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Afatinib treatment in a lung adenocarcinoma patient harboring a rare EGFR L747P mutation
Jisheng Li, Liping Zhu, Justin Stebbing, Ling PengJournal of Cancer Research and Therapeutics 2022 18(5):1436-1439 Classical activating alterations including exon 19 deletions and exon 21 L858R point mutations comprise the majority of epidermal growth factor receptor (EGFR) changes in non-small cell lung cancer. Patients with these exhibit excellent clinical responses to EGFR tyrosine kinase inhibitors (TKIs). However, rare alterations including point mutations, deletions, and insertions occur and are associated with poorer responses to EGFR TKIs. Herein, we report an unusual case of a patient with lung adenocarcinoma wit...
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Jisheng Li Liping Zhu Justin Stebbing Ling Peng Source Type: research

Bronchial artery chemoembolization with apatinib for treatment of central lung squamous cell carcinoma
Conclusion: BACE combined with apatinib is effective for treatment of advanced central LSCC, with definite short-term efficacy, controllable risk, and high safety. Investigation with a larger sample size is warranted to confirm study results. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Jun Zhu Xiaoqian Xu Yaoyong Chen Qiang Wang Quanji Yue Kaijian Lei Yuming Jia Guo Xiao Guohui Xu Source Type: research

Efficacy, safety, and prognostic factors of apatinib plus platinum doublet chemotherapy in advanced non-small cell lung cancer
Conclusion: Apatinib plus platinum doublet chemotherapy is effective and well-tolerated in treating patients with advanced NSCLC; moreover, reduced ECOG PS and lower lines of treatment relate to its better efficacy. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Jianping Xu Xiaoyan Liu Sheng Yang Yuankai Shi Source Type: research

Relationship of vitamin D intake, serum 25(OH) D, and solar ultraviolet-B radiation with the risk of gastric cancer: A meta-analysis
Xia Chen, Longquan Li, Yuan Liang, Taobi Huang, Huiyun Zhang, Shanlin Fan, Weiming Sun, Yuping WangJournal of Cancer Research and Therapeutics 2022 18(5):1417-1424 The purpose of this meta-analysis was to investigate whether vitamin D intake, serum 25(OH) D, and solar ultraviolet-B (UVB) radiation have an effect on the incidence of gastric cancer. Keyword searches of online databases were performed from January 2000 to October 2020. A comprehensive analysis was conducted on the relationship of vitamin D intake, serum 25(OH) D level, and UVB radiation with the risk of gastric cancer. A total of 11 articles were included an...
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Xia Chen Longquan Li Yuan Liang Taobi Huang Huiyun Zhang Shanlin Fan Weiming Sun Yuping Wang Source Type: research

A novel targeted iron oxide nanocarrier for inhibiting M2-type macrophages in the tumor microenvironment
Conclusions: The targeted nanocomplex AS1517499-USPION-CD163 showed high selectivity for M2-type macrophages. Therefore, iron oxide nanoparticles targeting TAMs may be an effective approach to TAM therapy. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Kaixuan Tian Ruiqing Feng Xiaoqing Wang Xiangyu Wu Long Li Wei Liu Rongde Wu Source Type: research

Analysis of antitumor immunity in mouse glioma microenvironment through intercellular communication
Conclusions: We described the previously underestimated complex communication between infiltrating T cells and brain cell populations. Our data suggest that the tolerogenic property of glioma TME is related to the immune privilege of CNS. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Yan Zhang Fenghua Lu Nannan Cai Lanjing Tang Yao Zhou Yalin Li Kai Liu Wengang Song Li Kang Hao He Source Type: research

Microwave ablation combined with I125 seed implantation for treatment of residual lesions of liver cancer after TACE
Conclusions: MWA combined with I125 seed implantation for the treatment of post-TACE residual lesions of primary liver cancer is safe and effective, and its efficacy is better than that of the simple MWA treatment. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Hao Zhang Jiajia Wang Wei Li Shifeng Liu Zixiang Li Xiaokun Hu Source Type: research

Surgical resection of chemotherapy-insensitive pulmonary metastases in children with hepatoblastoma in China: A single-center experience
Conclusion: In this pediatric group, patients with residual nodules after chemotherapy of HB could benefit from surgical treatment, but the appropriate surgical indication of metastasectomy needs to be further investigated. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Huawei Xie Gang Liu Zhou Shen Guodong Xing Qiao Xia Xianqiang Wang Liuming Huang Source Type: research

Hydrogen gas promotes apoptosis of lung adenocarcinoma A549 cells through X-linked inhibitor of apoptosis and baculoviral inhibitor of apoptosis protein repeat-containing 3
Conclusion: Hydrogen gas promoted apoptosis of A549 cells by reducing the expression of XIAP and BIRC3 protein. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Yu Zhang Gang Chen Zhenfeng Yan Lifei Wang Dongchang Wang Source Type: research

Delta and Notch-like epidermal growth factor-related receptor suppresses human glioma growth by inhibiting oncogene TOR4A
This study was performed to elucidate the specific mechanism by which DNER inhibits human glioma growth. RNA sequencing was used to detect differentially expressed genes after DNER inhibition in glioma cells. The functions of the Torsin family 4 member A (TOR4A) gene were explored through cell proliferation and clonogenic assays, flow cytometric analysis, in vitro cell migration and invasion assays, in vivo glioma transplantation, and human glioma tissue analysis using the Chinese Glioma Genome Atlas database. Protein expression levels were determined using the western blot assay. We found that TOR4A was highly expressed a...
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Qun Wang Yaqiong Li Jiamei Li Zhigang Yao Xiaochun Ma Ji-wei Ma Source Type: research

Correlation analysis of body image level and female sexual dysfunction in young patients with postoperative breast cancer
Conclusion: There is a negative correlation between the body image level and the prevalence of FSD in young patients with postoperative breast cancer. This suggests that clinical medical workers should develop an intervention plan to improve the body image level of postoperative young breast cancer patients according to the unique physiological and psychological characteristics of these patients while also reducing the prevalence of FSD. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Hua Du Chen Chen Fangzhen Yuan Anni Hu Jiangying Han Source Type: research

Risk factors of secondary infection/recurrence after ablation for liver cancers: A systemic review and meta-analysis
Conclusion: Our results indicated that the tumor size and location, number of tumor nodules, HBV DNA levels, serum AFP levels and serum albumin levels, Child-Pugh Class, and lack of antiviral therapy were the risk factors for post-ablation infection/recurrence in patients with liver cancer. Here, we have provided directions for the clinical prevention of secondary infection/recurrence in patients with liver cancer who underwent ablation therapy. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Gang Yin Nengwei Zhang AMin BuHe Wei Yan Tianxiong Li Jirun Peng Source Type: research

Delayed biopsy following completion of transarterial chemoembolization in patients with hepatocellular carcinoma: Effects on pathological outcomes and its advantages
Conclusion: In patients with HCC, delayed biopsy following completion of TACE did not affect pathological diagnosis results and yielded better embolization outcomes. Therefore, delayed biopsy following completion of TACE in patients with HCC is worth popularizing for clinical use. However, with the development of precision medicine, the diagnosis and treatment of tumor will certainly advance to the molecular level, whether the ischemic and oxygen-deficient tumor microenvironment caused by TACE treatment will have an impact on tumor tissue at molecular level remains unknown. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Weihua Zhi Jie Hou Shupeng Fan Yue Han Source Type: research

Circ-CCS enhances autophagy during imatinib resistance of gastrointestinal stromal tumor by regulating miR-197-3p/ATG10 signaling
Conclusions: By modulating the miR-197-3p/ATG10 axis, circ-CCS increased imatinib resistance in GIST cells, establishing a potential target for reversing medication resistance in such patients. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Shujing Sui Fei Ma Lei Mi Li Gao Wei Yu Ming Li Zhi Feng Yan Huang Qingcai Wang Source Type: research

Effects of the CRYAB gene on stem cell-like properties of colorectal cancer and its mechanism
Conclusions: CRYAB maintains CSC formation via the Wnt/β-catenin pathway in CRCs, which may, therefore, function as vital molecular targets for CRC therapeutic strategies. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 27, 2022 Category: Cancer & Oncology Authors: Ang Dai Xiaohong Guo Xiaoqing Yang Min Li Yanxin Fu Qing Sun Source Type: research