Conclusions: Our meta-analysis revealed that BRCA1 promoter methylation status is linked to tumor grade and LN metastasis of BC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Mei-Yang Sun Xin-Zhong Chang Gui-Ying Xu Yi Dong Zi-Jun Zhou Tao Liu Chang-Qing Wang Yong-Shuang Li Source Type: research

Keratinocyte growth factor binding to fibroblast growth factor receptor 2-IIIb promotes epithelial ovarian cancer cell proliferation and invasion
Conclusions: These results suggest that KGF might play an important role in the progression of ovarian cancer and could be an attractive target for ovarian cancer therapy. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Jun Wu Wei Han Weiwei Yang Hongyu Liu Chunhong Li Ling Guo Yan Jin Ruijie Zhang He Chen Source Type: research

The more potential performance of nidogen 2 methylation by tissue or plasma DNA over brichoalveolar lavage DNA in diagnosis of nonsmall cell lung cancer
Conclusions: Our study revealed the frequent occurrence of aberrant NID2 methylation in NSCLC and peripheral blood, which might be useful as a biomarker to predict NSCLC or to screen the high-risk population for NSCLC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Xu Feng Xiaoyong Xie Baoshi Zheng Chaoyang Peng Huafu Zhou Jiajin Qin Source Type: research

Clinical evaluation of potential usefulness of serum lactate dehydrogenase level in follow-up of small cell lung cancer
Conclusions: LDH is validated for its potential usefulness as markers for monitoring treatment response in SCLC and also suitable for discriminating between disease and disease-free periods. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Cheng Chen Ye-Han Zhu Jian-An Huang Source Type: research

The detection and significance of T cells in nasopharyngeal carcinoma patients
Conclusions: Our research determines the changes of T cell subsets in different stages of NPC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Man Chen Feng Jin Li Ma Source Type: research

Synergistic effect of thymoquinone and melatonin against breast cancer implanted in mice
Conclusions: The combination TQ and MLT act synergistically to inhibit breast cancer implanted in mice. The anticancer effect of this combination is mediated by induction of apoptosis, angiogenesis inhibition, and activation of T helper 1 anticancer immune response. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Lena Hisham Odeh Wamidh H Talib Iman A Basheti Source Type: research

Ultrasonography is valuable in evaluation of papillary thyroid microcarcinoma based on 5 mm tumor size
Conclusion: Larger tumor size of PTMC is more likely to involve in lymph node metastasis and advanced TNM stage. Correlation of tumor size with calcification, peripheral halo, vascularity, and blood supply do exist in PTMC. Ultrasound is of great value in the evaluation of PTMC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Shujun Xia Yijie Dong Huili Kang Weiwei Zhan Source Type: research

Human epidermal growth factor receptor 2 expressions and Janus-activated kinase/signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway may be associated with clinicopathological features and prognosis of gastric cancer
Conclusion: Our study revealed that HER-2 may participates in the development, invasion and metastasis of GC by affecting the JAK/STAT3 pathway. HER-2, STAT3, and SOCS3 serve as reference indexes for the prognosis of GC patients. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Wenjing Xu Jingwei Fu Hao Wu Weijian Sun Source Type: research

Peroxisome proliferators-activated receptor gamma polymorphisms and colorectal cancer risk
Conclusions: PPARγ Pro12Ala and His477His polymorphisms might be associated with susceptibility of CRC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Xuemin Liang Xiaohua Fan Kanglian Tan Li Zhang Lisi Jian Linchong Yu Source Type: research

Association between polymorphisms of interleukin-17A G197A and interleukin-17F A7488G and risk of colorectal cancer
Conclusion: This report from Malaysia shows the relationship of IL-17A197AA genotype with susceptibility to CRC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Golnaz Samiei Wai Kien Yip Pooi Pooi Leong Mohd Faisal Jabar Noraini Mohd Dusa Norhafizah Mohtarrudin Heng Fong Seow Source Type: research

Expression of microRNAs-106b in nonsmall cell lung cancer
Conclusions: These data suggest that aberrantly expressed miRNA-106b may contribute to the development of NSCLC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Yuan Li Jing Tian Zi-Jian Guo Zhu-Bo Zhang Chang-Yan Xiao Xiao-Chun Wang Source Type: research

The total number of lymph nodes harvested from pathological T3N0 rectal cancer patients: Prognostic significance and potential indication for postoperative radiotherapy
Conclusions: The number of lymph nodes harvested was independently associated with local relapse, treatment failure, and OS rates in pT3N0 rectal cancer patients who received initial TME with or without postoperative chemotherapy. Postoperative radiotherapy should not be omitted for pT3N0 rectal cancer patients who had <12 lymph nodes harvested. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Wei-Wei Xiao Lu-Ning Zhang Kai-Yun You Rong Huang Xin Yu Hui Chang Pei-Rong Ding Yuan-Hong Gao Source Type: research

Myeloperoxidase -463 G/A polymorphism is associated with lung cancer risk: A meta-analysis with 7420 cases and 9132 controls
Conclusion: The present meta-analysis suggested that the MPO -463 G/A polymorphism carriers had a protective role in lung cancer. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Shengqiang Zou Xin Pan Changsong Hua Min Wu Bin He Zhigang Chen Source Type: research

The effect of TGF- & #946; signaling on regulating proliferation of uterine leiomyoma cell via ER & #945; signaling activated by bisphenol A, octylphenol and nonylphenol in vitro
Conclusion: Both ERα signaling pathway and TGF-β signaling pathway have different roles in governing UL cell proliferation. The phenolic EEs can be a promoter to the proliferation of UL cells, which is mediated by ERα signaling pathway and cross-talked with TGF-β signaling pathway. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Yang Shen Qing Lu Peili Zhang Yanting Wu Mulan Ren Source Type: research

Triptolide: A new star for treating human malignancies
Ping Yan, Xiaotian SunJournal of Cancer Research and Therapeutics 2018 14(9):271-275 In recent years, cancer has become the most common human disease worldwide, and great attentions have been paid to clarifying the carcinogenesis and identifying new effective antitumor therapy. Although great progress has been made in this research field, human malignant diseases could still not be radically cured. Thunder god vine is a herbal medicine, which has proved to exert efficient antitumor activity in various human cancers such as lung cancer, pancreatic cancer, and colon cancer. In vivo and in vitro experiments showed that thund...
Source: Journal of Cancer Research and Therapeutics - June 29, 2018 Category: Cancer & Oncology Authors: Ping Yan Xiaotian Sun Source Type: research